Ischemia-Reperfusion Injury and Cellular Apoptosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

P.L.A Center of General Surgery, General Hospital of Chengdu Military Command,Chengdu 610083;

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Keywords：

Ischemia; Reperfusion; Apoptosis

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Objective To evaluate the phenomena of apoptosis and its relevant mechanism during ischemia-reperfusion period.
Methods The published papers to explore the apoptotic phenomena and its mechanism in organs or tissues which experienced ischemia-reperfusion injury were reviewed.
Results Apoptosis was common in ischemia-reperfusioned organ or tissue. The severity of apoptosis was influenced by many factors such as ischemia, hypoxia, oxygen free radials, intracellular free calcium ion overloading, various cytokines, et al; and also was regulated by bcl-2 family, caspase family and NF-κB，et al. Conclusion Apoptosis is a common phenomenum in ischemiareperfusioned organ or tissue which is affected and regulated by various factors.

Citation： WANG Yu,TIAN Fuzhou. Ischemia-Reperfusion Injury and Cellular Apoptosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(1): 61-64. doi: Copy

1.	Trieb K, Eberl T, Steger M, et al. Apoptosis is involved in endothelial cells damage during preservation and influenced by organ storage solutions [Ｊ]. Transplant Proc, 1997; 29（1-2）∶416.
2.	Momburg F, Neefjes JJ, Hammerling GJ. Peptide selection by MHCencoded TAP transperters [Ｊ]. Curr Opin In Immunol, 1994; 6（1）∶32.
3.	Eastman A. Apoptosis: a product of programmed and unprogrammed cell death [Ｊ]. Toxico Appl Pharmacol, 1993; 121（1）∶160.
4.	Shimamatsu K, Wanless IR. Role of ischemia in causing apoptosis, atrophy, and nodular hyperplasia in human liver [Ｊ]. Hepatology, 1997; 26(2)∶343.
5.	Li Y, Chopp M, Jiang N, et al. Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats [Ｊ]. Stroke, 1995; 26(7)∶1251.
6.	MacManus JP, Hill IE, Preston E, et al. Differences in DNA fragmentation following transiet cerebral or decapitation ischemia in rats [Ｊ]. J Cereb Blood Flow Matab, 1995; 15(3)∶728.
7.	Fliss H. Accelerated apoptosis in reperfused myocardium: friend of foe [Ｊ]? Basic Res Cardiol, 1998; 93(2)∶90.
8.	Sasaki H, Matsuno T, Tanaka N, et al. Activation of apoptosis during the reperfusion phase after rat liver ischemia [Ｊ]. Transplan Proc, 1996; 28(3)∶1908.
9.	Kuo PC, Drachenberg CI, de la Torre A, et al. Apoptosis and hepatic allograft reperfusion injury [Ｊ]. Clin Transplant, 1998; 12(3)∶219.
10.	Borghi G, Scoazec JY, Durand F, et al. Apoptosis after ischemiareperfusion in human liver allograft [Ｊ]. Liver Transpl Surg, 1997; 3(4)∶407.
11.	Sasaki H,Matsuno T, Ishikawa T, et al. Activation of apoptosis during early phase of reperfusion after liver transplantation [Ｊ]. Transplan Proc , 1997; 29(1)∶40.
12.	Ilan Y, Roy Chowdhury N, Prakash R, et al. Massive repopulation of rat liver by transplantation of hepatocytes into specific lobes of liver and ligation of portal vein branches to other lobes [Ｊ]. Transplantation, 1997; 64(1)∶ 8.
13.	Hayashi A, Ito H, Shomori K, et al. Frequent occurrence of hepatocytic apoptosis in acute rejection of the grafted rat liver [Ｊ]. Pathol Int, 1997; 47(8)∶518.
14.	Leist M, Gantner F, Bohlinger I, et al. Murine hepatocyte apoptosis induced in vitro and in vivo by TNFalpha requires transcriptional arrest [Ｊ]. J Immunol, 1994; 153(4)∶1778.
15.	Tsukidate L, Yamamoto K, Snyder, et al. Microtubule antagonists activate programmed cell death(apoptosis) in culture rat hepatocytes [Ｊ]. Am J Pathol, 1993; 143(3)∶918.
16.	Davis A, Chen A. Transforming growth factor beta liver regeneration: the stage may be set,but what’s the script [Ｊ]. Hepatology, 1996; 23(6)∶1703.
17.	Guide K, Patrice P, Nacoufal Z, et al. The biochemistry of programmed cell death [Ｊ]. FASEB, 1995; 9(3)∶1277.
18.	Dider D, Stephen G, Tamara H, et al. Bcl2 and bclXL, antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotheapeutic agents [Ｊ]. Cancer Res, 1997; 57(1)∶62.
19.	Zamzami N, Marchetti P, Coetedo M, et al. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lynphocyte death in vivo [Ｊ]. J Exp Med, 1995; 181(5)∶1662.
20.	Liu X, Kim CN, Yang J, et al. Induction of apoptotic program in cellfree eatracts: requirement for dATP and cytochrome C [Ｊ]. Cell, 1996; 86(1)∶147.
21.	Majno G, Joris I. Apoptosis, oncosis and necrosis.An overview of cell death [see comments] [Ｊ]. Am J Pathol, 1995; 146(1)∶ 3.
22.	Rodriguez I, Matsuura K, Khatib K, et al. A bcl2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by antiFas antibody injection [Ｊ]. J Exp Med, 1996; 183(3)∶1031.
23.	Lam A, Bhat MB, Nunez G, et al. Regulation of bclxL channel activity by calcium [Ｊ]. Biol Chem, 1998; 273(28)∶17307.
24.	Wei HF, Wei WL, Bredesen DE, et al. Bcl2 protects against apoptosis in neuronal cell line caused by thapsingargininduced depletion of intracellular calcium stores [Ｊ]. J Neurochem, 1998; 70(6)∶2305.
25.	Zamzami N, Brenner C, Marzo I, et al. Subcellular and submitochondrial mode of action of bcl2like oncoproteins [Ｊ]. Oncogene, 1998; 16(17)∶2265.
26.	Cai JY, Jones DP. Superoxide in apoptosis: mitochondrial generation triggered by cytochrome C loss [Ｊ]. J Biol Chem, 1998; 273(19)∶11401.
27.	Goto S, Matsumoto I, Kamada N, et al. The induction of immediate early genes in postischemic and transplanted livers in rats.Its relation to organ survival [Ｊ]. Transplantation, 1994; 58(7)∶840.
28.	Schlossberg H, Zhang Y, Dudus L, et al. Expression of cfos and cjun during hepatocellular remodeling following ischemia/reperfusion in mouse liver [Ｊ]. Hepatology, 1996; 23(6)∶1546.
29.	Chinnaiyan AM, O’Rourke K, Lane BR, et al. Interaction of CED4 with CED3 and CED9: a molecular framework for cell death [see comments] [Ｊ]. Science, 1997; 275(5303)∶1122.
30.	Kamada S,Washida M,Hasegawa JI,et al. Involvement of caspase4(like) protease in Fasmediated apoptotic pathway [Ｊ]. Oncogene, 1997; 15(3)∶285.
31.	Walach D,Mckenna KA,Bedi A.Pin1 kinase stimulates cMycmediated death signaling upstream of caspase3 (CPP32)like protesase activation [Ｊ]. TIBS, 1997; 22(1)∶107.
32.	Fuchs EJ,Mckenna KA,Bedi A,et al. p53dependent DNA damageinduced apoptosis requires Fas/APO1independent activation of CPP32 beta [Ｊ]. Cancer Res,1997; 57(13)∶2550.
33.	Kitanaka C, Namiki T, Noguchi K, et al. Caspasedependent apoptosis of cos7 cells induced by Bax overexpression: differential effects bcl2 and bclxL on Baxinduced caspase activation and apoptosis [Ｊ].Oncogene, 1997; 15(15)∶1763.
34.	Black WR, Agner RC. A metalloproteinase distintegrin that releases tumournecrosis factoralpha from cells [Ｊ]. Nature, 1997; 391(6666)∶ 450.
35.	Baeuerie PA ,Baltimore D. NFkappa B: ten years after [Ｊ]. Cell, 1996; 87(1)∶13.
36.	Parry G, Mackman N. A set of inducible genes expressed by activated human monocytic and endothelial cells contains kappa blike sites specifically bind cRelp65 heterodimers [Ｊ]. J Biol Chem, 1994; 269(33)∶ 20823.
37.	Wang CY, Mayo MW, Korneluk RG, et al. NFκB antiapoptosis: induction of TRAF1 and TRAF2 and cIAP1 and cIAP2 to suppress caspase8 activation [Ｊ]. Science, 1998; 281(11)∶1680.

1. Trieb K, Eberl T, Steger M, et al. Apoptosis is involved in endothelial cells damage during preservation and influenced by organ storage solutions [Ｊ]. Transplant Proc, 1997; 29（1-2）∶416.
2. Momburg F, Neefjes JJ, Hammerling GJ. Peptide selection by MHCencoded TAP transperters [Ｊ]. Curr Opin In Immunol, 1994; 6（1）∶32.
3. Eastman A. Apoptosis: a product of programmed and unprogrammed cell death [Ｊ]. Toxico Appl Pharmacol, 1993; 121（1）∶160.
4. Shimamatsu K, Wanless IR. Role of ischemia in causing apoptosis, atrophy, and nodular hyperplasia in human liver [Ｊ]. Hepatology, 1997; 26(2)∶343.
5. Li Y, Chopp M, Jiang N, et al. Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats [Ｊ]. Stroke, 1995; 26(7)∶1251.
6. MacManus JP, Hill IE, Preston E, et al. Differences in DNA fragmentation following transiet cerebral or decapitation ischemia in rats [Ｊ]. J Cereb Blood Flow Matab, 1995; 15(3)∶728.
7. Fliss H. Accelerated apoptosis in reperfused myocardium: friend of foe [Ｊ]? Basic Res Cardiol, 1998; 93(2)∶90.
8. Sasaki H, Matsuno T, Tanaka N, et al. Activation of apoptosis during the reperfusion phase after rat liver ischemia [Ｊ]. Transplan Proc, 1996; 28(3)∶1908.
9. Kuo PC, Drachenberg CI, de la Torre A, et al. Apoptosis and hepatic allograft reperfusion injury [Ｊ]. Clin Transplant, 1998; 12(3)∶219.
10. Borghi G, Scoazec JY, Durand F, et al. Apoptosis after ischemiareperfusion in human liver allograft [Ｊ]. Liver Transpl Surg, 1997; 3(4)∶407.
11. Sasaki H,Matsuno T, Ishikawa T, et al. Activation of apoptosis during early phase of reperfusion after liver transplantation [Ｊ]. Transplan Proc , 1997; 29(1)∶40.
12. Ilan Y, Roy Chowdhury N, Prakash R, et al. Massive repopulation of rat liver by transplantation of hepatocytes into specific lobes of liver and ligation of portal vein branches to other lobes [Ｊ]. Transplantation, 1997; 64(1)∶ 8.
13. Hayashi A, Ito H, Shomori K, et al. Frequent occurrence of hepatocytic apoptosis in acute rejection of the grafted rat liver [Ｊ]. Pathol Int, 1997; 47(8)∶518.
14. Leist M, Gantner F, Bohlinger I, et al. Murine hepatocyte apoptosis induced in vitro and in vivo by TNFalpha requires transcriptional arrest [Ｊ]. J Immunol, 1994; 153(4)∶1778.
15. Tsukidate L, Yamamoto K, Snyder, et al. Microtubule antagonists activate programmed cell death(apoptosis) in culture rat hepatocytes [Ｊ]. Am J Pathol, 1993; 143(3)∶918.
16. Davis A, Chen A. Transforming growth factor beta liver regeneration: the stage may be set,but what’s the script [Ｊ]. Hepatology, 1996; 23(6)∶1703.
17. Guide K, Patrice P, Nacoufal Z, et al. The biochemistry of programmed cell death [Ｊ]. FASEB, 1995; 9(3)∶1277.
18. Dider D, Stephen G, Tamara H, et al. Bcl2 and bclXL, antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotheapeutic agents [Ｊ]. Cancer Res, 1997; 57(1)∶62.
19. Zamzami N, Marchetti P, Coetedo M, et al. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lynphocyte death in vivo [Ｊ]. J Exp Med, 1995; 181(5)∶1662.
20. Liu X, Kim CN, Yang J, et al. Induction of apoptotic program in cellfree eatracts: requirement for dATP and cytochrome C [Ｊ]. Cell, 1996; 86(1)∶147.
21. Majno G, Joris I. Apoptosis, oncosis and necrosis.An overview of cell death [see comments] [Ｊ]. Am J Pathol, 1995; 146(1)∶ 3.
22. Rodriguez I, Matsuura K, Khatib K, et al. A bcl2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by antiFas antibody injection [Ｊ]. J Exp Med, 1996; 183(3)∶1031.
23. Lam A, Bhat MB, Nunez G, et al. Regulation of bclxL channel activity by calcium [Ｊ]. Biol Chem, 1998; 273(28)∶17307.
24. Wei HF, Wei WL, Bredesen DE, et al. Bcl2 protects against apoptosis in neuronal cell line caused by thapsingargininduced depletion of intracellular calcium stores [Ｊ]. J Neurochem, 1998; 70(6)∶2305.
25. Zamzami N, Brenner C, Marzo I, et al. Subcellular and submitochondrial mode of action of bcl2like oncoproteins [Ｊ]. Oncogene, 1998; 16(17)∶2265.
26. Cai JY, Jones DP. Superoxide in apoptosis: mitochondrial generation triggered by cytochrome C loss [Ｊ]. J Biol Chem, 1998; 273(19)∶11401.
27. Goto S, Matsumoto I, Kamada N, et al. The induction of immediate early genes in postischemic and transplanted livers in rats.Its relation to organ survival [Ｊ]. Transplantation, 1994; 58(7)∶840.
28. Schlossberg H, Zhang Y, Dudus L, et al. Expression of cfos and cjun during hepatocellular remodeling following ischemia/reperfusion in mouse liver [Ｊ]. Hepatology, 1996; 23(6)∶1546.
29. Chinnaiyan AM, O’Rourke K, Lane BR, et al. Interaction of CED4 with CED3 and CED9: a molecular framework for cell death [see comments] [Ｊ]. Science, 1997; 275(5303)∶1122.
30. Kamada S,Washida M,Hasegawa JI,et al. Involvement of caspase4(like) protease in Fasmediated apoptotic pathway [Ｊ]. Oncogene, 1997; 15(3)∶285.
31. Walach D,Mckenna KA,Bedi A.Pin1 kinase stimulates cMycmediated death signaling upstream of caspase3 (CPP32)like protesase activation [Ｊ]. TIBS, 1997; 22(1)∶107.
32. Fuchs EJ,Mckenna KA,Bedi A,et al. p53dependent DNA damageinduced apoptosis requires Fas/APO1independent activation of CPP32 beta [Ｊ]. Cancer Res,1997; 57(13)∶2550.
33. Kitanaka C, Namiki T, Noguchi K, et al. Caspasedependent apoptosis of cos7 cells induced by Bax overexpression: differential effects bcl2 and bclxL on Baxinduced caspase activation and apoptosis [Ｊ].Oncogene, 1997; 15(15)∶1763.
34. Black WR, Agner RC. A metalloproteinase distintegrin that releases tumournecrosis factoralpha from cells [Ｊ]. Nature, 1997; 391(6666)∶ 450.
35. Baeuerie PA ,Baltimore D. NFkappa B: ten years after [Ｊ]. Cell, 1996; 87(1)∶13.
36. Parry G, Mackman N. A set of inducible genes expressed by activated human monocytic and endothelial cells contains kappa blike sites specifically bind cRelp65 heterodimers [Ｊ]. J Biol Chem, 1994; 269(33)∶ 20823.
37. Wang CY, Mayo MW, Korneluk RG, et al. NFκB antiapoptosis: induction of TRAF1 and TRAF2 and cIAP1 and cIAP2 to suppress caspase8 activation [Ｊ]. Science, 1998; 281(11)∶1680.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Ischemia-Reperfusion Injury and Cellular Apoptosis

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