• Dept.of Ophthalmology ,the First Clinical Medical College,West China University of Medical College,West China Iniversity of Medical Sciences,Chengdu 610041,China;
Retina/pathology; Photic stimulation; Fluorescence; Disease models,animal
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Objective To observe the pathological and functional changes of retinal photochemical damages exposed to green flurescent light. Methods The Sprague Dawley rats were continually exposed to green fluorescent light with an illuminancem level of (1 900 plusmn;106.9) Lx for 24 hours.The changes of retinal morphology and morphometrics and flash electroretinogram were studied before light exposure and at the 6th hour,6th day and 14th day after light exposure. Results At the 6th hours after light exposure,the outer nuclear layer(ONL)of retina becoma thinner compared with that bfore light exposure.The thickness of ONL decreased by 23.91% and the inner and outer segments appeared disorderly arranged.At the 6th day after light exposure the thickness of ONL is thinner than that at the6th hour,i.e.decreased by 46.6%. At the 14th day after light exposure the thickness of ONL decreased by 42.40%.Flash electroretinogram showed that the amplitudes of a and b wave decreased continuously at the 6th hour and 6th day and unrecovered at the 14th day after light exposure. Conclusion This model might be an ideal one for research on retinal photochemical damage. (Chin J Ocul Fundus Dis,1998,14:101-103)

Citation： Xie Bolin,Yan Mi,Zhang Junjun,et al. Experimental study on retinal photochemical damage in rats exposed to the green fluorescent light. Chinese Journal of Ocular Fundus Diseases, 1998, 14(2): 101-103. doi: Copy