Research Status on Intraoperative Regional Chemotherapy of Advanced Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

PANG Junhao , WANG Chongshu.

The First Department of General Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, Sichuan Province, China;

Corresponding author：

Keywords：

Advanced gastric carcinoma; Regional chemotherapy; Intraperitoneal chemotherapy; Arterial infusion chemotherapy; Current status

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Objective To explore the feasibility, safety, efficacy and mechanism of intraoperative regional chemotherapy of advanced gastric cancer.
Methods The related literatures were reviewed and analyzed.
Results Compared with systemic chemotherapy, intraoperative regional chemotherapy of advanced gastric cancer could increase blood drug concentration of cancerous tissue, reduce the systemic toxic side effects, increase survival rate and improve the quality of life.
Conclusion Intraoperative regional chemotherapy, as an adjuvant treatment of advanced gastric cancer, has been gradually applied to clinic because of the definite curative effect, which is worth popularizing. However, it needs systemic researches and accumulation of cases.

Citation： PANG Junhao,WANG Chongshu.. Research Status on Intraoperative Regional Chemotherapy of Advanced Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(2): 205-208. doi: Copy

1.	Ajani JA. Evolving chemotherapy for advanced gastric cancer [J]. Oncologist, 2005; 10 Suppl 3: 4958.
2.	Sugarbaker PH. Adjuvant intraperitoneal chemotherapy for advanced primary gastric cancer [J]. Scand J Surg, 2006; 95(4): 270273.
3.	Newman E, Potmesil M, Ryan T, et al. Neoadjuvant chemotherapy, surgery, and adjuvant intraperitoneal chemotherapy in patients with locally advanced gastric or gastroesophageal junction carcinoma: a phase Ⅱ study [J]. Semin Oncol, 2005; 32(6 Suppl 9): S97S100.
4.	Allal AS, Zwahlen D, Bründler MA, et al. Neoadjuvant radiochemotherapy for locally advanced gastric cancer: longterm results of a phase Ⅰ trial [J]. Int J Radiat Oncol Biol Phys, 2005; 63(5): 12861289.
5.	Marrelli D, Roviello F, de Manzoni, et al. Different patterns of recurrence in gastric cancer depending on Lauren’s histological type: longitudinal study [J]. World J Surg, 2002; 26(9): 11601165.
6.	Paget S. The distribution of secondary growths in cancer of the breast. 1889 [J]. Cancer Metastasis Rev, 1989; 8(2): 98101.
7.	Sugarbaker PH, Cunliffe WJ, Belliveau J, et al. Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer [J]. Semin Oncol, 1989; 16(4 Suppl 6): 8397.
8.	Sethna KS, Sugarbaker PH. New prospects for the control of peritoneal surface dissemination of gastric cancer using perioperative intraperitoneal chemotherapy [J]. Cancer Therapy, 2004; 2: 7984.
9.	何涛, 杨志明, 伍晓汀. 胃癌腹膜播散转移机理的研究进展 [J]. 中国普外基础与临床杂志, 2005; 12(1): 4345.
10.	Sarner M. Treatment of pancreatic exocrine deficiency [J]. World J Surg, 2003; 27(11): 11921195.
11.	Araki K, Yamamoto H, Kobayashi M, et al. Experimental and clinical study on intraoperative local infusion chemotherapy (ILIC) for advanced gastric carcinoma [J]. Gan To Kagaku Ryoho, 1995; 22 (11): 15311534.
12.	Kobayashi M, Yamamoto H, Sugimoto T, et al. Intraoperative local infusion chemotherapy (ILIC) for gastric cancer [J]. Gan To Kagaku Ryoho, 1998; 25(9): 12811283.
13.	孙世良, 温海燕, 张连阳. 现代大肠癌诊断与治疗 [M]. 第1版. 重庆: 重庆出版社, 2004： 393298.
14.	Pohlen U, Rieger H, KunickPohlen S, et al. Phase Ⅱ study of regional chemotherapy using the hypoxic abdominal perfusion technique in advanced abdominal carcinoma. 5FU pharmacokinetics, complications and outcome [J]. Anticancer Res, 2007; 27(1B): 667674.
15.	Maurer CA, Borner M, Büchler MW. Regional chemotherapy of gastrointestinal cancer [J]. Dig Surg,1997; 14(1): 922.
16.	朱志东, 蒲永东. 氟尿嘧啶经胃左动脉和外周静脉化疗的药代动力学比较 [J]. 中国胃肠外科杂志, 2000; 3(1): 2830.
17.	Shchepotin IB, Chorny V, Hanfelh J, et al. Palliative superselective intraarterial chemotherapy for advanced nonresectable gastric cancer [J]. J Gastrointest Surg, 1999; 3(4): 426431.
18.	何运胜, 姜淮芜, 汪盛贤，等. 进展期胃癌术中动脉化疗对p53和ki67表达及细胞凋亡作用的影响 [J]. 中国现代普通外科进展, 2009; 12(3): 201205.
19.	杜江, 王崇树, 张才全, 等. 高效液相色谱法测定直肠癌术中区域化疗血液、盆腔液和组织5氟尿嘧啶浓度 [J]. 中国药房, 2006; 17(20): 15641566.
20.	金懋林. 晚期胃癌全身化学治疗最新进展 [J]. 中国处方药, 2008; 7(76): 7476.
21.	郭花，朱金水. 胃癌腹腔化疗进展 [J]. 国际消化病杂志, 2008; 28(1): 911.
22.	宰守峰, 王简, 郭明, 等. 胃癌患者术中腹腔内低渗温热腹腔灌注化疗的临床研究 [J]. 肿瘤基础与临床, 2006; 19(2): 122123.
23.	陈志新, 张波. 胃癌综合治疗现状及展望 [J]. 中国普外基础与临床杂志, 2008; 15(1): 7173.
24.	de Bree E, Rosing H, Beijnen JH, et al. Pharmacokinetic study of docetaxel in intraoperative hyperthermic i.p. chemotherapy for ovarian cancer [J]. Anticancer Drugs, 2003; 14(2): 103110.
25.	Brigand C, Arvieux C, Gilly FN, et al. Treatment of peritoneal carcinomatosis in gastric cancers [J]. Dig Dis, 2004; 22(4): 366373.
26.	倪家连, 刘晓明, 郑宝珍, 等. 活体胃血供的特点及其临床意义 [J]. 中国普通外科杂志, 2003; 12(4): 291293.
27.	邰生. 术中瘤区动脉灌注化疗胃癌、贲门癌65例体会 [J]. 镇江医学院报, 1999; 9(2): 249230.
28.	Ikeda O, Tamura Y, Nakasone Y, et al. Evaluation of extrahepatic perfusion of anticancer drugs in the right gastric arterial region on fused images using combined CT/SPECT: is extrahepatic perfusion predictive of gastric toxicity? [J]. Cardiovasc Intervent Radiol, 2007; 30(3): 392397.
29.	Garofalo A, Valle M, Garcia J, et al. Laparoscopic intraperitoneal hyperthermic chemotherapy for palliation of debilitating malignant ascites [J]. Eur J Surg Oncol, 2006; 32(6): 682685.
30.	Kuhn JA, McLoughlin JM, Harris DC, et al. Intraperitoneal hypert hermic chemot herapy: experience at Baylor University Medical Center [J]. Proc (Bayl Univ Med Cent), 2002; 15(4): 359362.
31.	金永锋. 胃癌根治术中腹腔热灌注化疗对预后的影响 [J]. 浙江临床医学, 2007; 9(3): 357358.
32.	肖乾虎, 彭兵, 赖毅, 等. 胃癌术中动脉区域灌注化疗与全身静脉化疗的临床疗效比较 [J]. 华西医科大学学报, 2001; 32(4): 585586.
33.	彭兵, 肖乾虎, 王向东, 等. 胃癌术前介入治疗、术中区域性动脉灌注化疗及全身化疗的疗效评价 [J]. 华西医科大学学报， 2002; 33(2): 314315.
34.	徐圣德, 高斌, 文刚, 等. 术前区域动脉热化疗对进展期胃癌病理学的影响 [J]. 医学影像学杂志, 2008; 18(10): 11561159.
35.	夏术森, 张才全, 王崇树, 等. 胃癌术中区域动脉灌注化疗作用的初步研究 [J]. 重庆医科大学学报, 2009; 34(3): 293296.
36.	张启文, 赵伟, 王德友, 等. 进展期胃癌术中化疗加低渗热疗的临床应用 [J]. 中国现代普通外科进展, 2004; 7(2): 72.
37.	Tentes AA, Markakidis SK, Karanikiotis C, et al. Intraarterial chemotherapy as an adjuvant treatment in locally advanced gastric cancer [J]. Langenbecks Arch Surg, 2006; 391(2): 124129.
38.	刘启领, 陈建华. 胃周血管离断术加动脉灌注化疗治疗晚期胃癌疗效分析 [J]. 中国药物与临床, 2007; 7(9): 716717.

1. Ajani JA. Evolving chemotherapy for advanced gastric cancer [J]. Oncologist, 2005; 10 Suppl 3: 4958.
2. Sugarbaker PH. Adjuvant intraperitoneal chemotherapy for advanced primary gastric cancer [J]. Scand J Surg, 2006; 95(4): 270273.
3. Newman E, Potmesil M, Ryan T, et al. Neoadjuvant chemotherapy, surgery, and adjuvant intraperitoneal chemotherapy in patients with locally advanced gastric or gastroesophageal junction carcinoma: a phase Ⅱ study [J]. Semin Oncol, 2005; 32(6 Suppl 9): S97S100.
4. Allal AS, Zwahlen D, Bründler MA, et al. Neoadjuvant radiochemotherapy for locally advanced gastric cancer: longterm results of a phase Ⅰ trial [J]. Int J Radiat Oncol Biol Phys, 2005; 63(5): 12861289.
5. Marrelli D, Roviello F, de Manzoni, et al. Different patterns of recurrence in gastric cancer depending on Lauren’s histological type: longitudinal study [J]. World J Surg, 2002; 26(9): 11601165.
6. Paget S. The distribution of secondary growths in cancer of the breast. 1889 [J]. Cancer Metastasis Rev, 1989; 8(2): 98101.
7. Sugarbaker PH, Cunliffe WJ, Belliveau J, et al. Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer [J]. Semin Oncol, 1989; 16(4 Suppl 6): 8397.
8. Sethna KS, Sugarbaker PH. New prospects for the control of peritoneal surface dissemination of gastric cancer using perioperative intraperitoneal chemotherapy [J]. Cancer Therapy, 2004; 2: 7984.
9. 何涛, 杨志明, 伍晓汀. 胃癌腹膜播散转移机理的研究进展 [J]. 中国普外基础与临床杂志, 2005; 12(1): 4345.
10. Sarner M. Treatment of pancreatic exocrine deficiency [J]. World J Surg, 2003; 27(11): 11921195.
11. Araki K, Yamamoto H, Kobayashi M, et al. Experimental and clinical study on intraoperative local infusion chemotherapy (ILIC) for advanced gastric carcinoma [J]. Gan To Kagaku Ryoho, 1995; 22 (11): 15311534.
12. Kobayashi M, Yamamoto H, Sugimoto T, et al. Intraoperative local infusion chemotherapy (ILIC) for gastric cancer [J]. Gan To Kagaku Ryoho, 1998; 25(9): 12811283.
13. 孙世良, 温海燕, 张连阳. 现代大肠癌诊断与治疗 [M]. 第1版. 重庆: 重庆出版社, 2004： 393298.
14. Pohlen U, Rieger H, KunickPohlen S, et al. Phase Ⅱ study of regional chemotherapy using the hypoxic abdominal perfusion technique in advanced abdominal carcinoma. 5FU pharmacokinetics, complications and outcome [J]. Anticancer Res, 2007; 27(1B): 667674.
15. Maurer CA, Borner M, Büchler MW. Regional chemotherapy of gastrointestinal cancer [J]. Dig Surg,1997; 14(1): 922.
16. 朱志东, 蒲永东. 氟尿嘧啶经胃左动脉和外周静脉化疗的药代动力学比较 [J]. 中国胃肠外科杂志, 2000; 3(1): 2830.
17. Shchepotin IB, Chorny V, Hanfelh J, et al. Palliative superselective intraarterial chemotherapy for advanced nonresectable gastric cancer [J]. J Gastrointest Surg, 1999; 3(4): 426431.
18. 何运胜, 姜淮芜, 汪盛贤，等. 进展期胃癌术中动脉化疗对p53和ki67表达及细胞凋亡作用的影响 [J]. 中国现代普通外科进展, 2009; 12(3): 201205.
19. 杜江, 王崇树, 张才全, 等. 高效液相色谱法测定直肠癌术中区域化疗血液、盆腔液和组织5氟尿嘧啶浓度 [J]. 中国药房, 2006; 17(20): 15641566.
20. 金懋林. 晚期胃癌全身化学治疗最新进展 [J]. 中国处方药, 2008; 7(76): 7476.
21. 郭花，朱金水. 胃癌腹腔化疗进展 [J]. 国际消化病杂志, 2008; 28(1): 911.
22. 宰守峰, 王简, 郭明, 等. 胃癌患者术中腹腔内低渗温热腹腔灌注化疗的临床研究 [J]. 肿瘤基础与临床, 2006; 19(2): 122123.
23. 陈志新, 张波. 胃癌综合治疗现状及展望 [J]. 中国普外基础与临床杂志, 2008; 15(1): 7173.
24. de Bree E, Rosing H, Beijnen JH, et al. Pharmacokinetic study of docetaxel in intraoperative hyperthermic i.p. chemotherapy for ovarian cancer [J]. Anticancer Drugs, 2003; 14(2): 103110.
25. Brigand C, Arvieux C, Gilly FN, et al. Treatment of peritoneal carcinomatosis in gastric cancers [J]. Dig Dis, 2004; 22(4): 366373.
26. 倪家连, 刘晓明, 郑宝珍, 等. 活体胃血供的特点及其临床意义 [J]. 中国普通外科杂志, 2003; 12(4): 291293.
27. 邰生. 术中瘤区动脉灌注化疗胃癌、贲门癌65例体会 [J]. 镇江医学院报, 1999; 9(2): 249230.
28. Ikeda O, Tamura Y, Nakasone Y, et al. Evaluation of extrahepatic perfusion of anticancer drugs in the right gastric arterial region on fused images using combined CT/SPECT: is extrahepatic perfusion predictive of gastric toxicity? [J]. Cardiovasc Intervent Radiol, 2007; 30(3): 392397.
29. Garofalo A, Valle M, Garcia J, et al. Laparoscopic intraperitoneal hyperthermic chemotherapy for palliation of debilitating malignant ascites [J]. Eur J Surg Oncol, 2006; 32(6): 682685.
30. Kuhn JA, McLoughlin JM, Harris DC, et al. Intraperitoneal hypert hermic chemot herapy: experience at Baylor University Medical Center [J]. Proc (Bayl Univ Med Cent), 2002; 15(4): 359362.
31. 金永锋. 胃癌根治术中腹腔热灌注化疗对预后的影响 [J]. 浙江临床医学, 2007; 9(3): 357358.
32. 肖乾虎, 彭兵, 赖毅, 等. 胃癌术中动脉区域灌注化疗与全身静脉化疗的临床疗效比较 [J]. 华西医科大学学报, 2001; 32(4): 585586.
33. 彭兵, 肖乾虎, 王向东, 等. 胃癌术前介入治疗、术中区域性动脉灌注化疗及全身化疗的疗效评价 [J]. 华西医科大学学报， 2002; 33(2): 314315.
34. 徐圣德, 高斌, 文刚, 等. 术前区域动脉热化疗对进展期胃癌病理学的影响 [J]. 医学影像学杂志, 2008; 18(10): 11561159.
35. 夏术森, 张才全, 王崇树, 等. 胃癌术中区域动脉灌注化疗作用的初步研究 [J]. 重庆医科大学学报, 2009; 34(3): 293296.
36. 张启文, 赵伟, 王德友, 等. 进展期胃癌术中化疗加低渗热疗的临床应用 [J]. 中国现代普通外科进展, 2004; 7(2): 72.
37. Tentes AA, Markakidis SK, Karanikiotis C, et al. Intraarterial chemotherapy as an adjuvant treatment in locally advanced gastric cancer [J]. Langenbecks Arch Surg, 2006; 391(2): 124129.
38. 刘启领, 陈建华. 胃周血管离断术加动脉灌注化疗治疗晚期胃癌疗效分析 [J]. 中国药物与临床, 2007; 7(9): 716717.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Status on Intraoperative Regional Chemotherapy of Advanced Gastric Cancer

Abstract Full text Figures/Tables Video References Cited by

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