Imaging Evaluation of Stem Cell Transplantation in Patients with Liver Cirrhosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LU Tao ¹ , HUANG Xiaolun. ²

1. Department of Radiology, Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China;;
2. Center of Cell Transplantation, Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, ChinaLU Tao1, HUANG Xiao-lun2.;

Corresponding author：

Keywords：

Liver cirrhosis; Stem cell transplantation; Radiology

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To review the value of imaging assessment of stem cell transplantation in treatment for liver cirrhosis.
Methods 　The related literatures in recent years were collected,and the applications of different radiological techniques and strategies of stem cell transplantation in treatment for liver cirrhosis were summarized.
Results　 Stem cell transplantation in treatment for liver cirrhosis was feasible and effective. Radiological assessment could supply the prompt and accurate information for clinic to choose the proper therapeutic method.The curative effect could also be accurately assessed by radiological techniques.
Conclusion 　Radiological examination is important for the assessment of stem cell transplantation in treatment for liver cirrhosis.

Citation： LU Tao,HUANG Xiaolun.. Imaging Evaluation of Stem Cell Transplantation in Patients with Liver Cirrhosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(2): 220-223. doi: Copy

1.	Gupta S, Chowdhary JR. Hepatocyte transplantation：back to the future[J]. Hepatology, 1992, 15(1)：156-162.
2.	Holzman MD, Rozga J, Neuzil DF, et al. Selective intraportal hepatocyte transplantation in analbuminemic and Gunn rats[J]. Transplantation, 1993, 55(6)：1213-1219.
3.	Ott M, Schmidt HH, Cichon G, et al. Emerging therapies in hepatology： liver-directed gene transfer and hepatocyte transplantation[J]. Cells Tissues Organs, 2000, 167(2-3)：81-87.
4.	Khan AA, Parveen N, Mahaboob VS, et al. Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure： a preliminary study[J]. Transplant Proc, 2008, 40(4)： 1140-1144.
5.	Muretto P, Angelucci E, Lucarelli G. Reversibility of cirrhosis in patients cured of thalassemia by bone marrow transplantation[J]. Ann Intern Med, 2002, 136(9)：667-672.
6.	Mohamadnejad M, Alimoghaddam K, Mohyeddin-Bonab M, et al. Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis[J]. Arch Iran Med, 2007, 10(4)：459-466.
7.	Terai S, Ishikawa T, Omori K, et al. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy[J]. Stem Cells, 2006, 24(10)：2292-2298.
8.	秦安成,廖彩仙,王宇,等.自体骨髓源性干细胞移植治疗肝炎后肝硬化的临床研究[ J].南方科技大学学报, 2010, 30(3)：529-531.
9.	江军, 范平, 李东良, 等. 40 例自体干细胞移植治疗失代偿期肝硬化的临床研究 [J]. 临床肝胆病杂志, 2010, 26(6)：610-612.
10.	Sato Y, Araki H, Kato J, et al. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion[J]. Blood, 2005, 106(2)：756-763.
11.	Alison MR, Islam S, Lim S. Stem cells in liver regeneration, fibrosis and cancer：the good, the bad and the ugly[J]. J Pathol, 2009, 217(2)：282-298.
12.	Dumble ML, Croager EJ, Yeoh GC, et al. Generation and characterization of p53 null transformed hepatic progenitor cells： oval cells give rise to hepatocellular carcinoma[J]. Carcinogenesis, 2003, 23(3)：435-445.
13.	Kung JW, Currie IS, Forbes SJ, et al. Liver development,regeneration, and carcinogenesis [J]. J Biomed Biotechnol,2010, 2010： 984248.
14.	徐鹏举, 严福华, 王建华, 等. 原位肝移植术前受体血管和肝实质的一次性MRI 评价 [J] . 中国医学计算机成像杂志, 2009, 15(1)： 46-51.
15.	吴苾, 宋彬. 肝硬变结节性病变的影像学和相关病理性表现[J]. 中国普外基础与临床杂志, 2003, 10(3)： 288-294.
16.	印隆林, 邓开鸿. 肝移植术前影像学评估 [J] . 华西医学, 2005,20(2)： 389-390.
17.	Libbrecht L, Bielen D, Verslype C, et al. Focal lesions in cirrhotic explant livers： pathological evaluation and accuracy of pretransplantation imaging examinations [J]. Liver Transpl, 2002, 8(9)：749-761.
18.	吴佳羽, 尹华发. 肝脏干细胞移植治疗肝硬化的研究进展 [J].临床医学, 2011, 31(3)： 111-113.
19.	陈卫霞, 周翔平, 李昌宪, 等. 肝移植术前影像学评价 [J].放射学实践, 2007, 22(3)： 114-118.
20.	刘曦娇, 宋彬, 陈光文. 肝移植围手术期的影像学评价 [J].中国普外基础与临床杂志, 2010, 17(10)： 1102-1105.
21.	Gallego C, Velasco M, Marcuello P, et al. Congenital and acquired anomalies of the portal venous system [J]. Radiographics,2002, 22(1)： 141-159.
22.	Takahashi S, Murakami T, Takamura M, et al. Multi-detector row helical CT angiography of hepatic vessels： depiction with dual-arterial phase acquisition during single breath hold [J]. Radiology,2002, 222(1)： 81-88.
23.	Stemmler BJ, Paulson EK, Thomton FJ, et al. Dual-phase 3D MDCT angiography for evaluation of the liver before hepatic resection [J]. AJR Am J Roentgenol, 2004, 183(6)： 1551-1557.
24.	Schiano TD, Bodian C, Schwartz ME, et al. Accuracy and significance of computed tomography scan assessment of hepatic volume in patients undergoing liver transplantation [J]. Transplantation,2000, 69(4)： 545-550.
25.	Redvanly RD, Nelson RC, Stieber AC, et al. Imaging in the preoperative evaluations of adult liver transplant candidates： goals,merits of various procedures and recommendations [J]. AJR Am J Roentgenol, 1995, 164(3)： 611-617.
26.	Miyagawa S, Makuuchi M, Kawasaki S, et al. Criteria for safe hepatic resection [J]. Am J Surg, 1995, 169(6)： 589-594.
27.	Kubota K, Machuuchi M, Kusaka K, et al. Measurement of liver volume and hepatic function reserve as a guide to decisionmaking in resectional surgery for hepatic tumors [J]. Hepatology,1997, 26(5)： 1176-1181.
28.	Frericks BB, Caldarone FC, Nashan B, et al. 3D CT modeling of hepatic vessel architecture and volume calculation in living donated liver transplantation [J]. Eur Radiol, 2004, 14(2)： 326-333.
29.	Mathew JB, Ann SF, Richard AS, et al. Use of imaging for living donor liver transplantation [J]. Radio graphics, 2001, 21(1)：39-52.
30.	Leelaudomlipi S, Sugawarn Y, Kaneko J, et al. Volumetric analysis of liver segments in 155 living donors [J]. Liver transpl, 2002, 8(7)： 612-614.
31.	Joyeux H, Berticelli J, Chemoneny S, et al. Semi-auto measurement of hepatic lobes. Application to study of liver volume. Analysis of 50 computed tomography of normal liver [J]. Ann Chir,2003, 128(4)： 251-255.
32.	Caldwell SH, Delange EE, Gaffey MJ, et al. Accuracy and significance of pretransplant liver volume measured by magnetic resonance imaging [J]. Liver Transpl Surg, 1996, 2(6)： 438-422.
33.	am Esch JS 2nd, Knoefel WT, Klein M, et al. Portal application of autologous CD133＋ bone marrow cells to the liver：a novel concept to support hepatic regeneration [J]. StemCells, 2005, 23(4)： 463-470.
34.	王方群, 王志慧. 自体干细胞移植治疗肝硬化腹水概况 [J]. 中国组织工程研究与临床康复, 2009, 13(1)：117-119.
35.	黄丽雯, 刘黎, 周健. 干细胞移植治疗肝硬化顽固性腹水的疗效观察 [J]. 胃肠病学和肝病学杂志, 2011, 20(3)：237-239.

1. Gupta S, Chowdhary JR. Hepatocyte transplantation：back to the future[J]. Hepatology, 1992, 15(1)：156-162.
2. Holzman MD, Rozga J, Neuzil DF, et al. Selective intraportal hepatocyte transplantation in analbuminemic and Gunn rats[J]. Transplantation, 1993, 55(6)：1213-1219.
3. Ott M, Schmidt HH, Cichon G, et al. Emerging therapies in hepatology： liver-directed gene transfer and hepatocyte transplantation[J]. Cells Tissues Organs, 2000, 167(2-3)：81-87.
4. Khan AA, Parveen N, Mahaboob VS, et al. Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure： a preliminary study[J]. Transplant Proc, 2008, 40(4)： 1140-1144.
5. Muretto P, Angelucci E, Lucarelli G. Reversibility of cirrhosis in patients cured of thalassemia by bone marrow transplantation[J]. Ann Intern Med, 2002, 136(9)：667-672.
6. Mohamadnejad M, Alimoghaddam K, Mohyeddin-Bonab M, et al. Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis[J]. Arch Iran Med, 2007, 10(4)：459-466.
7. Terai S, Ishikawa T, Omori K, et al. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy[J]. Stem Cells, 2006, 24(10)：2292-2298.
8. 秦安成,廖彩仙,王宇,等.自体骨髓源性干细胞移植治疗肝炎后肝硬化的临床研究[ J].南方科技大学学报, 2010, 30(3)：529-531.
9. 江军, 范平, 李东良, 等. 40 例自体干细胞移植治疗失代偿期肝硬化的临床研究 [J]. 临床肝胆病杂志, 2010, 26(6)：610-612.
10. Sato Y, Araki H, Kato J, et al. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion[J]. Blood, 2005, 106(2)：756-763.
11. Alison MR, Islam S, Lim S. Stem cells in liver regeneration, fibrosis and cancer：the good, the bad and the ugly[J]. J Pathol, 2009, 217(2)：282-298.
12. Dumble ML, Croager EJ, Yeoh GC, et al. Generation and characterization of p53 null transformed hepatic progenitor cells： oval cells give rise to hepatocellular carcinoma[J]. Carcinogenesis, 2003, 23(3)：435-445.
13. Kung JW, Currie IS, Forbes SJ, et al. Liver development,regeneration, and carcinogenesis [J]. J Biomed Biotechnol,2010, 2010： 984248.
14. 徐鹏举, 严福华, 王建华, 等. 原位肝移植术前受体血管和肝实质的一次性MRI 评价 [J] . 中国医学计算机成像杂志, 2009, 15(1)： 46-51.
15. 吴苾, 宋彬. 肝硬变结节性病变的影像学和相关病理性表现[J]. 中国普外基础与临床杂志, 2003, 10(3)： 288-294.
16. 印隆林, 邓开鸿. 肝移植术前影像学评估 [J] . 华西医学, 2005,20(2)： 389-390.
17. Libbrecht L, Bielen D, Verslype C, et al. Focal lesions in cirrhotic explant livers： pathological evaluation and accuracy of pretransplantation imaging examinations [J]. Liver Transpl, 2002, 8(9)：749-761.
18. 吴佳羽, 尹华发. 肝脏干细胞移植治疗肝硬化的研究进展 [J].临床医学, 2011, 31(3)： 111-113.
19. 陈卫霞, 周翔平, 李昌宪, 等. 肝移植术前影像学评价 [J].放射学实践, 2007, 22(3)： 114-118.
20. 刘曦娇, 宋彬, 陈光文. 肝移植围手术期的影像学评价 [J].中国普外基础与临床杂志, 2010, 17(10)： 1102-1105.
21. Gallego C, Velasco M, Marcuello P, et al. Congenital and acquired anomalies of the portal venous system [J]. Radiographics,2002, 22(1)： 141-159.
22. Takahashi S, Murakami T, Takamura M, et al. Multi-detector row helical CT angiography of hepatic vessels： depiction with dual-arterial phase acquisition during single breath hold [J]. Radiology,2002, 222(1)： 81-88.
23. Stemmler BJ, Paulson EK, Thomton FJ, et al. Dual-phase 3D MDCT angiography for evaluation of the liver before hepatic resection [J]. AJR Am J Roentgenol, 2004, 183(6)： 1551-1557.
24. Schiano TD, Bodian C, Schwartz ME, et al. Accuracy and significance of computed tomography scan assessment of hepatic volume in patients undergoing liver transplantation [J]. Transplantation,2000, 69(4)： 545-550.
25. Redvanly RD, Nelson RC, Stieber AC, et al. Imaging in the preoperative evaluations of adult liver transplant candidates： goals,merits of various procedures and recommendations [J]. AJR Am J Roentgenol, 1995, 164(3)： 611-617.
26. Miyagawa S, Makuuchi M, Kawasaki S, et al. Criteria for safe hepatic resection [J]. Am J Surg, 1995, 169(6)： 589-594.
27. Kubota K, Machuuchi M, Kusaka K, et al. Measurement of liver volume and hepatic function reserve as a guide to decisionmaking in resectional surgery for hepatic tumors [J]. Hepatology,1997, 26(5)： 1176-1181.
28. Frericks BB, Caldarone FC, Nashan B, et al. 3D CT modeling of hepatic vessel architecture and volume calculation in living donated liver transplantation [J]. Eur Radiol, 2004, 14(2)： 326-333.
29. Mathew JB, Ann SF, Richard AS, et al. Use of imaging for living donor liver transplantation [J]. Radio graphics, 2001, 21(1)：39-52.
30. Leelaudomlipi S, Sugawarn Y, Kaneko J, et al. Volumetric analysis of liver segments in 155 living donors [J]. Liver transpl, 2002, 8(7)： 612-614.
31. Joyeux H, Berticelli J, Chemoneny S, et al. Semi-auto measurement of hepatic lobes. Application to study of liver volume. Analysis of 50 computed tomography of normal liver [J]. Ann Chir,2003, 128(4)： 251-255.
32. Caldwell SH, Delange EE, Gaffey MJ, et al. Accuracy and significance of pretransplant liver volume measured by magnetic resonance imaging [J]. Liver Transpl Surg, 1996, 2(6)： 438-422.
33. am Esch JS 2nd, Knoefel WT, Klein M, et al. Portal application of autologous CD133＋ bone marrow cells to the liver：a novel concept to support hepatic regeneration [J]. StemCells, 2005, 23(4)： 463-470.
34. 王方群, 王志慧. 自体干细胞移植治疗肝硬化腹水概况 [J]. 中国组织工程研究与临床康复, 2009, 13(1)：117-119.
35. 黄丽雯, 刘黎, 周健. 干细胞移植治疗肝硬化顽固性腹水的疗效观察 [J]. 胃肠病学和肝病学杂志, 2011, 20(3)：237-239.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Imaging Evaluation of Stem Cell Transplantation in Patients with Liver Cirrhosis

Abstract Full text Figures/Tables Video References Cited by

Format

Content