Related Risk Factors for Recurrence of Venous Thromboembolism：A Meta-Analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LU Lu ¹ , WANG Yang ¹ ,  LUO Jun ¹ , WANG Haidong ² , LI Xinxi ¹ , BAI Chao ¹ , WANG Ke ¹ , HUANG Jie ¹

1.Department of Vascular and Thyroid Surgery， The First Affiliated Hospital， Xinjiang Medical University， Urumqi 830054， Xinjiang Uygur Autonomous Region， China;;
2.Department of Hepatobiliary Surgery， Hainan Provincial Nongken Hospital， Haikou 570311， Hainan Province， China;

Corresponding author：

LUO Jun, Email: xmuluo@163.com

Keywords：

Venous thromboembolism; Recurrence; Risk factor; Meta-analysis

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To study the related risk factors for recurrence of venous thromboembolism （VTE）.
Methods 　The literatures about the related factors for recurrence of VTE were searched. The relationships between the factors and recurrence of VTE were determined by meta-analysis.
Results 　A total of 12 literatures were included. The results of meta-analysis showed that factors such as males， age＜50 years old， malignant tumor， and antiphospholipid syndrome related with the recurrence of the first VTE after treatment， but there were no correlation between the recurrence of VTE， the type of first VTE， and causes of VTE.
Conclusions 　The recurrence of VTE correlate with various factors. In order to avoid the recurrence of VTE， the patients with the risk factors for recurrence of VTE should be appropriate to extend the duration of anticoagulation

Citation： LU Lu,WANG Yang,LUO Jun,WANG Haidong,LI Xinxi,BAI Chao,WANG Ke,HUANG Jie. Related Risk Factors for Recurrence of Venous Thromboembolism：A Meta-Analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(7): 787-792. doi: Copy

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8.	Hansson PO， Sörbo J， Eriksson H. Recurrent venous thromboembolism after deep vein thrombosis：incidence and risk factors[J]. Arch Intern Med， 2000， 160(6)：769-774.
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12.	Kim TM， Kim JS， Han SW， et al. Clinical predictors of recurrentvenous thromboembolism：a single institute experience in Korea[J]. Thromb Res， 2009， 123(3)：436-443.
13.	Prandoni P， Noventa F， Ghirarduzzi A， et al. The risk of recurrentvenous thromboembolism after discontinuing anticoagulation inpatients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1 626 patients[J]. Haem-atologica， 2007， 92(2)：199-205.
14.	Eichinger S， Weltermann A， Minar E， et al. Symptomatic pulmo-nary embolism and the risk of recurrent venous thromboembolism[J]. Arch Intern Med， 2004， 164(1)：92-96.
15.	Spencer FA， Gore JM， Lessard D， et al. Patient outcomes after deep vein thrombosis and pulmonary embolism：the Worcester venous Thromboembolism Study[J]. Arch Intern Med， 2008， 168(4)：425-430.
16.	Iorio A， Kearon C， Filippucci E， et al. Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor：a systematic review[J]. Arch Intern Med， 2010， 170(19)：1710-1716.
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20.	Lijfering WM， Rosendaal FR， Cannegieter SC. Risk factors for venous thrombosis—current understanding from an epidemiolo-gical point of view[J]. Br J Haematol， 2010， 149(6)：824-833.
21.	White RH， Romano PS， Zhou H， et al. Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty[J]. Arch Intern Med， 1998， 158(14)：1525-1531.
22.	Heit JA， Mohr DN， Silverstein MD， et al. Predictors of recurrenceafter deep vein thrombosis and pulmonary embolism：a population-based cohort study[J]. Arch Intern Med， 2000， 160(6)：761-768.
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24.	Research Committee of the British Thoracic Society. Optimum duration of anticoagulation for deep-vein thrombosis and pulmonaryembolism[J]. Lancet， 1992， 340(8824)：873-876.
25.	Brill-Edwards P， Ginsberg JS， Gent M， et al. Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of Clot in This Pregnancy Study Group[J]. N Engl J Med， 2000， 343(20)：1439-1444.
26.	Rosove MH， Brewer PM. Antiphospholipid thrombosis：clinicalcourse after the first thrombotic event in 70 patients[J]. Ann InternMed， 1992， 117(4)：303-308.
27.	Ho WK， Hankey GJ， Quinlan DJ， et al. Risk of recurrent venous thromboembolism in patients with common thrombophilia：a syst-ematic review[J]. Arch Intern Med， 2006， 166(7)：729-736.
28.	Zhu T， Martinez I， Emmerich J. venous thromboembolism：risk factors for recurrence[J]. Arterioscler Thromb Vasc Biol， 2009， 29(3)：298-310.
29.	(12)：901-907.

1. Anderson Jr FA， Spencer FA. Risk factors for venous thromboembolism[J]. Circulation， 2003， 107(23 Suppl 1)：I9- I16.
2. Olsen AH， Njor SH， Verjborg I， et al. Breast cancer mortality inCopenhagen after introduction of mammography screening：cohortstudy[J]. Br Med J， 2005， 330(7485)：220.
3. (12)：2152-2155.
4. Naess IA， Christiansen SC， Romundstad P， et al. Incidence and mortality of venous thrombosis：a population-based study[J]. J Thromb Haemost， 2007， 5(4)：692-699.
5. Kahn SR. The post-thrombotic syndrome：the forgotten morbidity of deep venous thrombosis[J]. J Thromb Thrombolysis， 21(1)：41-48.
6. Baglin T， Luddington R， Brown K， et al. High risk of recurrentvenous thromboembolism in men[J]. J Thromb Haemost， 2004，.
7. Christiansen SC， Lijfering WM， Helmerhorst FM， et al. Sex difference in risk of recurrent venous thrombosis and the risk profile for a second event[J]. J Thromb Haemost， 2010， 8(10)：2159-2168.
8. Hansson PO， Sörbo J， Eriksson H. Recurrent venous thromboembolism after deep vein thrombosis：incidence and risk factors[J]. Arch Intern Med， 2000， 160(6)：769-774.
9. Kyrle PA， Minar E， Bialonczyk C， et al. The risk of recurrent venous thromboembolism in men and women[J]. N Engl J Med， 2004， 350(25)：2558-2563.
10. Olié V， Zhu T， Martinez I， et al. Sex-specific risk factors for recurrent venous thromboembolism[J]. Thromb Res， 2012， 130 (1) ：16-20.
11. Tagalakis V， Kondal D， Ji Y， et al. Men had a higher risk of recu-rrent venous thromboembolism than women：a large population study[J]. Gend Med， 2012， 9(1)：33-43.
12. Kim TM， Kim JS， Han SW， et al. Clinical predictors of recurrentvenous thromboembolism：a single institute experience in Korea[J]. Thromb Res， 2009， 123(3)：436-443.
13. Prandoni P， Noventa F， Ghirarduzzi A， et al. The risk of recurrentvenous thromboembolism after discontinuing anticoagulation inpatients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1 626 patients[J]. Haem-atologica， 2007， 92(2)：199-205.
14. Eichinger S， Weltermann A， Minar E， et al. Symptomatic pulmo-nary embolism and the risk of recurrent venous thromboembolism[J]. Arch Intern Med， 2004， 164(1)：92-96.
15. Spencer FA， Gore JM， Lessard D， et al. Patient outcomes after deep vein thrombosis and pulmonary embolism：the Worcester venous Thromboembolism Study[J]. Arch Intern Med， 2008， 168(4)：425-430.
16. Iorio A， Kearon C， Filippucci E， et al. Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor：a systematic review[J]. Arch Intern Med， 2010， 170(19)：1710-1716.
17. Kearon C， Gent M， Hirsh J， et al. A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism[J]. N Engl J Med， 1999，.
18. Rosendaal FR. Risk factors for venous thrombotic disease[J]. Thromb Haemost， 1999， 82(2)：610-619.
19. McRae S， Tran H， Schulman S， et al. Effect of patient’s sex on risk of recurrent venous thromboembolism：a meta-analysis[J]. Lancet， 2006， 368(9533)：371-378.
20. Lijfering WM， Rosendaal FR， Cannegieter SC. Risk factors for venous thrombosis—current understanding from an epidemiolo-gical point of view[J]. Br J Haematol， 2010， 149(6)：824-833.
21. White RH， Romano PS， Zhou H， et al. Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty[J]. Arch Intern Med， 1998， 158(14)：1525-1531.
22. Heit JA， Mohr DN， Silverstein MD， et al. Predictors of recurrenceafter deep vein thrombosis and pulmonary embolism：a population-based cohort study[J]. Arch Intern Med， 2000， 160(6)：761-768.
23. Kearon C， Kahn SR， Agnelli G， et al. Antithrombotic therapy for venous thromboembolic disease：American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)[J]. Chest. 2008， 133(6 Suppl)：454S-545S.
24. Research Committee of the British Thoracic Society. Optimum duration of anticoagulation for deep-vein thrombosis and pulmonaryembolism[J]. Lancet， 1992， 340(8824)：873-876.
25. Brill-Edwards P， Ginsberg JS， Gent M， et al. Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of Clot in This Pregnancy Study Group[J]. N Engl J Med， 2000， 343(20)：1439-1444.
26. Rosove MH， Brewer PM. Antiphospholipid thrombosis：clinicalcourse after the first thrombotic event in 70 patients[J]. Ann InternMed， 1992， 117(4)：303-308.
27. Ho WK， Hankey GJ， Quinlan DJ， et al. Risk of recurrent venous thromboembolism in patients with common thrombophilia：a syst-ematic review[J]. Arch Intern Med， 2006， 166(7)：729-736.
28. Zhu T， Martinez I， Emmerich J. venous thromboembolism：risk factors for recurrence[J]. Arterioscler Thromb Vasc Biol， 2009， 29(3)：298-310.
29. (12)：901-907.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Related Risk Factors for Recurrence of Venous Thromboembolism：A Meta-Analysis

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