Objective To explore the feasibility of clinical application of hepatic artery (HA) or proper hepatic artery (PHA) anastomosing with superior mesenteric artery (SMA) and internal iliac vein (IIV) anastomosing with superior mesenteric vein (SMV) or portal vein (PV) in the extended pancreaticoduodenectomy combined with vascular resection.
Methods The HA,PHA,SMA, SMV, PV, and IIV were dissected on 20 adult corpses, and the length, thickness,and lumen diameter of blood vessels were measured and compared with the results of multislice spiral CT scan,magnetic resonance angiography,or color Doppler in 25 patients with pancreatic head carcinoma.The extended pancreaticoduodenectomy was carried out on 5 patients of pancreatic head carcinoma with vascular invasion according to the mathcing results,and the reconstructions of HA or PHA with SMA and IIV with SMV or PV were performed.
Results According to autopsy,HA-PHA was (5.50±1.50) cm in length,(0.20±0.01) mm in thickness,(5.02±1.32) mm in lumen diameter;and SMA was (4.00±1.00) cm in length,(0.21±0.01) mm in thickness,(6.05±1.06) mm in lumen diameter.The lumen diameter of left IIV,right IIV,and PV or SMV was (11.06±0.16) mm,(11.10±0.13) mm,and (11.56±0.20) mm,respectively.The thickness of left IIV,right IIV,and PV or SMV was (0.10±0.01) mm,(0.10±0.02) mm,and (0.10±0.02) mm,respectively.The multislice spiral CT scan,magnetic resonance angiography,color Doppler,and selective arteriography in vivo showed that the thickness and lumen diameter of HA-PHA and SMA were wider (0.1 mm and 0.3 mm) than those of the autopsy results,and there were no statistic
significances (P>0.05),but the length of HA-PHA was longer (1-2 cm) than that of SMA,and there was statistic significance (P<0.05). The survival of 5 patients with extended pancreaticoduodenectomy combined with PHA or SMA and IIV-PV/SMV resection and reconstruction was longer than that of palliative surgery patients or giving-up patients at the same period,and no long-term complications occurred.
Conclusions The vascular invasion of pancreatic head carcinoma is not an absolute contraindication of radical pancreaticoduodenectomy.The survival of 5 patients with vascular invasion of pancreatic head carcinoma in this group is prolonged by extended pancreaticoduodenectomy combined with vascular resection and reconstruction as compared with palliative surgery group at the same period.HA,PHA,and IIV are the best autologous vascular alternative materials without more complications. Being familiar with regional anatomy will guide the surgeons in extended pancreaticoduodenectomy.
Citation:
GUAN Xiaoqing,CHEN Yan,GU Shucheng,WU Ji,WU Jianqiang,WU Jisheng,HUI Benjun,ZHANG Yajin,CHEN Dongmin,LING Bing.. Feasibility Study on Clinical Application of Hepatic Artery,Proper Hepatic Artery,and Internal Iliac Vein Resection and Reconstruction in Extended Pancreaticoduodenectomy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(2): 181-187. doi:
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苗毅,戴存才.胰腺癌根治联合血管切除及血管重建[ J].中国实用外科杂志,2007,27(7):525-528.(11).
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吴伟顶,彭承宏,赵大建,等.联合肠系膜上静脉 -门静脉切除在胰腺癌根治术中的作用[ J].中华普通外科杂志, 2006, 21(9):620-622..
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洪德飞,彭淑牖.胰腺癌根治术联合血管切除术中血管切除的指征探讨[ J].外科理论与实践,2007,12(3):268-270..
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金星林,张松男.切除侵犯肠系膜上动脉的胰腺癌 11例报告[ J].天津医药,2008,36(1):14..
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黄庆娟,王小宁,厉申儿,等.螺旋电子计算机体层扫描双期扫描对胰腺癌可切除性的研究[ J].南京医科大学学报 (自然科学版 ),2000,20(6):447-449..
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凌华威,管永靖,丁蓓,等.多层螺旋 CT血管造影在胰腺癌周围血管侵犯术前评估中的应用价值[ J].中华放射学杂志, 2002,36(7):609-612..
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刘军桂,周宁新,李成刚,等.胰头癌可切除性的术前综合评估[ J].肝胆外科杂志,2008,16(2):100-102..
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付淑芬.肝动脉解剖分析及临床意义[ J].长春中医药大学学报, 2008,24(4):440-441..
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陈焰,管小青,张亚锦,等.髂内静脉在胰十二指肠扩大切除中的应用[ J].中华肝胆外科杂志,2009,15(11):861-862..
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陈焰,管小青,吴际生,等.髂内静脉在胰十二指肠扩大切除术中应用的可行性研究[ J].中国医师进修杂志, 2008, 31(10):15-17..
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陈福真,戈小虎,赵大健,等.联合血管重建的胰十二指肠切除 (附 42例报告 )[J].中国实用外科杂志, 2002,22(5): 273-275..
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洪磊,杨文奇,孟翔凌.胰头十二指肠切除术中肠系膜上动脉损伤二例[ J].临床外科杂志,2008,16(8):568..
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夏春波,蒋常文.肝总动脉分支解剖学观察[ J].解剖科学进展, 2009,15(1):128..
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陈小迅.肝动脉的解剖学观测及其临床意义[ J].中国临床解剖学杂志,1995,13(4):263-267..
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丁家明,李惠君.肝动脉的解剖学及其临床意义[ J].四川解剖学杂志,1996,4(2):103-106..
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陈明清,张国珠,李云峰.胰腺癌根治术时受侵肠系膜上动脉的切除并重建二例报告[ J].中华普通外科杂志,1999,14(2): 159..
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26. |
王文涛,严律南,赵纪春,等.肠系膜上动脉切除及重建的胰头癌扩大根治术 1例报告[ J].中国普外基础与临床杂志, 2006,13(5):529-530..
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- 1. 苗毅,戴存才.胰腺癌根治联合血管切除及血管重建[ J].中国实用外科杂志,2007,27(7):525-528.(11).
- 2. 彭承宏,刘颖斌,彭淑牖,等.胰十二指肠联合门静脉切除治疗胰头癌[ J].肝胆胰外科杂志,2001,13(2):83-85..
- 3. Fortner JG.Regional resection of cancer of the pancreas:a new surgical approach[J].Surgery,1973,73(2):307-320..
- 4. Fuhrman GM,Leach SD,Staley CA,et al.Rationale for en bloc vein resection in the treatment of pancreatic adenocarcinoma adherent to the superior mesenteric-portal vein confluence.Pancreatic Tumor Study Group[J].Ann Surg,1996,223(2):154162..
- 5. Ahmad NA,Lewis JD,Ginsberg GG,et al.Long term survival after pancreatic resection for pancreatic adenocarcinoma[J].Am J Gastroenterol,2001,96(9):2609-2615..
- 6. Takahashi S,Ogata Y,Tsuzuki T.Combined resection of the pancreas and portal vein for pancreatic cancer[J].Br J Surg, 1994,81(8):1190-1193..
- 7. Howard JM.Development and progress in resective surgery for pancreatic cancer[J].World J Surg,1999,23(9):901-906..
- 8. 彭淑牖,钱浩然.困难的胰十二指肠切除术[ J].中国普外基础与临床杂志,2006,13(5):496-497..
- 9. 吴伟顶,彭承宏,赵大建,等.联合肠系膜上静脉 -门静脉切除在胰腺癌根治术中的作用[ J].中华普通外科杂志, 2006, 21(9):620-622..
- 10. 洪德飞,彭淑牖.胰腺癌根治术联合血管切除术中血管切除的指征探讨[ J].外科理论与实践,2007,12(3):268-270..
- 11. 金星林,张松男.切除侵犯肠系膜上动脉的胰腺癌 11例报告[ J].天津医药,2008,36(1):14..
- 12. 黄庆娟,王小宁,厉申儿,等.螺旋电子计算机体层扫描双期扫描对胰腺癌可切除性的研究[ J].南京医科大学学报 (自然科学版 ),2000,20(6):447-449..
- 13. 凌华威,管永靖,丁蓓,等.多层螺旋 CT血管造影在胰腺癌周围血管侵犯术前评估中的应用价值[ J].中华放射学杂志, 2002,36(7):609-612..
- 14. 刘军桂,周宁新,李成刚,等.胰头癌可切除性的术前综合评估[ J].肝胆外科杂志,2008,16(2):100-102..
- 15. 付淑芬.肝动脉解剖分析及临床意义[ J].长春中医药大学学报, 2008,24(4):440-441..
- 16. 陈焰,管小青,张亚锦,等.髂内静脉在胰十二指肠扩大切除中的应用[ J].中华肝胆外科杂志,2009,15(11):861-862..
- 17. 陈焰,管小青,吴际生,等.髂内静脉在胰十二指肠扩大切除术中应用的可行性研究[ J].中国医师进修杂志, 2008, 31(10):15-17..
- 18. 陈福真,戈小虎,赵大健,等.联合血管重建的胰十二指肠切除 (附 42例报告 )[J].中国实用外科杂志, 2002,22(5): 273-275..
- 19. 洛树东,高振平.医用局部解剖学[ M].第 7版.北京:人民卫生出版社,2008:193..
- 20. 黄洁夫,陈孝平,董家鸿,等主译.肝胆胰外科学[ M].第 4版.北京:人民卫生出版社, 2010:37..
- 21. 洪磊,杨文奇,孟翔凌.胰头十二指肠切除术中肠系膜上动脉损伤二例[ J].临床外科杂志,2008,16(8):568..
- 22. 夏春波,蒋常文.肝总动脉分支解剖学观察[ J].解剖科学进展, 2009,15(1):128..
- 23. 陈小迅.肝动脉的解剖学观测及其临床意义[ J].中国临床解剖学杂志,1995,13(4):263-267..
- 24. 丁家明,李惠君.肝动脉的解剖学及其临床意义[ J].四川解剖学杂志,1996,4(2):103-106..
- 25. 陈明清,张国珠,李云峰.胰腺癌根治术时受侵肠系膜上动脉的切除并重建二例报告[ J].中华普通外科杂志,1999,14(2): 159..
- 26. 王文涛,严律南,赵纪春,等.肠系膜上动脉切除及重建的胰头癌扩大根治术 1例报告[ J].中国普外基础与临床杂志, 2006,13(5):529-530..