癫痫与阻塞性睡眠呼吸暂停综合征的关系_Journal of Epilepsy

Authors：

刘涵 ,  肖争

重庆医科大学附属第一医院神经内科(重庆400010);

Corresponding author：

肖争, Email: xiaozhenghf@126.com

Keywords：

癫痫; 阻塞性睡眠呼吸暂停综合征; 流行病学; 危险因素

DOI：

10.7507/2096-0247.20170081

Video：

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癫痫是多种原因导致的脑部神经元高度同步化异常放电所致的临床综合征，其病因复杂，发病率高，对患者日常生活影响大。睡眠占人生1/3的时间，是维持机体健康必不可少的生理过程。研究发现睡眠障碍与癫痫关系密切，文章选取睡眠障碍中发病率较高的阻塞性睡眠呼吸暂停综合征，从流行病学、病理生理联系、危险因素及治疗方面综述二者的关系。

Citation： 刘涵, 肖争. 癫痫与阻塞性睡眠呼吸暂停综合征的关系. Journal of Epilepsy, 2017, 3(6): 505-508. doi: 10.7507/2096-0247.20170081 Copy

1.	Brooks-Kayal AR, Bath KG, Berg AT, et al. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia, 2013, 54(Suppl4): 44-60.
2.	Schmidt D, Schachter SC. Drug treatment of epilepsy in adults. BMJ, 2014, 348: g254.
3.	Malow BA, Levy K, Maturen K, et al. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology, 2000, 55(7): 1002-1007.
4.	Devinsky O, Ehrenberg B, Barthlen GM, et al. Epilepsy and sleep apnea syndrome. Neurology, 1994, 44(11): 2060-2064.
5.	Vaughn BV, D'Cruz OF, Beach R, et al. Improvement of epileptic seizure control with treatment of obstructive sleep apnoea. Seizure, 1996, 5(1): 73-78.
6.	Manni R, Terzaghi M. Comorbidity between epilepsy and sleep disorders. Epilepsy Res, 2010, 90(3): 171-177.
7.	Beran RG, Plunkett MJ, Holland GJ. Interface of epilepsy and sleep disorders. Seizure, 1999, 8(2): 97-102.
8.	Frucht MM, Quigg M, Schwaner C, et al. Distribution of seizure precipitants among epilepsy syndromes. Epilepsia, 2000, 41(12): 1534-1539.
9.	Hrncic D, Grubac Z, Rasic-Markovic A, et al. Sleep disruption increases seizure susceptibility: behavioral and EEG evaluation of an experimental model of sleep apnea. Physiol Behav, 2016, 155: 188-194.
10.	Jenssen S, Gracely E, Mahmood T, et al. Subjective somnolence relates mainly to depression among patients in a tertiary care epilepsy center. Epilepsy Behav, 2006, 9(4): 632-635.
11.	Piperidou C, Karlovasitou A, Triantafyllou N, et al. Influence of sleep disturbance on quality of life of patients with epilepsy. Seizure, 2008, 17(7): 588-594.
12.	Rosenzweig I, Glasser M, Polsek D, et al. Sleep apnoea and the brain: a complex relationship. Lancet Respir Med, 2015, 3(5): 404-414.
13.	Vaughn BV, D'Cruz OF. Obstructive sleep apnea in epilepsy. Clin Chest Med, 2003, 24(2): 239-248.
14.	Malow BA, Foldvary-Schaefer N, Vaughn BV, et al. Treating obstructive sleep apnea in adults with epilepsy: a randomized pilot trial. Neurology, 2008, 71(8): 572-577.
15.	Hauser WA, Annegers JF, Kurland LT. Prevalence of epilepsy in Rochester, Minnesota: 1940-1980. Epilepsia, 1991, 32(4): 429-445.
16.	Gibson GJ. Obstructive sleep apnoea syndrome: underestimated and undertreated. Br Med Bull, 2004, 72: 49-65.
17.	Partinen M, Telakivi T. Epidemiology of obstructive sleep apnea syndrome. Sleep, 1992, 15(6 Suppl): 1-4.
18.	Escourrou P, Luriau S, Rehel M, et al. Needs and costs of sleep monitoring. Stud Health Technol Inform, 2000, 78: 69-85.
19.	Li P, Ghadersohi S, Jafari B, et al. Characteristics of refractory vs. medically controlled epilepsy patients with obstructive sleep apnea and their response to CPAP treatment. Seizure, 2012, 21(9): 717-721.
20.	Maurousset A, De Toffol B, Praline J, et al. High incidence of obstructive sleep apnea syndrome in patients with late-onset epilepsy. Neurophysiol Clin, 2017, 47(1): 55-61.
21.	Jain SV, Simakajornboon S, Shapiro SM, et al. Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta Neurol Scand, 2012, 125(1): e3-e6.
22.	Epstein LJ, Kristo D, Strollo PJ Jr, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med, 2009, 5(3): 263-276.
23.	Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med, 1993, 328(17): 1230-1235.
24.	Marshall NS, Barnes M, Travier N, et al. Continuous positive airway pressure reduces daytime sleepiness in mild to moderate obstructive sleep apnoea: a meta-analysis. Thorax, 2006, 61(5): 430-434.
25.	Escourrou P, Grote L, Penzel T, et al. The diagnostic method has a strong influence on classification of obstructive sleep apnea. J Sleep Res, 2015, 24(6): 730-738.
26.	Dement W, Kleitman N. Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming. Electroencephalogr Clin Neurophysiol, 1957, 9(4): 673-690.
27.	Jouvet M. Electrophysiologic and neuropharmacologic study of the stages of sleep. Actual Pharmacol(Paris), 1965, 18: 109-173.
28.	Ferini-Strambi L, Galbiati A, Marelli S. Sleep microstructure and memory function. Front Neurol, 2013, 4: 159.
29.	Parrino L, Halasz P, Tassinari CA, et al. CAP, epilepsy and motor events during sleep: the unifying role of arousal. Sleep Med Rev, 2006, 10(4): 267-285.
30.	Zucconi M, Oldani A, Smirne S, et al. The macrostructure and microstructure of sleep in patients with autosomal dominant nocturnal frontal lobe epilepsy. J Clin Neurophysiol, 2000, 17(1): 77-86.
31.	Derry CP, Duncan S. Sleep and epilepsy. Epilepsy Behav, 2013, 26(3): 394-404.
32.	De Paolis F, Colizzi E, Milioli G, et al. Effects of antiepileptic treatment on sleep and seizures in nocturnal frontal lobe epilepsy. Sleep Med, 2013, 14(7): 597-604.
33.	Jain SV, Horn PS, Simakajornboon N, et al. Obstructive sleep apnea and primary snoring in children with epilepsy. J Child Neurol, 2013, 28(1): 77-82.
34.	肖淑芬, 陶振峰, 宋琦.表现为癫痫大发作的阻塞性睡眠呼吸暂停综合征.临床误诊误治, 2012, 25(3): 90.
35.	Foldvary-Schaefer N, Andrews ND, Pornsriniyom D, et al. Sleep apnea and epilepsy: who's at risk. Epilepsy Behav, 2012, 25(3): 363-367.
36.	Ness-Abramof R, Apovian CM. Drug-induced weight gain. Drugs today(Barc), 2005, 41(8): 547-555.
37.	Ben-Menachem E. Weight issues for people with epilepsy-a review. Epilepsia, 2007, 48(Suppl 9): 42-45.
38.	Lambert MV, Bird JM. Obstructive sleep apnoea following rapid weight gain secondary to treatment with vigabatrin (Sabril). Seizure, 1997, 6(3): 233-235.
39.	Belcastro V, D'Egidio C, Striano P, et al. Metabolic and endocrine effects of valproic acid chronic treatment. Epilepsy Res, 2013, 107(1-2): 1-8.
40.	Pornsriniyom D, Kim H, Bena J, et al. Effect of positive airway pressure therapy on seizure control in patients with epilepsy and obstructive sleep apnea. Epilepsy Behav, 2014, 37: 270-275.
41.	Vendrame M, Auerbach S, Loddenkemper T, et al. Effect of continuous positive airway pressure treatment on seizure control in patients with obstructive sleep apnea and epilepsy. Epilepsia, 2011, 52(11): e168-e171.
42.	Nguyen-Michel VH, Pallanca O, Navarro V, et al. How are epileptic events linked to obstructive sleep apneas in epilepsy. Seizure, 2015, 24: 121-123.
43.	Miano S, Pelliccia A, Evangelisti M, et al. Role of continuous positive airway pressure therapy on the pathogenesis of sleep-related frontal lobe epilepsy in a child with obstructive sleep apnea syndrome. J Child Neurol, 2008, 23(1): 124-128.

1. Brooks-Kayal AR, Bath KG, Berg AT, et al. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia, 2013, 54(Suppl4): 44-60.
2. Schmidt D, Schachter SC. Drug treatment of epilepsy in adults. BMJ, 2014, 348: g254.
3. Malow BA, Levy K, Maturen K, et al. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology, 2000, 55(7): 1002-1007.
4. Devinsky O, Ehrenberg B, Barthlen GM, et al. Epilepsy and sleep apnea syndrome. Neurology, 1994, 44(11): 2060-2064.
5. Vaughn BV, D'Cruz OF, Beach R, et al. Improvement of epileptic seizure control with treatment of obstructive sleep apnoea. Seizure, 1996, 5(1): 73-78.
6. Manni R, Terzaghi M. Comorbidity between epilepsy and sleep disorders. Epilepsy Res, 2010, 90(3): 171-177.
7. Beran RG, Plunkett MJ, Holland GJ. Interface of epilepsy and sleep disorders. Seizure, 1999, 8(2): 97-102.
8. Frucht MM, Quigg M, Schwaner C, et al. Distribution of seizure precipitants among epilepsy syndromes. Epilepsia, 2000, 41(12): 1534-1539.
9. Hrncic D, Grubac Z, Rasic-Markovic A, et al. Sleep disruption increases seizure susceptibility: behavioral and EEG evaluation of an experimental model of sleep apnea. Physiol Behav, 2016, 155: 188-194.
10. Jenssen S, Gracely E, Mahmood T, et al. Subjective somnolence relates mainly to depression among patients in a tertiary care epilepsy center. Epilepsy Behav, 2006, 9(4): 632-635.
11. Piperidou C, Karlovasitou A, Triantafyllou N, et al. Influence of sleep disturbance on quality of life of patients with epilepsy. Seizure, 2008, 17(7): 588-594.
12. Rosenzweig I, Glasser M, Polsek D, et al. Sleep apnoea and the brain: a complex relationship. Lancet Respir Med, 2015, 3(5): 404-414.
13. Vaughn BV, D'Cruz OF. Obstructive sleep apnea in epilepsy. Clin Chest Med, 2003, 24(2): 239-248.
14. Malow BA, Foldvary-Schaefer N, Vaughn BV, et al. Treating obstructive sleep apnea in adults with epilepsy: a randomized pilot trial. Neurology, 2008, 71(8): 572-577.
15. Hauser WA, Annegers JF, Kurland LT. Prevalence of epilepsy in Rochester, Minnesota: 1940-1980. Epilepsia, 1991, 32(4): 429-445.
16. Gibson GJ. Obstructive sleep apnoea syndrome: underestimated and undertreated. Br Med Bull, 2004, 72: 49-65.
17. Partinen M, Telakivi T. Epidemiology of obstructive sleep apnea syndrome. Sleep, 1992, 15(6 Suppl): 1-4.
18. Escourrou P, Luriau S, Rehel M, et al. Needs and costs of sleep monitoring. Stud Health Technol Inform, 2000, 78: 69-85.
19. Li P, Ghadersohi S, Jafari B, et al. Characteristics of refractory vs. medically controlled epilepsy patients with obstructive sleep apnea and their response to CPAP treatment. Seizure, 2012, 21(9): 717-721.
20. Maurousset A, De Toffol B, Praline J, et al. High incidence of obstructive sleep apnea syndrome in patients with late-onset epilepsy. Neurophysiol Clin, 2017, 47(1): 55-61.
21. Jain SV, Simakajornboon S, Shapiro SM, et al. Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta Neurol Scand, 2012, 125(1): e3-e6.
22. Epstein LJ, Kristo D, Strollo PJ Jr, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med, 2009, 5(3): 263-276.
23. Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med, 1993, 328(17): 1230-1235.
24. Marshall NS, Barnes M, Travier N, et al. Continuous positive airway pressure reduces daytime sleepiness in mild to moderate obstructive sleep apnoea: a meta-analysis. Thorax, 2006, 61(5): 430-434.
25. Escourrou P, Grote L, Penzel T, et al. The diagnostic method has a strong influence on classification of obstructive sleep apnea. J Sleep Res, 2015, 24(6): 730-738.
26. Dement W, Kleitman N. Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming. Electroencephalogr Clin Neurophysiol, 1957, 9(4): 673-690.
27. Jouvet M. Electrophysiologic and neuropharmacologic study of the stages of sleep. Actual Pharmacol(Paris), 1965, 18: 109-173.
28. Ferini-Strambi L, Galbiati A, Marelli S. Sleep microstructure and memory function. Front Neurol, 2013, 4: 159.
29. Parrino L, Halasz P, Tassinari CA, et al. CAP, epilepsy and motor events during sleep: the unifying role of arousal. Sleep Med Rev, 2006, 10(4): 267-285.
30. Zucconi M, Oldani A, Smirne S, et al. The macrostructure and microstructure of sleep in patients with autosomal dominant nocturnal frontal lobe epilepsy. J Clin Neurophysiol, 2000, 17(1): 77-86.
31. Derry CP, Duncan S. Sleep and epilepsy. Epilepsy Behav, 2013, 26(3): 394-404.
32. De Paolis F, Colizzi E, Milioli G, et al. Effects of antiepileptic treatment on sleep and seizures in nocturnal frontal lobe epilepsy. Sleep Med, 2013, 14(7): 597-604.
33. Jain SV, Horn PS, Simakajornboon N, et al. Obstructive sleep apnea and primary snoring in children with epilepsy. J Child Neurol, 2013, 28(1): 77-82.
34. 肖淑芬, 陶振峰, 宋琦.表现为癫痫大发作的阻塞性睡眠呼吸暂停综合征.临床误诊误治, 2012, 25(3): 90.
35. Foldvary-Schaefer N, Andrews ND, Pornsriniyom D, et al. Sleep apnea and epilepsy: who's at risk. Epilepsy Behav, 2012, 25(3): 363-367.
36. Ness-Abramof R, Apovian CM. Drug-induced weight gain. Drugs today(Barc), 2005, 41(8): 547-555.
37. Ben-Menachem E. Weight issues for people with epilepsy-a review. Epilepsia, 2007, 48(Suppl 9): 42-45.
38. Lambert MV, Bird JM. Obstructive sleep apnoea following rapid weight gain secondary to treatment with vigabatrin (Sabril). Seizure, 1997, 6(3): 233-235.
39. Belcastro V, D'Egidio C, Striano P, et al. Metabolic and endocrine effects of valproic acid chronic treatment. Epilepsy Res, 2013, 107(1-2): 1-8.
40. Pornsriniyom D, Kim H, Bena J, et al. Effect of positive airway pressure therapy on seizure control in patients with epilepsy and obstructive sleep apnea. Epilepsy Behav, 2014, 37: 270-275.
41. Vendrame M, Auerbach S, Loddenkemper T, et al. Effect of continuous positive airway pressure treatment on seizure control in patients with obstructive sleep apnea and epilepsy. Epilepsia, 2011, 52(11): e168-e171.
42. Nguyen-Michel VH, Pallanca O, Navarro V, et al. How are epileptic events linked to obstructive sleep apneas in epilepsy. Seizure, 2015, 24: 121-123.
43. Miano S, Pelliccia A, Evangelisti M, et al. Role of continuous positive airway pressure therapy on the pathogenesis of sleep-related frontal lobe epilepsy in a child with obstructive sleep apnea syndrome. J Child Neurol, 2008, 23(1): 124-128.

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