Injection of carbon nanoparticle suspension for Surgical Patients with non-small cell lung cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHANG Qingfeng , KOU Yingli.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

Keywords：

Non-small cell lung cancer; Surgery; Carbon nanoparticles suspension; Lymph node tracing; Targeted chemotherapy

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Abstract： Surgery is an effective therapy for non-small cell lung cancer (NSCLC). The standard operation includes lobectomy and systematic dissection of lymph nodes. However, postoperative tumor recurrence is common even among incipient patients due to incomplete dissection of lymph nodes and micrometastasis of lymph nodes. Injecting a carbon nanoparticles suspension is a new technique aimed at preventing this recurrence. The carbon nanoparticles carry lymph node tracers that help surgeons locate lymph nodes in order to clean them thoroughly. The tracers also target the lymph nodes for chemotherapy, thus killing residual tumor cells intraoperatively to avoid postoperative cancer recurrence. Carbon nanoparticles suspension injection is already widely and successfully used in surgery for gastrointestinal and mammary gland tumors, and is being tested for effectiveness in NSCLC patients. Some studies have indicated that carbon nanoparticles suspension injection is effective in NSCLC patients and improves their prognoses. We reviewed the features, application methods, and clinical applications of studies of carbon nanoparticles suspension injection for NSCLC.

Citation： ZHANG Qingfeng,KOU Yingli.. Injection of carbon nanoparticle suspension for Surgical Patients with non-small cell lung cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2012, 19(1): 73-76. doi: Copy

1.	Izbicki JR, Passlick B, Hosch SB, et al. Mode of spread in the early phase of lymphatic metastasis in non-small-cell lung cancer： significance of nodal micrometastasis. J Thorac Cardiovasc Surg, 1996，112 (3)：623-630.
2.	张建鹏, 邹卫. 纳米活性炭在肿瘤外科的应用及在非小细胞肺癌手术中廓清淋巴结的意义.临床肺科杂志，2009, 14(6)：791-792.
3.	Toma A, Hagiwara A, Otsuji E，et al .Detection of sentinel lymphatic region with activated carbon particles in lymph node dissection for colorectal cancer.Gan To Kagaku Ryoho, 2002, 29(12): 2291-2293.
4.	Busch FM, Sayegh ES．Roentgenographic visualization of human testicular lymphatics：a preliminary report.J Urol, 1963, 89(14)：106-110.
5.	Cabanas RM．An approach for the treatment of penile carcinoma. Cancer, 1977, 39(2)：456-466.
6.	Minamiya Y, Ogawa J. Benefit of sentinel lymph node mapping in non-small cell lung cancer. Ann Thorac Cardiovasc Surg, 2006, 12(6)：381-382．.
7.	Minamiya Y, Ogawa J. The current status of sentinel lymph node mapping in non-small cell lung cancer. Ann Thorac Cardiovase Surg, 2005, 11(2)：67-72．.
8.	Ono T, Minamiya Y, Ito M, et al. Sentinel node mapping and micrometastasis in patients with clinical stage IA non-small cell lung cancer.Interact Cardiovasc Thorac Surg, 2009, 9(4)：659-661.
9.	李树本, 何建行, 陈汉章, 等．纳米炭在微创肺癌淋巴结清扫术中的应用.中华肿瘤杂志, 2008, 30(3)：228-230．.
10.	Liu CL, Yang TL, Chen BF. Sentinel lymph node mapping with emulsion of activated carbon particles in patients with pre-mastectomy diagnosis of intraductal carcinoma of the breast. J Chin Med Assoc, 2003, 66(7)：406-410.
11.	郑兰东, 皇甫深强, 王新涛, 等. 活性炭微粒子在胃癌淋巴结清除中的应用研究.中国现代普通外科进展, 2011, 14(9)：697-699.
12.	邓昊, 舒细记, 镇鸿燕, 等．结直肠癌淋巴结微转移对预后影响的意义．癌症, 2003, 22(7)：762-766．.
13.	Saha S, Wiese D, Badin J, et a1．Technical details of sentinel lymph node mapping in colorectal cancer and its impact on staging.Ann Surg Oncol, 2000, 7(2)：120-124．.
14.	Melfi FM, Chella A, Menconi GF, et al. Intraoperative radioguided sentinel lymph node biopsy in non-small cell lung cancer. Eur J Cardiothorac Surg, 2003, 23(2)：214-220.
15.	瞿欢, 张亚男. 纳米炭在乳腺癌治疗中的应用.中国普通外科杂志, 2009, 18(5 )：495-497.
16.	Akamo Y, Mizuno I, Takeyama H, et al. Chemotherapy targeting regional lymph nodes by gastric submucosal injection of liposomal adriamycin in patients with gastric cancer. Gan To Kagaku Ryoho, 1997, 24(12)：1712-1714.
17.	Natsugoe S, Shimada M, Kumanohoso T, et al. Enhanced efficacy of bleomycin adsorbed on silica particles against lymph node metastasis in patients with esophageal cancer：a pilot study. Surgery, 1995, 117(6)：636-641.
18.	Chen J，Wang L，Yao Q，et al. Drug concentrations in axillary lymph nodes after lymphatic chemotherapy on patients with breast cancer . Breast Cancer Res，2004，6(4)：R474-R477.
19.	鲍传庆, 许炳华, 沈晓明, 等．载药纳米炭在结肠癌手术中的应用. 江苏医药, 2007, 33(10)：1004-1005.
20.	吴武军, 曾健, 潘承恩．活性炭-表阿霉素混悬液对乳腺癌腋窝淋巴结转移的治疗作用．南方医科大学学报, 2006, 26(12)：1812-1814．.
21.	曲秋莲, 张英鸽, 孙岚. 纳米活性炭对丝裂霉素C的吸附与缓释性能研究.军事医学科学院院刊, 2004, 28(6)：552-554.
22.	Okamoto K, Sawai K, Minato H, et al. Number and anatomical extent of lymph node metastases in gastric cancer： analysis using intra-lymph node injection of activated carbon particles (CH40). Jpn J Clin Oncol, 1999, 29(2)：74-77.
23.	Yokota T, Saito T, Narushima Y, et al. Lymph-node staining with activated carbon CH40： a new method for axillary lymph-node dissection in breast cancer. Can J Surg, 2000, 43(3)： 191-196.
24.	Ko K, Han BK, Jang KM, et al．The value of ultrasound-guided tattooing localization of nonpalpable breast lesions.Korean J Radiol, 2007, 8(4)：295-301．.
25.	Tomizawa Y, Nakajima T, Kohno T, et al. Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. Cancer Res, 1998, 58(23)： 5478-5483.
26.	高红, 郑春雷, 庞达. 载药国产纳米活性炭在胃癌根治术中的应用.齐齐哈尔医学院学报, 2010, 31(18)：2859-2862.

1. 　Izbicki JR, Passlick B, Hosch SB, et al. Mode of spread in the early phase of lymphatic metastasis in non-small-cell lung cancer： significance of nodal micrometastasis. J Thorac Cardiovasc Surg, 1996，112 (3)：623-630.
2. 　张建鹏, 邹卫. 纳米活性炭在肿瘤外科的应用及在非小细胞肺癌手术中廓清淋巴结的意义.临床肺科杂志，2009, 14(6)：791-792.
3. 　Toma A, Hagiwara A, Otsuji E，et al .Detection of sentinel lymphatic region with activated carbon particles in lymph node dissection for colorectal cancer.Gan To Kagaku Ryoho, 2002, 29(12): 2291-2293.
4. 　Busch FM, Sayegh ES．Roentgenographic visualization of human testicular lymphatics：a preliminary report.J Urol, 1963, 89(14)：106-110.
5. 　Cabanas RM．An approach for the treatment of penile carcinoma. Cancer, 1977, 39(2)：456-466.
6. 　Minamiya Y, Ogawa J. Benefit of sentinel lymph node mapping in non-small cell lung cancer. Ann Thorac Cardiovasc Surg, 2006, 12(6)：381-382．.
7. 　Minamiya Y, Ogawa J. The current status of sentinel lymph node mapping in non-small cell lung cancer. Ann Thorac Cardiovase Surg, 2005, 11(2)：67-72．.
8. 　Ono T, Minamiya Y, Ito M, et al. Sentinel node mapping and micrometastasis in patients with clinical stage IA non-small cell lung cancer.Interact Cardiovasc Thorac Surg, 2009, 9(4)：659-661.
9. 　李树本, 何建行, 陈汉章, 等．纳米炭在微创肺癌淋巴结清扫术中的应用.中华肿瘤杂志, 2008, 30(3)：228-230．.
10. 　Liu CL, Yang TL, Chen BF. Sentinel lymph node mapping with emulsion of activated carbon particles in patients with pre-mastectomy diagnosis of intraductal carcinoma of the breast. J Chin Med Assoc, 2003, 66(7)：406-410.
11. 　郑兰东, 皇甫深强, 王新涛, 等. 活性炭微粒子在胃癌淋巴结清除中的应用研究.中国现代普通外科进展, 2011, 14(9)：697-699.
12. 　邓昊, 舒细记, 镇鸿燕, 等．结直肠癌淋巴结微转移对预后影响的意义．癌症, 2003, 22(7)：762-766．.
13. 　Saha S, Wiese D, Badin J, et a1．Technical details of sentinel lymph node mapping in colorectal cancer and its impact on staging.Ann Surg Oncol, 2000, 7(2)：120-124．.
14. 　Melfi FM, Chella A, Menconi GF, et al. Intraoperative radioguided sentinel lymph node biopsy in non-small cell lung cancer. Eur J Cardiothorac Surg, 2003, 23(2)：214-220.
15. 　瞿欢, 张亚男. 纳米炭在乳腺癌治疗中的应用.中国普通外科杂志, 2009, 18(5 )：495-497.
16. 　Akamo Y, Mizuno I, Takeyama H, et al. Chemotherapy targeting regional lymph nodes by gastric submucosal injection of liposomal adriamycin in patients with gastric cancer. Gan To Kagaku Ryoho, 1997, 24(12)：1712-1714.
17. 　Natsugoe S, Shimada M, Kumanohoso T, et al. Enhanced efficacy of bleomycin adsorbed on silica particles against lymph node metastasis in patients with esophageal cancer：a pilot study. Surgery, 1995, 117(6)：636-641.
18. 　Chen J，Wang L，Yao Q，et al. Drug concentrations in axillary lymph nodes after lymphatic chemotherapy on patients with breast cancer . Breast Cancer Res，2004，6(4)：R474-R477.
19. 　鲍传庆, 许炳华, 沈晓明, 等．载药纳米炭在结肠癌手术中的应用. 江苏医药, 2007, 33(10)：1004-1005.
20. 　吴武军, 曾健, 潘承恩．活性炭-表阿霉素混悬液对乳腺癌腋窝淋巴结转移的治疗作用．南方医科大学学报, 2006, 26(12)：1812-1814．.
21. 　曲秋莲, 张英鸽, 孙岚. 纳米活性炭对丝裂霉素C的吸附与缓释性能研究.军事医学科学院院刊, 2004, 28(6)：552-554.
22. 　Okamoto K, Sawai K, Minato H, et al. Number and anatomical extent of lymph node metastases in gastric cancer： analysis using intra-lymph node injection of activated carbon particles (CH40). Jpn J Clin Oncol, 1999, 29(2)：74-77.
23. 　Yokota T, Saito T, Narushima Y, et al. Lymph-node staining with activated carbon CH40： a new method for axillary lymph-node dissection in breast cancer. Can J Surg, 2000, 43(3)： 191-196.
24. 　Ko K, Han BK, Jang KM, et al．The value of ultrasound-guided tattooing localization of nonpalpable breast lesions.Korean J Radiol, 2007, 8(4)：295-301．.
25. 　Tomizawa Y, Nakajima T, Kohno T, et al. Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. Cancer Res, 1998, 58(23)： 5478-5483.
26. 　高红, 郑春雷, 庞达. 载药国产纳米活性炭在胃癌根治术中的应用.齐齐哈尔医学院学报, 2010, 31(18)：2859-2862.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Injection of carbon nanoparticle suspension for Surgical Patients with non-small cell lung cancer

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