• 1.Department of Hepatiobiliaripancreatic Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China;;
  • 2.Department of Hepatiobiliaripancreatic Surgery, Cancer Hospital of Liaoning Province, Shenyang 110043, Liaoning Province, China;
JIANG Xiaofeng, Email: jiang_xiaofeng@hotmail.com
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ObjectiveTo investigate the proportion of peripheral blood CD4+CD25+ regulatory T cells (Tregs) in patients with pancreatic head carcinoma, the dynamic changes of these cells before and after pancreatoduodenectomy were also analyzed. MethodsThe proportions of peripheral blood CD4+CD25+ Tregs in patients with pancreatic head carcinoma and normal individuals were examined by using flow cytometric analysis. The CD4+/CD8+ ratio was also studied before and after operation. ResultsThe patients with pancreatic head carcinoma showed higher ratio of CD4+CD25+ and CD4+CD25high Tregs compared with normal control before operation (P lt;0.05). However, the percentage of these T cells reduced significantly after pancreatoduodenectomy, which was most obviously on the 3rd day after operation (P lt;0.01, P lt;0.05). After operation, CA199 level began to decrease, which was obvious on the fourteen day after operation. This tendency of CD4+CD25high Tregs changes was similar to that of CA199. The patients showed an decreased ratios of CD4+/CD8+ compared with normal controls, which further declined after operation, and reached the lowest point on the seventh day after operation (P lt;0.05). ConclusionsPancreatoduodenectomy may be helpful for the recovery of antitumor immunity. The perioperative period of patients with pancreatic head carcinoma may be a beneficial windowphase for immune intervention and Tregs may be served as target cells.

Citation: LIN Lin ,LIANG Jian,MA Zuohong,GUO Dawei,WANG Xuefan,FU Qingcai,SUN Wenyu,JIANG Honglei,JIN Junzhe,JIANG Xiaofeng. Influence of Pancreatoduodenectomy on CD4+CD25+ T Cells in Patients with Pancreatic Head Carcinoma and Its Clinical Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(1): 51-54. doi: Copy

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