Study on Lymphatic Targeting in Rats of New Dosage Form of 5-Fluorouracil Carbon Nanoparticles_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZOU Zhiqiang ¹ , JI Qiang ¹ , CAO Junhan ² , ZHAO Shuwen ² , ZHANG Dan. ²

1.Department of General Surgery, Affiliated Hospital, Chengdu University, Chengdu 610081, Sichuan Province, China;;
2.West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding author：

Keywords：

Fluorouracil; Carbon nanoparticle; Lymphatic targeting

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ObjectiveTo investigate the lymphatic targeting of 5-fluorouracil (5-FU) carbon nanoparticles in rats. Methods5-FU concentration in lymphoid tissue of rats was determined by reversed phase high performance liquid chromatography after intraperitoneal injection of 5-FU carbon nanoparticle and 5-FU ordinary form (20 mg/kg body weight). Results5-FU concentration of lymphoid tissue in the 5-FU carbon nanoparticle group was higher than that in the 5-FU ordinary form group, and could sustain a longer time. Conclusion5-FU carbon nanoparticles injection can improve the drug concentration of target lymphatic organs, also has a good lymphatic targeting

Citation： ZOU Zhiqiang,JI Qiang,CAO Junhan,ZHAO Shuwen,ZHANG Dan.. Study on Lymphatic Targeting in Rats of New Dosage Form of 5-Fluorouracil Carbon Nanoparticles. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(10): 1060-1062. doi: Copy

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2. 邱存平. 恶性肿瘤的淋巴化疗 [J]. 国外医学口腔医学分册, 1998, 25(1): 1316.
3. 黄文才, 张春红, 苏玉芬, 等. 5氟尿嘧啶靶向性前药的研究进展 [J]. 华西药学杂志, 2008, 23(4): 462465.
4. 李超英, 蒋学华, 侯世祥. 淋巴靶向给药系统研究与应用 [J]. 中国新药杂志, 2001, 10(12): 903907.
5. 郭洪茹, 杨金凤. 高效液相色谱法测定5氟胞嘧啶片中氟尿嘧啶的含量 [J]. 河北化工, 2008, 31(5): 65, 77.
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7. Chen J, Yao Q, Li D, et al. Chemotherapy targeting regional lymphatic tissues to treat rabbits bearing VX2 tumor in the mammary glands [J]. Cancer Biol Ther, 2008, 7(5): 721725.
8. Lu H, Li B, Kang Y, et al. Paclitaxel nanoparticle inhibits growth of ovarian cancer xenografts and enhances lymphatic targeting [J]. Cancer Chemother Pharmacol, 2007, 59(2): 175181.
9. 苏伟, 周理. 高比表面积活性炭制备技术的研究进展 [J]. 化学工程, 2005, 33(2): 4447.
10. 赵文和, 王世夫, 丁伟, 等. 脱氧氟尿苷诱导胃腺癌细胞凋亡的临床研究 [J]. 中华普通外科杂志, 2005, 20(3): 184186.
11. 沓仁芝, 陈济民, 姚崇舜. 淋巴靶向制剂－吸附抗癌药毫微粒活性炭的研究进展 [J]. 沈阳药科大学学报, 2002, 19(1): 6669.
12. 梁寒, 王仆, 王晓娜, 等. 活性碳吸附丝裂霉素C腹腔化疗预防进展期胃癌术后复发 [J]. 中华外科杂志, 2003, 41(4): 274277.
13. Hagiwara A, Togawa T, Yamasaki J, et al. Extensive gastrectomy and carbonadsorbed mitomycin C for gastric cancer with peritoneal metastases. Case reports of survivors and their implications [J]. Hepatogastroenterology, 1999, 46(27): 16731677.
14. Fass J, Jansen M, Zengel K, et al. Results of intraperitoneal active charcoalmitomycin C therapy of stomach carcinoma with serosa invasion [J]. Langenbecks Arch Chir Suppl Kongressbd, 1998, 115: 13631366.
15. Rosen HR, Jatzko G, Repse S, et al. Adjuvant intraperitoneal chemotherapy with carbonadsorbed mitomycin in patients with gastric cancer: results of a randomized multicenter trial of the Austrian Working Group for Surgical Oncology [J]. J Clin Oncol, 1998, 16(8): 27332738.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Study on Lymphatic Targeting in Rats of New Dosage Form of 5-Fluorouracil Carbon Nanoparticles

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