Relationship Between Serum Hepatocyte Growth Factor and Colorectal Cancer with Hepatic Metastasis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

段小亮 , 李宏武 , 唐元新

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Keywords：

结直肠癌; 肝转移; 肝细胞生长因子; ELISA法

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　　目的　研究结直肠癌患者血清中肝细胞生长因子(hepatocyte growth factor,HGF)的表达水平及其与结直肠癌肝转移的关系。
　　方法　收集我院2006年9月至2009年1月期间手术治疗并经病理证实为结直肠癌患者35例，应用夹心ELISA法检测血清中HGF表达水平。
　　结果　血清中HGF表达在结直肠癌有远处转移者中为(0.37±0.11) ng/ml，明显高于无转移者的(0.20±0.06) ng/ml (P lt;0.05)； T3、T4期者为(0.32±0.29) ng/ml，亦明显高于T1、T2期者的(0.20±0.14) ng/ml (P lt;0.05)；肝转移者为(0.43±0.10) ng/ml，明显高于其他部位转移者的(0.31±0.09) ng/ml (P lt;0.05)。
　　结论　血清HGF水平与结直肠癌发展及肝转移发生有密切关系,血清HGF水平有望作为监测结直肠癌转移的临床指标。

Citation： 段小亮,李宏武,唐元新. Relationship Between Serum Hepatocyte Growth Factor and Colorectal Cancer with Hepatic Metastasis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(4): 383-384. doi: Copy

1.	Kindler HL, Shulman KL. Metastatic colorectal cancer [J]. Curr Treat Options Oncol, 2001; 2(6): 459-471.
2.	Lesko E, Majka M. The biological role of HGF-MET axis in tumor growth and development of metastasis [J]. Front Biosci, 2008; 13: 1271-1280.
3.	Brinkmann V, Foroutan H, Sachs M, et al. Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells [J]. J Cell Biol, 1995; 131(6 Pt 1): 1573-1586.
4.	You WK, McDonald DM. The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis [J]. BMB Rep, 2008; 41(12): 833-839.
5.	Toschi L, Jnne PA. Single-agent and combination therapeutic strategles to inhibit hepatocyte growth factor/MET signaling in cancer [J]. Clin Cancer Res, 2008; 14(19): 5941-5946.
6.	Cao R, Bjrndahl MA, Gallego MI, et al. Hepatocyte gr-owth factor is a lymphangiogenic factor with an indirect mechanism of action [J]. Blood, 2006; 107(9): 3531-3536.
7.	Zeng Q, Chen S, You Z, et al. Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NF kappa B [J]. J Biol Chem, 2002; 277(28): 25203-25208.
8.	尹家俊, 宋燕. 肝细胞生长因子及受体c-met 在乳腺癌中的研究进展 [J]. 中国普外基础与临床杂志, 2000; 7(5): 347-349.
9.	李宏武, 张趣, 梁健. 大肠癌细胞增殖中HGF/SF作用的观察 [J]. 中国普通外科杂志, 2006; 15(2): 111-115.
10.	李宏武, 单吉贤. HGF/SF对姜黄素诱导大肠癌细胞凋亡的作用 [J]. 中国普外基础与临床杂志, 2006; 13(1): 74-76.
11.	Zhang YW, Vande Woude GF. HGF/SF-met signaling in the control of branching morphogenesis and invasion [J]. J Cell Biochem, 2003; 88(2): 408-417.
12.	Ma J, Defrances MC, Zou C, et al. Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer [J]. J Clin Invest, 2009; 119(3): 478-491.
13.	Wislez M, Rabbe N, Marchal J, et al. Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma: role in tumor progression and death [J]. Cancer Res, 2003; 63(6): 1405-1412.
14.	Kim CH, Lee JS, Kang SO, et al. Serum hepatocyte growth factor as a marker of tumor activity in head and neck squamous cell carcinoma [J]. Oral Oncol, 2007; 43(10): 1021-1025.
15.	Baldus SE, Kort EJ, Schirmacher P, et al. Quantification of MET and hepatocyte growth factor/scatter factor expression in colorectal adenomas, carcinomas and non-neoplastic epithelia by quantitative laser scanning microscopy [J]. Int J Oncol, 2007; 31(1): 199-204.
16.	茹国庆, 赵仲生, 汤琪乐, 等. 碱性成纤维细胞生长因子和肝细胞生长因子在胃癌中的表达及意义 [J]. 中华医学杂志, 2008; 88(29): 2030-2035.
17.	Toiyama Y, Miki C, Inoue Y, et al. Serum hepatocyte growth factor as a prognostic marker for stage Ⅱ or Ⅲ colorectal cancer patients [J]. Int J Cancer, 2009; 125(7): 1657-1662.
18.	Miki C, Inoue Y, Hiro J, et al. Combined measurement of hepatocyte growth factor and carcinoembryonic antigen as a prognostic marker for patients with Dukes A and B colorectal cancer: results of a five-year study [J]. Dis Colon Rectum, 2006; 49(11): 1710-1718.
19.	Harlozinska A. Progress in molecular mechanisms of tumor metastasis and angiogenesis [J]. Anticancer Res, 2005; 25(5): 3327-3333.
20.	李静喆, 张辉, 唐梅, 等. 以HGF/c-Met为靶点治疗结肠癌及其与MEK2/ERK信号传导通路的关系 [J]. 中华实验外科杂志, 2005; 22(4): 504.
21.	Matsumoto K, Nakamura T. NK4 gene therapy targeting HGF-Met and angiogenesis [J]. Front Biosci, 2008; 13: 1943-1951.
22.	Jie JZ, Wang JW, Qu JG, et al. Suppression of human colon tumor growth by adenoviral vector-mediated NK4 expression in an athymic mouse model [J]. World J Gastroenterol, 2007; 13(13): 1938-1946.

1. Kindler HL, Shulman KL. Metastatic colorectal cancer [J]. Curr Treat Options Oncol, 2001; 2(6): 459-471.
2. 　Lesko E, Majka M. The biological role of HGF-MET axis in tumor growth and development of metastasis [J]. Front Biosci, 2008; 13: 1271-1280.
3. 　Brinkmann V, Foroutan H, Sachs M, et al. Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells [J]. J Cell Biol, 1995; 131(6 Pt 1): 1573-1586.
4. 　You WK, McDonald DM. The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis [J]. BMB Rep, 2008; 41(12): 833-839.
5. 　Toschi L, Jnne PA. Single-agent and combination therapeutic strategles to inhibit hepatocyte growth factor/MET signaling in cancer [J]. Clin Cancer Res, 2008; 14(19): 5941-5946.
6. 　Cao R, Bjrndahl MA, Gallego MI, et al. Hepatocyte gr-owth factor is a lymphangiogenic factor with an indirect mechanism of action [J]. Blood, 2006; 107(9): 3531-3536.
7. 　Zeng Q, Chen S, You Z, et al. Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NF kappa B [J]. J Biol Chem, 2002; 277(28): 25203-25208.
8. 　尹家俊, 宋燕. 肝细胞生长因子及受体c-met 在乳腺癌中的研究进展 [J]. 中国普外基础与临床杂志, 2000; 7(5): 347-349.
9. 　李宏武, 张趣, 梁健. 大肠癌细胞增殖中HGF/SF作用的观察 [J]. 中国普通外科杂志, 2006; 15(2): 111-115.
10. 　李宏武, 单吉贤. HGF/SF对姜黄素诱导大肠癌细胞凋亡的作用 [J]. 中国普外基础与临床杂志, 2006; 13(1): 74-76.
11. 　Zhang YW, Vande Woude GF. HGF/SF-met signaling in the control of branching morphogenesis and invasion [J]. J Cell Biochem, 2003; 88(2): 408-417.
12. 　Ma J, Defrances MC, Zou C, et al. Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer [J]. J Clin Invest, 2009; 119(3): 478-491.
13. 　Wislez M, Rabbe N, Marchal J, et al. Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma: role in tumor progression and death [J]. Cancer Res, 2003; 63(6): 1405-1412.
14. 　Kim CH, Lee JS, Kang SO, et al. Serum hepatocyte growth factor as a marker of tumor activity in head and neck squamous cell carcinoma [J]. Oral Oncol, 2007; 43(10): 1021-1025.
15. 　Baldus SE, Kort EJ, Schirmacher P, et al. Quantification of MET and hepatocyte growth factor/scatter factor expression in colorectal adenomas, carcinomas and non-neoplastic epithelia by quantitative laser scanning microscopy [J]. Int J Oncol, 2007; 31(1): 199-204.
16. 　茹国庆, 赵仲生, 汤琪乐, 等. 碱性成纤维细胞生长因子和肝细胞生长因子在胃癌中的表达及意义 [J]. 中华医学杂志, 2008; 88(29): 2030-2035.
17. 　Toiyama Y, Miki C, Inoue Y, et al. Serum hepatocyte growth factor as a prognostic marker for stage Ⅱ or Ⅲ colorectal cancer patients [J]. Int J Cancer, 2009; 125(7): 1657-1662.
18. 　Miki C, Inoue Y, Hiro J, et al. Combined measurement of hepatocyte growth factor and carcinoembryonic antigen as a prognostic marker for patients with Dukes A and B colorectal cancer: results of a five-year study [J]. Dis Colon Rectum, 2006; 49(11): 1710-1718.
19. 　Harlozinska A. Progress in molecular mechanisms of tumor metastasis and angiogenesis [J]. Anticancer Res, 2005; 25(5): 3327-3333.
20. 　李静喆, 张辉, 唐梅, 等. 以HGF/c-Met为靶点治疗结肠癌及其与MEK2/ERK信号传导通路的关系 [J]. 中华实验外科杂志, 2005; 22(4): 504.
21. 　Matsumoto K, Nakamura T. NK4 gene therapy targeting HGF-Met and angiogenesis [J]. Front Biosci, 2008; 13: 1943-1951.
22. 　Jie JZ, Wang JW, Qu JG, et al. Suppression of human colon tumor growth by adenoviral vector-mediated NK4 expression in an athymic mouse model [J]. World J Gastroenterol, 2007; 13(13): 1938-1946.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Serum Hepatocyte Growth Factor and Colorectal Cancer with Hepatic Metastasis

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