In order to study the influence of biliary tract obstruction on enteromicroflora,we ligate the canine biliary tract to observe the acrobic and anerobic bacteria in the duodenum and ileum at intervals of post-ligation(the 10th,20th,30th days),and to study the pathogenesis and ultramicroscopic of the ileal mucosa at the same intervals.The results showed that:the population and species of enteroflora in small intestine gradually increased after biliary obstruction.Bacteria(especialy E.coli) ascended to the upper part of small intestine,from their normal habitant of lower part of small intestine.Therefore the radio of general aerobia and E.coli risen obviously in duodenum.The longer the obstruction,the more pathologic changes were observed in ileal mucosa.such as edema,leukocytes infiltration and destruction of epithelial villi.All of those changed may be the causative factor of biliary tract infection.So that,in the programs of preventing enterogenic infection at the state of biliary tract obstruction,the protection and adjusting of normal enteroflora should be adventently considered.
Citation：
Jiang Yi,Wu Aiping.. THE INFLUENCE OF ENTEROMICROFLORA BY CANINE BILIARY TRACT OBSTRUCTION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1995, 2(3): 132-135. doi:
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- 1. Stacey M,Webb M.Stadies on the antibacterial properties of the acids and some compounds derived from cholanic acid.Proc Roy Soc,1947;134:523.
- 2. Burke V,Stone DE,Beaman J,Gracey M.Effects of biliary diversion on intestinal microflora in the rat.J Med Microbiol,1977;10:244.
- 3. Sacquet E,Raibaud D.Etude comparee de la microflora de Ⅰ’ estomac, de Ⅰ’ intestin grele et du caecum du rat holoxenique,et de ses modifications a la suite de diverses,interventions chirurgicales:anse avengle jejunale,deviations biliaires.Annle Inst Pasteus Paris,1971;121:501.
- 4. Brown WR,Savage DC,Dubois RS,et al.Intestinal microflora of immunoglobulin-deficient and human subjects.Gastroenterol,1972;62:1143.
- 5. Deitch EA,Sttig K,Ma Li,et al.Obstructive jaundice promotes bacterial translocation from the gut.Am J Surg,1990;159:79.
- 6. Househam KC.Duodenal microflora in infants with acute diarrheal diease.J Padiatr Gastroenterol Nutr,1986;5:721.
