儿童睡眠障碍的研究进展_Journal of Epilepsy

Authors：

侯芬莲 ¹ , 陈蓓蓓 ² , 张文娟 ² ,  刘永红 ²

1. ;
2. ;

Corresponding author：

刘永红, Email: liuredred@163.com

Keywords：

睡眠障碍; 失眠; 异态睡眠; 发作性睡病

DOI：

10.7507/2096-0247.20170082

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

睡眠障碍是儿童神经科常见的问题，可单独发生或伴随其他神经疾病发生。睡眠障碍对儿童在认知、情绪、社会发展和行为表现等多方面造成损害。但是，一直以来，神经科医师对儿童睡眠障碍的认识相对较少，也缺乏睡眠评估和诊治的能力。失眠是儿科最常见的睡眠障碍，慢性睡眠障碍导致患儿白天出现精神行为异常及认知功能障碍，睡眠日记是诊断失眠的有力工具，行为咨询是儿童失眠管理的基础，认知行为治疗是治疗失眠的有效方法。异态睡眠和发作性睡病可能被误诊为癫痫发作等其他神经科疾病，导致不能得到及时有效的生活管理，出现不适当的药物暴露。文章着重介绍儿童失眠、异态睡眠和发作性睡病相应的临床表现、病理生理、诊断、治疗及研究现状，以期帮助神经科医生在诊治存在睡眠障碍的儿童过程中，准确诊断、提高对睡眠症状的评估及干预水平，优化疾病管理，改善患儿的睡眠状况，缓解家庭压力及照顾者的负担。

Citation： 侯芬莲, 陈蓓蓓, 张文娟, 刘永红. 儿童睡眠障碍的研究进展. Journal of Epilepsy, 2017, 3(6): 509-514. doi: 10.7507/2096-0247.20170082 Copy

1.	Liu X, Zhao Z, Jia C.Insomnia symptoms, behavioral/emotional problems, and suicidality among adolescents of insomniac and non-insomniac parents.Psychiatry Res, 2015, 228(3): 797-802.
2.	Becker SP, Langberg JM, Evans SW.Sleep problems predict comorbid externalizing behaviors and depression in young adolescents with attention-deficit/hyperactivity disorder.Eur Child Adolesc Psychiatry, 2015, 24(8): 897-907.
3.	Gujar N, Yoo SS, Hu P, et al. Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences.J Neurosci, 2011, 31(12): 4466-4474.
4.	Baglioni C, Spiegelhalder K, Regen W, et al. Insomnia disorder is associated with increased amygdala reactivity to insomnia-related stimuli.Sleep, 2014, 37(12): 1907-1917.
5.	Wilhelm I, Diekelmann S, Born J.Sleep in children improves memory performance on declarative but not procedural tasks.Learn Mem, 2008, 15(5): 373-377.
6.	Prehn-Kristensen A, Munz M, Molzow I, et al. Sleep promotes consolidation of emotional memory in healthy children but not in children with attention-deficit hyperactivity disorder.PLoS One, 2013, 8(5): e65098.
7.	Riemann D, Spiegelhalder K, Feige B, et al. The hyperarousal model of insomnia: a review of the concept and its evidence.Sleep Med Rev, 2010, 14(1): 19-31.
8.	Riedner BA, Goldstein MR, Plante DT, et al. Regional patterns of elevated alpha and high-frequency electroencephalographic activity during nonrapid eye movement sleep in chronic insomnia: a pilot study.Sleep, 2016, 39(4): 801-812.
9.	Tordjman S, Anderson GM, Kermarrec S, et al. Altered circadian patterns of salivary cortisol in low-functioning children and adolescents with autism.Psychoneuroendocrinology, 2014, 50(12): 227-245.
10.	Tordjman S, Anderson GM, Pichard N, et al. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder.Biol Psychiatry, 2005, 57(2): 134-138.
11.	Malow BA, Adkins KW, Reynolds A, et al. Parent-based sleep education for children with autism spectrum disorders.J Autism Dev Disord 2014, 44(1): 216-228.
12.	Taibi DM, Landis CA, Vitiello MV.Concordance of polysomnographic and actigraphic measurement of sleep and wake in older women with insomnia.J Clin Sleep Med, 2013, 9(3): 217-225.
13.	Meltzer LJ, Mindell JA.Systematic review and meta-analysis of behavioral interventions for pediatric insomnia.J Pediatr Psychol, 2014, 39(8): 932-948.
14.	de Bruin EJ, Bogels SM, Oort FJ, et al. Efficacy of cognitive behavioral therapy for insomnia in adolescents: a randomized controlled trial with internet therapy, group therapy and a waiting list condition.Sleep, 2015, 38(12): 1913-1926.
15.	Morin CM, Bootzin RR, Buysse DJ, et al. Psychological and behavioral treatment of insomnia: update of the recent evidence (1998-2004).Sleep, 2006, 29(11): 1398-1414.
16.	Rossignol DA, Frye RE.Melatonin in autism spectrum disorders: a systematic review and meta-analysis.Dev Med Child Neurol 2011, 53(9): 783-792.
17.	Petit D, Touchette E, Tremblay RE, et al. Dyssomnias and parasomnias in early childhood.Pediatrics, 2007, 119(5): 1016-1025.
18.	Petit D, Pennestri MH, Paquet J, et al. Childhood sleepwalking and sleep terrors: a longitudinal study of prevalence and familial aggregation.JAMA Pediatr, 2015, 169(7): 653-658.
19.	Terzano MG, Parrino L.Origin and significance of the cyclic alternating pattern (cap).Review article.Sleep Med Rev, 2000, 4(1): 101-123.
20.	Horvath A, Papp A, Szucs A.Progress in elucidating the pathophysiological basis of nonrapid eye movement parasomnias: not yet informing therapeutic strategies.Nat Sci Sleep, 2016, 8: 73-79.
21.	Bassetti C, Vella S, Donati F, et al. SPECT during sleepwalking.Lancet, 2000, 356(9228): 484-485.
22.	Dang-Vu TT, Zadra A, Labelle MA, et al. Sleep deprivation reveals altered brain perfusion patterns in somnambulism.PLoS One, 2015, 10(8): e0133474.
23.	Licis AK, Desruisseau DM, Yamada KA, et al. Novel genetic findings in an extended family pedigree with sleepwalking.Neurology, 2011, 76(1): 49-52.
24.	Manni R, Terzaghi M.Comorbidity between epilepsy and sleep disorders.Epilepsy Res, 2010, 90(3): 171-177.
25.	Parisi P, Bruni O, Pia Villa M, et al. The relationship between sleep and epilepsy: the effect on cognitive functioning in children.Dev Med Child Neurol, 2010, 52(9): 805-810.
26.	Derry CP, Harvey AS, Walker MC, et al. NREM arousal parasomnias and their distinction from nocturnal frontal lobe epilepsy: a video EEG analysis.Sleep, 2009, 32(12): 1637-1644.
27.	Silber MH, Krahn LE, Olson EJ, et al. The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study.Sleep, 2002, 25(2): 197-202.
28.	Longstreth WT Jr, Koepsell TD, Ton TG, et al. The epidemiology of narcolepsy.Sleep, 2007, 30(1): 13-26.
29.	史亮, 马铁, 白洁, 等.视频脑电图对发作性睡病的诊断(附3例报告)癫痫与神经电生理学杂志, 2015, 24(2): 104-107.
30.	Aran A, Lin L, Nevsimalova S, et al. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset.Sleep, 2009, 32(8): 979-983.
31.	Han F, Lin L, Warby SC, et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China.Ann Neurol, 2011, 70(3): 410-417.
32.	Kornum BR, Pizza F, Knudsen S, et al. Cerebrospinal fl uid cytokine levels in type 1 narcolepsy patients very close to onset.Brain Behav Immun, 2015, 49(5): 54-58.
33.	史亮, 马铁, 刘永红.发作性睡病的临床研究进展.临床神经病学杂志, 2015, 28(5): 394-395.
34.	Han F, Lin L, Li J, et al. TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.Sleep Med, 2012, 13(3): 269-272.
35.	Komum BR, Faraco J, Mignot E.Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain.Curr Opin Neurobiol, 2011, 21(6): 897-903.
36.	Kim SJ, Lyoo IK, Lee YS, et al. Increased GABA levels in medial prefrontal cortex of young adults with narcolepsy.Sleep, 2008, 31(3): 342-347.

1. Liu X, Zhao Z, Jia C.Insomnia symptoms, behavioral/emotional problems, and suicidality among adolescents of insomniac and non-insomniac parents.Psychiatry Res, 2015, 228(3): 797-802.
2. Becker SP, Langberg JM, Evans SW.Sleep problems predict comorbid externalizing behaviors and depression in young adolescents with attention-deficit/hyperactivity disorder.Eur Child Adolesc Psychiatry, 2015, 24(8): 897-907.
3. Gujar N, Yoo SS, Hu P, et al. Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences.J Neurosci, 2011, 31(12): 4466-4474.
4. Baglioni C, Spiegelhalder K, Regen W, et al. Insomnia disorder is associated with increased amygdala reactivity to insomnia-related stimuli.Sleep, 2014, 37(12): 1907-1917.
5. Wilhelm I, Diekelmann S, Born J.Sleep in children improves memory performance on declarative but not procedural tasks.Learn Mem, 2008, 15(5): 373-377.
6. Prehn-Kristensen A, Munz M, Molzow I, et al. Sleep promotes consolidation of emotional memory in healthy children but not in children with attention-deficit hyperactivity disorder.PLoS One, 2013, 8(5): e65098.
7. Riemann D, Spiegelhalder K, Feige B, et al. The hyperarousal model of insomnia: a review of the concept and its evidence.Sleep Med Rev, 2010, 14(1): 19-31.
8. Riedner BA, Goldstein MR, Plante DT, et al. Regional patterns of elevated alpha and high-frequency electroencephalographic activity during nonrapid eye movement sleep in chronic insomnia: a pilot study.Sleep, 2016, 39(4): 801-812.
9. Tordjman S, Anderson GM, Kermarrec S, et al. Altered circadian patterns of salivary cortisol in low-functioning children and adolescents with autism.Psychoneuroendocrinology, 2014, 50(12): 227-245.
10. Tordjman S, Anderson GM, Pichard N, et al. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder.Biol Psychiatry, 2005, 57(2): 134-138.
11. Malow BA, Adkins KW, Reynolds A, et al. Parent-based sleep education for children with autism spectrum disorders.J Autism Dev Disord 2014, 44(1): 216-228.
12. Taibi DM, Landis CA, Vitiello MV.Concordance of polysomnographic and actigraphic measurement of sleep and wake in older women with insomnia.J Clin Sleep Med, 2013, 9(3): 217-225.
13. Meltzer LJ, Mindell JA.Systematic review and meta-analysis of behavioral interventions for pediatric insomnia.J Pediatr Psychol, 2014, 39(8): 932-948.
14. de Bruin EJ, Bogels SM, Oort FJ, et al. Efficacy of cognitive behavioral therapy for insomnia in adolescents: a randomized controlled trial with internet therapy, group therapy and a waiting list condition.Sleep, 2015, 38(12): 1913-1926.
15. Morin CM, Bootzin RR, Buysse DJ, et al. Psychological and behavioral treatment of insomnia: update of the recent evidence (1998-2004).Sleep, 2006, 29(11): 1398-1414.
16. Rossignol DA, Frye RE.Melatonin in autism spectrum disorders: a systematic review and meta-analysis.Dev Med Child Neurol 2011, 53(9): 783-792.
17. Petit D, Touchette E, Tremblay RE, et al. Dyssomnias and parasomnias in early childhood.Pediatrics, 2007, 119(5): 1016-1025.
18. Petit D, Pennestri MH, Paquet J, et al. Childhood sleepwalking and sleep terrors: a longitudinal study of prevalence and familial aggregation.JAMA Pediatr, 2015, 169(7): 653-658.
19. Terzano MG, Parrino L.Origin and significance of the cyclic alternating pattern (cap).Review article.Sleep Med Rev, 2000, 4(1): 101-123.
20. Horvath A, Papp A, Szucs A.Progress in elucidating the pathophysiological basis of nonrapid eye movement parasomnias: not yet informing therapeutic strategies.Nat Sci Sleep, 2016, 8: 73-79.
21. Bassetti C, Vella S, Donati F, et al. SPECT during sleepwalking.Lancet, 2000, 356(9228): 484-485.
22. Dang-Vu TT, Zadra A, Labelle MA, et al. Sleep deprivation reveals altered brain perfusion patterns in somnambulism.PLoS One, 2015, 10(8): e0133474.
23. Licis AK, Desruisseau DM, Yamada KA, et al. Novel genetic findings in an extended family pedigree with sleepwalking.Neurology, 2011, 76(1): 49-52.
24. Manni R, Terzaghi M.Comorbidity between epilepsy and sleep disorders.Epilepsy Res, 2010, 90(3): 171-177.
25. Parisi P, Bruni O, Pia Villa M, et al. The relationship between sleep and epilepsy: the effect on cognitive functioning in children.Dev Med Child Neurol, 2010, 52(9): 805-810.
26. Derry CP, Harvey AS, Walker MC, et al. NREM arousal parasomnias and their distinction from nocturnal frontal lobe epilepsy: a video EEG analysis.Sleep, 2009, 32(12): 1637-1644.
27. Silber MH, Krahn LE, Olson EJ, et al. The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study.Sleep, 2002, 25(2): 197-202.
28. Longstreth WT Jr, Koepsell TD, Ton TG, et al. The epidemiology of narcolepsy.Sleep, 2007, 30(1): 13-26.
29. 史亮, 马铁, 白洁, 等.视频脑电图对发作性睡病的诊断(附3例报告)癫痫与神经电生理学杂志, 2015, 24(2): 104-107.
30. Aran A, Lin L, Nevsimalova S, et al. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset.Sleep, 2009, 32(8): 979-983.
31. Han F, Lin L, Warby SC, et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China.Ann Neurol, 2011, 70(3): 410-417.
32. Kornum BR, Pizza F, Knudsen S, et al. Cerebrospinal fl uid cytokine levels in type 1 narcolepsy patients very close to onset.Brain Behav Immun, 2015, 49(5): 54-58.
33. 史亮, 马铁, 刘永红.发作性睡病的临床研究进展.临床神经病学杂志, 2015, 28(5): 394-395.
34. Han F, Lin L, Li J, et al. TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.Sleep Med, 2012, 13(3): 269-272.
35. Komum BR, Faraco J, Mignot E.Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain.Curr Opin Neurobiol, 2011, 21(6): 897-903.
36. Kim SJ, Lyoo IK, Lee YS, et al. Increased GABA levels in medial prefrontal cortex of young adults with narcolepsy.Sleep, 2008, 31(3): 342-347.

Previous Article
癫痫与阻塞性睡眠呼吸暂停综合征的关系
Next Article
人类疱疹病毒6与难治性癫痫相关性的研究进展

Journal of Epilepsy

儿童睡眠障碍的研究进展

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content