The Expression of Growth Hormone Receptor in Human Hepatocellular Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041;

Corresponding author：

Keywords：

Hepatocellular carcinoma; Immunohistochemistry; Growth hormone receptor

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo explore whether the growth hormone receptor (GHR) is present in human hepatocellular carcinoma (HCC). MethodsThe GHR were measured in samples of human HCC (50 cases), the liver tissues adjacent to hepatocellular carcinoma (49 cases), cirrhotic liver tissues (30 cases) and control liver tissues (30 cases) by immunohistochemistry technique. ResultsThe GHR positive expression rate was 42.0% in samples of human hepatocellular carcinoma, and 95.9% in adjacent tissue of HCC, 96.7% in cirrhotic liver tissues, and 93.3% in normal liver tissues; the significance of the differences in the GHR positive expression rate was seen between HCC and the compared groups.ConclusionThe lower expression of GHR in HCC is present. The growth hormone administration can be used in patients of HCC with radical resection or GHR negative expression patient.

Citation： XIANG Chunhua,YAN Lnan,LIN Qiyuan,et al.. The Expression of Growth Hormone Receptor in Human Hepatocellular Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(4): 255-257. doi: Copy

1.	Donaghy A, Ross R, Wicks C， et al. Growth hormone therapy in patients with cirrhosis: a pilot study of efficacy and safety [J]. Gastroenterology， 1997； 113(5)∶1617.
2.	周涌,吴言涛,贾乾斌，等. hGH对肝部分切除术后促进肝再生的动物实验研究 [J]. 中国普外基础与临床杂志,2001； 8(5)∶298.
3.	严律南. 重组生长激素对肝叶切除术后肝再生作用的临床研究 [J]. 中国实用外科杂志,1999； 19(增刊)∶46.
4.	UICC. TNM classification of maliganant tumors [M]. 4th Ed. Berlin： Springer, 1987∶53～54.
5.	朱立平，陈学清主编. 免疫学常用实验方法 [M]. 人民军医出版社,2000∶399.
6.	Chang TC, Lin JJ, Yu SC, et al. Absence of growthhormone receptor in hepatocellular carcinoma and cirrhotic liver [J]. Hepatology, 1990； 11(1)∶123.
7.	Gatmaitan Z, Jefferson DM, RuizOpazo N, et al. Regulation of growth and differentiation of a rat hepatoma cell line by the synergistic interactions of hormones and collagenous substrata [J]. J Cell Biol, 1983； 97(4)∶1179.
8.	GarciaCaballero T, Mertani HM, Lambert A, et al. Increased expression of growth hormone and prolactin receptors in hepatocellular carcinomas [J]. Endocrine, 2000； 12(3)∶265.
9.	Zogopoulos G, Steffen A, Torsten P, et al. Fetal and tumorspecific regulation of growth hormone receptor messenger RNA expression in human liver [J]. Cancer Res,1996； 56(13)∶2949.
10.	Zogopoulos G, Figueiredo R, Jenab A, et al. Expression of exon 3retaining and deleted human growth hormone receptor messenger ribonucleic acid isoforms during development [J]. J Clin Endocrinol Metab, 1996； 81(2)∶775.
11.	Levinovitz A, Husman B, Eriksson LC, et al. Decreased expression of the growth hormone receptor and growth hormone binding protein in rat liver nodules [J]. Mol Carcinog, 1990； 3(3)∶157.
12.	王洪涛，陈双，区庆嘉，等. 实验性肝硬化过程中生长激素受体的动态变化 [J]. 中国实用外科杂志，1999； 19(增刊)∶58.
13.	徐希岳，黄詠齐，王启之，等. 肝炎后肝硬化患者血浆生长激素水平的变化 [J]. 蚌埠医学院学报,1997； 22（4）∶225.
14.	Tamar A, Moussa BHY, Zeev H. Does serum growth hormone(GH) binding protein reflect human GH receptor function? [J]. J Clin Endocrinol Metab, 2000； 85(3)∶927.

1. Donaghy A, Ross R, Wicks C， et al. Growth hormone therapy in patients with cirrhosis: a pilot study of efficacy and safety [J]. Gastroenterology， 1997； 113(5)∶1617.
2. 周涌,吴言涛,贾乾斌，等. hGH对肝部分切除术后促进肝再生的动物实验研究 [J]. 中国普外基础与临床杂志,2001； 8(5)∶298.
3. 严律南. 重组生长激素对肝叶切除术后肝再生作用的临床研究 [J]. 中国实用外科杂志,1999； 19(增刊)∶46.
4. UICC. TNM classification of maliganant tumors [M]. 4th Ed. Berlin： Springer, 1987∶53～54.
5. 朱立平，陈学清主编. 免疫学常用实验方法 [M]. 人民军医出版社,2000∶399.
6. Chang TC, Lin JJ, Yu SC, et al. Absence of growthhormone receptor in hepatocellular carcinoma and cirrhotic liver [J]. Hepatology, 1990； 11(1)∶123.
7. Gatmaitan Z, Jefferson DM, RuizOpazo N, et al. Regulation of growth and differentiation of a rat hepatoma cell line by the synergistic interactions of hormones and collagenous substrata [J]. J Cell Biol, 1983； 97(4)∶1179.
8. GarciaCaballero T, Mertani HM, Lambert A, et al. Increased expression of growth hormone and prolactin receptors in hepatocellular carcinomas [J]. Endocrine, 2000； 12(3)∶265.
9. Zogopoulos G, Steffen A, Torsten P, et al. Fetal and tumorspecific regulation of growth hormone receptor messenger RNA expression in human liver [J]. Cancer Res,1996； 56(13)∶2949.
10. Zogopoulos G, Figueiredo R, Jenab A, et al. Expression of exon 3retaining and deleted human growth hormone receptor messenger ribonucleic acid isoforms during development [J]. J Clin Endocrinol Metab, 1996； 81(2)∶775.
11. Levinovitz A, Husman B, Eriksson LC, et al. Decreased expression of the growth hormone receptor and growth hormone binding protein in rat liver nodules [J]. Mol Carcinog, 1990； 3(3)∶157.
12. 王洪涛，陈双，区庆嘉，等. 实验性肝硬化过程中生长激素受体的动态变化 [J]. 中国实用外科杂志，1999； 19(增刊)∶58.
13. 徐希岳，黄詠齐，王启之，等. 肝炎后肝硬化患者血浆生长激素水平的变化 [J]. 蚌埠医学院学报,1997； 22（4）∶225.
14. Tamar A, Moussa BHY, Zeev H. Does serum growth hormone(GH) binding protein reflect human GH receptor function? [J]. J Clin Endocrinol Metab, 2000； 85(3)∶927.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Expression of Growth Hormone Receptor in Human Hepatocellular Carcinoma

Abstract Full text Figures/Tables Video References Cited by

Format

Content