Nuclear Factor-κB and Colon Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WU Bin ¹ , SHI De ²

Department of General Surgery, Affiliated Hospital of Luzhou Medial College, Luzhou 646000, China;

Corresponding author：

Keywords：

Nuclear factor kappa gene binding; Apopotosis; Malignant tumor; Colon cancer

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ObjectiveTo explore the relationship between nuclear factor κB (NFκB) and the occurrence, metastasis, and treatment of colon cancer. MethodsThe literature on the structure and the property of molecular biology of NFκB, the relationship between NFκB and apopotosis, malignant tumor and colon cancer were reviewed.ResultsNFκB had action of antiapopotosis. The occurrence of malignant tumor had close relation with the oncogene by NFκB, the metastasis of malignant tumor was that cell of cancer escaped the killing and supervising of immunity by NFκB. NFκB affected the occurrence and metastasis of colon cancer by regulating cmyc, Cox2, ICAM1.Conclusion NFκB has important action in the occurrence and metastasis of colon cancer. It will become a new target of treatment.

Citation： WU Bin,SHI De. Nuclear Factor-κB and Colon Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(2): 173-175. doi: Copy

1.	Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences 　[J]. Cell, 1986；　46(5)∶705.
2.	Baldwin AS Jr. The NFκB and IκB proteins: new discoveries and insights 　[J]. Annu Rev Immunol, 1996；　14(2)∶649.
3.	Lee JI, Pharm D, Gilbert J, et al. Nuclear factor κB: Important transcription factor and therapeutic target 　[J]. J Clin Pharmcol, 1998；　38(11)∶981.
4.	Flohe L, Brigelius FFlohe R, Saliou C, et al. Redox regulation of NFκB activation 　[J]. Free Radic Biol Med, 1997；　22(6)∶1115.
5.	May MJ, Ghosh S. Signal transduction through NFκB　[J]. Immunol Today, 1998；　19(2)∶80.
6.	Stancovski I, Baltimore D. NFκB activation: the IκB kinase revealed? 　[J]. Cell, 1997；　91(3)∶299.
7.	Han Y,Weinman S,Boldogh I,et al.Tumor necrosis factoralphainducible IκB alpha proteolysis mediated by cytosolic mcalpain.A mechanism parallel to the ubiquitinproteasome pathway for nuclear factorκB activation 　[J]. J Biol Chem,1999；　274(2)∶787.
8.	Ghosh S， May MJ, Kopp EB. NFκB and Rel proteins: evolutionarily conservecl mediators of immune responses 　[J]. Annu Rev Immunol, 1998；　16(1)∶225.
9.	Wang CY, Guttridge DC, Mayo MW, et al. NFκB induces expression of the Bcl2 homologue A1/Bfl1 to preferentinally suppress chemotherapyinduced apoptosis 　[J]. Mol Cell Biol, 1999；　19(9)∶5923.
10.	Lee HH, Dadgostar H, Cheng Q, et al. NFκBmediated upregulation of BclX and Bfl/A1 is required for CD40 survival signaling in B lymphocytes 　[J]. Proc Natl Acad Sci USA, 1999；　96(16)∶9136.
11.	Wang CY, Mayo MW, Korneluk RG, et al. NFκB antiapoptosis: induction of TRAF1 and TRAF2 and cIAP1 and cIAP2 to suppress caspase8 activation 　[J]. Science, 1998；　 281(5383)∶1680.
12.	Marianneau P, Cardona A, Edelman L, et al. Dengue virus replication in human hepatoma cells activates NFκB which in turn induces apoptotic cell death 　[J]. J Virol, 1997；　71(4)∶3244.
13.	Trede NS,Tsytsykova AV,Chatila T,et al.Transcriptional activation of the human TNFalpha promoter by superantigen in human monocytic cells: role of NFκB 　[J]. J Immunol,1995；　155(2)∶902.
14.	Mayo MW, Wang CY, Cogswell PC, et al. Requirement of NFκB activation to suppress p53independent apoptosis induced by oncogenic Ras 　[J]. Science,1997；　278(5344)∶1812.
15.	Chen F, Castranova V, Shi X, et al. New insights into the role of nuclear factorκB, a ubiquitous transcription factor in the initiation of diseases 　[J]. Clin Chem,1999；　45(1)∶7.
16.	Sovak MA,Bellas RE, Kim DW, et al. Aberrant nuclear factorκB/Rel expression and pathogenesis of breast cancer 　[J]. J Clin Invest,1997；　100(12)∶2952.
17.	Gilmore TD, Koedood M, Piffat KA, et al. Rel/ NFκB/IκB proteins and cancer 　[J]. Oncogene,1996；　13(7)∶1367.
18.	BhatNakshatri P, Newton TR, Goulet R Jr, et al. NFkappa B activation and interleukin 6 production in fibroblasts by estrogen receptornegative breast cancer cellderived interleukin 1 alpha　[J]. Proc Natl Acad Sci USA, 1998; 95(12)∶6971.
19.	Rodriguez F, Peran F, Garrido F, et al. Upmodulation by estrogen of HLA class Ⅰ expression in breast tumor cell lines [J]. Immunogenetics， 1994；　39(3)∶161.
20.	Kurt RA,Urba WJ,Smith JW,et al.Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules　[J].Int J Cancer,1998; 78(1)∶16.
21.	Pizer ES, Chrest FJ, DiGiuseppe JA, et al. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines 　[J]. Cancer Res, 1998；　58(20)∶4611.
22.	杨晓东，王杉，于永祥,等. 细胞核因子NFκB在人大肠癌组织中的表达及意义　[J]. 中华普通外科杂志, 2000；　15（6）∶ 367.
23.	陈尧,刘执玉，李瑞祥,等. 人直肠腺癌淋巴管内皮细胞ICAM1的转录调节　[J]. 华西医科大学学报， 2000；　31（3）∶ 315.
24.	La Rosa F, Pierce JW, Sonenshein GE. Differential regulation of the cmyc oncogene promoter by the NFκB rel family of transcription factors　[J]. Mol Cell Biol, 1994；　 14 (2)∶1039.
25.	Sano H, Kawahito Y, Wilder RL, et al.　Expression of cyclooxygenase1 and 2 in human colorectal cancer　[J]. Cancer Res,　1995; 55(17)∶3785.
26.	Tsujii M, Kowano S, DuBois RN. Cycloxygenase2 expression in human colon cancer cells increases metastatic potential 　[J]. Proc Natl Acad Sci USA, 1997；　94(7)∶ 3336.
27.	Dustin ML,Springer TA.Lymphocyte functionassociated antigen1(LFA1) interaction with intercellular adhesion molecule1(ICAM1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cell 　[J]. J Cell Biol,1988；　107(1)∶321.
28.	Makgoba MW, Sanders ME, Ginther Luce GE, et al.　ICAM1 a ligand for LFA1dependent adhesion of B, T and myeloid cells Nature [J]. 1988; 331(6151)∶86.
29.	Auphan N, DiDonato JA, Rosette C, et al. Immunosuppression by glucocorticoids: inhibition of NFκB activity through induction of IκB synthesis 　[J]. Science, 1995；　270(5234)∶286.
30.	Paillard F. Induction of apoptosis with IκB, the inhibitor of NFκB 　[J]. Hum Gene Ther, 1999；　10(1)∶1.

1. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences 　[J]. Cell, 1986；　46(5)∶705.
2. Baldwin AS Jr. The NFκB and IκB proteins: new discoveries and insights 　[J]. Annu Rev Immunol, 1996；　14(2)∶649.
3. Lee JI, Pharm D, Gilbert J, et al. Nuclear factor κB: Important transcription factor and therapeutic target 　[J]. J Clin Pharmcol, 1998；　38(11)∶981.
4. Flohe L, Brigelius FFlohe R, Saliou C, et al. Redox regulation of NFκB activation 　[J]. Free Radic Biol Med, 1997；　22(6)∶1115.
5. May MJ, Ghosh S. Signal transduction through NFκB　[J]. Immunol Today, 1998；　19(2)∶80.
6. Stancovski I, Baltimore D. NFκB activation: the IκB kinase revealed? 　[J]. Cell, 1997；　91(3)∶299.
7. Han Y,Weinman S,Boldogh I,et al.Tumor necrosis factoralphainducible IκB alpha proteolysis mediated by cytosolic mcalpain.A mechanism parallel to the ubiquitinproteasome pathway for nuclear factorκB activation 　[J]. J Biol Chem,1999；　274(2)∶787.
8. Ghosh S， May MJ, Kopp EB. NFκB and Rel proteins: evolutionarily conservecl mediators of immune responses 　[J]. Annu Rev Immunol, 1998；　16(1)∶225.
9. Wang CY, Guttridge DC, Mayo MW, et al. NFκB induces expression of the Bcl2 homologue A1/Bfl1 to preferentinally suppress chemotherapyinduced apoptosis 　[J]. Mol Cell Biol, 1999；　19(9)∶5923.
10. Lee HH, Dadgostar H, Cheng Q, et al. NFκBmediated upregulation of BclX and Bfl/A1 is required for CD40 survival signaling in B lymphocytes 　[J]. Proc Natl Acad Sci USA, 1999；　96(16)∶9136.
11. Wang CY, Mayo MW, Korneluk RG, et al. NFκB antiapoptosis: induction of TRAF1 and TRAF2 and cIAP1 and cIAP2 to suppress caspase8 activation 　[J]. Science, 1998；　 281(5383)∶1680.
12. Marianneau P, Cardona A, Edelman L, et al. Dengue virus replication in human hepatoma cells activates NFκB which in turn induces apoptotic cell death 　[J]. J Virol, 1997；　71(4)∶3244.
13. Trede NS,Tsytsykova AV,Chatila T,et al.Transcriptional activation of the human TNFalpha promoter by superantigen in human monocytic cells: role of NFκB 　[J]. J Immunol,1995；　155(2)∶902.
14. Mayo MW, Wang CY, Cogswell PC, et al. Requirement of NFκB activation to suppress p53independent apoptosis induced by oncogenic Ras 　[J]. Science,1997；　278(5344)∶1812.
15. Chen F, Castranova V, Shi X, et al. New insights into the role of nuclear factorκB, a ubiquitous transcription factor in the initiation of diseases 　[J]. Clin Chem,1999；　45(1)∶7.
16. Sovak MA,Bellas RE, Kim DW, et al. Aberrant nuclear factorκB/Rel expression and pathogenesis of breast cancer 　[J]. J Clin Invest,1997；　100(12)∶2952.
17. Gilmore TD, Koedood M, Piffat KA, et al. Rel/ NFκB/IκB proteins and cancer 　[J]. Oncogene,1996；　13(7)∶1367.
18. BhatNakshatri P, Newton TR, Goulet R Jr, et al. NFkappa B activation and interleukin 6 production in fibroblasts by estrogen receptornegative breast cancer cellderived interleukin 1 alpha　[J]. Proc Natl Acad Sci USA, 1998; 95(12)∶6971.
19. Rodriguez F, Peran F, Garrido F, et al. Upmodulation by estrogen of HLA class Ⅰ expression in breast tumor cell lines [J]. Immunogenetics， 1994；　39(3)∶161.
20. Kurt RA,Urba WJ,Smith JW,et al.Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules　[J].Int J Cancer,1998; 78(1)∶16.
21. Pizer ES, Chrest FJ, DiGiuseppe JA, et al. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines 　[J]. Cancer Res, 1998；　58(20)∶4611.
22. 杨晓东，王杉，于永祥,等. 细胞核因子NFκB在人大肠癌组织中的表达及意义　[J]. 中华普通外科杂志, 2000；　15（6）∶ 367.
23. 陈尧,刘执玉，李瑞祥,等. 人直肠腺癌淋巴管内皮细胞ICAM1的转录调节　[J]. 华西医科大学学报， 2000；　31（3）∶ 315.
24. La Rosa F, Pierce JW, Sonenshein GE. Differential regulation of the cmyc oncogene promoter by the NFκB rel family of transcription factors　[J]. Mol Cell Biol, 1994；　 14 (2)∶1039.
25. Sano H, Kawahito Y, Wilder RL, et al.　Expression of cyclooxygenase1 and 2 in human colorectal cancer　[J]. Cancer Res,　1995; 55(17)∶3785.
26. Tsujii M, Kowano S, DuBois RN. Cycloxygenase2 expression in human colon cancer cells increases metastatic potential 　[J]. Proc Natl Acad Sci USA, 1997；　94(7)∶ 3336.
27. Dustin ML,Springer TA.Lymphocyte functionassociated antigen1(LFA1) interaction with intercellular adhesion molecule1(ICAM1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cell 　[J]. J Cell Biol,1988；　107(1)∶321.
28. Makgoba MW, Sanders ME, Ginther Luce GE, et al.　ICAM1 a ligand for LFA1dependent adhesion of B, T and myeloid cells Nature [J]. 1988; 331(6151)∶86.
29. Auphan N, DiDonato JA, Rosette C, et al. Immunosuppression by glucocorticoids: inhibition of NFκB activity through induction of IκB synthesis 　[J]. Science, 1995；　270(5234)∶286.
30. Paillard F. Induction of apoptosis with IκB, the inhibitor of NFκB 　[J]. Hum Gene Ther, 1999；　10(1)∶1.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Nuclear Factor-κB and Colon Cancer

Abstract Full text Figures/Tables Video References Cited by

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