Research Progress on Roles of Survivin Gene in Tumor_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHOU Mingli , ZHANG Shuyou

Department of General Surgery, Nanhua Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, China;

Corresponding author：

Keywords：

Survivin gene; Tumor; Cell apoptosis; Tumor suppressor gene; Gene therapy

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ObjectiveTo summarize the role of survivin gene in tumor. MethodsThe research status on biological characteristics the role of survivin gene in tumor for gene therapy and clinical application was retrospectively analyzed after related domestic and foreign literatures were reviewed. ResultsSurvivin gene was by far found to be the best powerful apoptosis inhibition gene, which played antiapoptosis role mainly through inhibiting directly the activity of caspase-3 and caspase-7 in the downstream of cascade reaction. Survivin gene promoted tumor cell proliferation and differentiation through speeding up tumor cells transition of G1→S phase and eluding the recognition of tumor cells to the apoptosis in G2/M phase. Survivin gene played important role in the intermediate links of vasiformation through angiogenic factor (VEGF, bFGF, Ang-1, and COX-2). ConclusionSurvivin gene may inhibit the apoptosis, promote the proliferation and differentiation of tumor cells and tumor angiogenesis, suggested that survivin gene has potential to act as a novel tumor marker and become an indicator of malignant tumor.

Citation： ZHOU Mingli,ZHANG Shuyou. Research Progress on Roles of Survivin Gene in Tumor. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(7): 779-782. doi: Copy

1.	Andersen MH, Svane IM, Becker JC, et al. The universal character of the tumorassociated antigen survivin [J]. Clin Cancer Res, 2007, 13(20): 59915994.
2.	Montorsi M, Maggioni M, Falleni M, et al. Survivin gene expression in chronic liver disease and hepatocellular carcinoma[J]. Hepatogastroenterology, 2007, 54(79): 20402044.
3.	Kitamura H, Torigoe T, Honma I, et al. Expression and antigenicity of survivin, an inhibitor of apoptosis family member, in bladder cancer: implications for specific immunotherapy[J]. Urology, 2006, 67(5): 955959.
4.	Ambrosini G, Adida C, Altieri DC. A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma[J]. Nat Med, 1997, 3(8): 917921.
5.	NikolovskaColeska Z, Meagher JL, Jiang S, et al. Interaction of a cyclic, bivalent smac mimetic with the xlinked inhibitor of apoptosis protein[J]. Biochemistry, 2008, 47(37): 98119824.
6.	Colnaghi R, Connell CM, Barrett RM, et al. Separating the antiapoptotic and mitotic roles of survivin[J]. J Biol Chem, 2006, 281(44): 3345033456.
7.	Knauer SK, Bier C, Schlag P, et al. The survivin isoform survivin3B is cytoprotective and can function as a chromosomal passenger complex protein[J]. Cell Cycle, 2007, 6(12): 15021509.
8.	Atlasi Y, Mowla SJ, Ziaee SA. Differential expression of survivin and its splice variants, survivinDeltaEx3 and survivin2B, in bladder cancer[J]. Cancer Detect Prev, 2009, 32(4): 308313.
9.	Suzuki A, Ito T, Kawano H, et al. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fasmediated cell death[J]. Oncogene, 2000, 19(10): 13461353.
10.	Verdecia MA, Huang H, Dutil E, et al. Structure of the human antiapoptotic protein survivin reveals a dimeric arrangement[J]. Nat Struct Biol, 2006, 7(7): 602608.
11.	Marusawa H, Matsuzawa S, Welsh K, et al. HBXIP functions as a cofactor of survivin in apoptosis suppression[J]. EMBO J, 2003, 22(11): 27292740.
12.	Zhao J, Tenev T, Martins LM, et al. The ubiquitinproteasome pathway regulates survivin degradation in a cell cycledependent manner[J]. J Cell Sci, 2000, 113 (Pt 23): 43634371.
13.	Wolanin K, Piwocka K. Role of survivin in mitosis[J]. Postepy Biochem, 2007, 53(1): 1018.
14.	Suzuki A, Hayashida M, Ito T, et al. Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16（INK4a）and Cdk2/cyclin E complex activation[J]. Oncogene, 2000, 19(29): 32253234.
15.	Mita AC, Mita MM, Nawrocki ST, et al. Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics[J]. Clin Cancer Res, 2008, 14(16): 50005005.
16.	Li YH, Hu CF, Shao Q, et al. Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma[J]. J Transl Med, 2008, 6: 1.
17.	Ma ACh, Lin R, Chan PK, et al. The role of survivin in angiogenesis during Zebrafish embryonic development[J]. BMC Dev Biol, 2007, 7: 50.
18.	孔令建, 赵晶, 曲波, 等. Survivin、COX2及VEGF在大肠癌中的表达及与肿瘤微血管密度的关系 [J]. 世界华人消化杂志, 2009, 17(20): 20482053.
19.	Abe S, Hasegawa M, Yamamoto K, et al. Rapid induction of IAP family proteins and Smac/DIABLO expression after proapoptotic stimulation with doxorubicin in RPMI 8226 multiple myeloma cells[J]. Exp Mol Pathol, 2007, 83(3): 405412.
20.	管小青, 吴骥, 顾书成, 等. survivin与p53、Ki67在复发转移性乳腺癌组织中表达及相关性研究 [J]. 中国普外基础与临床杂志, 2011, 18(3): 290294.
21.	崔斐, 陈斌, 陈锦章, 等. 凋亡抑制蛋白Survivin和血管内皮生长因子在肝细胞癌中的表达及其临床意义 [J]. 南方医科大学学报, 2008, 28(5): 761763.
22.	Chao JI, Kuo PC, Hsu TS. Downregulation of survivin in nitric oxideinduced cell growth inhibition and apoptosis of the human lung carcinoma cells[J]. J Biol Chem, 2004, 279(19): 2026720276.
23.	Li F, Ling X. Survivin study: an update of “what is the next wave”?[J]. J Cell Physiol, 2006, 208(3): 476486.
24.	Romagnoli M, Séveno C, Bataille R, et al. Survivin in cancerology: molecular aspects and therapeutic applications[J]. Med Sci (Paris), 2008, 24(10): 821827.
25.	Pennati M, Folini M, Zaffaroni N. Targeting survivin in cancer therapy: fulfilled promises and open questions[J].Carcinogenesis, 2007, 28(6): 11331139.
26.	何满西, 李耿, 姚有贵, 等. 胰腺癌细胞survivin表达RNAi抑制载体的构建及其抑制作用的研究 [J]. 中国普外基础与临床杂志, 2008, 15(11): 829834.
27.	姜丹丹, 杨生生, 陈欢, 等. siRNA干扰ski基因的表达对人肝癌HepG2 细胞生物学功能的影响 [J]. 第二军医大学学报, 2008， 29(9): 10251029.
28.	刘世呈, 李靖, 黄小兵, 等. BC047440 siRNA 对肝癌HepG2 细胞增殖抑制及其分子机制的初步探讨 [J]. 第三军医大学学报, 2007， 29(3): 22072211.
29.	廖维甲, 梅铭惠, 徐静, 等. 小干扰RNA 抑制肝癌细胞株BEL7402 ICAM1 基因表达的研究 [J]. 中国现代医学杂志, 2006, 16(20): 36653669.
30.	李静, 朴云峰, 蒋政, 等. siRNA 沉默STAT3 基因对人肝癌细胞的抑制及对相关生长调控基因的调节 [J]. 世界华人消化杂志, 2007, 15(19): 21012107.
31.	刘权焰, 刘志苏, 邬开朗, 等. MAT2A 基因小干扰RNA诱导人肝癌细胞凋亡的分子机制 [J]. 中国生物化学与分子生物学报, 2006, 22(7): 575583.
32.	段瑞红, 闫歌, 公茂庆, 等. siRNA腺病毒抑制Survivin基因表达诱导肝癌细胞凋亡 [J]. 中国病原生物学杂志, 2007, 2(5): 321325.
33.	曾桃英, 刘蓓, 王琼. Livin基因特异性siRNA对肝癌细胞增殖、转移的影响 [J]. 中国现代医学杂志, 2008, 18(24): 35583561, 3565.
34.	杨仕明, 房殿春, 刘爱民, 等. 端粒酶蛋白催化亚单位反义基因对HepG2细胞恶性表型的逆转作用 [J]. 中华肝脏病杂志, 2002, 10(2): 9799.
35.	宋文哲, 宋燕, 谭岩, 等. 靶向survivin的反义寡核苷酸联合三苯氧胺治疗乳腺癌的研究 [J].中国普外基础与临床杂志, 2010, 17(9): 922926.
36.	郑斌, 段体德, 左铁. VEGFASODN转染对胃癌细胞VEGF表达及生长的抑制作用 [J]. 中国普外基础与临床杂志, 2008, 15(5): 347351.
37.	刘海威, 程乐, 吴非, 等. 脂质体转染survivin反义寡核苷酸对人胰腺癌细胞凋亡的影响 [J].中国普外基础与临床杂志, 2010, 17(10): 10561061.
38.	潘克俭, 刘小菁, 杨春蕾, 等. Survivin反义核酸对SMMC7721细胞增殖和凋亡的影响 [J]. 生物医学工程学杂志, 2006, 23(3): 625629.

1. Andersen MH, Svane IM, Becker JC, et al. The universal character of the tumorassociated antigen survivin [J]. Clin Cancer Res, 2007, 13(20): 59915994.
2. Montorsi M, Maggioni M, Falleni M, et al. Survivin gene expression in chronic liver disease and hepatocellular carcinoma[J]. Hepatogastroenterology, 2007, 54(79): 20402044.
3. Kitamura H, Torigoe T, Honma I, et al. Expression and antigenicity of survivin, an inhibitor of apoptosis family member, in bladder cancer: implications for specific immunotherapy[J]. Urology, 2006, 67(5): 955959.
4. Ambrosini G, Adida C, Altieri DC. A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma[J]. Nat Med, 1997, 3(8): 917921.
5. NikolovskaColeska Z, Meagher JL, Jiang S, et al. Interaction of a cyclic, bivalent smac mimetic with the xlinked inhibitor of apoptosis protein[J]. Biochemistry, 2008, 47(37): 98119824.
6. Colnaghi R, Connell CM, Barrett RM, et al. Separating the antiapoptotic and mitotic roles of survivin[J]. J Biol Chem, 2006, 281(44): 3345033456.
7. Knauer SK, Bier C, Schlag P, et al. The survivin isoform survivin3B is cytoprotective and can function as a chromosomal passenger complex protein[J]. Cell Cycle, 2007, 6(12): 15021509.
8. Atlasi Y, Mowla SJ, Ziaee SA. Differential expression of survivin and its splice variants, survivinDeltaEx3 and survivin2B, in bladder cancer[J]. Cancer Detect Prev, 2009, 32(4): 308313.
9. Suzuki A, Ito T, Kawano H, et al. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fasmediated cell death[J]. Oncogene, 2000, 19(10): 13461353.
10. Verdecia MA, Huang H, Dutil E, et al. Structure of the human antiapoptotic protein survivin reveals a dimeric arrangement[J]. Nat Struct Biol, 2006, 7(7): 602608.
11. Marusawa H, Matsuzawa S, Welsh K, et al. HBXIP functions as a cofactor of survivin in apoptosis suppression[J]. EMBO J, 2003, 22(11): 27292740.
12. Zhao J, Tenev T, Martins LM, et al. The ubiquitinproteasome pathway regulates survivin degradation in a cell cycledependent manner[J]. J Cell Sci, 2000, 113 (Pt 23): 43634371.
13. Wolanin K, Piwocka K. Role of survivin in mitosis[J]. Postepy Biochem, 2007, 53(1): 1018.
14. Suzuki A, Hayashida M, Ito T, et al. Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16（INK4a）and Cdk2/cyclin E complex activation[J]. Oncogene, 2000, 19(29): 32253234.
15. Mita AC, Mita MM, Nawrocki ST, et al. Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics[J]. Clin Cancer Res, 2008, 14(16): 50005005.
16. Li YH, Hu CF, Shao Q, et al. Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma[J]. J Transl Med, 2008, 6: 1.
17. Ma ACh, Lin R, Chan PK, et al. The role of survivin in angiogenesis during Zebrafish embryonic development[J]. BMC Dev Biol, 2007, 7: 50.
18. 孔令建, 赵晶, 曲波, 等. Survivin、COX2及VEGF在大肠癌中的表达及与肿瘤微血管密度的关系 [J]. 世界华人消化杂志, 2009, 17(20): 20482053.
19. Abe S, Hasegawa M, Yamamoto K, et al. Rapid induction of IAP family proteins and Smac/DIABLO expression after proapoptotic stimulation with doxorubicin in RPMI 8226 multiple myeloma cells[J]. Exp Mol Pathol, 2007, 83(3): 405412.
20. 管小青, 吴骥, 顾书成, 等. survivin与p53、Ki67在复发转移性乳腺癌组织中表达及相关性研究 [J]. 中国普外基础与临床杂志, 2011, 18(3): 290294.
21. 崔斐, 陈斌, 陈锦章, 等. 凋亡抑制蛋白Survivin和血管内皮生长因子在肝细胞癌中的表达及其临床意义 [J]. 南方医科大学学报, 2008, 28(5): 761763.
22. Chao JI, Kuo PC, Hsu TS. Downregulation of survivin in nitric oxideinduced cell growth inhibition and apoptosis of the human lung carcinoma cells[J]. J Biol Chem, 2004, 279(19): 2026720276.
23. Li F, Ling X. Survivin study: an update of “what is the next wave”?[J]. J Cell Physiol, 2006, 208(3): 476486.
24. Romagnoli M, Séveno C, Bataille R, et al. Survivin in cancerology: molecular aspects and therapeutic applications[J]. Med Sci (Paris), 2008, 24(10): 821827.
25. Pennati M, Folini M, Zaffaroni N. Targeting survivin in cancer therapy: fulfilled promises and open questions[J].Carcinogenesis, 2007, 28(6): 11331139.
26. 何满西, 李耿, 姚有贵, 等. 胰腺癌细胞survivin表达RNAi抑制载体的构建及其抑制作用的研究 [J]. 中国普外基础与临床杂志, 2008, 15(11): 829834.
27. 姜丹丹, 杨生生, 陈欢, 等. siRNA干扰ski基因的表达对人肝癌HepG2 细胞生物学功能的影响 [J]. 第二军医大学学报, 2008， 29(9): 10251029.
28. 刘世呈, 李靖, 黄小兵, 等. BC047440 siRNA 对肝癌HepG2 细胞增殖抑制及其分子机制的初步探讨 [J]. 第三军医大学学报, 2007， 29(3): 22072211.
29. 廖维甲, 梅铭惠, 徐静, 等. 小干扰RNA 抑制肝癌细胞株BEL7402 ICAM1 基因表达的研究 [J]. 中国现代医学杂志, 2006, 16(20): 36653669.
30. 李静, 朴云峰, 蒋政, 等. siRNA 沉默STAT3 基因对人肝癌细胞的抑制及对相关生长调控基因的调节 [J]. 世界华人消化杂志, 2007, 15(19): 21012107.
31. 刘权焰, 刘志苏, 邬开朗, 等. MAT2A 基因小干扰RNA诱导人肝癌细胞凋亡的分子机制 [J]. 中国生物化学与分子生物学报, 2006, 22(7): 575583.
32. 段瑞红, 闫歌, 公茂庆, 等. siRNA腺病毒抑制Survivin基因表达诱导肝癌细胞凋亡 [J]. 中国病原生物学杂志, 2007, 2(5): 321325.
33. 曾桃英, 刘蓓, 王琼. Livin基因特异性siRNA对肝癌细胞增殖、转移的影响 [J]. 中国现代医学杂志, 2008, 18(24): 35583561, 3565.
34. 杨仕明, 房殿春, 刘爱民, 等. 端粒酶蛋白催化亚单位反义基因对HepG2细胞恶性表型的逆转作用 [J]. 中华肝脏病杂志, 2002, 10(2): 9799.
35. 宋文哲, 宋燕, 谭岩, 等. 靶向survivin的反义寡核苷酸联合三苯氧胺治疗乳腺癌的研究 [J].中国普外基础与临床杂志, 2010, 17(9): 922926.
36. 郑斌, 段体德, 左铁. VEGFASODN转染对胃癌细胞VEGF表达及生长的抑制作用 [J]. 中国普外基础与临床杂志, 2008, 15(5): 347351.
37. 刘海威, 程乐, 吴非, 等. 脂质体转染survivin反义寡核苷酸对人胰腺癌细胞凋亡的影响 [J].中国普外基础与临床杂志, 2010, 17(10): 10561061.
38. 潘克俭, 刘小菁, 杨春蕾, 等. Survivin反义核酸对SMMC7721细胞增殖和凋亡的影响 [J]. 生物医学工程学杂志, 2006, 23(3): 625629.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress on Roles of Survivin Gene in Tumor

Abstract Full text Figures/Tables Video References Cited by

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