Present and Advance in Surgical Diagnosis and Treatment of Pancreatic Endocrine Tumors_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Shanglong , ZHANG Taiping , ZHAO Ypei

Department of General Surgery， Peking Union Medical College Hospital， Chinese Academy of Medical Sciences and Peking Union Medical College， Beijing 100730， China;

Corresponding author：

Keywords：

Pancreas; Endocrine tumors; Diagnosis; Surgical treatment

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To approach the recent advances in diagnosis and surgical treatment of pancreatic endocrine tumors （PETs）.
Methods 　Articles relevant to diagnosis and treatment of PETs were collected and reviewed.
Results 　PETs are characterized by their ability to over-produce peptides and hormones， which cause specific clinical syndromes. Because of rare incidence and complex clinical syndromes， there are still impediments to early diagnosis of these tumors. Monitoring of serum hormones and imaging method allow early tumor detection. PETs have been investigated for the past several decades. With the great knowledge of these tumors in molecular genetic level， clinical managements have been greatly changed.
Conclusions 　Avoiding misdiagnosis is important for treatment of PETs. Surgical approach is still considered as the preferred option for curtailing the malignant progression of PETs and controlling the associated biochemical syndromes.

Citation： LIU Shanglong,ZHANG Taiping,ZHAO Ypei. Present and Advance in Surgical Diagnosis and Treatment of Pancreatic Endocrine Tumors. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(10): 1059-1062. doi: Copy

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8.	Vanderveen K， Grant C. Insulinoma[J]. Cancer Treat Res， 2010， 153：235-252.
9.	de Herder WW， Niederle B， Scoazec JY， et al. Well-differentiated pancreatic tumor/carcinoma：insulinoma[J]. Neuroendocrinology， 2006， 84(3)：183-188.
10.	Christ E， Wild D， Forrer F， et al. Glucagon-like peptide-1receptor imaging for localization of insulinomas[J]. J Clin Endocrinol Metab， 2009， 94(11)：4398-4405.
11.	Ellison EC， Johnson JA. The Zollinger-Ellison syndrome：a comprehensive review of historical， scientific， and clinical considerations[J]. Curr Probl Surg， 2009， 46(1)：13-106.
12.	Bosman FT， Carneiro F， Hruban RH， et al. World HealthOrganization classification of tumors and genetics of the digestive system[M]. 4th ed. Lyon ：IARC Press， 2010.
13.	Osefo N， Ito T， Jensen RT. Gastric acid hypersecretory states：recent insights and advances[J]. Curr Gastroenterol Rep， 2009， 11(6)：433-441.
14.	Vinik AI， Woltering EA， Warner RR， et al. NANETS consensus guidelines for the diagnosis of neuroendocrine tumor[J]. Pancreas，.
15.	Patel KK， Kim MK. Neuroendocrine tumors of the pancreas：endoscopic diagnosis[J]. Curr Opin Gastroenterol， 2008， 24(5)：638-642.
16.	Norton JA， Jensen RT. Resolved and unresolved controversies in the surgical management of patients with Zollinger-Ellison syndrome[J]. Ann Surg， 2004， 240(5)：757-773.
17.	Jensen RT， Niederle B， Mitry E， et al. Gastrinoma (duodenal and pancreatic)[J]. Neuroendocrinology，2006， 84(3)：173-182.
18.	O’Toole D， Salazar R， Falconi M， et al. Rare functioning pancreatic endocrine tumors[J]. Neuroendocrinology， 2006， 84(3)：189-195.
19.	Morrow EH， Norton JA. Surgical management of Zollinger-Ellison syndrome； state of the art[J]. Surg Clin North Am， 2009， 89(5)：1091-1103.
20.	Elias D， Goéré D， Leroux G， et al. Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver[J]. Eur J Surg Oncol， 2009， 35(10)：1092-1097.
21.	Bettini R， Partelli S， Boninsegna L， et al. Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor[J]. Surgery， 2011， 150(1)：75-82.
22.	Fjallskog ML， Janson ET， Falkmer UG， et al. Treatment with combined streptozotocin and liposomal doxorubicin in metastatic endocrine pancreatic tumors[J]. Neuroendocrinology， 2008， 88(1)：53-58.
23.	Kouvaraki MA， Ajani JA， Hoff P， et al. Fluorouracil， doxorubicin， and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas[J]. J Clin Oncol， 2004， 22(23)：4762-4771.
24.	Arnold R， Rinke A， Klose KJ， et al. Octreotide versus octreotide plus interferon-alpha in endocrine gastroenteropancreatic tumors：a randomized trial[J]. Clin Gastroenterol Hepatol， 2005， 3(8)：761-771.
25.	Raymond E， Dahan L， Raoul JL， et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors[J]. N Engl J Med， 2011， 364(6)：501-513.
26.	Jensen RT， Delle Fave G. Promising advances in the treatment of malignant pancreatic endocrine tumors[J]. N Engl J Med， 2011， 364(6)：564-565.
27.	Kulke MH， Bergsland EK， Yao JC. Glycemic control in patients with insulinoma treated with everolimus[J]. N Engl J Med， 2009， 360(2)：195-197.
28.	Ojeaburu JV， Ito T， Crafa P， et al. Mechanism of acid hypersecretion post curative gastrinoma resection[J]. Dig Dis Sci， 2011， 56(1)：139-154.
29.	Yang YX， Metz DC. Safety of proton pump inhibitor exposure[J]. Gastroenterology， 2010， 139(4)：1115-1127.
30.	， 39(6)：713-734.

1. Oberg K， Eriksson B. Endocrine tumours of the pancreas[J]. Best Pract Res Clin Gastroenterol， 2005， 19(5)：753-781.
2. 赵玉沛，张太平. 重视胰腺内分泌肿瘤的诊断和治疗[J]. 中华外科杂志， 2009， 47(5)：321-322.
3. Oberg K. Pancreatic endocrine tumors[J]. Semin Oncol， 2010， 37(6)：594-618.
4. Metz DC， Jensen RT. Gastrointestinal neuroendocrine tumors：pancreatic endocrine tumors[J]. Gastroenterology， 2008， 135(5)：1469-1492.
5. Mathur A， Gorden P， Libutti SK. Insulinoma[J]. Surg Clin North Am， 2009， 89(5)：1105-1121.
6. Jonkers YM， Claessen SM， Perren A， et al. DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients[J]. Endocr Relat Cancer， 2007， 14(3)：769-779.
7. Jensen RT， Cadiot G， Brandi ML， et al. ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms：functional pancreatic endocrine tumor syndromes[J]. Neuroendocrinology， 2012， 95(2)：98-119.
8. Vanderveen K， Grant C. Insulinoma[J]. Cancer Treat Res， 2010， 153：235-252.
9. de Herder WW， Niederle B， Scoazec JY， et al. Well-differentiated pancreatic tumor/carcinoma：insulinoma[J]. Neuroendocrinology， 2006， 84(3)：183-188.
10. Christ E， Wild D， Forrer F， et al. Glucagon-like peptide-1receptor imaging for localization of insulinomas[J]. J Clin Endocrinol Metab， 2009， 94(11)：4398-4405.
11. Ellison EC， Johnson JA. The Zollinger-Ellison syndrome：a comprehensive review of historical， scientific， and clinical considerations[J]. Curr Probl Surg， 2009， 46(1)：13-106.
12. Bosman FT， Carneiro F， Hruban RH， et al. World HealthOrganization classification of tumors and genetics of the digestive system[M]. 4th ed. Lyon ：IARC Press， 2010.
13. Osefo N， Ito T， Jensen RT. Gastric acid hypersecretory states：recent insights and advances[J]. Curr Gastroenterol Rep， 2009， 11(6)：433-441.
14. Vinik AI， Woltering EA， Warner RR， et al. NANETS consensus guidelines for the diagnosis of neuroendocrine tumor[J]. Pancreas，.
15. Patel KK， Kim MK. Neuroendocrine tumors of the pancreas：endoscopic diagnosis[J]. Curr Opin Gastroenterol， 2008， 24(5)：638-642.
16. Norton JA， Jensen RT. Resolved and unresolved controversies in the surgical management of patients with Zollinger-Ellison syndrome[J]. Ann Surg， 2004， 240(5)：757-773.
17. Jensen RT， Niederle B， Mitry E， et al. Gastrinoma (duodenal and pancreatic)[J]. Neuroendocrinology，2006， 84(3)：173-182.
18. O’Toole D， Salazar R， Falconi M， et al. Rare functioning pancreatic endocrine tumors[J]. Neuroendocrinology， 2006， 84(3)：189-195.
19. Morrow EH， Norton JA. Surgical management of Zollinger-Ellison syndrome； state of the art[J]. Surg Clin North Am， 2009， 89(5)：1091-1103.
20. Elias D， Goéré D， Leroux G， et al. Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver[J]. Eur J Surg Oncol， 2009， 35(10)：1092-1097.
21. Bettini R， Partelli S， Boninsegna L， et al. Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor[J]. Surgery， 2011， 150(1)：75-82.
22. Fjallskog ML， Janson ET， Falkmer UG， et al. Treatment with combined streptozotocin and liposomal doxorubicin in metastatic endocrine pancreatic tumors[J]. Neuroendocrinology， 2008， 88(1)：53-58.
23. Kouvaraki MA， Ajani JA， Hoff P， et al. Fluorouracil， doxorubicin， and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas[J]. J Clin Oncol， 2004， 22(23)：4762-4771.
24. Arnold R， Rinke A， Klose KJ， et al. Octreotide versus octreotide plus interferon-alpha in endocrine gastroenteropancreatic tumors：a randomized trial[J]. Clin Gastroenterol Hepatol， 2005， 3(8)：761-771.
25. Raymond E， Dahan L， Raoul JL， et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors[J]. N Engl J Med， 2011， 364(6)：501-513.
26. Jensen RT， Delle Fave G. Promising advances in the treatment of malignant pancreatic endocrine tumors[J]. N Engl J Med， 2011， 364(6)：564-565.
27. Kulke MH， Bergsland EK， Yao JC. Glycemic control in patients with insulinoma treated with everolimus[J]. N Engl J Med， 2009， 360(2)：195-197.
28. Ojeaburu JV， Ito T， Crafa P， et al. Mechanism of acid hypersecretion post curative gastrinoma resection[J]. Dig Dis Sci， 2011， 56(1)：139-154.
29. Yang YX， Metz DC. Safety of proton pump inhibitor exposure[J]. Gastroenterology， 2010， 139(4)：1115-1127.
30. ， 39(6)：713-734.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Present and Advance in Surgical Diagnosis and Treatment of Pancreatic Endocrine Tumors

Abstract Full text Figures/Tables Video References Cited by

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