RELATIONSHIP OF ANGIOGENESIS WITH PROGRESSION AND PROGNOSIS OF GALLBLADDER CARCINOMA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

BAI Tao ¹ , GUO Renxuan ¹ , WANG Hao. ²

Department of General Surgery, The First Affiliated Hospital, China University of Medical Sciences, Shenyang 110001;

Corresponding author：

Keywords：

Gallbladder cancer Angiogenesis Microvessel density

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Objective To investigate the relationship between microvessel density(MVD) and lymph node metastasis and prognosis in gallbladder carcinoma.
Methods The MVD in 42 gallbladder carcinoma by immunohistochemical SP method using a polyclonal antibody to FⅧ and the relationship between MVD and histologic types, depth of invasion, lymph node metastasis, distant metastasis and prognosis was studied.
Results The value of MVD was correlated with the depth of invasion (P＜0.05), lymph node metastasis (P＜0.01) and distant metastasis (P＜0.05). It was not significantly related to the pathologic pattern and tumor differentiation. The significantly negtive correlation was found between MVD and 5-year survival in patients with gallbladder carcinoma.
Conclusion MVD is bly related to the metastasis of gallbladder carcinoma. It may serve as a prognotic factor.

Citation： BAI Tao,GUO Renxuan,WANG Hao.. RELATIONSHIP OF ANGIOGENESIS WITH PROGRESSION AND PROGNOSIS OF GALLBLADDER CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(2): 101-103. doi: Copy

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1. Folkman J. Tumor angiogenesis:therapeutic implications [J]. N Engl J Med, 1971; 285∶1182.
2. Moscatelli D, Gross J, Rifkin D. Angiogenesis factors stimulate plasminogen activator and collagenase production by capillary endothelial cells [J]. J Cell Biol, 1981; 91∶201.
3. Toi M, Kashitani J, Tominaga T. Tumor angiogenesis is an indepent prognostic indicator in primary breast carcinoma [J]. Int J Cancer, 1993; 55∶371.
4. Weidner N, Carroll PR, Flax J. Tumor Angiogenesis Correlates with Metastasis in Invasive Prostate Carcinoma [J]. Am J Pathol, 1993; 143∶401.
5. Macchiarini P, Fontanini G, Hardin MJ, et al. Relation of neovascularisation to metastasis of nonsmallcell lung cancer [J]. Lancet, 1992; 340∶145.
6. Weidner N. Current Pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors [J]. Breast Cancer Res Treat, 1995; 36∶169.
7. Jianxin Wu. Apoptosis and angiogenesis: two promising tumor markers in breast cancer [J]. Anticancer Res, 1996; 16∶2233.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

RELATIONSHIP OF ANGIOGENESIS WITH PROGRESSION AND PROGNOSIS OF GALLBLADDER CARCINOMA

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