Advancement of Heat Shock Protein 70 Vaccine in Alimentary Canal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Sheng , YING Mingang

Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, China;

Corresponding author：

Keywords：

Heat shock protein 70; Vaccine; Alimentary canal cancer

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To review the advancement of heat shock protein 70 (HSP70) vaccine in alimentary canal cancer.
Methods 　Related articles were reviewed.
Results 　HSP70 can integrate with tumor special antigen to form HSP70 polypeptide compound. To activate the special and nonspecial immune response of body, HSP70 can participate in the process of tumor immunity as a “molecular partner”.
Conclusion 　HSP70 has shown alluring perspective in the precaution and treatment of alimentary canal cancer.

Citation： LIU Sheng,YING Mingang. Advancement of Heat Shock Protein 70 Vaccine in Alimentary Canal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(6): 728-730. doi: Copy

1.	Yokota S, Kitahara M, Nagata K. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells [J]. Cancer Res, 2000; 60(11)∶2942.
2.	Ozdemirler Erata G, Kanbaqli O, Durlanik O, et al. Induced oxidative stress and decreased expression of inducible heat shock protein 70 (ihsp 70) in patients with colorectal adenocarcinomas [J]. Jpn J Clin Oncol， 2005; 35(2)∶74.
3.	Ueda G, Tamura Y, Hirai I, et al. Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity [J]. Cancer Sci， 2004; 95(3)∶248.
4.	Maier T, Tun-Kyi A, Tassis A, et al. Vaccination of patients with cutaneous T-cell lymphoma using intranodal injection of autologous tumor-lysate-pulsed dendritic cells [J]. Blood， 2003; 102(7)∶2338.
5.	Musch MW, Kaplan B, Chang EB. Role of increased basal expression of heat shock protein 72 in colonic epithelial c2BBE adenocarcinoma cells [J]. Cell Growth Differ， 2001; 12(8)∶419.
6.	王小平, 刘国贞, 宋爱利, 等. 人肝癌组织热休克蛋白70的表达 [J]. 首都医科大学学报, 2004; 25(2)∶186.
7.	李春梅, 刘志峰, 张红绪, 等. Hsp70和PCNA在NIH小鼠前胃癌变过程中的表达及意义 [J]. 细胞与分子免疫学杂志, 2004; 20(5)∶625.
8.	Wang XP, Qiu FR, Liu GZ, et al. Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma [J]. World J Gastroenterol， 2005; 11(7)∶1056.
9.	Massé D, Ebstein F, Bougras G, et al. Increased expression of inducible HSP70 in apoptotic cells is correlated with their efficacy for antitumor vaccine therapy [J]. Int J Cancer， 2004; 111(4)∶575.
10.	Massa C, Melani C, Colombo MP. Chaperon and adjuvant activity of hsp70: different natural killer requirement for cross-priming of chaperoned and bystander antigens [J]. Cancer Res， 2005; 65(17)∶7942.
11.	Krause SW, Gastpar R, Andreesen R, et al. Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase Ⅰ trial [J]. Clin Cancer Res， 2004; 10(11)∶3699.
12.	Wan T, Zhou X, Chen G, et al. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant [J]. Blood， 2004; 103(5)∶1747.
13.	史斌, 陈以娟, 王申五, 等. 热休克蛋白-树突状细胞疫苗对慢性髓系白血病免疫治疗作用的体外研究 [J]. 中华内科杂志, 2004; 43(5)∶380.
14.	钱世鹍, 闵军, 褚忠华, 等. 热休克蛋白对树突状细胞成熟的影响研究 [J]. 中国病理生理杂志, 2004; 20(7)∶1190.
15.	万敏, 张培因, 王宣军, 等. 热休克蛋白融合蛋白对人树突状细胞分化成熟的刺激作用 [J]. 吉林大学学报（医学版）, 2004; 30(6)∶835.
16.	Srivastava PK, MR Das. The serologically unique cell surface of zajdela ascitic hepatoma is also it tumor-associated transplantation antigen [J]. Int J Cancer, 1984; 33(3)∶417.
17.	黄波, 冯作化, 张桂梅. Hsp70-肿瘤抗原肽复合物修饰的DC疫苗体内外特异性抗瘤作用 [J]. 中国免疫学杂志, 2002; 18(9)∶614.
18.	陈代雄, 苏艳蓉, 钱振超. HSP70-肿瘤肽对小鼠肝癌的抗肿瘤免疫效应 [J]. 中国肿瘤生物治疗杂志, 2002; 9(3)∶163.
19.	袁庆文, 刘学政, 刘学农, 等. 胃癌Hsp70-肽复合物致敏树突状细胞抗肿瘤作用的研究 [J]. 江西医学院学报, 2005; 45(3)∶1.
20.	华贇鹏, 梁力建, 黄洁夫. 热休克蛋白与肝缺血再灌注损伤 [J]. 中国普外基础与临床杂志, 2000; 7(4)∶269.
21.	Todryk SM, Eaton J, Birchall L, et al. Heated tumour cells of autologous and allogeneic origin elicit anti-tumour immunity [J]. Cancer Immunol Immunother， 2004; 53(4)∶323.
22.	Nylandsted J, Wick W, Hirt UA, et al. Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion [J]. Cancer Res， 2002; 62(24)∶7139.
23.	邱健, 李国威, 隋延仿, 等. 热休克肿瘤细胞抗原负载的树突状细胞瘤苗对原位接种结肠肿瘤的免疫预防作用 [J]. 世界华人消化杂志, 2005; 13(5)∶635.

1. 　Yokota S, Kitahara M, Nagata K. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells [J]. Cancer Res, 2000; 60(11)∶2942.
2. 　Ozdemirler Erata G, Kanbaqli O, Durlanik O, et al. Induced oxidative stress and decreased expression of inducible heat shock protein 70 (ihsp 70) in patients with colorectal adenocarcinomas [J]. Jpn J Clin Oncol， 2005; 35(2)∶74.
3. 　Ueda G, Tamura Y, Hirai I, et al. Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity [J]. Cancer Sci， 2004; 95(3)∶248.
4. 　Maier T, Tun-Kyi A, Tassis A, et al. Vaccination of patients with cutaneous T-cell lymphoma using intranodal injection of autologous tumor-lysate-pulsed dendritic cells [J]. Blood， 2003; 102(7)∶2338.
5. 　Musch MW, Kaplan B, Chang EB. Role of increased basal expression of heat shock protein 72 in colonic epithelial c2BBE adenocarcinoma cells [J]. Cell Growth Differ， 2001; 12(8)∶419.
6. 　王小平, 刘国贞, 宋爱利, 等. 人肝癌组织热休克蛋白70的表达 [J]. 首都医科大学学报, 2004; 25(2)∶186.
7. 　李春梅, 刘志峰, 张红绪, 等. Hsp70和PCNA在NIH小鼠前胃癌变过程中的表达及意义 [J]. 细胞与分子免疫学杂志, 2004; 20(5)∶625.
8. 　Wang XP, Qiu FR, Liu GZ, et al. Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma [J]. World J Gastroenterol， 2005; 11(7)∶1056.
9. 　Massé D, Ebstein F, Bougras G, et al. Increased expression of inducible HSP70 in apoptotic cells is correlated with their efficacy for antitumor vaccine therapy [J]. Int J Cancer， 2004; 111(4)∶575.
10. 　Massa C, Melani C, Colombo MP. Chaperon and adjuvant activity of hsp70: different natural killer requirement for cross-priming of chaperoned and bystander antigens [J]. Cancer Res， 2005; 65(17)∶7942.
11. 　Krause SW, Gastpar R, Andreesen R, et al. Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase Ⅰ trial [J]. Clin Cancer Res， 2004; 10(11)∶3699.
12. 　Wan T, Zhou X, Chen G, et al. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant [J]. Blood， 2004; 103(5)∶1747.
13. 　史斌, 陈以娟, 王申五, 等. 热休克蛋白-树突状细胞疫苗对慢性髓系白血病免疫治疗作用的体外研究 [J]. 中华内科杂志, 2004; 43(5)∶380.
14. 　钱世鹍, 闵军, 褚忠华, 等. 热休克蛋白对树突状细胞成熟的影响研究 [J]. 中国病理生理杂志, 2004; 20(7)∶1190.
15. 　万敏, 张培因, 王宣军, 等. 热休克蛋白融合蛋白对人树突状细胞分化成熟的刺激作用 [J]. 吉林大学学报（医学版）, 2004; 30(6)∶835.
16. 　Srivastava PK, MR Das. The serologically unique cell surface of zajdela ascitic hepatoma is also it tumor-associated transplantation antigen [J]. Int J Cancer, 1984; 33(3)∶417.
17. 　黄波, 冯作化, 张桂梅. Hsp70-肿瘤抗原肽复合物修饰的DC疫苗体内外特异性抗瘤作用 [J]. 中国免疫学杂志, 2002; 18(9)∶614.
18. 　陈代雄, 苏艳蓉, 钱振超. HSP70-肿瘤肽对小鼠肝癌的抗肿瘤免疫效应 [J]. 中国肿瘤生物治疗杂志, 2002; 9(3)∶163.
19. 　袁庆文, 刘学政, 刘学农, 等. 胃癌Hsp70-肽复合物致敏树突状细胞抗肿瘤作用的研究 [J]. 江西医学院学报, 2005; 45(3)∶1.
20. 　华贇鹏, 梁力建, 黄洁夫. 热休克蛋白与肝缺血再灌注损伤 [J]. 中国普外基础与临床杂志, 2000; 7(4)∶269.
21. 　Todryk SM, Eaton J, Birchall L, et al. Heated tumour cells of autologous and allogeneic origin elicit anti-tumour immunity [J]. Cancer Immunol Immunother， 2004; 53(4)∶323.
22. 　Nylandsted J, Wick W, Hirt UA, et al. Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion [J]. Cancer Res， 2002; 62(24)∶7139.
23. 　邱健, 李国威, 隋延仿, 等. 热休克肿瘤细胞抗原负载的树突状细胞瘤苗对原位接种结肠肿瘤的免疫预防作用 [J]. 世界华人消化杂志, 2005; 13(5)∶635.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Advancement of Heat Shock Protein 70 Vaccine in Alimentary Canal Cancer

Abstract Full text Figures/Tables Video References Cited by

Format

Content