RT-PCR法检测常规病理检查淋巴结阴性胃癌的淋巴结微转移_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

肖卫东 ¹ , 彭承宏 ¹ , 王梦龙 ² , 邹叶青 ² , 程华 ² , 朱培谦 ²

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Keywords：

胃癌; 淋巴结; 微转移; CEA; RT-PCR

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淋巴结转移是胃癌行根治性切除术后转移和复发的主要途径之一，有无淋巴结转移及转移淋巴结数目的多少与胃癌的预后密切相关［1］。常规组织学检查淋巴结有可能忽略微转移的存在，这将直接影响着临床分期的准确性、预后预测以及辅助治疗的选择。为此，我们采用靶向癌胚抗原（CEA）mRNA的巢式逆转录聚合酶链反应（Nested RTPCR）方法，检测常规病理检查淋巴结阴性胃癌的淋巴结微转移情况并探讨其临床意义。

Citation： 肖卫东,彭承宏,王梦龙,邹叶青,程华,朱培谦. RT-PCR法检测常规病理检查淋巴结阴性胃癌的淋巴结微转移. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(5): 487-488. doi: Copy

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2. Mori M, Mimori K, Inoue H, et al. Detection of cancer micrometastasis in lymph nodes by reverse transcriptasepolymerase chain reaction [Ｊ]. Cancer Res, 1995; 55(15)∶3417.
3. Brown DC, Purushotham AD, Birnie GD, et al. Detection of intraoperative tumor cell dissemination in patients with breast cancer by use of reverse transcription and polymerase chain reaction [Ｊ]. Surgery, 1995; 117(1)∶95.
4. Japanses Gastric Carcinoma Association. Japanese Classification of gastric carcinoma2nd English Edition [Ｊ]. Gastric Cancer, 1998; 1(1)∶10.
5. Roder JD, Bottcher K, Busch R, et al. Classification of regional lymph node metastasis from gastric carcinoma [Ｊ]. Cancer, 1998; 82(4)∶621.
6. Baba H, Maehara Y, Takeuchi H, et al. Effect of lymph node dissection on the prognosis in patients with nodenegative early gastric cancer [Ｊ]. Surgery, 1995; 117(2)∶165.
7. Mori M, Mimori K, Ueo H, et al. Clinical significance of molecular detection of carcinoma cells in lymph nodes and peripheral blood by reverse transcriptionpolymerase chain reaction in patients with gastrointestinal or breast carcinomas [Ｊ]. J Clin Oncol, 1998; 16(1)∶128.
8. Harrison LE, Choe JK, Goldstein M, et al. Prognostic significance of immunohistochemical micrometastases in node negative gastric cancer patients [Ｊ]. J Surg Oncol, 2000; 73(3)∶153.
9. Nakajo A, Natsugoe S, Ishigamis S, et al. Detection and prodiction of micrometastasis in the lymph nodes of patients with pN0 gastric cancer [Ｊ]. Ann Surg Oncol, 2001; 8(2)∶158.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

RT-PCR法检测常规病理检查淋巴结阴性胃癌的淋巴结微转移

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