Objective To explore the effects of recombinant human growth hormone （rhGH） on senile patients after pancreaticoduodenectomy. MethodsFortysix patients were divided into the therapeutic group (rhGH, n=17) and control group (n=29). Both were treated with parenteral nutrition. In the therapeutic group, rhGH (8 u/d) was given hypodermically for 7 days. After operation the levels of albumin, prealbumin, transferrin, and immunoglobulin were measured. Postoperative fatigue syndrome and the average length of stay in hospital were observed too. ResultsAfter operation the levels of albumin, prealbumin, transferrin, and immunoglobulin in the therapeutic group were significantly higher than those of control group. The degree of postoperative fatigue syndrome in the therapeutic group was less than that of control group. The average length of stay in hospital was significantly shortened. Conclusion The early application of rhGH in senile patients after pancreaticoduodenectomy can enhance immune function, reduce the incidence of infection, promote the postoperative recovery, shorten the average length of stay in hospital,decrease the mortality, increase the safety of operation and improve the postoperative life quality of senile patients.
Citation：
LINGRui,LI Jipeng,ZHANG Hongwei,WANG Ling,WANG Weizhong,CHEN Dongli. Application of Growth Hormone in Senile Patients after Pancreaticoduodenectomy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(6): 542-544. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. |
吴阶平， 裘法祖主编. 黄家驷外科学 [M]. 第6版. 北京： 人民卫生出版社， 1999∶1311～1314.
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Cameron JL， Pitt HA ，Yeo CJ， et al. One hundred and fortyfive consecutive pancreaticoduodenectomies without mortality [Ｊ]. Ann Surg, 1993; 217(5)∶430.
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顾军, 黎介寿, 李维勤, 等. 重组生长激素对严重感染后蛋白质代谢影响的实验研究 [Ｊ].中华外科杂志， 1997; 35(2)∶104.
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| 4. |
Christensen T, Kehlet H. Postoperative fatigue [Ｊ]. World J Surg, 1993; 17(2)∶220.
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| 5. |
Carli F, Webster JD, Halliday D. Growth hormone modulates amino acid oxidation in the surgical patient: leucine kinetics during the fasted and fed state using moderate nitrogenous and caloric diet and recombinant human growth hormone [Ｊ].Metabolism, 1997; 46(1)∶23.
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| 6. |
Carli F, Webster JD, Halliday D. A nitrogenfree hypocaloric diet and recombinant human growth hormone stimulate postoperative protein synthesis: fasted and fed leuicne kinetics in the surgical patient [Ｊ]. Metabolism, 1997; 46(7)∶796.
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| 7. |
李立， 冉江华， 张炳彦， 等. 应用重组人生长激素对肝胆胰外科患者术后氮平衡及营养状况的影响 [Ｊ]. 中国普外基础与临床杂志， 2000； 7（6）∶383.
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刘金钢， 那延立， 郭宏斌， 等. 生长激素减轻梗阻性黄疸时肠菌及内毒素移位的实验研究 [Ｊ].中国普外基础与临床杂志， 2002； 9（3）∶172.
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| 9. |
VaraThorbeck R, Guerrero JA, Rosell J, et al. Exogenous growth hormone: effects on the catabolic response to surgically produced acute stress and on postoperative immune function [Ｊ]. World J Surg, 1993; 17(4)∶530.
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| 10. |
王彤， 姜秀峰， 王琛， 等.重组人生长激素对梗阻性黄疸作用的实验研究 [Ｊ]. 中国普外基础与临床杂志， 2002； 9（6）∶408.
|
| 11. |
VaraThorbeck R, Guerrero JA, Ruizrequena E, et al. Can the use of growth hormone reduced the postoperative ratigue syndrome? [Ｊ]. World J Surg, 1996; 20(1)∶81.
|
| 12. |
凌瑞， 王为忠， 张洪伟， 等. 生长激素在门脉高压症大出血断流术后的应用体会 [Ｊ].肠外及肠内营养， 2001； 8（2）∶73.
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| 13. |
Tacke J, Bolder U, Herrmann A, et al. Longterm risk of gastrointestinal tumor recurrence after postoperative treatment with recombinant human growth hormone [Ｊ]. JPEN J Parenter Enteral Nutr, 2000; 24(3)∶140.
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- 1. 吴阶平， 裘法祖主编. 黄家驷外科学 [M]. 第6版. 北京： 人民卫生出版社， 1999∶1311～1314.
- 2. Cameron JL， Pitt HA ，Yeo CJ， et al. One hundred and fortyfive consecutive pancreaticoduodenectomies without mortality [Ｊ]. Ann Surg, 1993; 217(5)∶430.
- 3. 顾军, 黎介寿, 李维勤, 等. 重组生长激素对严重感染后蛋白质代谢影响的实验研究 [Ｊ].中华外科杂志， 1997; 35(2)∶104.
- 4. Christensen T, Kehlet H. Postoperative fatigue [Ｊ]. World J Surg, 1993; 17(2)∶220.
- 5. Carli F, Webster JD, Halliday D. Growth hormone modulates amino acid oxidation in the surgical patient: leucine kinetics during the fasted and fed state using moderate nitrogenous and caloric diet and recombinant human growth hormone [Ｊ].Metabolism, 1997; 46(1)∶23.
- 6. Carli F, Webster JD, Halliday D. A nitrogenfree hypocaloric diet and recombinant human growth hormone stimulate postoperative protein synthesis: fasted and fed leuicne kinetics in the surgical patient [Ｊ]. Metabolism, 1997; 46(7)∶796.
- 7. 李立， 冉江华， 张炳彦， 等. 应用重组人生长激素对肝胆胰外科患者术后氮平衡及营养状况的影响 [Ｊ]. 中国普外基础与临床杂志， 2000； 7（6）∶383.
- 8. 刘金钢， 那延立， 郭宏斌， 等. 生长激素减轻梗阻性黄疸时肠菌及内毒素移位的实验研究 [Ｊ].中国普外基础与临床杂志， 2002； 9（3）∶172.
- 9. VaraThorbeck R, Guerrero JA, Rosell J, et al. Exogenous growth hormone: effects on the catabolic response to surgically produced acute stress and on postoperative immune function [Ｊ]. World J Surg, 1993; 17(4)∶530.
- 10. 王彤， 姜秀峰， 王琛， 等.重组人生长激素对梗阻性黄疸作用的实验研究 [Ｊ]. 中国普外基础与临床杂志， 2002； 9（6）∶408.
- 11. VaraThorbeck R, Guerrero JA, Ruizrequena E, et al. Can the use of growth hormone reduced the postoperative ratigue syndrome? [Ｊ]. World J Surg, 1996; 20(1)∶81.
- 12. 凌瑞， 王为忠， 张洪伟， 等. 生长激素在门脉高压症大出血断流术后的应用体会 [Ｊ].肠外及肠内营养， 2001； 8（2）∶73.
- 13. Tacke J, Bolder U, Herrmann A, et al. Longterm risk of gastrointestinal tumor recurrence after postoperative treatment with recombinant human growth hormone [Ｊ]. JPEN J Parenter Enteral Nutr, 2000; 24(3)∶140.
