To evaluate the significance of bcl-2 protein, estrogen receptor (ER), progesterone receptor (PR) and p53 oncogene in invasive breast cancer of ductal and lobular type. Tumor tissues were examined immunohistochemically in paraffin embedded tissues from 125 patients. Results: The invasive ductal breast carcinomas expressed bcl-2 protein significantly less frequently than the lobular type (Ｐ＜0.001). And the expression of bcl-2 protein was significantly correlated with ER, PR (Ｐ＜0.001) and p53 (Ｐ＜0.001), also correlated with primary tumor size and grade. No statistical evidence was found to indicate the relationship between bcl-2 protein expression and anxillary lymph node metastasis. Conclusions: The expression of bcl-2 protein may be regarded as a biological index and may play important role in evaluating the biological characteristics of breast cancer.
Citation：
Lin Qing,Gao Dongchen,Zhang Changhuai,et al.. THE SIGNIFICANCE OF BCL-2 PROTEIN EXPRESSION IN HUMAN BREAST CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 263-265. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 1. Shunzo K, Hirotaka I, Yukashi I, et al. Clinical significance of bcl-2 gene expression in human breast cancer tissue. Breast Cancer Res Treatment, 1997; 42(2)∶173.
- 2. Lee WY, Jin YT, Tzeng CC, et al. Reciprocal expression of bcl-2 and p53 in breast ductal carcinoma. Anticancer Research, 1996; 16(5A)∶3007.
- 3. Julia MWG, John FRR, Ian OE, et al. Immunocytochemical localization of bcl-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy. Int J Cancer, 1994; 59(5)∶619.
- 4. Hellemans P, Van Dam PA, Weyle J. Prognostic value of bcl-2 expression in invasive breast cancer. Br J Cancer, 1995; 72(2)∶354.
- 5. Gasparini G, Barbareschi M, Doglioni C, et al. Expression of bcl-2 protein predicts efficacy of adjuvant treatment in operable nodepositive breast cancer. Clin Cancer Res, 1995; 1(2)∶189.
