HAN Mingqiang , HUANG Tao , TIAN Yuan.
Breast neoplasm Estradiol Tamoxifen
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【Abstract】  Objective  To study the effects of different levels estradiol on inhibitory of tamoxifen on human mammary cancer cells(ER+) in vitro. Methods  Estrogen receptor (ER) positive MCF7 human breast cancer cell line was treated by the same level of tamoxifen and different levels of estradiol in vitro. Cell proliferation was evaluated by MTT assay. Results  E2 at concentrations between 1 × 10-12 mol/L to 1× 10-7 mol / L significantly stimulated the growth of MCF 7 . TAM (10 μmol/ L) inhabited the growth of MCF7 significantly. E2 at different levels may influence inhibitory of tamoxifen on MCF7 cell lines. E2 (1×10-8 mol/L) makes inhibitory of tamoxifen on MCF7 cell lines valueless.

Conclusion  E2 is the risk factor of breast cancer, and the concentration around breast cancer cells may influence the effects of TAM.

Citation： HAN Mingqiang,HUANG Tao,TIAN Yuan.. Study of Effects of Different Levels of Estradiol on Inhibitory of Tamoxifen on Human Mammary Cancer Cells(ER+) in Vitro. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(6): 589-590下转594. doi: Copy