The effects of all-trans retinoic acid (ATRA) on primary gastric carcinoma models made by subcutaneous implanting gastric cancer to mice were observed. Thirty-two cancer bearing nude mice were randomly divided into 4 groups: control group (group Ⅰ)， ATRA low dose feeding group (100μg/day， group Ⅱ), moderate dose feeding group (300μg/day， group Ⅲ), and high dose feeding group (1 000 μg/day, group Ⅳ). The alteration of tumor growth, morphology, cytobiology, and immuno-histochemical assay were perfermed. The results showed significant inhibition of tumor growth and inducing differentiation in the group Ⅲ and group Ⅳ as compared with group Ⅰ (Ｐ＜0.01),and inhibited expression of p53, p21 protein in implanted tumor. The authors consider that ATRA has some effects of growth inhibition and differentiation on gastric cancer cells in vivo, and these is related to the inhibition of expression p53 and p21 onco-gene of cancer cells and accelerate apoptosis of carcinoma cells.
Citation：
Huang Chengliang,Wang Daike,Liu Baohua. THE ANTI-PROLIFERATION AND INDUCING DIFFERENTIATION EFFECTS OF ALL-TRANS RETINOIC ACID ON GASTRIC CANCER IN NUDE MICE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(3): 129-131. doi:
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- 1. Shibata MA, Krust A, Nisslon N, et al. Modification of BHA forestomach carcinogenesis in rats: inhibition by diethymaleste or indomethacin and enhance by retinoid. Carcinogenesis, 1993; 14(7)∶1265.
- 2. D.施梅尔著.恶性肿瘤的发生、生长和化疗.第1版.北京：科学技术出版社，1984∶445.
- 3. 张胜本，张连阳主编.肿瘤化学治疗敏感性与抗药性.第1版.成都：四川科学技术出版社， 1995∶91.
- 4. Brooc JSJ. Analytic false positivity with immunohistochemistry. Am J Clin Pathol, 1984; 82(1)∶134.
- 5. 沈敏，许建明，童菊芳等.全反式维甲酸对胃癌细胞株SGC7901的抗增殖及诱导分化作用的研究.中国药学杂志， 1991； 26(12)∶722.
- 6. Skashita A, Ress J, Kadin M, et al. 9cis retinoic acid: effects on normal and leukemia hepatopoiesis in vitro. Blood, 1996; 81(5)∶1009.
- 7. Gwyn T, Saurit G, Moria C, et al. Molecular regulation of apoptosis: genetic controls on cell death. Cell, 1993; 74(6)∶777.
- 8. Kerin JK, Green MH, Berg J, et al. Evidence for the involvement of RAR dependent signaling pathway in the induction of tissue transglutaminase and apoptosis by retinoids. J Bio Chem, 1995; 11(2)∶6022.
