Application and Prospect of Susceptibility Weighted Imaging in Diagnosis of Hepatic Disease_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Dan , SONG Bin , HUANG Zixing

Department of Radiology， West China Hospital of Sichuan University， Chengdu 610041，Sichuan Province， China;

Corresponding author：

Keywords：

Susceptibility weighted imaging; Hepatic disease; Application

Video：

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Objective 　To summarize the application and prospect of susceptibility weighted imaging （SWI） in diagnosis of hepatic disease.
Methods 　The application of SWI in diagnosis of hepatic disease was analyzed retrospectively via reviewed the literatures home and abroad, and to look forward to the future of the clinical values of SWI.
Results　 A number of hepatic diseases such as cirrhosis, hematochromatosis， and malignant tumors could induce iron overload in hepatic cell and Kuffper cell. Because of SWI is sensitive to vein， vascular abnormality, haemorrhage （including all kinds of metabolities after bleeding）， iron overload， calcification, and so on, so the use of SWI in hepatic disease is explored continually.
Conclusions 　SWI may be a new method for diagnosis of hepatic disease, which can supply more valuable information for clinician.

Citation： LIU Dan,SONG Bin,HUANG Zixing,.. Application and Prospect of Susceptibility Weighted Imaging in Diagnosis of Hepatic Disease. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(6): 675-678. doi: Copy

1.	Reichenbach JR， Venkatesan R， Schillinger DJ， et al. Small vessels in the human brain：MR venography with deoxyhemoglobin as an intrinsic contrast agent [J]. Radiology， 1997， 204(1)：272-277.
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11.	Nielsen P， Engelhardt R， Düllmann J， et al. Non-invasive liver iron quantification by SQUID-biosusceptometry and serum ferritin iron as new diagnostic parameters in hereditary hemochromatosis [J]. Blood Cells Mol Dis， 2002， 29(3)：451-458.
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13.	Ludwig J， Hashimoto E， Porayko MK， et al. Hemosiderosis in cirrhosis：a study of 447 native livers [J]. Gastroenterology， 1997， 112(3)：882-888.
14.	Piga A， Fischer R， St Pierre T， et al. Comparison of LIC obtained from biopsy， BLS and R2-MRI in iron overload patients with B-thalassemia， treated with deferasirox [J]. Blood， 2005，106(11)：abstract 2698.
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16.	Angelucci E， Giovagnoni A， Valeri G， et al. Limitations of magnetic resonance imaging in measurement of hepatic iron [J].Blood， 1997， 90(12)：4736-4742.
17.	Westphalen AC， Qayyum A， Yeh Bm， et al. Liver fat：effect of hepatic iron deposition on evaluation with opposed-phase MR imaging [J]. Radiology， 2007， 242(2)：450-455.
18.	Cooper AD， Campeau NG， Meissner I. Susceptibility–weighted imaging in familial cerebral cavernous malformations [J]. Neurology，2008， 71(5)：382.
19.	李秋云，肖恩华，李华兵，等. 磁敏感成像技术在肝脏局灶性病变的初步应用 [J]. 中国临床医学影像杂志， 2011， 22(2)：100-104.
20.	孙晓力，李国威，扬少毅，等. 肝海绵状血管瘤超微结构及其与临床特征的关系 [J]. 世界华人消化杂志， 2006， 14(32)：3107-3110.
21.	Cha S， Knopp EA， Johnson G， et al. Intracranial mass lesions：dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion MR imaging [J]. Radiology， 2002， 223(1)：11-29.
22.	Sehgal V， Delproposto Z， Haddar D， et al. Susceptibilityweighted imaging to visualize blood products and improve tumor contrast in the study of brain masses [J]. Magn Reson Imaging，2006， 24(1)：41-51.
23.	赵睿. 铁超载与肝细胞癌关系的研究进展 [J]. 临床肝胆病杂志， 2011， 27(6)：670-672.
24.	李兴胜，王世锦，谭戈峰. 肝脏转移瘤的表现及病理分析 [J].临床肝胆病杂志， 2006， 22(8)：264-266.
25.	Mittal S， Wu Z， Neelavalli J， et al. Susceptibility-weighted imaging：technical aspects and clinical applications， part 2 [J].AJNR Am J Neuroradiol， 2009， 30(2)：232-252.
26.	Li C， Ai B， Li Y， et al. Susceptibility-weighted imaging in grading brain astrocytomas [J]. Eur J Radiol， 2010， 75(1)：e81-e85.

1. Reichenbach JR， Venkatesan R， Schillinger DJ， et al. Small vessels in the human brain：MR venography with deoxyhemoglobin as an intrinsic contrast agent [J]. Radiology， 1997， 204(1)：272-277.
2. 王丽娟，刘玉波. 磁敏感加权成像原理概述 [J]. 磁共振成像，2010， 1(3)：227-230.
3. Machann J， Haap M， Liebig G， et al. Susceptibility weighted MRI for assessment of ferritin content in liver and spleen in people at high risk for type 2 diabetes and detection of changes after phlebotomy [J]. Proc Intl Soc Mag Reson Med， 2007， 15：219.
4. Dai Y， Zeng M， Li R， et al. Improving detection of siderotic nodules in cirrhotic liver with a multi-breath-hold susceptibilityweighted imaging technique [J]. J Magn Reson Imaging， 2011，34(2)：318-325.
5. Takeuchi M， Matsuzaki K， Nishitani H. Susceptibility-weighted MRI of endometrioma：preliminary results [J]. AJR Am J Roentgenol， 2008， 191(5)：1366-1370.
6. Idbaih A， Boukobza M， Crassard I， et al. MRI of clot in cerebral venous thrombosis：high diagnostic value of susceptibilityweighted images [J]. Stroke， 2006， 37(4)：991-995.
7. Yamada N， Imakita S， Sakuma T， et al. Intracranial calcification on gradient-echo phase image：depiction of diamagnetic susceptibility [J]. Radiology， 1996， 198(1)：171-178.
8. Xu Y， Haacke EM. The role of voxel aspect ratio in determining apparent vascular phase behavior in susceptibility weighted imaging [J]. Magn Reson Imaging， 2006， 24(2)：155-160.
9. Rauscher A， Sedlacik J， Barth M， et al. Magnetic susceptibilityweighted MR phase imaging of the human brain [J]. AJNR Am J Neuroradiol， 2005， 26(4)：736-742.
10. Li D， Waight DJ， Wang Y. In vivo correlation between blood T2* and oxygen saturation [J]. Magn Reson Imaging， 1998， 8(6)：1236-1239.
11. Nielsen P， Engelhardt R， Düllmann J， et al. Non-invasive liver iron quantification by SQUID-biosusceptometry and serum ferritin iron as new diagnostic parameters in hereditary hemochromatosis [J]. Blood Cells Mol Dis， 2002， 29(3)：451-458.
12. Angelucci E， Barosi G， Camaschella C， et al. Italian society of hematology practice guidelines for the management of iron overload in thalassemia major and related disorders [J]. Haematologica，2008， 93(5)：741-752.
13. Ludwig J， Hashimoto E， Porayko MK， et al. Hemosiderosis in cirrhosis：a study of 447 native livers [J]. Gastroenterology， 1997， 112(3)：882-888.
14. Piga A， Fischer R， St Pierre T， et al. Comparison of LIC obtained from biopsy， BLS and R2-MRI in iron overload patients with B-thalassemia， treated with deferasirox [J]. Blood， 2005，106(11)：abstract 2698.
15. Gandon Y， Olivié D， Guyader D， et al. Non-invasive assessment of hepatic iron stores by MRI [J]. Lancet， 2004， 363(9406)：357-362.
16. Angelucci E， Giovagnoni A， Valeri G， et al. Limitations of magnetic resonance imaging in measurement of hepatic iron [J].Blood， 1997， 90(12)：4736-4742.
17. Westphalen AC， Qayyum A， Yeh Bm， et al. Liver fat：effect of hepatic iron deposition on evaluation with opposed-phase MR imaging [J]. Radiology， 2007， 242(2)：450-455.
18. Cooper AD， Campeau NG， Meissner I. Susceptibility–weighted imaging in familial cerebral cavernous malformations [J]. Neurology，2008， 71(5)：382.
19. 李秋云，肖恩华，李华兵，等. 磁敏感成像技术在肝脏局灶性病变的初步应用 [J]. 中国临床医学影像杂志， 2011， 22(2)：100-104.
20. 孙晓力，李国威，扬少毅，等. 肝海绵状血管瘤超微结构及其与临床特征的关系 [J]. 世界华人消化杂志， 2006， 14(32)：3107-3110.
21. Cha S， Knopp EA， Johnson G， et al. Intracranial mass lesions：dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion MR imaging [J]. Radiology， 2002， 223(1)：11-29.
22. Sehgal V， Delproposto Z， Haddar D， et al. Susceptibilityweighted imaging to visualize blood products and improve tumor contrast in the study of brain masses [J]. Magn Reson Imaging，2006， 24(1)：41-51.
23. 赵睿. 铁超载与肝细胞癌关系的研究进展 [J]. 临床肝胆病杂志， 2011， 27(6)：670-672.
24. 李兴胜，王世锦，谭戈峰. 肝脏转移瘤的表现及病理分析 [J].临床肝胆病杂志， 2006， 22(8)：264-266.
25. Mittal S， Wu Z， Neelavalli J， et al. Susceptibility-weighted imaging：technical aspects and clinical applications， part 2 [J].AJNR Am J Neuroradiol， 2009， 30(2)：232-252.
26. Li C， Ai B， Li Y， et al. Susceptibility-weighted imaging in grading brain astrocytomas [J]. Eur J Radiol， 2010， 75(1)：e81-e85.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Application and Prospect of Susceptibility Weighted Imaging in Diagnosis of Hepatic Disease

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