Relationship Between Galectin-3 and Thyroid Diseases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Tingting , CHENG Ruochuan

Department of Gastrointestinal and Thyroid Surgery, The First Affiliated Hospital of Kunming Medical College, Kunming 650031, Yunnan Province, China;

Corresponding author：

Keywords：

Galectin-3; Papillary thyroid carcinoma; Thyroid adenoma; Hashimoto’s thyroiditis; Subacute thyroid inflammation

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ObjectiveTo investigate the structure, ligand, and tissue distribution of galectin-3, the relationship of galectin3 with tumor and the expression of galectin-3 in several thyroid diseases. MethodsRelated articles were reviewed. ResultsGalectin-3 was expressed in normal and tumor cell that regulated cell growth, differentiation, adhesion, apoptosis, and angiogenesis, which participated invasion and metastasis of tumor. ConclusionGalectin-3 may be used to discriminate benign and malignant thyroid tumor.

Citation： YANG Tingting,CHENG Ruochuan,.. Relationship Between Galectin-3 and Thyroid Diseases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(8): 907-910. doi: Copy

1.	杨国华，刘海鹰． Galectin3与肿瘤的研究进展 [J]．中华肿瘤防治杂志， 2007， 14（22）： 17551758．.
2.	NangiaMakker P, Balan V, Raz A. Regulation of tumor progression by extracellular galectin3 [J]. Cancer Microenviron, 2008, 1(1): 4351.
3.	Davidson PJ, Li SY, Lohse AG, et al. Transport of galectin3 between the nucleus and cytoplasm.I.conditions and signals for nuclear import [J]. Glycobiology, 2006, 16(7): 602611.
4.	Li SY, Davidson PJ, Lin NY, et al. Transport of galectin3 between the nucleus and cytoplasm.Ⅱ.identification of the signal for nuclear export [J]. Glycobiology, 2006, 16(7): 612622.
5.	Davidson PJ, Davis MJ, Patterson RJ, et al. Shuttling of galectin3 between the nucleus and cytoplasm [J]. Glycobiology, 2002, 12(5): 329337.
6.	Dumic J, Dabelic S, Flgel M. Galectin3: an openended story [J]. Biochim Biophys Acta, 2006, 1760(4): 616635.
7.	杨志明，伍晓汀，何涛． Galectin3与肿瘤转移 [J]．中国普外基础与临床杂志， 2005， 12（3）： 310313．.
8.	Hughes RC. Secretion of the galectin family of mammalian carbohydratebinding proteins [J]. Biochim Biophys Acta, 1999, 1473(1): 172185.
9.	Nickel W. Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells [J]. Traffic, 2005, 6(8): 607614.
10.	Gong HC, Honjo Y, Nangiamakker P, et al. The NH2 terminus of galectin3 governs cellular compartmentalization and functions in cancer cells [J]. Cancer Res, 1999, 59(24): 62396245.
11.	Sato S, Hughes RC. Control of mac2 surface expression on murine macrophage cell lines [J]. Eur J Immunol, 1994, 24(1): 216221.
12.	Mehul B, Hughes RC. Plasma membrane targetting, vesicular budding and release of galectin 3 from the cytoplasm of mammalian cells during secretion [J]. J Cell Sci, 1997, 110(Pt 10): 11691178.
13.	Sato S, Hughes RC. Regulation of secretion and surface expression of Mac2, a galactosidebinding protein of macrophages [J]. J Biol Chem, 1994, 269(6): 44244430.
14.	Théry C, Boussac M, Véron P, et al. Proteomic analysis of dendritic cellderived exosomes:a secreted subcellular compartment distinct from apoptotic vesicles [J]. J Immunol, 2001, 166(12): 73097318.
15.	Baptiste TA, Ashley J, Saria M, et al. Mechanotransduction mediated secretion and uptake of galectin3 in breast carcinoma cells: implications in the extracellular functions of the lectin [J]. Exp Cell Res, 2007, 313(4): 652664.
16.	Glinsky VV, Glinsky VV, RittenhouseOlson K, et al. The role of thomsenfriedenreich antigen in adhesion of human breast and prostate cancer cell s to the endothelium [J]. Cancer Res, 2001, 61(12): 48514857.
17.	Stillman BN, Hsu DK, Pang M, et al. Galectin3 and galectin1 bind distinct cell surface glycoprotein receptors to induce T cell death [J]. J Immunol, 2006, 176(2): 778789.
18.	Moiseeva EP, Javed Q, Spring EL, et al. Galectin 1 is involved in vascular smooth muscle cell proliferation [J]. Cardiovasc Res, 2000, 45(2): 493502.
19.	Xu XC, Elnaggar AK, Lotan R. Differential expression of galectin1 and galectin3 in thyroid tumors. potential diagnostic implications [J]. Am J Pathol, 1995, 147(3): 815822.
20.	彭年春，郭晓蕙，袁振芳，等． CD26/DPPⅣ,galectin3在甲状腺乳头状癌的表达及意义[J]．基础医学与临床， 2009， 29（10）： 10791082．.
21.	Kawachi K, Matsushita Y, Yonezawa S, et al. Galectin3 expression in various thyroid neoplasms and its possible role in metastasis formation [J]. Hum Pathol, 2000, 31(4): 428433.
22.	Htwe TT, Karim N, Wong J, et al. Differential expression of galectin3 in advancing thyroid cancer cells: a clue toward understanding tumour progression and metastasis [J]. Singapore Med J, 2010, 51(11): 856859.
23.	de Matos PS, Ferreira AP, de Oliveira Facuri F, et al. Usefulness of HBME1,cytokeratin 19 and galectin3 immunostaining in the diagnosis of thyroid malignancy [J]. Histopathology, 2005, 47(4): 391401.
24.	Coli A, Bigotti G, Zucchetti F, et al. Galectin3, a marker of welldifferentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia [J]. Histopathology, 2002, 40(1): 8087.
25.	Cvejic D, Savin S, Paunovic I, et al. Immunohistochemical localization of galectin3 in malignant and benign human thyroid tissue [J]. Anticancer Res, 1998, 18(4A): 26372641.
26.	Bartolazzi A, Gasbarri A, Mauro P, et al. Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions [J]. Lancet, 2001, 357(9269): 16441650.
27.	Saggiorato E, Cappia S, De GP, et al. Galectin3 as a presurgical immunocytodiagnostic marker of minimally invasive follicular thyroid carcinoma [J]. J Clin Endocrinol Metab, 2001, 86(11): 51525158.
28.	吴文君，许岚，朱圣炜，等． Galectin3对甲状腺乳头状癌早期病变的诊断意义 [J]．肿瘤防治研究， 2007， 34（7）： 518519, 548．.
29.	徐其银． Galectin3和Cytokeratin19在桥本甲状腺炎并发微小乳头状癌中不同区域的表达 [D]．昆明：昆明医学院， 2010．.
30.	张晓，邱新光．桥本病伴结节样变中Galectin3, CK19的表达及其临床意义 [J]．中国实用医刊， 2008， 35（12）： 910．.
31.	Müller S, Schaffer T, Flogerzi B, et al. Galectin3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBD [J]. Inflamm Bowel Dis, 2006, 12(7): 588597.
32.	王冬． Galectin3在甲状腺炎中的表达及其临床意义 [D]．长春：吉林大学， 2010．.
33.	Das DK, Sharma PN. Diagnosis of papillary thyroid carcinoma in fine needle aspiration smears: factors that affect decision making [J]. Acta Cytol, 2009, 53(5): 497506.
34.	Sapio MR, Guerra A, Posca D, et al. Combined analysis of galectin3 and brafv600E improves the accuracy of fineneedle aspiration biopsy with cytological findings suspicious for papillary thyroid carcinoma [J]. Endocr Relat Cancer, 2007, 14(4): 10891097.
35.	Bartolazzi A, D’Alessandria C, Parisella MG, et al. Thyroid cancer imaging in vivo by targeting the antiapoptotic molecule galectin3 [J]. PLoS One, 2008, 3(11): e3768.
36.	Nangiamakker P, Honjo Y, Sarvis R, et al. Galectin3 induces endothelial cell morphogenesis and angiogenesis [J]. Am J Pathol, 2000, 156(3): 899909.
37.	Lin C, Whang EE, Donner DB, et al. Galectin3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer [J]. Molecular Cancer Research: MCR, 2009, 7(10): 16551662.

1. 杨国华，刘海鹰． Galectin3与肿瘤的研究进展 [J]．中华肿瘤防治杂志， 2007， 14（22）： 17551758．.
2. NangiaMakker P, Balan V, Raz A. Regulation of tumor progression by extracellular galectin3 [J]. Cancer Microenviron, 2008, 1(1): 4351.
3. Davidson PJ, Li SY, Lohse AG, et al. Transport of galectin3 between the nucleus and cytoplasm.I.conditions and signals for nuclear import [J]. Glycobiology, 2006, 16(7): 602611.
4. Li SY, Davidson PJ, Lin NY, et al. Transport of galectin3 between the nucleus and cytoplasm.Ⅱ.identification of the signal for nuclear export [J]. Glycobiology, 2006, 16(7): 612622.
5. Davidson PJ, Davis MJ, Patterson RJ, et al. Shuttling of galectin3 between the nucleus and cytoplasm [J]. Glycobiology, 2002, 12(5): 329337.
6. Dumic J, Dabelic S, Flgel M. Galectin3: an openended story [J]. Biochim Biophys Acta, 2006, 1760(4): 616635.
7. 杨志明，伍晓汀，何涛． Galectin3与肿瘤转移 [J]．中国普外基础与临床杂志， 2005， 12（3）： 310313．.
8. Hughes RC. Secretion of the galectin family of mammalian carbohydratebinding proteins [J]. Biochim Biophys Acta, 1999, 1473(1): 172185.
9. Nickel W. Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells [J]. Traffic, 2005, 6(8): 607614.
10. Gong HC, Honjo Y, Nangiamakker P, et al. The NH2 terminus of galectin3 governs cellular compartmentalization and functions in cancer cells [J]. Cancer Res, 1999, 59(24): 62396245.
11. Sato S, Hughes RC. Control of mac2 surface expression on murine macrophage cell lines [J]. Eur J Immunol, 1994, 24(1): 216221.
12. Mehul B, Hughes RC. Plasma membrane targetting, vesicular budding and release of galectin 3 from the cytoplasm of mammalian cells during secretion [J]. J Cell Sci, 1997, 110(Pt 10): 11691178.
13. Sato S, Hughes RC. Regulation of secretion and surface expression of Mac2, a galactosidebinding protein of macrophages [J]. J Biol Chem, 1994, 269(6): 44244430.
14. Théry C, Boussac M, Véron P, et al. Proteomic analysis of dendritic cellderived exosomes:a secreted subcellular compartment distinct from apoptotic vesicles [J]. J Immunol, 2001, 166(12): 73097318.
15. Baptiste TA, Ashley J, Saria M, et al. Mechanotransduction mediated secretion and uptake of galectin3 in breast carcinoma cells: implications in the extracellular functions of the lectin [J]. Exp Cell Res, 2007, 313(4): 652664.
16. Glinsky VV, Glinsky VV, RittenhouseOlson K, et al. The role of thomsenfriedenreich antigen in adhesion of human breast and prostate cancer cell s to the endothelium [J]. Cancer Res, 2001, 61(12): 48514857.
17. Stillman BN, Hsu DK, Pang M, et al. Galectin3 and galectin1 bind distinct cell surface glycoprotein receptors to induce T cell death [J]. J Immunol, 2006, 176(2): 778789.
18. Moiseeva EP, Javed Q, Spring EL, et al. Galectin 1 is involved in vascular smooth muscle cell proliferation [J]. Cardiovasc Res, 2000, 45(2): 493502.
19. Xu XC, Elnaggar AK, Lotan R. Differential expression of galectin1 and galectin3 in thyroid tumors. potential diagnostic implications [J]. Am J Pathol, 1995, 147(3): 815822.
20. 彭年春，郭晓蕙，袁振芳，等． CD26/DPPⅣ,galectin3在甲状腺乳头状癌的表达及意义[J]．基础医学与临床， 2009， 29（10）： 10791082．.
21. Kawachi K, Matsushita Y, Yonezawa S, et al. Galectin3 expression in various thyroid neoplasms and its possible role in metastasis formation [J]. Hum Pathol, 2000, 31(4): 428433.
22. Htwe TT, Karim N, Wong J, et al. Differential expression of galectin3 in advancing thyroid cancer cells: a clue toward understanding tumour progression and metastasis [J]. Singapore Med J, 2010, 51(11): 856859.
23. de Matos PS, Ferreira AP, de Oliveira Facuri F, et al. Usefulness of HBME1,cytokeratin 19 and galectin3 immunostaining in the diagnosis of thyroid malignancy [J]. Histopathology, 2005, 47(4): 391401.
24. Coli A, Bigotti G, Zucchetti F, et al. Galectin3, a marker of welldifferentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia [J]. Histopathology, 2002, 40(1): 8087.
25. Cvejic D, Savin S, Paunovic I, et al. Immunohistochemical localization of galectin3 in malignant and benign human thyroid tissue [J]. Anticancer Res, 1998, 18(4A): 26372641.
26. Bartolazzi A, Gasbarri A, Mauro P, et al. Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions [J]. Lancet, 2001, 357(9269): 16441650.
27. Saggiorato E, Cappia S, De GP, et al. Galectin3 as a presurgical immunocytodiagnostic marker of minimally invasive follicular thyroid carcinoma [J]. J Clin Endocrinol Metab, 2001, 86(11): 51525158.
28. 吴文君，许岚，朱圣炜，等． Galectin3对甲状腺乳头状癌早期病变的诊断意义 [J]．肿瘤防治研究， 2007， 34（7）： 518519, 548．.
29. 徐其银． Galectin3和Cytokeratin19在桥本甲状腺炎并发微小乳头状癌中不同区域的表达 [D]．昆明：昆明医学院， 2010．.
30. 张晓，邱新光．桥本病伴结节样变中Galectin3, CK19的表达及其临床意义 [J]．中国实用医刊， 2008， 35（12）： 910．.
31. Müller S, Schaffer T, Flogerzi B, et al. Galectin3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBD [J]. Inflamm Bowel Dis, 2006, 12(7): 588597.
32. 王冬． Galectin3在甲状腺炎中的表达及其临床意义 [D]．长春：吉林大学， 2010．.
33. Das DK, Sharma PN. Diagnosis of papillary thyroid carcinoma in fine needle aspiration smears: factors that affect decision making [J]. Acta Cytol, 2009, 53(5): 497506.
34. Sapio MR, Guerra A, Posca D, et al. Combined analysis of galectin3 and brafv600E improves the accuracy of fineneedle aspiration biopsy with cytological findings suspicious for papillary thyroid carcinoma [J]. Endocr Relat Cancer, 2007, 14(4): 10891097.
35. Bartolazzi A, D’Alessandria C, Parisella MG, et al. Thyroid cancer imaging in vivo by targeting the antiapoptotic molecule galectin3 [J]. PLoS One, 2008, 3(11): e3768.
36. Nangiamakker P, Honjo Y, Sarvis R, et al. Galectin3 induces endothelial cell morphogenesis and angiogenesis [J]. Am J Pathol, 2000, 156(3): 899909.
37. Lin C, Whang EE, Donner DB, et al. Galectin3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer [J]. Molecular Cancer Research: MCR, 2009, 7(10): 16551662.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Galectin-3 and Thyroid Diseases

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