Clinical Research Status of Auxiliary Heterotopic Liver Transplantation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XU Anshu , SUN Zhiwei , TANG Jianzhong.

Department of Hepatobiliary Surgery, The Kunhua Affiliated Hospital of Kunming Medical College (The First People’s Hospital of Yunnan Province), Kunming 650032, China;

Corresponding author：

Keywords：

Auxiliary; Heterotopic; Liver transplantation; Liver failure

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Objective To summarize clinical application status of auxiliary heterotopic liver transplantation.
Methods Reviewed relevant literatures and made a summary. Indications, contraindications, surgical treatment, therapeutic efficacy, and existing problems of auxiliary heterotopic liver transplantation were summed up. Results Main indication of auxiliary heterotopic liver transplantation is fulminant liver failure, and with no absolute contraindications. Partial liver transplantation is more popular. The therapeutic efficacy of auxiliary heterotopic liver transplantation is confirmed, but there are still some problems needed to be solved.
Conclusion Auxiliary heterotopic liver transplantation is an effective method and replacement therapy for acute and chronic liver failure.

Citation： XU Anshu,SUN Zhiwei,TANG Jianzhong.. Clinical Research Status of Auxiliary Heterotopic Liver Transplantation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(5): 439-441. doi: Copy

1.	朱鹏, 陈孝平. 中国活体肝移植现状 [J]. 腹部外科, 2006; 19(6): 359-362.
2.	严律南，曾勇，王文涛, 等. 成人间双供体活体肝脏移植成功2例报告 [J]. 中国普外基础与临床杂志， 2005; 12（4）： 399-402.
3.	陈永权, 金孝岠, 柳兆芳, 等. 幼猪辅助性部分肝移植围术期血气及电解质变化的研究 [J]. 中国病理生理杂志, 2008; 24(4): 807-808.
4.	彭承宏, 肖卫东, 吴伟顶, 等. 小体积肝移植和辅助性原位小体积肝移植治疗猪急性肝功能衰竭的近期疗效观察 [J]. 中华肝胆外科杂志, 2006; 12(10): 699-703.
5.	Welch CS． A note on transplantation of the whole liver in dogs [J]. Transplant Bull, 1955; 2(1): 54-55.
6.	Absolon KB, Hagihara PF, Griffen WO Jr, et al. Experimental and clinical heterotopic liver homotransplantation [J]. Rev Int Hepatol, 1965; 15(8): 1481-1490.
7.	吴伟顶，彭承宏，肖卫东, 等. 猪原位辅助性部分肝移植治疗急性肝功能衰竭的模型 [J]. 中华器官移植杂志, 2005; 26(12): 709-712.
8.	陈南晖, 沈权平. 肝功能衰竭172例临床分析 [J]. 中华临床医学杂志, 2008; 9(6)： 80-81.
9.	Lodge JP, Dasgupta D, Prasad KR, et al. Emergency subtotal hepatectomy: a new concept for acetaminophen-induced acute liver failure: temporary hepatic support by auxiliary orthotopic liver transplantation enables long-term success [J]. Ann Surg, 2008; 247(2): 238-249.
10.	Kato T, Selvaggi G, Levi D, et al. Routine use of auxiliary partial orthotopic liver transplantation for children with fulminant hepatic failure: Preliminary report [J]. Transplant Proc, 2006; 38(10): 3607-3608.
11.	Soejima Y, Taguchi T, Ogita K, et al. Auxiliary partial orthotopic living donor liver transplantation for a child with congenital absence of the portal vein [J]. Liver Transpl, 2006; 12(5): 845-849.
12.	刘雪来, 李龙, 吴璇昭, 等. 犬辅助性原位肝左叶移植模型的建立 [J]. 中华实验外科杂志, 2006; 23(4): 622-624.
13.	郑卫萍, 沈中阳. 急性肝功能衰竭的综合治疗 [J]. 中国急救医学, 2007; 27(10): 946-948.
14.	王营, 曲明, 史彦芬, 等. 暴发性肝功能衰竭的急诊肝脏移植治疗 [J]. 实用医药杂志, 2008; 25(2): 129-131.
15.	陆翔，彭承宏. 辅助性部分原位肝移植的临床研究现状 [J]. 肝胆胰外科杂志, 2005; 17(3): 246-248, 251.
16.	Liou IW, Larson AM. Role of liver transplantation in acute liver failure [J]. Semin Liver Dis, 2008; 28(2): 201-209.
17.	陈雨信, 寿楠海, 董家鸿. 辅助性肝移植 [J]. 消化外科, 2005; 4(6): 457-460.
18.	Shakil AO. Predicting the outcome of fulminant hepatic failure [J]． Liver Transpl, 2005; 11(9): 1028-1030．.
19.	陈立天, 沈中阳. 辅助性肝移植的研究进展 [J]. 天津医科大学学报, 2007; 13(3): 463-465.
20.	彭承宏, 韩宝三. 肝脏外科疾病的诊断与治疗: 肝脏移植术式进展 [J]. 中国医师进修杂志, 2006; 29(6): 1-3.
21.	Rela M, Battula N, Madanur M, et al. Auxiliary liver transplantation for propionic acidemia: a 10-year follow-up. [J]. Am J Transplant, 2007; 7(9): 2200-2203.
22.	Puppi J, Tan N, Mitry RR, et al. Hepatocyte transplantation followed by auxiliary liver transplantation--a novel treatment for ornithine transcarbamylase deficiency [J]. Am J Transplant, 2008; 8(2): 452-457.
23.	Broering DC, Walter J, Bassas AF. Overcoming the portal steal phenomenon in auxiliary partial orthotopic liver transplantation by modulation of the venous outflow of the native liver [J]. Liver Transpl, 2005; 11(9): 1140-1143.
24.	Takei Y, Ikeda S, Ikegami T, et al. Ten years of experience with liver transplantation for familial amyloid polyneuropathy in Japan: outcomes of living donor liver transplantations [J]. Intern Med, 2005; 44(11): 1151-1156.
25.	季茹, 陶开山, 遆振宇, 等. 脾窝异位辅助性活体肝移植治疗Wilson’s病的多方位思考 [J]. 医学与哲学(临床决策论坛版), 2009; 30(5): 31-33, 50.
26.	李宝定, 窦科峰. 辅助性活体肝部分移植术 [J]. 国外医学外科学分册, 2004; 31(6)： 360-363.
27.	Ko S, Tanaka I, Kanehiro H, et al. Preclinical experiment of auxiliary partial orthotopic liver transplantation as a curative treatment for hemophilia [J]. Liver Transpl, 2005; 11(5): 579-584.
28.	Yazaki M, Hashikura Y, Takei Y, et al. Feasibility of auxiliary partial orthotopic liver transplantation from living donors for patients with adult-onset type Ⅱ citrullinemia [J]. Liver Transpl, 2004; 10(4): 550-554.
29.	郝迪斯, 王毓利, 乔海泉. 辅助肝移植研究进展 [J]. 黑龙江医学, 2002; 26(7): 499-500.
30.	Terpstra OT. Auxiliary liver grafting: a new concept in liver transplantation [J]. Lancet, 1993; 342(8874): 758.
31.	Haberal M, Arda IS, Karakayali H, et al. Heterotopic segmental liver transplantation in children [J]. Transplant Proc, 2000; 32(3): 535-536.
32.	van Hoek B, de Boer J, Boudjema K, et al. Auxiliary versus orthotopic liver transplantation for acute liver failure. EURALT Study Group. European Auxiliary Liver Transplant Registry [J]. J Hepatol, 1999; 30(4): 699-705.
33.	Sze YK, Dhawan A, Taylor RM, et al. Pediatric liver transplantation for metabolic liver disease: experience at King’s College Hospital [J]. Transplantation, 2009; 87(1): 87-93.
34.	阿永俊，李立，李晓延, 等. 人工肝支持系统在肝衰竭和肝脏移植中的临床应用研究 [J].中国普外基础与临床杂志， 2005; 12（5）： 496-498.
35.	Tarhan NC, Uslu Tutar N, Yologˇlu Z, et al. Volume measurement by computed tomography in auxiliary heterotopic partial liver transplant recipients: follow-up results [J]. Transplant Proc, 2000; 32(3): 601-603.
36.	Sakahara H, Kiuchi T, Nishizawa S, et al. Asialoglycoprotein receptor scintigraphy in evaluation of auxiliary partial orthotopic liver transplantation [J]. J Nucl Med, 1999; 40(9): 1463-1467.

1. 朱鹏, 陈孝平. 中国活体肝移植现状 [J]. 腹部外科, 2006; 19(6): 359-362.
2. 严律南，曾勇，王文涛, 等. 成人间双供体活体肝脏移植成功2例报告 [J]. 中国普外基础与临床杂志， 2005; 12（4）： 399-402.
3. 陈永权, 金孝岠, 柳兆芳, 等. 幼猪辅助性部分肝移植围术期血气及电解质变化的研究 [J]. 中国病理生理杂志, 2008; 24(4): 807-808.
4. 彭承宏, 肖卫东, 吴伟顶, 等. 小体积肝移植和辅助性原位小体积肝移植治疗猪急性肝功能衰竭的近期疗效观察 [J]. 中华肝胆外科杂志, 2006; 12(10): 699-703.
5. Welch CS． A note on transplantation of the whole liver in dogs [J]. Transplant Bull, 1955; 2(1): 54-55.
6. Absolon KB, Hagihara PF, Griffen WO Jr, et al. Experimental and clinical heterotopic liver homotransplantation [J]. Rev Int Hepatol, 1965; 15(8): 1481-1490.
7. 吴伟顶，彭承宏，肖卫东, 等. 猪原位辅助性部分肝移植治疗急性肝功能衰竭的模型 [J]. 中华器官移植杂志, 2005; 26(12): 709-712.
8. 陈南晖, 沈权平. 肝功能衰竭172例临床分析 [J]. 中华临床医学杂志, 2008; 9(6)： 80-81.
9. Lodge JP, Dasgupta D, Prasad KR, et al. Emergency subtotal hepatectomy: a new concept for acetaminophen-induced acute liver failure: temporary hepatic support by auxiliary orthotopic liver transplantation enables long-term success [J]. Ann Surg, 2008; 247(2): 238-249.
10. Kato T, Selvaggi G, Levi D, et al. Routine use of auxiliary partial orthotopic liver transplantation for children with fulminant hepatic failure: Preliminary report [J]. Transplant Proc, 2006; 38(10): 3607-3608.
11. Soejima Y, Taguchi T, Ogita K, et al. Auxiliary partial orthotopic living donor liver transplantation for a child with congenital absence of the portal vein [J]. Liver Transpl, 2006; 12(5): 845-849.
12. 刘雪来, 李龙, 吴璇昭, 等. 犬辅助性原位肝左叶移植模型的建立 [J]. 中华实验外科杂志, 2006; 23(4): 622-624.
13. 郑卫萍, 沈中阳. 急性肝功能衰竭的综合治疗 [J]. 中国急救医学, 2007; 27(10): 946-948.
14. 王营, 曲明, 史彦芬, 等. 暴发性肝功能衰竭的急诊肝脏移植治疗 [J]. 实用医药杂志, 2008; 25(2): 129-131.
15. 陆翔，彭承宏. 辅助性部分原位肝移植的临床研究现状 [J]. 肝胆胰外科杂志, 2005; 17(3): 246-248, 251.
16. Liou IW, Larson AM. Role of liver transplantation in acute liver failure [J]. Semin Liver Dis, 2008; 28(2): 201-209.
17. 陈雨信, 寿楠海, 董家鸿. 辅助性肝移植 [J]. 消化外科, 2005; 4(6): 457-460.
18. Shakil AO. Predicting the outcome of fulminant hepatic failure [J]． Liver Transpl, 2005; 11(9): 1028-1030．.
19. 陈立天, 沈中阳. 辅助性肝移植的研究进展 [J]. 天津医科大学学报, 2007; 13(3): 463-465.
20. 彭承宏, 韩宝三. 肝脏外科疾病的诊断与治疗: 肝脏移植术式进展 [J]. 中国医师进修杂志, 2006; 29(6): 1-3.
21. Rela M, Battula N, Madanur M, et al. Auxiliary liver transplantation for propionic acidemia: a 10-year follow-up. [J]. Am J Transplant, 2007; 7(9): 2200-2203.
22. Puppi J, Tan N, Mitry RR, et al. Hepatocyte transplantation followed by auxiliary liver transplantation--a novel treatment for ornithine transcarbamylase deficiency [J]. Am J Transplant, 2008; 8(2): 452-457.
23. Broering DC, Walter J, Bassas AF. Overcoming the portal steal phenomenon in auxiliary partial orthotopic liver transplantation by modulation of the venous outflow of the native liver [J]. Liver Transpl, 2005; 11(9): 1140-1143.
24. Takei Y, Ikeda S, Ikegami T, et al. Ten years of experience with liver transplantation for familial amyloid polyneuropathy in Japan: outcomes of living donor liver transplantations [J]. Intern Med, 2005; 44(11): 1151-1156.
25. 季茹, 陶开山, 遆振宇, 等. 脾窝异位辅助性活体肝移植治疗Wilson’s病的多方位思考 [J]. 医学与哲学(临床决策论坛版), 2009; 30(5): 31-33, 50.
26. 李宝定, 窦科峰. 辅助性活体肝部分移植术 [J]. 国外医学外科学分册, 2004; 31(6)： 360-363.
27. Ko S, Tanaka I, Kanehiro H, et al. Preclinical experiment of auxiliary partial orthotopic liver transplantation as a curative treatment for hemophilia [J]. Liver Transpl, 2005; 11(5): 579-584.
28. Yazaki M, Hashikura Y, Takei Y, et al. Feasibility of auxiliary partial orthotopic liver transplantation from living donors for patients with adult-onset type Ⅱ citrullinemia [J]. Liver Transpl, 2004; 10(4): 550-554.
29. 郝迪斯, 王毓利, 乔海泉. 辅助肝移植研究进展 [J]. 黑龙江医学, 2002; 26(7): 499-500.
30. Terpstra OT. Auxiliary liver grafting: a new concept in liver transplantation [J]. Lancet, 1993; 342(8874): 758.
31. Haberal M, Arda IS, Karakayali H, et al. Heterotopic segmental liver transplantation in children [J]. Transplant Proc, 2000; 32(3): 535-536.
32. van Hoek B, de Boer J, Boudjema K, et al. Auxiliary versus orthotopic liver transplantation for acute liver failure. EURALT Study Group. European Auxiliary Liver Transplant Registry [J]. J Hepatol, 1999; 30(4): 699-705.
33. Sze YK, Dhawan A, Taylor RM, et al. Pediatric liver transplantation for metabolic liver disease: experience at King’s College Hospital [J]. Transplantation, 2009; 87(1): 87-93.
34. 阿永俊，李立，李晓延, 等. 人工肝支持系统在肝衰竭和肝脏移植中的临床应用研究 [J].中国普外基础与临床杂志， 2005; 12（5）： 496-498.
35. Tarhan NC, Uslu Tutar N, Yologˇlu Z, et al. Volume measurement by computed tomography in auxiliary heterotopic partial liver transplant recipients: follow-up results [J]. Transplant Proc, 2000; 32(3): 601-603.
36. Sakahara H, Kiuchi T, Nishizawa S, et al. Asialoglycoprotein receptor scintigraphy in evaluation of auxiliary partial orthotopic liver transplantation [J]. J Nucl Med, 1999; 40(9): 1463-1467.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Research Status of Auxiliary Heterotopic Liver Transplantation

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