Using MCM2 as A Novel Cell Replication Marker in Diagnosing Colorectal Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Yong , ZHOU Zongguang , LI Hongguang.

Department of Digestive Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Colorectal carcinoma Colonic adenoma Minichromosome maintenance protein 2

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

【Abstract】ObjectiveTo study the current research status of minichromosome maintenance protein 2 (MCM2), the cell cycle proliferation marker, in the diagnosis of colorectal carcinoma.
MethodsLiteratures about the application of MCM2 in the study of colorectal carcinoma were collected and reviewed.
ResultsMCM2, as a marker of cell dysplasia and malignancy, was usually used in the study of carcinoma. The study on expression of MCM2 in the cell of colorectum in different proliferational stage might help to screen colorectal carcinoma as early as possible.
ConclusionAs a relatively specific and sensitive marker of cell proliferation, MCM2 might become a promising mark for diagnosing colorectal carcinoma in the early stage.

Citation： WANG Yong,ZHOU Zongguang,LI Hongguang.. Using MCM2 as A Novel Cell Replication Marker in Diagnosing Colorectal Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(1): 123-124. doi: Copy

1.	Markowitz AJ, Winawer SJ. Management of colorectal polyps [J]. CA Cancer J Clin， 1997; 47(2)∶93.
2.	Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup [J]. N Engl J Med， 1993; 329(27)∶1977.
3.	莫善兢主编. 大肠癌临床研究的进展 [A]. 肿瘤学新理论与新技术 [M]. 上海：上海科技教育出版社， 1997∶782~788.
4.	Jessup JM, Menck HR, Fremgen A, et al. Diagnosing colorectal carcinoma: clinical and molecular approaches [J]. CA Cancer J Clin， 1997; 47(2)∶70.
5.	Murakami R, Tsukuma H, Kanamori S, et al. Natural history of colorectal polyps and the effect of polypectomy on occurrence of subsequent cancer [J]. Int J Cancer, 1990; 46(2)∶159.
6.	Todorov IT, Werness BA, Wang HQ, et al. HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues [J]. Lab Invest， 1998; 78(1)∶73.
7.	Davies RJ, Freeman A, Morris LS, et al. Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool [J]. Lancet， 2002; 359(9321)∶1917.
8.	Tan DF, Huberman JA, Hyland A, et al. MCM2——a promising marker for premalignant lesions of the lung: a cohort study [J]. BMC Cancer， 2001; 1∶6.
9.	Williams GH, Romanowski P, Morris L, et al. Improved cervical smear assessment using antibodies against proteins that regulate DNA replication [J]. Proc Natl Acad Sci USA， 1998; 95(25)∶14932.
10.	Gonzalez MA, Pinder SE, Callagy G, et al. Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer [J]. J Clin Oncol， 2003; 21(23)∶4306.
11.	Freeman A, Morris LS, Mills AD, et al. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy [J]. Clin Cancer Res，1999; 5(8)∶2121.
12.	Going JJ, Keith WN, Neilson L, et al. Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki67 in dysplastic squamous oesophageal epithelium and Barrett’s mucosa [J]. Gut， 2002; 50(3)∶373.
13.	Ramnath N, Hernandez FJ, Tan DF, et al. MCM2 is an independent predictor of survival in patients with nonsmallcell lung cancer [J]. J Clin Oncol， 2001; 19(22)∶4259.

1. Markowitz AJ, Winawer SJ. Management of colorectal polyps [J]. CA Cancer J Clin， 1997; 47(2)∶93.
2. Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup [J]. N Engl J Med， 1993; 329(27)∶1977.
3. 莫善兢主编. 大肠癌临床研究的进展 [A]. 肿瘤学新理论与新技术 [M]. 上海：上海科技教育出版社， 1997∶782~788.
4. Jessup JM, Menck HR, Fremgen A, et al. Diagnosing colorectal carcinoma: clinical and molecular approaches [J]. CA Cancer J Clin， 1997; 47(2)∶70.
5. Murakami R, Tsukuma H, Kanamori S, et al. Natural history of colorectal polyps and the effect of polypectomy on occurrence of subsequent cancer [J]. Int J Cancer, 1990; 46(2)∶159.
6. Todorov IT, Werness BA, Wang HQ, et al. HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues [J]. Lab Invest， 1998; 78(1)∶73.
7. Davies RJ, Freeman A, Morris LS, et al. Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool [J]. Lancet， 2002; 359(9321)∶1917.
8. Tan DF, Huberman JA, Hyland A, et al. MCM2——a promising marker for premalignant lesions of the lung: a cohort study [J]. BMC Cancer， 2001; 1∶6.
9. Williams GH, Romanowski P, Morris L, et al. Improved cervical smear assessment using antibodies against proteins that regulate DNA replication [J]. Proc Natl Acad Sci USA， 1998; 95(25)∶14932.
10. Gonzalez MA, Pinder SE, Callagy G, et al. Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer [J]. J Clin Oncol， 2003; 21(23)∶4306.
11. Freeman A, Morris LS, Mills AD, et al. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy [J]. Clin Cancer Res，1999; 5(8)∶2121.
12. Going JJ, Keith WN, Neilson L, et al. Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki67 in dysplastic squamous oesophageal epithelium and Barrett’s mucosa [J]. Gut， 2002; 50(3)∶373.
13. Ramnath N, Hernandez FJ, Tan DF, et al. MCM2 is an independent predictor of survival in patients with nonsmallcell lung cancer [J]. J Clin Oncol， 2001; 19(22)∶4259.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Using MCM2 as A Novel Cell Replication Marker in Diagnosing Colorectal Carcinoma

Abstract Full text Figures/Tables Video References Cited by

Format

Content