Diagnosis and Treatment for Pregnancy-Associated Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HUANG Yuankun ^1,2 ,  ZHOU Leilei ²

1.Zunyi Medical College， Zunyi 563003， Guizhou Province， China;;
2.Department of Breast Surgery， Sichuan Provincial People’s Hospital， Chengdu 610072， Sichuan Province， China;

Corresponding author：

ZHOU Leilei, Email: zhouleilei2006d@126.com

Keywords：

Pregnancy-associated breast cancer; Diagnosis; Treatment

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To summarize the recent studies on diagnosis and treatment for pregnancy-associated breast cancer （PABC） to provide evidence for diagnosis and treatment for PABC.
Methods 　By PubMed， Medline， and CNKI retrieval system， with “pregnancy-associated breast cancer or PABC， diagnosis of pregnancy-associated breast cancer or PABC， treatment of pregnancy-associated breast cancer or PABC” as key words to retrieval for the recent researches about PABC. All of the publications about studies on diagnosis and treatment for PABC were reviewed and summarized.
Results 　Diagnosis of PABC included ultrasound， mammography， magnetic resonance imaging， needle biopsy， and so on， and the treatment contained surgery， chemotherapy， endocrine therapy， radiation therapy， and targeted therapy. However， when diagnosis and treatment for PABC involved， the impact to patients with pregnancy and fetus must be considered in priority.
Conclusions 　By reviewing the studies of relevant papers about diagnosis and treatment for PABC which can provide a clinical guidance for clinicians. Usage of bevacizumab and lapatinib still needs to further be studied.

Citation： HUANG Yuankun,ZHOU Leilei. Diagnosis and Treatment for Pregnancy-Associated Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(8): 862-866. doi: Copy

1.	Pentheroudakis G， Orecchia R， Hoekstra HJ， et al. Cancer， fertility and pregnancy：ESMO Clinical Practice Guidelines for diagnosis， treatment and follow-up[J]. Ann Oncol， 2010， 21 Suppl 5：v266-v273.
2.	Middleton LP， Amin M， Gwyn K， et al. Breast carcinoma in pregnant women：assessment of clinicopathologic and immunohistochemical features[J]. Cancer， 2003， 98(5)：1055-1060.
3.	Bonnier P， Romain S， Dilhuydy JM， et al. Influence of pregnancy on the outcome of breast cancer：a case-control study. Societe Francaise de Senologie et de Pathologie Mammaire Study Group[J]. Int J Cancer， 1997， 72(5)：720-727.
4.	Greskovich JF， Macklis RM. Radiation therapy in pregnancy：risk calculation and risk minimization[J]. Semin Oncol， 2000， 27(6)：633-645.
5.	Osei EK， Faulkner K. Fetal doses from radiological examinations[J]. Br J Radiol， 1999， 72(860)： 773-780.
6.	Yang WT， Dryden MJ， Gwyn K， et al. Imaging of breast cancer diagnosed and treated with chemotherapy during pregnancy[J]. Radiology， 2006， 239(1)：52-60.
7.	沈镇宙，邵志敏. 乳腺肿瘤学[M]. 上海：上海科学技术出版社， 2005： 92 -121.
8.	Vashi R， Hooley R， Butler R， et al. Breast imaging of the pregnant and lactating patient：imaging modalities and pregnancy-asso-ciated breast cancer[J]. AJR Am J Roentgenol， 2013， 200(2)：321-328.
9.	NCCN Clinical Practice Guidelines in Oncology. Breast cancer[EB/OL]. Version 2. 2012. Available online：http：//www. nccn.com.
10.	Rovera F， Frattini F， Coglitore A， et al. Breast cancer in pregnancy[J]. Breast J， 2010， 16 Suppl 1：S22-S25.
11.	Molckovsky A， Madarnas Y. Breast cancer in pregnancy：a literature review [J]. Breast Cancer Res Treat， 2008， 108(3)：333-338.
12.	Navrozoglou I， Vrekoussis T， Kontostolis E， et al. Breast cancer during pregnancy：a mini-review[J]. Eur J Surg Oncol， 2008， 34(8)：837-843.
13.	Vinatier E， Merlot B， Poncelet E， et al. Breast cancer duringpregnancy[J]. Eur J Obstet Gynecol Reprod Biol， 2009， 147(1)：9-14.
14.	Amant F， Loibl S， Neven P， et al. Breast cancer in pregnancy[J]. Lancet， 2012， 379(9815)：570-579.
15.	Gentilini O， Cremonesi M， Trifirò G， et al. Safety of sentinel node biopsy in pregnant patients with breast cancer[J]. Ann Oncol， 2004， 15(9)：1348-1351.
16.	Gentilini O， Cremonesi M， Toesca A， et al. Sentinel lymph node biopsy in pregnant patients with breast cancer[J]. Eur J Nucl Med Mol Imaging， 2010， 37(1)：78-83.
17.	Khera SY， Kiluk JV， Hasson DM， et al. Pregnancy-associated breast cancer patients can safely undergo lymphatic mapping[J]. Breast J， 2008， 14(3)：250-254.
18.	Azim H Jr， Gentilini O， Locatelli M， et al. Managing pregnant women with cancer：personal considerations and a review of the literature[J]. Ecancermedicalscience， 2011， 5：204.
19.	Behrman RH， Homer MJ， Yang WT， et al. Mammography and fetal dose[J]. Radiology， 2007， 243(2)：605-606.
20.	Martin DD. Review of radiation therapy in the pregnant cancer patient[J]. Clin Obstet Gynecol， 2011， 54(4)：591-601.
21.	Guidroz JA， Scott-Conner CE， Weigel RJ. Management of pregnant women with breast cancer[J]. Surg Oncol， 2011， 103(4)：337-340.
22.	Amant F， Deckers S， Van Calsteren K， et al. Breast cancer in pregnancy：recommendations of an international consensus meeting[J]. Eur J Cancer， 2010， 46(18)：3158-3168.
23.	Ring AE， Smith IE， Jones A， et al. Chemotherapy for breast cancer during pregnancy：an 18-year experience from five Londonteaching hospitals[J]. Clin Oncol， 2005， 23(18)：4192-4197.
24.	Hahn KM， Johnson PH， Gordon N， et al. Treatment of pregnantbreast cancer patients and outcomes of children exposed to chemo-therapy in utero[J]. Cancer， 2006， 107(6)：1219-1226.
25.	Azim HA Jr， Peccatori FA， Pavlidis N. Treatment of the pregnantmother with cancer：a systematic review on the use of cytotoxic， endocrine， targeted agents and immunotherapy during pregnancy. PartⅠ：Solid tumors[J]. Cancer Treat Rev， 2010， 36(2)：101-109.
26.	Loibl S， von Minckwitz G， Gwyn K， et al. Breast carcinoma during pregnancy. International recommendations from an expert meeting[J]. Cancer， 2006， 106(2)：237-246.
27.	Zagouri F， Sergentanis TN， Chrysikos D， et al. Taxanes for breast cancer during pregnancy：a systematic review[J]. Clin Breast Cancer， 2013， 13(1)：16-23.
28.	Cardonick E， Bhat A， Gilmandyar D， et al. Maternal and fetal outcomes of taxane chemotherapy in breast and ovarian cancer during pregnancy：case series and review of the literature[J]. Ann Oncol， 2012， 23(12)：3016-3023.
29.	Berveiller P， Mir O. Taxanes during pregnancy：probably safe， but still to be optimized[J]. Oncology， 2012， 83(4)：239-240.
30.	Azim HA， Del Mastro L， Scarfone G， et al. Treatment of breast cancer during pregnancy：regimen selection， pregnancy monitoringand more[J]. Breast， 2011， 20(1)：1-6.
31.	Azim HA， Azim H， Peccatori FA. Treatment of cancer during pregnancy with monoclonal antibodies：a real challenge[J]. Expert Rev Clin Immunol， 2010， 6(6)：821-826.
32.	Zagouri F， Sergentanis TN， Chrysikos D， et al. Trastuzumab administration during pregnancy：a systematic review and meta-analysis[J]. Breast Cancer Res Treat， 2013， 137(2)：349-357.
33.	Goodyer MJ， Ismail JR， O’Reilly SP， et al. Safety of trastuzumab(Herceptin®) during pregnancy：two case reports[J]. Cases J， 2009， 2：9329.
34.	Waterston AM， Graham J. Effect of adjuvant trastuzumab on pregnancy[J]. Clin Oncol， 2006， 24(2)：321-322.
35.	Azim HA， Peccatori FA， Liptrott SJ， et al. Breast cancer and pregnancy：how safe is trastuzumab?[J]. Nat Rev Clin Oncol， 2009， 6(6)：367-370.
36.	Pentsuk N， van der Laan JW. An interspecies comparison of plac-ental antibody transfer：new insights into developmental toxicity testing of monoclonal antibodies[J]. Birth Defects Res B Dev Reprod Toxicol， 2009， 86(4)：328-344.
37.	Piccart-Gebhart MJ， Procter M， Leyland-Jones B， et al. Trastuz-umab after adjuvant chemotherapy in HER2-positive breast cancer[J]. N Engl J Med， 2005， 353(16)：1659-1672.
38.	Abusief ME， Missmer SA， Ginsburg ES， et al. The effects of paclitaxel， dose density， and trastuzumab on treatment-related amenorrhea in premenopausal women with breast cancer[J]. Cancer， 2010， 116(4)：791-798.
39.	Azim HA Jr， Metzger-Filho O， de Azambuja E， et al. Pregnancy occurring during or following adjuvant trastuzumab in patients enrolled in the HERA trial (BIG 01-01)[J]. Breast Cancer Res Treat， 2012， 133(1)：387-391.
40.	Kelly H， Graham M， Humes E， et al. Delivery of a healthy baby after first-trimester maternal exposure to lapatinib[J]. Clin Breast Cancer， 2006， 7(4)：339-341.
41.	Braems G， Denys H， De Wever O， et al. Use of tamoxifen before and during pregnancy[J]. Oncologist， 2011， 16(11)：1547-1551.
42.	Tiboni GM， Marotta F， Rossi C， et al. Effects of the aromataseinhibitor letrozole on in utero development in rats[J]. Hum Reprod，.
43.	， 23(8)：1719-1723.

1. Pentheroudakis G， Orecchia R， Hoekstra HJ， et al. Cancer， fertility and pregnancy：ESMO Clinical Practice Guidelines for diagnosis， treatment and follow-up[J]. Ann Oncol， 2010， 21 Suppl 5：v266-v273.
2. Middleton LP， Amin M， Gwyn K， et al. Breast carcinoma in pregnant women：assessment of clinicopathologic and immunohistochemical features[J]. Cancer， 2003， 98(5)：1055-1060.
3. Bonnier P， Romain S， Dilhuydy JM， et al. Influence of pregnancy on the outcome of breast cancer：a case-control study. Societe Francaise de Senologie et de Pathologie Mammaire Study Group[J]. Int J Cancer， 1997， 72(5)：720-727.
4. Greskovich JF， Macklis RM. Radiation therapy in pregnancy：risk calculation and risk minimization[J]. Semin Oncol， 2000， 27(6)：633-645.
5. Osei EK， Faulkner K. Fetal doses from radiological examinations[J]. Br J Radiol， 1999， 72(860)： 773-780.
6. Yang WT， Dryden MJ， Gwyn K， et al. Imaging of breast cancer diagnosed and treated with chemotherapy during pregnancy[J]. Radiology， 2006， 239(1)：52-60.
7. 沈镇宙，邵志敏. 乳腺肿瘤学[M]. 上海：上海科学技术出版社， 2005： 92 -121.
8. Vashi R， Hooley R， Butler R， et al. Breast imaging of the pregnant and lactating patient：imaging modalities and pregnancy-asso-ciated breast cancer[J]. AJR Am J Roentgenol， 2013， 200(2)：321-328.
9. NCCN Clinical Practice Guidelines in Oncology. Breast cancer[EB/OL]. Version 2. 2012. Available online：http：//www. nccn.com.
10. Rovera F， Frattini F， Coglitore A， et al. Breast cancer in pregnancy[J]. Breast J， 2010， 16 Suppl 1：S22-S25.
11. Molckovsky A， Madarnas Y. Breast cancer in pregnancy：a literature review [J]. Breast Cancer Res Treat， 2008， 108(3)：333-338.
12. Navrozoglou I， Vrekoussis T， Kontostolis E， et al. Breast cancer during pregnancy：a mini-review[J]. Eur J Surg Oncol， 2008， 34(8)：837-843.
13. Vinatier E， Merlot B， Poncelet E， et al. Breast cancer duringpregnancy[J]. Eur J Obstet Gynecol Reprod Biol， 2009， 147(1)：9-14.
14. Amant F， Loibl S， Neven P， et al. Breast cancer in pregnancy[J]. Lancet， 2012， 379(9815)：570-579.
15. Gentilini O， Cremonesi M， Trifirò G， et al. Safety of sentinel node biopsy in pregnant patients with breast cancer[J]. Ann Oncol， 2004， 15(9)：1348-1351.
16. Gentilini O， Cremonesi M， Toesca A， et al. Sentinel lymph node biopsy in pregnant patients with breast cancer[J]. Eur J Nucl Med Mol Imaging， 2010， 37(1)：78-83.
17. Khera SY， Kiluk JV， Hasson DM， et al. Pregnancy-associated breast cancer patients can safely undergo lymphatic mapping[J]. Breast J， 2008， 14(3)：250-254.
18. Azim H Jr， Gentilini O， Locatelli M， et al. Managing pregnant women with cancer：personal considerations and a review of the literature[J]. Ecancermedicalscience， 2011， 5：204.
19. Behrman RH， Homer MJ， Yang WT， et al. Mammography and fetal dose[J]. Radiology， 2007， 243(2)：605-606.
20. Martin DD. Review of radiation therapy in the pregnant cancer patient[J]. Clin Obstet Gynecol， 2011， 54(4)：591-601.
21. Guidroz JA， Scott-Conner CE， Weigel RJ. Management of pregnant women with breast cancer[J]. Surg Oncol， 2011， 103(4)：337-340.
22. Amant F， Deckers S， Van Calsteren K， et al. Breast cancer in pregnancy：recommendations of an international consensus meeting[J]. Eur J Cancer， 2010， 46(18)：3158-3168.
23. Ring AE， Smith IE， Jones A， et al. Chemotherapy for breast cancer during pregnancy：an 18-year experience from five Londonteaching hospitals[J]. Clin Oncol， 2005， 23(18)：4192-4197.
24. Hahn KM， Johnson PH， Gordon N， et al. Treatment of pregnantbreast cancer patients and outcomes of children exposed to chemo-therapy in utero[J]. Cancer， 2006， 107(6)：1219-1226.
25. Azim HA Jr， Peccatori FA， Pavlidis N. Treatment of the pregnantmother with cancer：a systematic review on the use of cytotoxic， endocrine， targeted agents and immunotherapy during pregnancy. PartⅠ：Solid tumors[J]. Cancer Treat Rev， 2010， 36(2)：101-109.
26. Loibl S， von Minckwitz G， Gwyn K， et al. Breast carcinoma during pregnancy. International recommendations from an expert meeting[J]. Cancer， 2006， 106(2)：237-246.
27. Zagouri F， Sergentanis TN， Chrysikos D， et al. Taxanes for breast cancer during pregnancy：a systematic review[J]. Clin Breast Cancer， 2013， 13(1)：16-23.
28. Cardonick E， Bhat A， Gilmandyar D， et al. Maternal and fetal outcomes of taxane chemotherapy in breast and ovarian cancer during pregnancy：case series and review of the literature[J]. Ann Oncol， 2012， 23(12)：3016-3023.
29. Berveiller P， Mir O. Taxanes during pregnancy：probably safe， but still to be optimized[J]. Oncology， 2012， 83(4)：239-240.
30. Azim HA， Del Mastro L， Scarfone G， et al. Treatment of breast cancer during pregnancy：regimen selection， pregnancy monitoringand more[J]. Breast， 2011， 20(1)：1-6.
31. Azim HA， Azim H， Peccatori FA. Treatment of cancer during pregnancy with monoclonal antibodies：a real challenge[J]. Expert Rev Clin Immunol， 2010， 6(6)：821-826.
32. Zagouri F， Sergentanis TN， Chrysikos D， et al. Trastuzumab administration during pregnancy：a systematic review and meta-analysis[J]. Breast Cancer Res Treat， 2013， 137(2)：349-357.
33. Goodyer MJ， Ismail JR， O’Reilly SP， et al. Safety of trastuzumab(Herceptin®) during pregnancy：two case reports[J]. Cases J， 2009， 2：9329.
34. Waterston AM， Graham J. Effect of adjuvant trastuzumab on pregnancy[J]. Clin Oncol， 2006， 24(2)：321-322.
35. Azim HA， Peccatori FA， Liptrott SJ， et al. Breast cancer and pregnancy：how safe is trastuzumab?[J]. Nat Rev Clin Oncol， 2009， 6(6)：367-370.
36. Pentsuk N， van der Laan JW. An interspecies comparison of plac-ental antibody transfer：new insights into developmental toxicity testing of monoclonal antibodies[J]. Birth Defects Res B Dev Reprod Toxicol， 2009， 86(4)：328-344.
37. Piccart-Gebhart MJ， Procter M， Leyland-Jones B， et al. Trastuz-umab after adjuvant chemotherapy in HER2-positive breast cancer[J]. N Engl J Med， 2005， 353(16)：1659-1672.
38. Abusief ME， Missmer SA， Ginsburg ES， et al. The effects of paclitaxel， dose density， and trastuzumab on treatment-related amenorrhea in premenopausal women with breast cancer[J]. Cancer， 2010， 116(4)：791-798.
39. Azim HA Jr， Metzger-Filho O， de Azambuja E， et al. Pregnancy occurring during or following adjuvant trastuzumab in patients enrolled in the HERA trial (BIG 01-01)[J]. Breast Cancer Res Treat， 2012， 133(1)：387-391.
40. Kelly H， Graham M， Humes E， et al. Delivery of a healthy baby after first-trimester maternal exposure to lapatinib[J]. Clin Breast Cancer， 2006， 7(4)：339-341.
41. Braems G， Denys H， De Wever O， et al. Use of tamoxifen before and during pregnancy[J]. Oncologist， 2011， 16(11)：1547-1551.
42. Tiboni GM， Marotta F， Rossi C， et al. Effects of the aromataseinhibitor letrozole on in utero development in rats[J]. Hum Reprod，.
43. ， 23(8)：1719-1723.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Diagnosis and Treatment for Pregnancy-Associated Breast Cancer

Abstract Full text Figures/Tables Video References Cited by

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