The Clinical Significance of the Contents of CD44v5 in Peripheral Blood of Patients with Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Surgery,The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029;

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Keywords：

Peripheral blood lymphocyteCD44 variant 5Gastric cancer

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ObjectiveTo study the contents of CD44 that shared exon variant 5 (CD44v5) in peripheral blood lymphocytes (PBL) of patients with gastric carcinoma and the expression of CD44v5 in tumor tissue and their clinical significance. MethodsThe contents of CD44v5 were determined by FlowCytometry in PBL of 31 patients with gastric carcinoma before surgery and 10 normal controls. Tissue expression of CD44v5 in 33 patients with gastric carcinoma was investigated by immunohistochemistry. ResultsThe contents of CD44v5 were significantly higher in PBL of patients with gastric carcinoma before surgery than those of controls (P＜0.01). Nodepositive gastric cancer patients showed significantly elevated contents of CD44v5 in PBL in comparison with nodenegative gastric cancer (P＜0.01）. Significant correlations were noted between the contents of CD44v5 in PBL of patients with gastric carcinoma before surgery and tumor size, depth of invasion, lymph node metastasis and different the Vnion International Centre Le Cancer (VICC) stages of tumor (P＜0.05). The expression of CD44v5 could be detected in 69.7% of tumor tissue,but was not detected in adjacent normal gastric mucosa. Significant correlations were noted between CD44v5 expression and depth of invasion,and lymph node metastasis.The presence of CD44v5 protein was correlated with the lymph node involvement rate. Conclusion CD44v5 in PBL or tumor tissue may be useful as a metastatic marker. It may be of important clinical value in the diagnosis of metastasis and judgement of development for the patients with gastric cancer.

Citation： CHEN Guoyu,ZHAO Qinhong,YUAN Jinglun,et al.. The Clinical Significance of the Contents of CD44v5 in Peripheral Blood of Patients with Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(3): 148-150. doi: Copy

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1. Saito H, Tsujiatani S, Katano K, et al. Serum concentration of CD44 variant 6 and its relation to prognosis in patients with gastric carcinoma [J]. Cancer， 1998; 83（6）∶1094.
2. Naot D, Sionov RV, Ish SD, et al. CD44: structure, function, and association with the malignant process [J]. Adv Cancer Res， 1997； 71(2)∶241.
3. Gunthert U, Hofmann M, Rudy W, et al. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells [J]. Cell， 1991； 65（1）∶13.
4. Harn HJ, Ho LI，Chang JY, et al. Differential expression of the human metastasis adhesion molecule CD44v in normal and carcinomatous stomach mucosa of Chinese subjects [J]. Cancer， 1995； 75（5）∶1065.
5. Muller W, Scheiders A, Heider KH,et al.Expression and prognostic value of the CD44 splicing variants v5 and v6 in gastric cancer [J]. J Path， 1997; 183（2）∶222.
6. Arch R，Wirth K, Hofmann M, et al. Participation in normal immune responses of a metastasisinducing splice variant of CD44 [J]. Science， 1992； 257（5070）∶682.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Clinical Significance of the Contents of CD44v5 in Peripheral Blood of Patients with Gastric Cancer

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