Research progress on the quality of life of patients with symptomatic epilepsy_Journal of Epilepsy

Authors：

HAN Tianai ,  SUN Meizhen

Department of Neurology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China;

Corresponding author：

SUN Meizhen, Email: sunmeizhen213@126.com

Keywords：

Symptomatic epilepsy; Quality of life; Structural etiology; Infectious causes

DOI：

10.7507/2096-0247.202407008

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Epilepsy is one of the most common neurological diseases, and symptomatic epilepsy patients are the main group of epilepsy patients, and their etiologies mainly include structural, infectious, metabolic and autoimmune, and the seizures caused by each etiology may have different degrees of impact on the quality of life of patients. The purpose of this article is to review the research on the quality of life of patients with symptomatic epilepsy caused by structural and infectious etiologies, including cerebrovascular diseases, neurodegenerative diseases, brain tumors, traumatic brain injuries and neurocysticercosis, in order to help clinicians understand the quality of life of patients with symptomatic epilepsy and benefit patients in clinical practice.

Citation： HAN Tianai, SUN Meizhen. Research progress on the quality of life of patients with symptomatic epilepsy. Journal of Epilepsy, 2024, 10(5): 426-430. doi: 10.7507/2096-0247.202407008 Copy

1.	Saito M. Symptomatic Epilepsy. Brain Nerve, 2023, 75(4): 317-321.
2.	Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 512-521.
3.	梁锦平. 国际抗癫痫联盟2017年版癫痫分类特点及其解读. 中国实用儿科杂志, 2020, 35(1): 47-54.
4.	于长禾, 孙亚男, 何丽云, 等. 健康相关生活质量在中西医测量量表中概念异同的比较研究. 中华中医药杂志, 2016, 31(11): 4773-4778.
5.	胡音, 郭谊, 王奕琪, 等. 成人癫痫患者生活质量问卷-31-P的信度和效度分析. 浙江大学学报(医学版), 2009, 38(06): 605-610.
6.	Zhao Y, Li X, Zhang K, et al. The progress of epilepsy after stroke. Curr Neuropharmacol, 2018, 16(1): 71-78.
7.	Mishra NK, Kwan P, Tanaka T, et al. International Post-Stroke Epilepsy Research Consortium (IPSERC); International Post Stroke Epilepsy Research Consortium (IPSERC). Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR). BMJ Open, 2023, 13(11): e078684.
8.	von Stülpnagel C, Kutschker S, Sperl W, et al. Childhood stroke: long-term outcomes and health-related quality of life with a special focus on the development of epilepsy. Neuropediatrics, 2021, 52(6): 469-474.
9.	Tao S, Sun J, Hao F, et al. Effects of sodium valproate combined with lamotrigine on quality of life and serum inflammatory factors in patients with poststroke secondary epilepsy. J Stroke Cerebrovasc Dis, 2020, 29(5): 104644.
10.	覃百灵, 李通, 胡敏婷, 等. 不同频率重复经颅磁刺激对卒中后癫痫患者的疗效及其对神经功能、认知功能、生活质量的影响. 神经损伤与功能重建, 2023, 18(5): 304-306+310.
11.	李英. 综合护理干预应用于脑卒中继发癫痫的影响. 中国社区医师, 2022, 38(14): 118-120.
12.	Neri S, Mastroianni G, Gardella E, et al. Epilepsy in neurodegenerative diseases. Epileptic Disord, 2022, 24(2): 249-273.
13.	Chiu ATG, Wong SSN, Wong NWT, et al. Quality of life and symptom burden in children with neurodegenerative diseases: using PedsQL and SProND, a new symptom-based scale. Orphanet J Rare Dis, 2022, 17(1): 334.
14.	Avila EK, Tobochnik S, Inati SK, et al. Brain tumor-related epilepsy management: a Society for Neuro-oncology (SNO) consensus review on current management. Neuro Oncol, 2024, 26(1): 7-24.
15.	Hauff NS, Storstein A. Seizure management and prophylaxis considerations in patients with brain tumors. Curr Oncol Rep, 2023, 25(7): 787-792.
16.	Krajewski S, Wójcik M, Harat M, et al. Influence of epilepsy on the quality of life of patients with brain tumors. Int J Environ Res Public Health, 2021, 18(12): 6390.
17.	吴哓哓, 李娟, 王芳, 等. 首发原发性脑肿瘤患者生命质量现状及其影响因素研究. 中国慢性病预防与控制, 2018, 26(11): 853-857.
18.	Rahman Z, Wong CH, Dexter M, et al. Epilepsy in patients with primary brain tumors: the impact on mood, cognition, and HRQOL. Epilepsy Behav, 2015, 48: 88-95.
19.	Klein M, Engelberts NH, van der Ploeg HM, et al. Epilepsy in low-grade gliomas: the impact on cognitive function and quality of life. Ann Neurol, 2003, 54(4): 514-520.
20.	Dirven L, Reijneveld JC, Taphoorn MJB. Health-related quality of life or quantity of life: a difficult trade-off in primary brain tumors? Semin Oncol, 2014, 41(4): 541-552.
21.	Coppola A, Zarabla A, Maialetti A, et al. Perampanel confirms to be effective and well-tolerated as an add-on treatment in patients with brain tumor-related epilepsy (PERADET study). Front Neurol, 2020, 11: 592.
22.	Maschio M, Zarabla A, Maialetti A, et al. Quality of life, mood and seizure control in patients with brain tumor related epilepsy treated with lacosamide as add-on therapy: a prospective explorative study with a historical control group. Epilepsy Behav, 2017, 73: 83-89.
23.	Rudà R, Houillier C, Maschio M, et al. Effectiveness and tolerability of lacosamide as add-on therapy in patients with brain tumor-related epilepsy: results from a prospective, noninterventional study in European clinical practice (VIBES). Epilepsia, 2020, 61(4): 647-656.
24.	Mo F, Meletti S, Belcastro V, et al. Lacosamide in monotherapy in BTRE (brain tumor-related epilepsy): results from an Italian multicenter retrospective study. J Neurooncol, 2022, 157(3): 551-559.
25.	Maschio M, Dinapoli L, Zarabla A, et al. Zonisamide in brain tumor-related epilepsy: an observational pilot study. Clin Neuropharmacol, 2017, 40(3): 113-119.
26.	Maschio M, Dinapoli L, Sperati F, et al. Levetiracetam monotherapy in patients with brain tumor-related epilepsy: seizure control, safety, and quality of life. J Neurooncol, 2011, 104(1): 205-214.
27.	Maschio M, Dinapoli L, Sperati F, et al. Oxcarbazepine monotherapy in patients with brain tumor-related epilepsy: open-label pilot study for assessing the efficacy, tolerability and impact on quality of life. J Neurooncol, 2012, 106(3): 651-656.
28.	Semple BD, Zamani A, Rayner G, et al. Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy. Neurobiol Dis, 2019, 123: 27-41.
29.	Ngadimon IW, Aledo-Serrano A, Arulsamy A, et al. An interplay between post-traumatic epilepsy and associated cognitive decline: a systematic review. Front Neurol, 2022, 13: 827571.
30.	胡旭, 徐小梅, 董吉荣等. 外伤后癫痫患者的神经心理学评估. 癫痫杂志, 2022, 8(1): 57-61.
31.	Pugh MJ, Kennedy E, Gugger JJ, et al. The military injuries: understanding post-traumatic epilepsy study: understanding relationships among lifetime traumatic brain injury history, epilepsy, and quality of life. J Neurotrauma, 2021, 38(20): 2841-2850.
32.	Liu SY, Han XM, Yan YY, et al. Quality of life and its influencing factors in patients with post-traumatic epilepsy. Chin J Traumatol, 2011, 14(2): 100-103.
33.	Saletti PG, Ali I, Casillas-Espinosa PM, et al. In search of antiepileptogenic treatments for post-traumatic epilepsy. Neurobiol Dis, 2019, 123: 86-99.
34.	Bonello M, Michael BD, Solomon T. Infective causes of epilepsy. Semin Neurol, 2015, 35(3): 235-244.
35.	方红军, 胡文静, 江志, 等. 阿昔洛韦联合奥卡西平对单纯性疱疹病毒性脑炎伴癫痫患儿的疗效及安全性. 实用药物与临床, 2020, 23(4): 345-349.
36.	Fujimoto A, Okanishi T, Nishimura M, et al. Vagus nerve stimulation therapy improves quality of life in patients with intractable postencephalitic epilepsy, a study of five patients. Neurol. Asia, 2018, 23: 1-5.
37.	Qian Y, Zang X, Li H, et al. Assessment of the health-related quality of life in neurocysticercosis patients in hot spot areas - China, 2017-2018. China CDC Wkly, 2022, 4(28): 618-621.
38.	Nau AL, Mwape KE, Wiefek J, et al. Cognitive impairment and quality of life of people with epilepsy and neurocysticercosis in Zambia. Epilepsy Behav, 2018, 80: 354-359.
39.	Zapata WR, Yang SY, Bustos JA, et al. Cysticercosis Working Group In Peru. Quality of life in patients with symptomatic epilepsy due to neurocysticercosis. Epilepsy Behav, 2022, 131(Pt A): 108668.
40.	Garcia HH, Del Brutto OH. Cysticercosis Working Group in Peru. Antiparasitic treatment of neurocysticercosis--the effect of cyst destruction in seizure evolution. Epilepsy Behav, 2017, 76: 158-162.
41.	Bustos JA, García HH, Del Brutto OH. Antiepileptic drug therapy and recommendations for withdrawal in patients with seizures and epilepsy due to neurocysticercosis. Expert Rev Neurother, 2016, 16(9): 1079-1085.
42.	Santhosh AP, Kumar Goyal M, Modi M, et al. Carbamazepine versus levetiracetam in epilepsy due to neurocysticercosis. Acta Neurol Scand, 143(3): 242-247.
43.	Walton D, Castell H, Collie C, et al. Antiepileptic drugs for seizure control in people with neurocysticercosis. Cochrane Database Syst Rev, 2021, 11(11): CD009027.

1. Saito M. Symptomatic Epilepsy. Brain Nerve, 2023, 75(4): 317-321.
2. Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 512-521.
3. 梁锦平. 国际抗癫痫联盟2017年版癫痫分类特点及其解读. 中国实用儿科杂志, 2020, 35(1): 47-54.
4. 于长禾, 孙亚男, 何丽云, 等. 健康相关生活质量在中西医测量量表中概念异同的比较研究. 中华中医药杂志, 2016, 31(11): 4773-4778.
5. 胡音, 郭谊, 王奕琪, 等. 成人癫痫患者生活质量问卷-31-P的信度和效度分析. 浙江大学学报(医学版), 2009, 38(06): 605-610.
6. Zhao Y, Li X, Zhang K, et al. The progress of epilepsy after stroke. Curr Neuropharmacol, 2018, 16(1): 71-78.
7. Mishra NK, Kwan P, Tanaka T, et al. International Post-Stroke Epilepsy Research Consortium (IPSERC); International Post Stroke Epilepsy Research Consortium (IPSERC). Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR). BMJ Open, 2023, 13(11): e078684.
8. von Stülpnagel C, Kutschker S, Sperl W, et al. Childhood stroke: long-term outcomes and health-related quality of life with a special focus on the development of epilepsy. Neuropediatrics, 2021, 52(6): 469-474.
9. Tao S, Sun J, Hao F, et al. Effects of sodium valproate combined with lamotrigine on quality of life and serum inflammatory factors in patients with poststroke secondary epilepsy. J Stroke Cerebrovasc Dis, 2020, 29(5): 104644.
10. 覃百灵, 李通, 胡敏婷, 等. 不同频率重复经颅磁刺激对卒中后癫痫患者的疗效及其对神经功能、认知功能、生活质量的影响. 神经损伤与功能重建, 2023, 18(5): 304-306+310.
11. 李英. 综合护理干预应用于脑卒中继发癫痫的影响. 中国社区医师, 2022, 38(14): 118-120.
12. Neri S, Mastroianni G, Gardella E, et al. Epilepsy in neurodegenerative diseases. Epileptic Disord, 2022, 24(2): 249-273.
13. Chiu ATG, Wong SSN, Wong NWT, et al. Quality of life and symptom burden in children with neurodegenerative diseases: using PedsQL and SProND, a new symptom-based scale. Orphanet J Rare Dis, 2022, 17(1): 334.
14. Avila EK, Tobochnik S, Inati SK, et al. Brain tumor-related epilepsy management: a Society for Neuro-oncology (SNO) consensus review on current management. Neuro Oncol, 2024, 26(1): 7-24.
15. Hauff NS, Storstein A. Seizure management and prophylaxis considerations in patients with brain tumors. Curr Oncol Rep, 2023, 25(7): 787-792.
16. Krajewski S, Wójcik M, Harat M, et al. Influence of epilepsy on the quality of life of patients with brain tumors. Int J Environ Res Public Health, 2021, 18(12): 6390.
17. 吴哓哓, 李娟, 王芳, 等. 首发原发性脑肿瘤患者生命质量现状及其影响因素研究. 中国慢性病预防与控制, 2018, 26(11): 853-857.
18. Rahman Z, Wong CH, Dexter M, et al. Epilepsy in patients with primary brain tumors: the impact on mood, cognition, and HRQOL. Epilepsy Behav, 2015, 48: 88-95.
19. Klein M, Engelberts NH, van der Ploeg HM, et al. Epilepsy in low-grade gliomas: the impact on cognitive function and quality of life. Ann Neurol, 2003, 54(4): 514-520.
20. Dirven L, Reijneveld JC, Taphoorn MJB. Health-related quality of life or quantity of life: a difficult trade-off in primary brain tumors? Semin Oncol, 2014, 41(4): 541-552.
21. Coppola A, Zarabla A, Maialetti A, et al. Perampanel confirms to be effective and well-tolerated as an add-on treatment in patients with brain tumor-related epilepsy (PERADET study). Front Neurol, 2020, 11: 592.
22. Maschio M, Zarabla A, Maialetti A, et al. Quality of life, mood and seizure control in patients with brain tumor related epilepsy treated with lacosamide as add-on therapy: a prospective explorative study with a historical control group. Epilepsy Behav, 2017, 73: 83-89.
23. Rudà R, Houillier C, Maschio M, et al. Effectiveness and tolerability of lacosamide as add-on therapy in patients with brain tumor-related epilepsy: results from a prospective, noninterventional study in European clinical practice (VIBES). Epilepsia, 2020, 61(4): 647-656.
24. Mo F, Meletti S, Belcastro V, et al. Lacosamide in monotherapy in BTRE (brain tumor-related epilepsy): results from an Italian multicenter retrospective study. J Neurooncol, 2022, 157(3): 551-559.
25. Maschio M, Dinapoli L, Zarabla A, et al. Zonisamide in brain tumor-related epilepsy: an observational pilot study. Clin Neuropharmacol, 2017, 40(3): 113-119.
26. Maschio M, Dinapoli L, Sperati F, et al. Levetiracetam monotherapy in patients with brain tumor-related epilepsy: seizure control, safety, and quality of life. J Neurooncol, 2011, 104(1): 205-214.
27. Maschio M, Dinapoli L, Sperati F, et al. Oxcarbazepine monotherapy in patients with brain tumor-related epilepsy: open-label pilot study for assessing the efficacy, tolerability and impact on quality of life. J Neurooncol, 2012, 106(3): 651-656.
28. Semple BD, Zamani A, Rayner G, et al. Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy. Neurobiol Dis, 2019, 123: 27-41.
29. Ngadimon IW, Aledo-Serrano A, Arulsamy A, et al. An interplay between post-traumatic epilepsy and associated cognitive decline: a systematic review. Front Neurol, 2022, 13: 827571.
30. 胡旭, 徐小梅, 董吉荣等. 外伤后癫痫患者的神经心理学评估. 癫痫杂志, 2022, 8(1): 57-61.
31. Pugh MJ, Kennedy E, Gugger JJ, et al. The military injuries: understanding post-traumatic epilepsy study: understanding relationships among lifetime traumatic brain injury history, epilepsy, and quality of life. J Neurotrauma, 2021, 38(20): 2841-2850.
32. Liu SY, Han XM, Yan YY, et al. Quality of life and its influencing factors in patients with post-traumatic epilepsy. Chin J Traumatol, 2011, 14(2): 100-103.
33. Saletti PG, Ali I, Casillas-Espinosa PM, et al. In search of antiepileptogenic treatments for post-traumatic epilepsy. Neurobiol Dis, 2019, 123: 86-99.
34. Bonello M, Michael BD, Solomon T. Infective causes of epilepsy. Semin Neurol, 2015, 35(3): 235-244.
35. 方红军, 胡文静, 江志, 等. 阿昔洛韦联合奥卡西平对单纯性疱疹病毒性脑炎伴癫痫患儿的疗效及安全性. 实用药物与临床, 2020, 23(4): 345-349.
36. Fujimoto A, Okanishi T, Nishimura M, et al. Vagus nerve stimulation therapy improves quality of life in patients with intractable postencephalitic epilepsy, a study of five patients. Neurol. Asia, 2018, 23: 1-5.
37. Qian Y, Zang X, Li H, et al. Assessment of the health-related quality of life in neurocysticercosis patients in hot spot areas - China, 2017-2018. China CDC Wkly, 2022, 4(28): 618-621.
38. Nau AL, Mwape KE, Wiefek J, et al. Cognitive impairment and quality of life of people with epilepsy and neurocysticercosis in Zambia. Epilepsy Behav, 2018, 80: 354-359.
39. Zapata WR, Yang SY, Bustos JA, et al. Cysticercosis Working Group In Peru. Quality of life in patients with symptomatic epilepsy due to neurocysticercosis. Epilepsy Behav, 2022, 131(Pt A): 108668.
40. Garcia HH, Del Brutto OH. Cysticercosis Working Group in Peru. Antiparasitic treatment of neurocysticercosis--the effect of cyst destruction in seizure evolution. Epilepsy Behav, 2017, 76: 158-162.
41. Bustos JA, García HH, Del Brutto OH. Antiepileptic drug therapy and recommendations for withdrawal in patients with seizures and epilepsy due to neurocysticercosis. Expert Rev Neurother, 2016, 16(9): 1079-1085.
42. Santhosh AP, Kumar Goyal M, Modi M, et al. Carbamazepine versus levetiracetam in epilepsy due to neurocysticercosis. Acta Neurol Scand, 143(3): 242-247.
43. Walton D, Castell H, Collie C, et al. Antiepileptic drugs for seizure control in people with neurocysticercosis. Cochrane Database Syst Rev, 2021, 11(11): CD009027.

Journal of Epilepsy

Research progress on the quality of life of patients with symptomatic epilepsy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content