1. |
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008 [J]. CA Cancer J Clin, 2008; 58(2): 71-96. .
|
2. |
Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis [J]. Nature, 2004; 432(7015): 324-331. .
|
3. |
Bailey JM, Singh PK, Hollingsworth MA. Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins [J]. J Cell Biochem, 2007; 102(4): 829-839. .
|
4. |
Wilson A, Radtke F. Multiple functions of Notch signaling in self-renewing organs and cancer [J]. FEBS Lett, 2006; 580(12): 2860-2868. .
|
5. |
Habbe N, Shi G, Meguid RA, et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice [J]. Proc Natl Acad Sci USA, 2008; 105(48): 18913-18918. .
|
6. |
Zhu L, Shi G, Schmidt CM, et al. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia [J]. Am J Pathol, 2007; 171(1): 263-273. .
|
7. |
Mullendore ME, Koorstra JB, Li YM, et al. Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer [J]. Clin Cancer Res, 2009; 15(7): 2291-2301. .
|
8. |
Morgan TH. The theory of the gene [J]. Am Nat, 1917; LI(609): 513-544. .
|
9. |
Borggrefe T, Oswald F. The Notch signaling pathway: transcriptional regulation at Notch target genes [J]. Cell Mol Life Sci, 2009; 66(10): 1631-1646. .
|
10. |
Gordon WR, Arnett KL, Blacklow SC. The molecular logic of Notch signaling-a structural and biochemical perspective [J]. J Cell Sci, 2008; 121(Pt 19): 3109-3119. .
|
11. |
Kolev V, Kacer D, Trifonova R, et al. The intracellular domain of Notch ligand Delta1 induces cell growth arrest [J]. FEBS Lett, 2005; 579(25): 5798-5802. .
|
12. |
Lewis J, Hanisch A, Holder M. Notch signaling, the segmentation clock, and the patterning of vertebrate somites [J]. J Biol, 2009; 8(4): 44-50. .
|
13. |
Blaumueller CM, Qi H, Zagouras P, et al. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane [J]. Cell, 1997; 90(2): 281-291. .
|
14. |
Edbauer D, Winkler E, Regula JT, et al. Reconstitution of gamma-secretase activity [J]. Nat Cell Biol, 2003; 5(5): 486-488. .
|
15. |
Matsuno K, Eastman D, Mitsiades T, et al. Human deltex is a conserved regulator of Notch signalling [J]. Nat Genet, 1998; 19(1): 74-78. .
|
16. |
Yamamoto N, Yamamoto S, Inagaki F, et al. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor [J]. J Biol Chem, 2001; 276(48): 45031-45040. .
|
17. |
Hori K, Fostier M, Ito M, et al. Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling [J]. Development, 2004; 131(22): 5527-5537. .
|
18. |
Kiaris H, Politi K, Grimm LM, et al. Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium [J]. Am J Pathol, 2004; 165(2): 695-705. .
|
19. |
Liu WH, Lai MZ. Deltex regulates T-cell activation by targeted degradation of active MEKK1 [J]. Mol Cell Biol, 2005; 25(4): 1367-1378. .
|
20. |
Sade H, Krishna S, Sarin A. The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells [J]. J Biol Chem, 2004; 279(4): 2937-2944. .
|
21. |
Edlund H. Pancreatic organogenesis-developmental mechanisms and implications for therapy [J]. Nat Rev Genet, 2002; 3(7): 524-532. .
|
22. |
Murtaugh LC. Pancreas and beta-cell development: from the actual to the possible [J]. Development, 2007; 134(3): 427-438. .
|
23. |
Lammert E, Brown J, Melton DA. Notch gene expression during pancreatic organogenesis [J]. Mech Dev, 2000; 94(1-2): 199-203. .
|
24. |
Jensen JN, Cameron E, Garay MV, et al. Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration [J]. Gastroenterology, 2005; 128(3): 728-741. .
|
25. |
Fujikura J, Hosoda K, Iwakura H, et al. Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas [J]. Cell Metab, 2006; 3(1): 59-65. .
|
26. |
Nakhai H, Siveke JT, Klein B, et al. Conditional ablation of Notch signaling in pancreatic development [J]. Development, 2008; 135(16): 2757-2765. .
|
27. |
Murtaugh LC, Stanger BZ, Kwan KM, et al. Notch signaling controls multiple steps of pancreatic differentiation [J]. Proc Natl Acad Sci USA, 2003; 100(25): 14920-14925. .
|
28. |
Hald J, Hjorth JP, German MS, et al. Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development [J]. Dev Biol, 2003; 260(2): 426-437. .
|
29. |
Siveke JT, Lubeseder-Martellato C, Lee M, et al. Notch signaling is required for exocrine regeneration after acute pancreatitis [J]. Gastroenterology, 2008; 134(2): 544-555. .
|
30. |
Pasca di Magliano M, Sekine S, Ermilov A, et al. Hedgehog/Ras interactions regulate early stages of pancreatic cancer [J]. Genes Dev, 2006; 20(22): 3161-3173. .
|
31. |
Strobel O, Dor Y, Alsina J, et al. In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia [J]. Gastroenterology, 2007; 133(6): 1999-2009. .
|
32. |
Bhanot U, Khntop R, Hasel C, et al. Evidence of Notch pathway activation in the ectatic ducts of chronic pancreatitis [J]. J Pathol, 2008; 214(3): 312-319. .
|
33. |
Miyamoto Y, Maitra A, Ghosh B, et al. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis [J]. Cancer Cell, 2003; 3(6): 565-576. .
|
34. |
Büchler P, Gazdhar A, Schubert M, et al. The Notch signaling pathway is related to neurovascular progression of pancreatic cancer [J]. Ann Surg, 2005; 242(6): 791-800. .
|
35. |
De La O JP, Emerson LL, Goodman JL, et al. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia [J]. Proc Natl Acad Sci USA, 2008; 105(48): 18907-18912. .
|
36. |
Sawey ET, Johnson JA, Crawford HC. Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway [J]. Proc Natl Acad Sci USA, 2007; 104(49): 19327-19332. .
|
37. |
Guerra C, Schuhmacher AJ, Caamero M, et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice [J]. Cancer Cell, 2007; 11(3): 291-302. .
|
38. |
梁珊, 杨竹林. 慢性胰腺炎与胰腺癌相互关系的研究进展 [J]. 肝胆胰外科杂志, 2006; 18(3): 197-198, 201. .
|
39. |
Plentz R, Park JS, Rhim AD, et al. Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma [J]. Gastroenterology, 2009; 136(5): 1741-1749.
|