THE SIGNIFICANCE OF BCL-2 PROTEIN EXPRESSION IN HUMAN BREAST CARCINOMA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, Affiliated Beijing Tongren Hospital, Capital Medical University, Beijing 100730;

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Keywords：

Breast cancer; Bcl-2 protein; Apoptosis

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To evaluate the significance of bcl-2 protein, estrogen receptor (ER), progesterone receptor (PR) and p53 oncogene in invasive breast cancer of ductal and lobular type. Tumor tissues were examined immunohistochemically in paraffin embedded tissues from 125 patients. Results: The invasive ductal breast carcinomas expressed bcl-2 protein significantly less frequently than the lobular type (Ｐ＜0.001). And the expression of bcl-2 protein was significantly correlated with ER, PR (Ｐ＜0.001) and p53 (Ｐ＜0.001), also correlated with primary tumor size and grade. No statistical evidence was found to indicate the relationship between bcl-2 protein expression and anxillary lymph node metastasis. Conclusions: The expression of bcl-2 protein may be regarded as a biological index and may play important role in evaluating the biological characteristics of breast cancer.

Citation： Lin Qing,Gao Dongchen,Zhang Changhuai,et al.. THE SIGNIFICANCE OF BCL-2 PROTEIN EXPRESSION IN HUMAN BREAST CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 263-265. doi: Copy

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE SIGNIFICANCE OF BCL-2 PROTEIN EXPRESSION IN HUMAN BREAST CARCINOMA

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