Injury Mechanism of Vascular Endothelial Cells in Atherosclerosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHAO Quan ¹ , DENG Jingyu ² , LUO Kaiyuan ¹ , SHI De. ²

Department of General Surgery, The Second Hospital of Yunnan Province, Kunming 650021, China;

Corresponding author：

Keywords：

Atherosclerosis; Vascular endothelial cell; Adhesive molecule

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ObjectiveTo summarize the progress on the injury mechanism of vascular endothelial cells in atherosclerosis.MethodsThe latest progress was reviewed in recent literatures.ResultsAll kinds of etiological factors have activated NF-kappa B and cytokines in the development of atherosclerosis, which lead to expression of cell adhesive molecules and adhesion of monocytes to vascular endothelial cells.A variety of inflammatory mediums are released, which can directly damage endothelial cells.Besides, the inflammatory mediums make monocytes and neutrophils attach to endothelial cells by immune mechanisms, which injure the endothelial cells more severely. Meanwhile the damaged membrance structure leads to the production of AECA which activates the complementary system. Then the vascular endothelial cell injury is aggravated and the development of atherosclerosis accelerated. ConclusionIt is very important to recognize the injury mechanism of vascular endothelial cells in the development of atherosclerosis for prevention and treatment of atherosclerosis.

Citation： ZHAO Quan,DENG Jingyu,LUO Kaiyuan,SHI De.. Injury Mechanism of Vascular Endothelial Cells in Atherosclerosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(4): 325-327. doi: Copy

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1. Reiner Z, TedeschiReiner E. New information on the pathophysiology of atherosclerosis [J]. Lijec Vjesn, 2001; 123(1-2)∶26.
2. Steinberg D. Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis [J]. Circulation, 1997; 95(4)∶1062.
3. Colome C, MartinezGonzalez J, Vidal F, et al. Small oxidative changes in atherogenic LDL concentrations irreversibly regulate adhesiveness of human endothelial cells: effect of the lazaroid U74500A [J].Atherosclerosis, 2000; 149(2)∶295.
4. Cockerill GW, Saklatvala J, Ridley SH, et al. Highdensity lipoproteins differentially modulate cytokineinduced expression of Eselectin and cyclooxygenase2 [J]. Arterioscler Thromb Vasc Biol, 1999; 19(4)∶910.
5. Khan BV, Harrison DG, Olbrych MT, et al. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redoxsensitive transcriptional events in human vascular endothelial cells [J]. Proc Natl Acad Sci USA, 1996; 93(17)∶9114.
6. Keck C, Herchenbach D, Pfisterer J, et al. Effects of 17betaestradiol and progesterone on interleukin6 production and proliferation of human umbilical vein endothelial cells [J]. Exp Clin Endocrinol Diabetes, 1998; 106(4)∶334.
7. Walsh BA, Mullick AE, Banka CE, et al. 17betaestradiol acts separately on the LDL particle and artery wall to reduce LDL accumulation [J]. J Lipid Res, 2000; 41(1)∶134.
8. Spyridopoulos I, Sullivan AB, Kearney M, et al. Estrogen receptor mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor [J]. Circulation, 1997； 95(6)∶1505.
9. Best PJ, Berger PB, Miller VM, et al. The effect of estrogen replacement therapy on plasma nitric oxide and endothelin1 levels in postmenopausal women [J]. Ann Intern Med, 1998; 128(4)∶285.
10. Simoncini T, Maffei S, Basta G, et al. Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule1 expression by different transcriptional mechanisms [J]. Circ Res, 2000; 87(1)∶19.
11. CaulinGlaser T, Farrell WJ, Pfau SE, et al. Modulation of circulating cellular adhesion molecules in postmenopausal women with coronary artery disease [J]. J Am Coll Cardiol, 1998; 31(7)∶1555.
12. Manduteanu L, Voinea M, Serban G, et al. High glucose induces enhanced monocyte adhesion to valvular endothelial cells via a mechanism involving ICAM1, VCAM1 and CD18 [J]. Endothelium, 1999; 6(4)∶315.
13. Kado S, Nagata N. Circulating intercellular adhesion molecule1, vascular cell adhesion molecule1, and Eselectin in patients with type 2 diabetes mellitus [J]. Diabetes Res Clin Pract, 1999; 46(2)∶143.
14. Ribau JC, Hadcock SJ, Teoh K, et al. Endothelial adhesion molecule expression is enhanced in the aorta and internal mammary artery of diabetic patients [J]. J Surg Res, 1999; 85(2)∶225.
15. Kol A, Bourcier T, Lichtman AH, et al. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages [J].J Clin Invest， 1999; 103(4)∶571.
16. Shen Y, Rattan V, Sultana C, et al. Cigarette smoke condensateinduced adhesion molecule expression and transendothelial migration of monocytes [J]. Am J Physiol, 1996; 270(5 Pt 2)∶H1624.
17. Rosenbaum J, Pottinger BE, Woo P, et al. Measurement and charactersation of circulating antiendothelial cell IgG connective tissue diseases [J]. Clin Exp Immunol, 1998; 72(3)∶450.
18. Kawana S. The membrane attack complex of complement alters the membrane integrity of cultured endothelial cells: a possible pathophysiology for immune complex vasculitis [J]. Acta Derm Venereol, 1996; 76(1)∶13.
19. Miyagawa S, Shirakura R, Mikata S, et al. Functional feature of C5b8step lysis of swine endothelial cell transfected CD59 [J]. Transplant Proc, 1996; 28(2)∶597.
20. McCurry KR, Kooyman DL, Diamond LE, et al. Transgenic expression of human complement regulatory proteins in mice results in diminished complement deposition during organ xenoperfusion [J]. Transplantation, 1995; 59(8)∶1177.
21. Li W, Tada T, Miwa T, et al. mRNA expression of complement components and regulators in rat arterial smooth muscle cells [J]. Microbiol Immunol, 1999; 43(6)∶585.
22. Seifert PS, Roth I, Schmiedt W, et al. CD59 (homologous restriction factor 20), a plasma membrane protein that protects against complement C5b9 attack, in human atherosclerotic lesions [J]. Atherosclerosis, 1992; 96(2-3)∶135.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Injury Mechanism of Vascular Endothelial Cells in Atherosclerosis

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