Expression of Lumican in Colorectal Cancer and Its Significance_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Xulin , CAO Hongtao , HOU Yulong , SUN Mengzhe , SUN Hongjian , LI Ming.

The First Department of Tumor, Central Hospital of Jiamusi City, Jiamusi 154002, Heilongjiang Province, China;

Corresponding author：

Keywords：

Lumican; Colorectal cancer; Immunohistochemistry

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ObjectiveTo study the expression of Lumican in colorectal cancer tissues and investigate its role in the carcinogenesis and progression of colorectal cancer. MethodsLumican expression in 114 colorectal cancer and 43 normal tissues was detected by immunohistochemical SP method. ResultsLumican expression was negative in 43 normal colorectal tissues，while 79.82%（91/114） positive in cancer tissues, the difference of which was significant (P lt;0.05). The intensity of Lumican expression correlated conversely to the grade of differentiation for the colorectal cancer (P lt;0.05). So Lumican expression was statistically higher in Dukes A+B group than that in C+D group (P lt;0.05). There was no difference of Lumican expression in age and gender (P gt;0.05). ConclusionsLumican didn’t express in normal colorectal tissues while expressed in cancer tissues, which suggests that Lumican may play a role in the carcinogenesis of colorectal cancer. The expression of Lumican is correlated with tumor differentiation grade and Dukes staging, which could be considered as an valuable index to biological features of colorectal cancer.

Citation： WANG Xulin,CAO Hongtao,HOU Yulong,SUN Mengzhe,SUN Hongjian,LI Ming.. Expression of Lumican in Colorectal Cancer and Its Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(5): 549-552. doi: Copy

1.	江州华, 俞继卫, 姜波健. 基质金属蛋白酶对胃癌微环境调控作用的研究进展 [J]. 中国普外基础与临床杂志, 2009, 16(9): 768772.
2.	Arvatz G, Shafat I, LevyAdam F, et al. The heparanase system and tumor metastasis: is heparanase the seed and soil? [J]. Cancer Metastasis Rev, 2011, 30(2): 253268.
3.	Hamaguchi T, Wakabayashi H, Matsumine A, et al. TNF inhibitor suppresses bone metastasis in a breast cancer cell line [J]. Biochem Biophys Res Commun, 2011, 407(3): 525530.
4.	Mohan RR, Tovey JC, Gupta R, et al. Decorin biology, expression, function and therapy in the cornea [J]. Curr Mol Med, 2011, 11(2): 110128.
5.	肖毅, 冯云路, 钱家鸣, 等. 乙酰肝素酶在结直肠癌中的表达及意义 [J]. 中国普外基础与临床杂志, 2007, 14(4): 442447.
6.	Watanabe T, Komuro Y, Kiyomatsu T, et al. Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles [J]. Cancer Res, 2006, 66(7): 33703374.
7.	Hayashi Y, Call MK, Chikama T, et al. Lumican is required for neutrophil extravasation following corneal injury and wound healing [J]. J Cell Sci, 2010, 123(Pt 17): 29872995.
8.	Guggenheim JA, Zayats T, Hammond C, et al. Lumican and muscarinic acetylcholine receptor 1 gene polymorphisms associated with high myopia [J]. Eye (Lond), 2010, 24(8): 14111412.
9.	Brezillon S, Zeltz C, Schneider L, et al. Lumican inhibits B16F1 melanoma cell lung metastasis [J]. J Physiol Pharmacol, 2009, 60 Suppl 4: 1522.
10.	Zeltz C, Brézillon S, Perreau C, et al. Lumcorin: a leucinerich repeat 9derived peptide from human lumican inhibiting melanoma cell migration [J]. FEBS Lett, 2009, 583(18): 30273032.
11.	Nikitovic D, Katonis P, Tsatsakis A, et al. Lumican, a small leucinerich proteoglycan [J]. IUBMB Life, 2008, 60(12): 818823.
12.	Salgado RM, Favaro RR, Zorn TM. Modulation of small leucinerich proteoglycans (SLRPs) expression in the mouse uterus by estradiol and progesterone [J]. Reprod Biol Endocrinol, 2011, 9: 22.
13.	Baghy K, Dezso K, László V, et al. Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice [J]. Lab Invest, 2011, 91(3): 439451.
14.	Yuan X, Hua X, Wilhelmus KR. Expression of small leucinerich proteoglycans during experimental fungal keratitis [J]. Cornea, 2010, 29(6): 674679.
15.	Saika S, Okada Y, Miyamoto T, et al. Smad translocation and growth suppression in lens epithelial cells by endogenous TGFbeta2 during wound repair [J]. Exp Eye Res, 2001, 72(6): 679686.
16.	Saika S, Miyamoto T, Ishida I, et al. TGFbetaSmad signalling in postoperative human lens epithelial cells [J]. Br J Ophthalmol, 2002, 86(12): 14281433.
17.	罗海蓉, 刘连新, 姜洪池. 抑癌基因Lumican在胃癌中的表达及其临床意义 [J]. 中国普外基础与临床杂志, 2007, 14(5): 551553.
18.	Matsuda Y, Yamamoto T, Kudo M, et al. Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma [J]. Int J Oncol, 2008, 33(6): 11771185.
19.	Ishiwata T, Yamamoto T, Kawahara K, et al. Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells [J]. Exp Mol Pathol, 2010, 88(3): 363370.
20.	Radwanska A, Baczynska D, Nowak D, et al. Lumican affects actin cytoskeletal organization in human melanoma A375 cells [J]. Life Sci, 2008, 83(1920): 651660.
21.	Ying S, Shiraishi A, Kao CW, et al. Characterization and expression of the mouse lumican gene [J]. J Biol Chem, 1997, 272(48): 3030630313.
22.	Leygue E, Snell L, Dotzlaw H, et al. Lumican and decorin are differentially expressed in human breast carcinoma [J]. J Pathol, 2000, 192(3): 313320.
23.	Leygue E, Snell L, Dotzlaw H, et al. Expression of lumican in human breast carcinoma [J]. Cancer Res, 1998, 58(7): 13481352.
24.	Ishiwata T, Cho K, Kawahara K, et al. Role of lumican in cancer cells and adjacent stromal tissues in human pancreatic cancer [J]. Oncol Rep, 2007, 18(3): 537543.
25.	Naito Z, Ishiwata T, Kurban G, et al. Expression and accumulation of lumican protein in uterine cervical cancer cells at the periphery of cancer nests [J]. Int J Oncol, 2002, 20(5): 943948.

1. 江州华, 俞继卫, 姜波健. 基质金属蛋白酶对胃癌微环境调控作用的研究进展 [J]. 中国普外基础与临床杂志, 2009, 16(9): 768772.
2. Arvatz G, Shafat I, LevyAdam F, et al. The heparanase system and tumor metastasis: is heparanase the seed and soil? [J]. Cancer Metastasis Rev, 2011, 30(2): 253268.
3. Hamaguchi T, Wakabayashi H, Matsumine A, et al. TNF inhibitor suppresses bone metastasis in a breast cancer cell line [J]. Biochem Biophys Res Commun, 2011, 407(3): 525530.
4. Mohan RR, Tovey JC, Gupta R, et al. Decorin biology, expression, function and therapy in the cornea [J]. Curr Mol Med, 2011, 11(2): 110128.
5. 肖毅, 冯云路, 钱家鸣, 等. 乙酰肝素酶在结直肠癌中的表达及意义 [J]. 中国普外基础与临床杂志, 2007, 14(4): 442447.
6. Watanabe T, Komuro Y, Kiyomatsu T, et al. Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles [J]. Cancer Res, 2006, 66(7): 33703374.
7. Hayashi Y, Call MK, Chikama T, et al. Lumican is required for neutrophil extravasation following corneal injury and wound healing [J]. J Cell Sci, 2010, 123(Pt 17): 29872995.
8. Guggenheim JA, Zayats T, Hammond C, et al. Lumican and muscarinic acetylcholine receptor 1 gene polymorphisms associated with high myopia [J]. Eye (Lond), 2010, 24(8): 14111412.
9. Brezillon S, Zeltz C, Schneider L, et al. Lumican inhibits B16F1 melanoma cell lung metastasis [J]. J Physiol Pharmacol, 2009, 60 Suppl 4: 1522.
10. Zeltz C, Brézillon S, Perreau C, et al. Lumcorin: a leucinerich repeat 9derived peptide from human lumican inhibiting melanoma cell migration [J]. FEBS Lett, 2009, 583(18): 30273032.
11. Nikitovic D, Katonis P, Tsatsakis A, et al. Lumican, a small leucinerich proteoglycan [J]. IUBMB Life, 2008, 60(12): 818823.
12. Salgado RM, Favaro RR, Zorn TM. Modulation of small leucinerich proteoglycans (SLRPs) expression in the mouse uterus by estradiol and progesterone [J]. Reprod Biol Endocrinol, 2011, 9: 22.
13. Baghy K, Dezso K, László V, et al. Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice [J]. Lab Invest, 2011, 91(3): 439451.
14. Yuan X, Hua X, Wilhelmus KR. Expression of small leucinerich proteoglycans during experimental fungal keratitis [J]. Cornea, 2010, 29(6): 674679.
15. Saika S, Okada Y, Miyamoto T, et al. Smad translocation and growth suppression in lens epithelial cells by endogenous TGFbeta2 during wound repair [J]. Exp Eye Res, 2001, 72(6): 679686.
16. Saika S, Miyamoto T, Ishida I, et al. TGFbetaSmad signalling in postoperative human lens epithelial cells [J]. Br J Ophthalmol, 2002, 86(12): 14281433.
17. 罗海蓉, 刘连新, 姜洪池. 抑癌基因Lumican在胃癌中的表达及其临床意义 [J]. 中国普外基础与临床杂志, 2007, 14(5): 551553.
18. Matsuda Y, Yamamoto T, Kudo M, et al. Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma [J]. Int J Oncol, 2008, 33(6): 11771185.
19. Ishiwata T, Yamamoto T, Kawahara K, et al. Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells [J]. Exp Mol Pathol, 2010, 88(3): 363370.
20. Radwanska A, Baczynska D, Nowak D, et al. Lumican affects actin cytoskeletal organization in human melanoma A375 cells [J]. Life Sci, 2008, 83(1920): 651660.
21. Ying S, Shiraishi A, Kao CW, et al. Characterization and expression of the mouse lumican gene [J]. J Biol Chem, 1997, 272(48): 3030630313.
22. Leygue E, Snell L, Dotzlaw H, et al. Lumican and decorin are differentially expressed in human breast carcinoma [J]. J Pathol, 2000, 192(3): 313320.
23. Leygue E, Snell L, Dotzlaw H, et al. Expression of lumican in human breast carcinoma [J]. Cancer Res, 1998, 58(7): 13481352.
24. Ishiwata T, Cho K, Kawahara K, et al. Role of lumican in cancer cells and adjacent stromal tissues in human pancreatic cancer [J]. Oncol Rep, 2007, 18(3): 537543.
25. Naito Z, Ishiwata T, Kurban G, et al. Expression and accumulation of lumican protein in uterine cervical cancer cells at the periphery of cancer nests [J]. Int J Oncol, 2002, 20(5): 943948.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Lumican in Colorectal Cancer and Its Significance

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