HAO Jia , YOU Kai , XIAO Yingbin.
  • Military Center of Cardiovascular Surgery, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, P.R. China;
Amniotic fluidderived stem cell; Cardiovascular disease; Regeneration medicine
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Abstract: The amniotic fluidderived stem cells (AFSC) possess considerable advantageous characteristics including high proliferation potential, easy availability, low immunogenicity and oncogenicity，and accordance with medical ethnics. Moreover, they do not require the sacrifice of human embryos for their isolation and the cells can differentiate into all three kinds of germs. Accordingly，they initiate a new and very promising field in stem cell research and they will be a potential source of stem cells for therapies related to regeneration medicine of cardiovascular diseases. The research about the AFSC utilization in cardiovascular diseases is just started. Though there were some exciting breakthroughs, there still remain many challenges. In the article，we will discuss AFSC characteristics, influence of amniotic fluid harvesting time on stem cells, isolation and purification, emphasizing mainly on the potential of AFSC differentiation into cardiovascular cells, current situation and problems in this field.

Citation： HAO Jia,YOU Kai,XIAO Yingbin.. Current Status of Research on Amniotic Fluidderived Stem Cells. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2010, 17(5): 399-403. doi: Copy