The level of androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR) of carcinoma and pericarcinoma tissue were determined in 30 cases of male hepatocellular carcinoma (HCC) patients operated by streptavidin peroxdase conjugated method, meanwhile used 20 patients with benign liver disease as a contrast group. The results showed that the positive rate of AR in tumor tisse was 80.0%, significantly higher than that in peritumor tissue (46.7%) and liver tissue of benign diseases (40.0%), Ｐ＜0.01, and there was no significantly difference between the latter two groups (Ｐ＞0.05). The positive rate of ER in carcinoma tissue (43.3%) was notably lower than that in pericarcinoma tissue (80.0%), Ｐ＜0.01. Statistically significantly difference wasn’t achieved in contrast with the benign diseases group (50.0%), Ｐ＞0.05. The positive rate of PR had no significantly difference among the three groups (Ｐ＞0.05). The authors suggest that sex hormone is related to initializing and developing of HCC by the action via its receptor, the level of AR and ER can be used as a prognosis determine index of HCC.
Citation：
Xiao Kaiyin,Li Shaosen,Lu Quanshu.. THE EXPRESSION AND CLINICAL SIGNIFICANCE OF SEX HORMONE RECEPTOR IN HEPATOCELLULAR CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(2): 96-97. doi:
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- 1. 李永国， 杨竹林， 云正芬等. 性激素和凝集素受体在胆囊癌组织中的表达及意义. 临床肝胆病杂志， 1994； 10(1)∶25.
- 2. Lqbal M, Wilkin P, Johnson M, et al. Sex steroid receptor proteins in fetal, adult and malignant human liver tissue. Br J Cancer, 1983; 48(6)∶791.
- 3. Nagasue N, Ito A, Yakaya H, et al. Androgen and estrogen receptors in hepatocellular carcinoma and surounding parenchyma. Gastroentrology, 1985; 89(3)∶643.
- 4. Nagasue N, Kohno H, Chang YC, et al. Androgen and estrogen receptors in hepatocellular carcinoma and the surounding liver in women. Cancer, 1989; 63(1)∶112.
- 5. 滨崎启介. 肝癌患者雌激素和雄激素受体研究. 国外医学肿瘤学分册， 1989； 16(3)∶175.
- 6. Nagasue N, Yakaya H, Chang YC, et al. Active uptake of testosterone by androgen receptor of hepatocellular carcinoma in human. Cancer, 1986; 57(1)∶2162.
- 7. 顾公望. 性激素与肝脏肿瘤. 国外医学肿瘤学分册， 1987； 14(6)∶324.
- 8. Yu L, Nagasue N, Makino Y, et al. Effect of androgens and their manipulation on cell growth and androgen receptor levels in ARpostive and negative human hepatocellular carcinoma. J Hepatol, 1995; 22(3)∶295.
- 9. Nagasue N, Chang YC, Hayashi T, et al. Androgen receptor in hepatocellular carcinoma as a prognostic factor after hepatic resectioin. Ann Surg, 1989; 209(4)∶424.
