Clinical Study of Internal Radiotherapy with Hepatic Intraarterial Iodine131 Labeled Material for Hepatocellular Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

U Shaoping , LU Wusheng

Department of Radiotherapy, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Iodine131Hepatocellular carcinomaChemoembolizationInternal radiation therapy

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ObjectiveTo discuss the clinical value of internal radiation therapy with hepatic intraarterial iodine131 labeled material for the treatment of hepatocellular carcinoma (HCC). MethodsThis summarized paper was made on literature review. ResultsIodine131lipiodol and several reported iodine131labeled antibodies to HCC associated antigens were concentrated in the foci of HCC with a high tumortonormaltissue absorbed dose ratios. No severe side effects occurred. It was used in various kinds of HCC patients, and mostly showed a significant tumor response. Survival rate of HCC patients was raised in several clinical trials.Conclusion Internal radiotherapy with hepatic intraarterial iodine131 labeled material may be considered as an effective method to treat HCC.

Citation： U Shaoping,LU Wusheng. Clinical Study of Internal Radiotherapy with Hepatic Intraarterial Iodine131 Labeled Material for Hepatocellular Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(5): 513-515. doi: Copy

1.	Liu CL, Fan ST. Nonresectional therapies for hepatocellular carcinoma [J]. Am J Surg, 1997; 173(4)∶358.
2.	Lau WY, Leung TW, Ho SK, et al. Adjuvant intraarterial iodine131labelled lipiodol for resectable hepatocellular carcinoma: a prospective randomised trial [J]. Lancet, 1999; 353(9155)∶797.
3.	de Baere T, Taourel P, Tubiana JM, et al. Hepatic intraarterial 131I iodized oil for treatment of hepatocellular carcinoma in patients with impeded portal venous flow [J]. Radiology, 1999; 212(3)∶665.
4.	Raoul JL, Bourguet P, Bretagne JF, et al. Hepatic artery injection of I131labeled lipiodol. Part Ⅰ. Biodistribution study results in patients with hepatocellular carcinoma and liver metastases [J]. Radiology, 1988; 168(2)∶541.
5.	Ychou M, Pelegrin A, Faurous P, et al. PhaseI/II radioimmunotherapy study with iodine131labeled antiCEA monoclonal antibody F6 F(ab’)2 in patients with nonresectable liver metastases from colorectal cancer [J]. Int J Cancer, 1998; 75(4)∶615.
6.	隋延仿,何风昌,陈志南.131碘肝癌单克隆抗体Fab片段偶合物体内放射免疫显像研究 [J]. 中华医学杂志, 1999; 78(7)∶537.
7.	Novell R, Hilson A, Hobbs K. Ablation of recurrent primary liver cancer using 131Ilipiodol [J]. Postgrad Med J, 1991; 67（786） ∶393.
8.	Ho S,Lau WY,Leung TW, et al. Internal radiation therapy for patients with primary or metastatic hepatic cancer： a review [J]. Cancer, 1998; 83(9)∶1894.
9.	Risse JH,Grunwald F,Strunk H, et al. I131lipiodol therapy in liver neoplasms [J]. Hybridoma, 1999; 18(1)∶83.
10.	Brans B,De Winter F,Defreyne L, et al. The antitumoral activity of neoadjuvant intraarterial 131Ilipiodol treatment for hepatocellular carcinoma： a pilot study [J]. Cancer Biother Radiopharm, 2001; 16(4)∶333.
11.	Partensky C, Sassolas G, Henry L, et al. Intraarterial iodine 131labeled lipiodol as adjuvant therapy after curative liver resection for hepatocellular carcinoma: a phase 2 clinical study [J]. Arch Surg, 2000; 135(11)∶1298.
12.	Tan SB, Machin D, Cheung YB, et al. Following a trial that stopped early: what next for adjuvant hepatic intraarterial iodine131 lipiodol in resectable hepatocellular carcinoma? [J]. J Chin Oncol. 2002; 20(6)∶1709.
13.	吴英德, 杨克政, 刘由庚, 等.131I抗AFP抗体导向治疗肝癌的临床观察 [J]. 肿瘤, 1994; 14(4)∶200.
14.	Zeng ZC, Tang ZY, Liu KD, et al. Improved longterm survival for unresectable hepatocellular carcinoma (HCC) with a combination of surgery and intrahepatic arterial infusion of 131IantiHCC mAb. Phase I/II clinical trials [J]. J Cancer Res Clin Oncol, 1998; 124(5)∶275.
15.	项明，朱上林，林言箴，等.131IHepama1单克隆抗体导向治疗肝癌的初步观察 [J]. 中国肿瘤临床, 1998； 25(4)∶289.
16.	Abrams RA, Pajak TF, Haulk TL, et al. Survival results among patients with alphafetoproteinpositive,unresectable hepatocellular carcinoma: analysis of three sequential treatments of the RTOG and Johns Hopkins Oncology Center [J]. Cancer J Sci Am, 1998; 4(3)∶178.

1. Liu CL, Fan ST. Nonresectional therapies for hepatocellular carcinoma [J]. Am J Surg, 1997; 173(4)∶358.
2. Lau WY, Leung TW, Ho SK, et al. Adjuvant intraarterial iodine131labelled lipiodol for resectable hepatocellular carcinoma: a prospective randomised trial [J]. Lancet, 1999; 353(9155)∶797.
3. de Baere T, Taourel P, Tubiana JM, et al. Hepatic intraarterial 131I iodized oil for treatment of hepatocellular carcinoma in patients with impeded portal venous flow [J]. Radiology, 1999; 212(3)∶665.
4. Raoul JL, Bourguet P, Bretagne JF, et al. Hepatic artery injection of I131labeled lipiodol. Part Ⅰ. Biodistribution study results in patients with hepatocellular carcinoma and liver metastases [J]. Radiology, 1988; 168(2)∶541.
5. Ychou M, Pelegrin A, Faurous P, et al. PhaseI/II radioimmunotherapy study with iodine131labeled antiCEA monoclonal antibody F6 F(ab’)2 in patients with nonresectable liver metastases from colorectal cancer [J]. Int J Cancer, 1998; 75(4)∶615.
6. 隋延仿,何风昌,陈志南.131碘肝癌单克隆抗体Fab片段偶合物体内放射免疫显像研究 [J]. 中华医学杂志, 1999; 78(7)∶537.
7. Novell R, Hilson A, Hobbs K. Ablation of recurrent primary liver cancer using 131Ilipiodol [J]. Postgrad Med J, 1991; 67（786） ∶393.
8. Ho S,Lau WY,Leung TW, et al. Internal radiation therapy for patients with primary or metastatic hepatic cancer： a review [J]. Cancer, 1998; 83(9)∶1894.
9. Risse JH,Grunwald F,Strunk H, et al. I131lipiodol therapy in liver neoplasms [J]. Hybridoma, 1999; 18(1)∶83.
10. Brans B,De Winter F,Defreyne L, et al. The antitumoral activity of neoadjuvant intraarterial 131Ilipiodol treatment for hepatocellular carcinoma： a pilot study [J]. Cancer Biother Radiopharm, 2001; 16(4)∶333.
11. Partensky C, Sassolas G, Henry L, et al. Intraarterial iodine 131labeled lipiodol as adjuvant therapy after curative liver resection for hepatocellular carcinoma: a phase 2 clinical study [J]. Arch Surg, 2000; 135(11)∶1298.
12. Tan SB, Machin D, Cheung YB, et al. Following a trial that stopped early: what next for adjuvant hepatic intraarterial iodine131 lipiodol in resectable hepatocellular carcinoma? [J]. J Chin Oncol. 2002; 20(6)∶1709.
13. 吴英德, 杨克政, 刘由庚, 等.131I抗AFP抗体导向治疗肝癌的临床观察 [J]. 肿瘤, 1994; 14(4)∶200.
14. Zeng ZC, Tang ZY, Liu KD, et al. Improved longterm survival for unresectable hepatocellular carcinoma (HCC) with a combination of surgery and intrahepatic arterial infusion of 131IantiHCC mAb. Phase I/II clinical trials [J]. J Cancer Res Clin Oncol, 1998; 124(5)∶275.
15. 项明，朱上林，林言箴，等.131IHepama1单克隆抗体导向治疗肝癌的初步观察 [J]. 中国肿瘤临床, 1998； 25(4)∶289.
16. Abrams RA, Pajak TF, Haulk TL, et al. Survival results among patients with alphafetoproteinpositive,unresectable hepatocellular carcinoma: analysis of three sequential treatments of the RTOG and Johns Hopkins Oncology Center [J]. Cancer J Sci Am, 1998; 4(3)∶178.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Study of Internal Radiotherapy with Hepatic Intraarterial Iodine131 Labeled Material for Hepatocellular Carcinoma

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