Effect of ω-3 Polyunsaturated Fatty Acid on Promoting The Postoperative Rehabilitation of Patients with Gastrointestinal Malignancies_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Liu ¹ , ZHUANG Wen ¹ , CHEN Zhong ²

1.Surgery Center of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China;;
2.Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

ω-3 polyunsaturated fatty acid; Gastric cancer; Colorectal cancer; Postoperative; Parenteral nutrition

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Objective To research the effect of ω-3 polyunsaturated fatty acid (PUFA) on promoting the postoperative rehabilitation of patients with gastrointestinal malignancies in order to decrease the incidence of postoperative complications and the days of postoperative hospital stay. Methods Forty patients with gastrointestinal malignancies in West China Hospital of Sichuan University from February 1st, 2009 to June 1st, 2009 were included and allocated to experimental group (20 cases) and control group (20 cases) randomly. Seven days parenteral nutrition was provided to them after operation. Compared with control group, ω-3 PUFA with a dose of 10 g was given to experimental group every day additionally. Blood samples were gained before operation, on the morning of day 2 and day 8 after operation respectively to measure hepatorenal and immune indexes. Temperature before and 1-7 d after operation, time of passing flatus to normal, postoperative complications and the postoperative hospital stay were recorded. Results There was no statistical difference in the baselines between experimental group and control group （P gt;0.05）. The level of total bilirubin in experimental group was lower and the levels of NK cell and B cell in experimental group were higher than those in control group on day 2 after operation, there were statistical differences between them (P lt;0.05). The levels of ALT, AST and blood urea mitrogen in experimental group were lower and the levels of CD4+ cell and NK cell in experimental group were higher than those in control group on day 8 after operation, there were statistical differences between them, too (P lt;0.05). The time of passing flatus to normal and days of staying in hospital after operation in experimental group were shorter than those in control group, there were statistical differences between them (P lt;0.05). There was no statistical difference in postoperative average temperature and incidence of complications between two groups （P gt;0.05）. Conclusions ω-3 PUFA has positive influence on the recovery of hepatorenal, immune and gastrointestinal function, and can shorten the days of postoperative hospital stay; but there is no effect on incidence of complications after operation.

Citation： LIU Liu,ZHUANG Wen,CHEN Zhong. Effect of ω-3 Polyunsaturated Fatty Acid on Promoting The Postoperative Rehabilitation of Patients with Gastrointestinal Malignancies. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(11): 895-899. doi: Copy

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13.	Calder PC. ω-3 polyunsaturated fatty acids and cytokine production in health and disease [Ｊ]. Ann Nutr Metab, 1997; 41(4): 203-234.
14.	Pratt VC, Tredget EE, Clandinin MT, et al. Alterations in lymphocyte function and relation to phospholipid composition after burn injury in humans [Ｊ]. Crit Care Med, 2002; 30(8): 1753-1761.
15.	Wallace FA, Miles EA, Calder PC. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects [Ｊ]. Br J Nutr, 2003; 89(5): 679-689.
16.	张维康, 龙跃平, 陈俊华. ω-3鱼油脂肪乳对胃肠道恶性肿瘤患者术后恢复的作用 [Ｊ]. 临床外科杂志, 2007； 15(9): 606-608.

1. Imamura Y, Yoshimi I. Comparison of cancer mortality (sto-mach cancer) in five countries: France, Italy, Japan, UK and USA from the WHO mortality database (1960-2000) [Ｊ]. Jpn J Clin Oncol， 2005; 35(2): 103-105.
2. Boyle P, Leon ME. Epidemiology of colorectal cancer [Ｊ]. Br Med Bull, 2002; 64: 1-25.
3. Jeschke MG, Klein D, Herndon DN. Insulin treatment improves the systemic inflammatory reaction to severe trauma [Ｊ]. Ann Surg, 2004; 239(4): 553-560.
4. 任成山，陆海华, 杜晓锋, 等. 重度创伤后全身炎症反应综合征和多器官功能障碍综合征 [Ｊ]. 中国危重病急救医学, 2001； 13(11): 690-693.
5. Breil I, Koch T, Heller A, et al. Alteration of ω-3 fatty acid composition in lung tissue after short-term infusion of fish oil emulsion attenuates inflammatory vascular reaction [Ｊ]. Crit Care Med, 1996; 24(11): 1893-1902.
6. Moore FA, Moore EE, Kudsk KA, et al. Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding [Ｊ]. J Trauma, 1994; 37(4): 607-615.
7. 贾云鹤, 江志伟, 佴永军, 等. 胃癌术后感染和排空障碍与术前营养不良及营养指标的相关研究 [Ｊ]. 肠外与肠内营养, 2005； 12(3)： 143-145.
8. Wu GH, Zhang YW, Wu ZH. Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients [Ｊ]. World J Gastroenterol, 2001; 7(3): 357-362.
9. Alexander JW. Nutritional pharmacology in surgical patients [Ｊ]. Am J Surg, 2002; 183(4): 349-352.
10. Heys SD, Walker LG, Smith I, et al. Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials [Ｊ]. Ann Surg, 1999; 229(4): 467-477.
11. Braga M, Gianotti L, Radaelli G, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double-blind phase 3 trial [Ｊ]. Arch Surg, 1999; 134(4): 428-433.
12. Calder PC. ω-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic [Ｊ]. Lipids, 2003; 38(4): 343-352.
13. Calder PC. ω-3 polyunsaturated fatty acids and cytokine production in health and disease [Ｊ]. Ann Nutr Metab, 1997; 41(4): 203-234.
14. Pratt VC, Tredget EE, Clandinin MT, et al. Alterations in lymphocyte function and relation to phospholipid composition after burn injury in humans [Ｊ]. Crit Care Med, 2002; 30(8): 1753-1761.
15. Wallace FA, Miles EA, Calder PC. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects [Ｊ]. Br J Nutr, 2003; 89(5): 679-689.
16. 张维康, 龙跃平, 陈俊华. ω-3鱼油脂肪乳对胃肠道恶性肿瘤患者术后恢复的作用 [Ｊ]. 临床外科杂志, 2007； 15(9): 606-608.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of ω-3 Polyunsaturated Fatty Acid on Promoting The Postoperative Rehabilitation of Patients with Gastrointestinal Malignancies

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