Objective To examine the relationship between ratio of proliferating cell nuclear antigen (PCNA)/apoptosis and biology of hepatocellular carcinoma.
Methods Thirty five cases of hepatocellular carcinoma were studied with TUNEL and immunohistochemistry. Results Positive rate of apoptosis in grade Ⅰ, Ⅱ, Ⅲand Ⅳ was 1.37%,0.70%, 0.67% and 0.25% respectively. Positive rate of PCNA in grade Ⅰ, Ⅱ, Ⅲ and Ⅳ was 17%, 19%, 75% and 80%. Ratio of PCNA/apoptosis in grade Ⅰ,Ⅱ,Ⅲ and Ⅳ was 19.04, 75.51, 138.01 and 345.52.
Conclusion Ratio of PCNA/apoptosis is correlated with histological classification.
Citation：
HE Yong,ZHOU Jun,DOU Kefeng.. THE EXAMINATION OF APOPTOSIS AND EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN IN HEPATOCELLULAR CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(4): 249-251. doi:
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- 2. 郑德先. 细胞凋亡的研究进展 〔Ｊ〕. 中华病理学杂志， 1996； 25（1）∶50.
- 3. Willims GT, Smith CA. Molecular regulation of apoptosis: genetic controls on cell death 〔Ｊ〕. Cell, 1993; 74(3)∶777.
- 4. Miyachi K. Autoantibody to a nuclear antigen in proliferating cells 〔Ｊ〕. Journal of Immunology, 1978; 121(10)∶2228.
- 5. Mathews MB, Bernstein RM, Franza BR Jr, et al. Identity of the proliferating cell nuclear antigen and cyclin 〔Ｊ〕. Nature, 1984; 309(5966)∶374.
- 6. Tuusa J, Uitto L, Syvaoja JE, Human DNA polymerase epsilon is expressed during cell proliferation in a manner characteristic of replicative DNA polymerases 〔Ｊ〕. Nucleic Acid Res, 1995; 23(12)∶2178.
- 7. Irene OL, Edward CS, Sheung T, et al. Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma 〔Ｊ〕. Cancer, 1994; 73(9)∶2268.
- 8. Soini Y, Virkajarvi N, Lehto VP, et al. Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shorted survival 〔Ｊ〕. Br J Cancer, 1996; 73(4)∶1025.
- 9. Hino N, Higashi T, Nouso K, et al. Apoptosis and proliferation of human hepatocellular carcinoma 〔Ｊ〕. Liver, 1996; 16(2)∶123.
