Role of Related Cytokines in Severe Acute Pancreatitis Associated Lung Injury_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Qizhi ¹ , WU Xinmin ² , GUO Yamin ²

min2. 1.Medical College of Qinghai University, Xining 810001, Qinghai Province, China;;
2.Department of General Surgery, People’s Hospital of Qinghai Province, Xining 810007, Qinghai Province, China;

Corresponding author：

Keywords：

Severe acute pancreatitis; Lung injury; Cytokines

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ObjectiveTo summarize the changes and interaction of the cytokine in severe acute pancreatitis associated lung injury. MethodsThe published literatures at domestic and aboard in recent years about severe acute pancreatitis associated lung injury were collected and reviewed. ResultsThe cytokines had a chain effect, and influenced each other when severe acute pancreatitis with lung injury attacked. ConclusionsRelated cytokines play important roles in severe acute pancreatitis associated lung injury. Researching the related cytokines will contribute to the diagnosis and treatment for severe acute pancreatitis with lung injury.

Citation： LI Qizhi ,WU Xinmin,GUO Yamin. Role of Related Cytokines in Severe Acute Pancreatitis Associated Lung Injury. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(3): 258-260. doi: Copy

1.	Marsboom G, Janssens S. Endothelial progenitor cells: new perspectives and applications in cardiovascular therapies [J]. Expert Rev Cardiovasc Ther, 2008, 6(5): 687701.
2.	Leme AS, Lichtenstein A, ArantesCosta FM, et al. Acute lung injury in experimental pancreatitis in rats: pulmonary protective effects of crotapotin and Nacetylcysteine [J]. Shock, 2002, 18(5): 428433.
3.	Flaishon R, Szold O, Weinbroum AA. Acute lung injury following pancreas ischaemiareperfusion: role of xanthine oxidase [J]. Eur J Clin Invest, 2006, 36(11): 831837.
4.	陆海华, 史忠, 刘波, 等. 急性胰腺炎相关性肺损伤早期血清TNFα、IL1、IL6的变化及其临床意义 [J]. 重庆医学, 2007, 36(18): 18181819.
5.	Inagaki T, Hoshino M, Hayakawa T, et al. Interleukin6 is a useful marker for early prediction of the severity of acute pancreatitis [J]. Pancreas, 1997, 14(1): 18.
6.	Stimac D, Fisic＇ E, Milic＇ S, et al. Prognostic values of IL6, IL8, and IL10 in acute pancreatitis [J]. J Clin Gastroenterol, 2006, 40(3): 209212.
7.	Yu JH, Lim JW, Namkung W, et al. Suppression of ceruleininduced cytokine expression by antioxidants in pancreatic acinar cells [J]. Lab Invest, 2002, 82(10): 13591368.
8.	Hattar K, Fink L, Fietzner K, et al. Cell density regulates neutrophil IL8 synthesis: role of IL1 receptor antagonist and soluble TNF receptors [J]. J Immunol, 2001, 166(10): 62876293.
9.	Pastor CM, Matthay MA, Frossard JL. Pancreatitisassociated acute lung injury: new insights [J]. Chest, 2003, 124(6): 23412351.
10.	周粼，梁道明，陈嘉勇，等. 依达拉奉对大鼠重症急性胰腺炎肺损伤的影响 [J]. 中国普外基础与临床杂志, 2010, 17(2): 125154.
11.	Altavilla D, Famulari C, Passaniti M, et al. Lipid peroxidation inhibition reduces NFκB activation and attenuates ceruleininduced pancreatitis [J]. Free Radic Res, 2003, 37(4): 425435.
12.	Mirshafiey A, Mohsenzadegan M. The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis [J]. Iran J Allergy Asthma Immunol, 2008, 7(4): 195202.
13.	Malleo G, Mazzon E, Siriwardena AK, et al. TNFá as a therapeutic target in acute pancreatitis－lessons from experimental models [J]. Scientific World Journal, 2007, 7: 431448.
14.	Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NFkappa B [J]. Annu Rev Cell Biol, 1994, 10: 405455.
15.	Jaffray C, Yang J, Carter G, et al. Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitisassociated adult respiratory distress syndrome [J]. Surgery, 2000, 128(2): 225231.
16.	莫坚, 刘欣, 何海燕, 等. 倍他米松对大鼠重症急性胰腺炎肺损伤NFκB、 ICAM1及IL6的影响 [J]. 湖北民族学院学报(医学版), 2005, 22(4): 1416.
17.	Slavin J, Ghaneh P, Sutton R, et al. Management of necrotizing pancreatitis [J]. World J Gastroenterol, 2001, 7(4): 476481.
18.	张喜平, 吴迪炯. 细胞黏附分子在重症急性胰腺炎并发急性肺损伤中的作用 [J]. 医学研究杂志, 2008, 37(8): 112114.
19.	Schmidt J, Rattner DW, Lewandrowski K, et al. A better model of acute pancreatitis for evaluating therapy [J]. Ann Surg, 1992, 215(1): 4456.
20.	Zhao X, Dib M, Wang X, et al. Influence of mast cells on the expression of adhesion molecules on circulating and migrating leukocytes in acute pancreatitisassociated lung injury [J]. Lung, 2005, 183(4): 253264．.
21.	Cunningham C, Sanderson DJ. Malaise in the water maze: untangling the effects of LPS and IL1β on learning and memory [J]. Brain Behav Immun, 2008, 22(8): 11171127.
22.	杨学良, 王广义. 重症急性胰腺炎肺损伤大鼠ICAM1和LFA1变化及丹参注射液的干预作用 [J]. 中国老年学杂志, 2010, 30(8): 11081110.
23.	殷涛, 王卫星, 余佳, 等. ICAM1在大鼠急性胰腺炎肺损伤中的作用 [J]. 中国药师, 2009, 12(5): 551553.
24.	汪良芝, 沈云志．ICAM1表达在大鼠重症急性胰腺炎肺损伤中的作用 [J]. 胰腺病学, 2005, 5(1): 4042．.
25.	鲍世韵, 伍天崇, 郭跃华, 等. ICAM1高表达在大鼠重症急性胰腺炎早期急性肺损伤中的作用 [J]. 广东医学, 2010, 31(4): 418421.
26.	Granger J, Remick D. Acute pancreatitis: models, markers, and mediators [J]. Shock, 2005, 24 Suppl 1: 4551.
27.	姜战武, 李厚祥, 邵苏吉. 血清PLA2对急性胰腺炎的诊断和预后判断价值 [J]. 南通医学院学报, 1996, 16(3): 326327.
28.	Strieter RM, Lynch JP 3rd, Basha MA, et al. Host responses in mediating sepsis and adult respiratory distress syndrom [J]. Semin Respir Infect, 1990, 5(3): 233247.
29.	Ohtsuki M, Taketomi Y, Arata S, et al. Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction [J]. J Biol Chem, 2006, 281(47): 3642036433.
30.	Rongione AJ, Kusske AM, Kwan K, et al. Interleukin 10 reduces the severity of acute pancreatitis in rats [J]. Gastroenterology, 1997, 112(3): 960967.
31.	Van Laethem JL, Marchant A, Delvaux A, et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis [J]. Gastroenterology, 1995, 108(6): 19171922.
32.	付林, 程书榜, 高海斌, 等. IL10区域动脉灌注减轻急性胰腺炎大鼠肺损伤的实验研究 [J]. 中国普通外科杂志, 2006, 15(8): 619621.
33.	Kaufmann P, Tilz GP, Lueger A, et al. Elevated plasma levels of soluble tumor necrosis factor receptor (sTNFRp60) reflect severity of acute pancreatitis [J]. Intensive Care Med,1997, 23(8): 841848.
34.	Keck T, Balcom JH 4th, Fernándezdel Castillo C, et al. Matrix metalloproteinase9 promotes neutrophil migration and alveolar capillary leakage in pancreatitisassociated lung injury in the rat [J]. Gastroenterology, 2002, 122(1): 188201.

1. Marsboom G, Janssens S. Endothelial progenitor cells: new perspectives and applications in cardiovascular therapies [J]. Expert Rev Cardiovasc Ther, 2008, 6(5): 687701.
2. Leme AS, Lichtenstein A, ArantesCosta FM, et al. Acute lung injury in experimental pancreatitis in rats: pulmonary protective effects of crotapotin and Nacetylcysteine [J]. Shock, 2002, 18(5): 428433.
3. Flaishon R, Szold O, Weinbroum AA. Acute lung injury following pancreas ischaemiareperfusion: role of xanthine oxidase [J]. Eur J Clin Invest, 2006, 36(11): 831837.
4. 陆海华, 史忠, 刘波, 等. 急性胰腺炎相关性肺损伤早期血清TNFα、IL1、IL6的变化及其临床意义 [J]. 重庆医学, 2007, 36(18): 18181819.
5. Inagaki T, Hoshino M, Hayakawa T, et al. Interleukin6 is a useful marker for early prediction of the severity of acute pancreatitis [J]. Pancreas, 1997, 14(1): 18.
6. Stimac D, Fisic＇ E, Milic＇ S, et al. Prognostic values of IL6, IL8, and IL10 in acute pancreatitis [J]. J Clin Gastroenterol, 2006, 40(3): 209212.
7. Yu JH, Lim JW, Namkung W, et al. Suppression of ceruleininduced cytokine expression by antioxidants in pancreatic acinar cells [J]. Lab Invest, 2002, 82(10): 13591368.
8. Hattar K, Fink L, Fietzner K, et al. Cell density regulates neutrophil IL8 synthesis: role of IL1 receptor antagonist and soluble TNF receptors [J]. J Immunol, 2001, 166(10): 62876293.
9. Pastor CM, Matthay MA, Frossard JL. Pancreatitisassociated acute lung injury: new insights [J]. Chest, 2003, 124(6): 23412351.
10. 周粼，梁道明，陈嘉勇，等. 依达拉奉对大鼠重症急性胰腺炎肺损伤的影响 [J]. 中国普外基础与临床杂志, 2010, 17(2): 125154.
11. Altavilla D, Famulari C, Passaniti M, et al. Lipid peroxidation inhibition reduces NFκB activation and attenuates ceruleininduced pancreatitis [J]. Free Radic Res, 2003, 37(4): 425435.
12. Mirshafiey A, Mohsenzadegan M. The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis [J]. Iran J Allergy Asthma Immunol, 2008, 7(4): 195202.
13. Malleo G, Mazzon E, Siriwardena AK, et al. TNFá as a therapeutic target in acute pancreatitis－lessons from experimental models [J]. Scientific World Journal, 2007, 7: 431448.
14. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NFkappa B [J]. Annu Rev Cell Biol, 1994, 10: 405455.
15. Jaffray C, Yang J, Carter G, et al. Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitisassociated adult respiratory distress syndrome [J]. Surgery, 2000, 128(2): 225231.
16. 莫坚, 刘欣, 何海燕, 等. 倍他米松对大鼠重症急性胰腺炎肺损伤NFκB、 ICAM1及IL6的影响 [J]. 湖北民族学院学报(医学版), 2005, 22(4): 1416.
17. Slavin J, Ghaneh P, Sutton R, et al. Management of necrotizing pancreatitis [J]. World J Gastroenterol, 2001, 7(4): 476481.
18. 张喜平, 吴迪炯. 细胞黏附分子在重症急性胰腺炎并发急性肺损伤中的作用 [J]. 医学研究杂志, 2008, 37(8): 112114.
19. Schmidt J, Rattner DW, Lewandrowski K, et al. A better model of acute pancreatitis for evaluating therapy [J]. Ann Surg, 1992, 215(1): 4456.
20. Zhao X, Dib M, Wang X, et al. Influence of mast cells on the expression of adhesion molecules on circulating and migrating leukocytes in acute pancreatitisassociated lung injury [J]. Lung, 2005, 183(4): 253264．.
21. Cunningham C, Sanderson DJ. Malaise in the water maze: untangling the effects of LPS and IL1β on learning and memory [J]. Brain Behav Immun, 2008, 22(8): 11171127.
22. 杨学良, 王广义. 重症急性胰腺炎肺损伤大鼠ICAM1和LFA1变化及丹参注射液的干预作用 [J]. 中国老年学杂志, 2010, 30(8): 11081110.
23. 殷涛, 王卫星, 余佳, 等. ICAM1在大鼠急性胰腺炎肺损伤中的作用 [J]. 中国药师, 2009, 12(5): 551553.
24. 汪良芝, 沈云志．ICAM1表达在大鼠重症急性胰腺炎肺损伤中的作用 [J]. 胰腺病学, 2005, 5(1): 4042．.
25. 鲍世韵, 伍天崇, 郭跃华, 等. ICAM1高表达在大鼠重症急性胰腺炎早期急性肺损伤中的作用 [J]. 广东医学, 2010, 31(4): 418421.
26. Granger J, Remick D. Acute pancreatitis: models, markers, and mediators [J]. Shock, 2005, 24 Suppl 1: 4551.
27. 姜战武, 李厚祥, 邵苏吉. 血清PLA2对急性胰腺炎的诊断和预后判断价值 [J]. 南通医学院学报, 1996, 16(3): 326327.
28. Strieter RM, Lynch JP 3rd, Basha MA, et al. Host responses in mediating sepsis and adult respiratory distress syndrom [J]. Semin Respir Infect, 1990, 5(3): 233247.
29. Ohtsuki M, Taketomi Y, Arata S, et al. Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction [J]. J Biol Chem, 2006, 281(47): 3642036433.
30. Rongione AJ, Kusske AM, Kwan K, et al. Interleukin 10 reduces the severity of acute pancreatitis in rats [J]. Gastroenterology, 1997, 112(3): 960967.
31. Van Laethem JL, Marchant A, Delvaux A, et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis [J]. Gastroenterology, 1995, 108(6): 19171922.
32. 付林, 程书榜, 高海斌, 等. IL10区域动脉灌注减轻急性胰腺炎大鼠肺损伤的实验研究 [J]. 中国普通外科杂志, 2006, 15(8): 619621.
33. Kaufmann P, Tilz GP, Lueger A, et al. Elevated plasma levels of soluble tumor necrosis factor receptor (sTNFRp60) reflect severity of acute pancreatitis [J]. Intensive Care Med,1997, 23(8): 841848.
34. Keck T, Balcom JH 4th, Fernándezdel Castillo C, et al. Matrix metalloproteinase9 promotes neutrophil migration and alveolar capillary leakage in pancreatitisassociated lung injury in the rat [J]. Gastroenterology, 2002, 122(1): 188201.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Role of Related Cytokines in Severe Acute Pancreatitis Associated Lung Injury

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