Activation and Significance of Nuclear Transcription FactorκB in Primary Breast Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

GUO Shuangping ¹

Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032;

Corresponding author：

Keywords：

Nuclear transcription factor-κB Breast carcinoma Immunohistochemistry

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Objective To investigate the activation and significance of nuclear transcription factorκB (NFκB) in primary breast carcinoma. MethodsImmunohistochemical staining method was used to detect expression of NFκB in 28 cases of primary breast carcinoma and 21 cases of breast tissues closely adjacent to carcinoma tissues. ResultsIt showed that there was expression of NFκB in 28 cases of breast carcinoma tissues and 21 cases of breast tissues closely adjacent to carcinoma. In 21 cases of breast tissues closely adjacent to carcinoma, NFκB was localized mainly in cytoplasm of epithelium cells of ducts and lobular acini. In 28 cases of breast carcinoma NFκB was mainly expressed in cytoplasm and /or nuclei of breast carcinoma cells. Conclusion NFκB is expressed in breast tissues closely adjacent to carcinoma and primary breast carcinoma tissues, and the expression style in the two situation was different. In the breast tissues closely adjacent to carcinoma, NFκB is localized in cytoplasm of epithelium cells of breast acini and duct in an inactive state. In breast carcinoma tissues, NFκB is localized in both cytoplasm and nuclei of carcinoma cells. This study suggests that NFκB is activated in breast carcinoma and plays a significant role in its tumorigenesis and development.

Citation： GUO Shuangping,WANG Wenliang,ZHAI Yuqiang,et al.. Activation and Significance of Nuclear Transcription FactorκB in Primary Breast Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 306-309. doi: Copy

1.	郭双平, 王文亮, 翟宇强. 核转录因子NFκB的研究进展 [J].中华病理学杂志, 2000； 29（5）∶379.
2.	Baeuerle PA， Baltimore D.NFkappa B: ten years after [J]. Cell,1996； 87(1)∶13.
3.	Mayo MW， Baldwin AS. The transcription factor NFkappa B: control of oncogenesis and cancer therapy resistance [J]. Biochim Biophy Acta,2000； 1470(2)∶M55.
4.	Burow ME, Weldon CB, Melnik LI, et al. PI3K/AKT regulation of NFkappa B signaling events in suppression of TNFinduced apoptosis [J]. Biochem Biophys Res Commun, 2000; 271(2)∶342.
5.	Baeuerle PA. Ikappa BNFkappa B structures: at the interface of inflammation control [J]. Cell, 1998； 95(6)∶729.
6.	Baeuerle PA, Henkel T. Function and activation of NFkappa B in the immune system [J]. Annu Rev Immunol,1994; 12(1)∶141.
7.	Beg AA, Sha W, Bronson RT, et al. Embryonic lethality and liver degeneration in mice lacking the Rel A component of NF kappa B [J]. Nature,1995； 376(6536)∶167.
8.	Bellas RE, FitzGerald MJ,Fausto N, et al. Inhibition of NFkappa B activity induces apoptosis in murine hepatocytes [J]. Am J Pathol,1997； 151(4)∶891.
9.	Beg AA， Baltimore D. An essential role for NFkappa B in preventing TNFalphainduced cell death [J].Science, 1996； 274(5288)∶782.
10.	Wang W, Abbruzzese JL, Evans DB,et al. The nuclear factorkappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells [J]. Clin Cancer Res, 1999； 5(1)∶119.
11.	Jo H, Zhang R, Zhang H, et al. NFkappa B is required for Hras oncogene induced abnormal cell proliferation and tumorigenesis [J].Oncogene, 2000; 19(7)∶841.
12.	Norris JL， Baldwin AS Jr. Oncogenic Ras enhances NFkappa B transcriptional activity through Rafdependent and Rafindependent mitogenactivated protein kinase signaling pathways [J]. J Biol Chem, 1999; 274(20)∶13841.
13.	Hinz M, Krappmann D, Eichten A, et al. NFkappa B function in growth control: regulation of cyclin D1 expression and G0/G1to Sphase transition [J]. Mol Cell Bio,1999； 19(4)∶2690.

1. 郭双平, 王文亮, 翟宇强. 核转录因子NFκB的研究进展 [J].中华病理学杂志, 2000； 29（5）∶379.
2. Baeuerle PA， Baltimore D.NFkappa B: ten years after [J]. Cell,1996； 87(1)∶13.
3. Mayo MW， Baldwin AS. The transcription factor NFkappa B: control of oncogenesis and cancer therapy resistance [J]. Biochim Biophy Acta,2000； 1470(2)∶M55.
4. Burow ME, Weldon CB, Melnik LI, et al. PI3K/AKT regulation of NFkappa B signaling events in suppression of TNFinduced apoptosis [J]. Biochem Biophys Res Commun, 2000; 271(2)∶342.
5. Baeuerle PA. Ikappa BNFkappa B structures: at the interface of inflammation control [J]. Cell, 1998； 95(6)∶729.
6. Baeuerle PA, Henkel T. Function and activation of NFkappa B in the immune system [J]. Annu Rev Immunol,1994; 12(1)∶141.
7. Beg AA, Sha W, Bronson RT, et al. Embryonic lethality and liver degeneration in mice lacking the Rel A component of NF kappa B [J]. Nature,1995； 376(6536)∶167.
8. Bellas RE, FitzGerald MJ,Fausto N, et al. Inhibition of NFkappa B activity induces apoptosis in murine hepatocytes [J]. Am J Pathol,1997； 151(4)∶891.
9. Beg AA， Baltimore D. An essential role for NFkappa B in preventing TNFalphainduced cell death [J].Science, 1996； 274(5288)∶782.
10. Wang W, Abbruzzese JL, Evans DB,et al. The nuclear factorkappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells [J]. Clin Cancer Res, 1999； 5(1)∶119.
11. Jo H, Zhang R, Zhang H, et al. NFkappa B is required for Hras oncogene induced abnormal cell proliferation and tumorigenesis [J].Oncogene, 2000; 19(7)∶841.
12. Norris JL， Baldwin AS Jr. Oncogenic Ras enhances NFkappa B transcriptional activity through Rafdependent and Rafindependent mitogenactivated protein kinase signaling pathways [J]. J Biol Chem, 1999; 274(20)∶13841.
13. Hinz M, Krappmann D, Eichten A, et al. NFkappa B function in growth control: regulation of cyclin D1 expression and G0/G1to Sphase transition [J]. Mol Cell Bio,1999； 19(4)∶2690.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Activation and Significance of Nuclear Transcription FactorκB in Primary Breast Carcinoma

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