ObjectiveTo investigate the protective mechanism of prostaglandin E1 against hepatic ischemia reperfusion injury.MethodsUsing 45minute ischemiareperfusion rat model in normal temperature, PGE1 was injected into portal vein before ischemia. An hour later blood was taken from portal vein to examine the enzyme levels, including GOT, GPT, LDH and TNFα, ET1. The alteration of pathological morphology of the ischemia lobe was observed.ResultsThe three enzemes, TNFα, ET1 levels of ischemiareperfusion group were significantly higher than those of the control group (P＜0.01). The indices of the PGE1 group were much lower than those of the ischemiareperfusion group (P＜0.01), but little higher than those of the control group (P＞0.05). The control group had obvious alteration in pathological morphology, but only slight alteration in PGE1 group, compared with the control group. ConclusionPGE1 protects against ischemiareperfusion injury of the liver.
Citation：
JI Degang,LIU Bingyi,ZHENG Zelin,WANG Wei. Prostaglandin E1 Protects Against IschemiaReperfusion Injury of the Rats Liver. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(1): 36-38. doi:
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- 4. Ishikawa T, Yamamoto Y, Takeuchi K. Relationship between peri and postoperative plasma concentration of endothelin1 and liver dysfunction in rat liver transplantation [Ｊ]. Transplant Proc, 1995; 27（1）∶524.
- 5. Natori S, Fujii Y, Kurosawa H, et al. Prostaglandine E1 protects against ischemiareperfusion injury of the liver by inhibition of neutrophil adherence to endothelial cells [Ｊ]. Transplantation, 1997; 64（11）∶1514.
- 6. 贾因堂,王守义,解中坚.前列腺素E1对肿瘤坏死因子水平及磷脂酶A2活性的影响 [Ｊ]. 中华肝病杂志, 1997； 5（3）∶172.
- 7. Xu HS, Rosenlof LK, Rruett TL, et al. Prostaglandin E1 increases survival with extended anhepatic phase during liver transplantation [Ｊ]. Ann Surg, 1994; 220（1）∶53.
- 8. Greig PD, Woolf GM, Sinclair SB, et al. Treatment of primary liver graft nonfunction with prostaglandin E1 [Ｊ]. Transplantation, 1989; 48（3）∶447.
