Gaseous Signal Molecule Hydrogen Sulfide and Diseases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

KANG Kai ¹ , JIANG Hongchi. ²

1.Department of ICU, The First Clinical College of Haerbin Medical University, Haerbin 150001, China;;
2.Department of General Surgery, The First Clinical College of Haerbin Medical University, Haerbin 150001, ChinaCorresponding author： JIANG Hong-chi, E-mail：jianghc@vip.163.com;

Corresponding author：

Keywords：

Hydrogen sulfide; Gaseous signal molecule; Disease

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Objective To investigate the relation between gaseous signal molecule hydrogen sulfide (H2S) and diseases. Methods Literatures about the advancement of H2S were reviewed and analyzed. Results H2S is recognized as a novel gaseous signal molecule. By acting specially on ＫATPchannels, H2S can relax smooth muscle cells to regulate blood pressure.It even plays an important roles in pulmonary hypertension, ischemia/reperfusion injury, neurotransmission， apoptosis and inflammatory reaction. Conclusion H2S has been regarded as the third gaseous signal molecule， which exerts many physiological and pathological effects on mammals, and will pave way for development of new drugs and provide therapeutic intervention for various diseases.

Citation： KANG Kai,JIANG Hongchi.. Gaseous Signal Molecule Hydrogen Sulfide and Diseases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(2): 170-173. doi: Copy

1.	10 杨广东，王睿. 硫化氢与细胞的增殖和凋亡[J]. 生物学报,2007; 59(2)： 133 11Bhatia M. Hydrogen sulfide as a vasodilator[J].IUBMB Life， 2005; 57(9)： 603.
2.	Kimura H. Hydrogen sulfide as a neuromodulator[J].Mol Neurobiol, 2002; 26(1)：13.
3.	Zhao W, Zhang J, Lu Y, et al. The vasorelaxant effect of H2S as a novel endogenous gaseous K(ATP) channel opener[J].EMBO J, 2001； 20(21)： 6008.
4.	Geng B, Yang J, Qi Y, et al. H2S generated by heart in rat and its effects on cardiac function[J]. Biochem Biophys Res Commun, 2004; 313（2）：362.
5.	Zhao W, Wang R.H2S-induced vasorelaxation and underlying cellular and molecular mechanisms[J]. Am J Physiol Heart Circ Physiol, 2002; 283(2)：H474.
6.	Stipanuk MH, Beck PW. Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat[J].Biochem J, 1982； 206(2)： 267.
7.	Hosoki R，　Matsuki N, 　Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide[J].Biochem Biophys Res Commun, 1997; 237(3)： 527.
8.	Zhao W, Ndisang JF, Wang R. Modulation of endogenous production of H2S in rat tissues[J].Can J Physiol Pharmacol, 2003; 81(9)： 848.
9.	owicka E, Betowski J. Hydrogen sulfide (H2S)-the third gas of interest for pharmacologists[J].Pharmacol Rep, 2007;59(1)： 4.
10.	Yang G，　Sun X，　Wang R. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3[J].FASEB J， 2004; 18(14)： 1782.
11.	张清友，杜军保，张春雨，等.低氧性肺动脉高压形成中气体信号分子硫化氢对一氧化碳／血红素加氧酶途径的影响[J]. 中华结核和呼吸杂志， 2004； 27（10）： 659.
12.	陈晓波, 杜军保, 张春雨，等. 新型气体信号分子硫化氢对低氧大鼠肺动脉平滑肌细胞凋亡的影响[J].北京大学学报(医学版),2004； 36(4)： 341.
13.	阎辉，杜军保，唐朝枢.硫化氢对自发性高血压大鼠胸主动脉舒张反应的影响[J].中国药理学通报， 2003； 19（6）： 633.
14.	Ali MY, Ping CY, Mok YY， et al. Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?[J]. Br J Pharmacol,2006； 149（6）：625.
15.	Webb GD, Lim LH, Oh VM， et al.Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery[J]. J Pharmacol Exp Ther,2008； 324(2)： 876.
16.	Elrod JW, Calvert JW, Morrison J, et al. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function [J]. Proc Natl Acad Sci U S A， 2007; 104(39)： 15560.
17.	Chen YH， Yao WZ， Geng B， et al. Endogenous hydrogen sulfide in patients with COPD [J].Chest,2005; 128(5)：3205.
18.	伍蕊, 姚婉贞,陈亚红,等. 硫化氢在大鼠急性支气管哮喘模型中的变化及意义 [J].中华结核和呼吸杂志, 2007;30(7)： 522.
19.	Eto K, Ogasawara M, Umemura K, et al. Hydrogen sulfide is produced in response to neuronal excitation [J]. J Neurosci, 2002; 22(9)：3386.
20.	Lee SW, Hu YS, Hu LF, et al. Hydrogen sulphide regulates calcium homeostasis in microglial cells [J]. Glia, 2006; 54(2)：116.
21.	García-Bereguiaín MA, Samhan-Arias AK, Martín-Romero FJ, et al. Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels[J]. Antioxid Redox Signal,2008； 10(1)：31.
22.	Eto K, Asada T, Arima K, et al. Brain hydrogen sulfide is severely decreased in Alzheimer’s disease [J].Biochem Biophys Res Commun, 2002； 293（5）： 1485.
23.	Zhi L, Ang AD, Zhang H, et al. Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway [J]. J Leukoc Biol,2007； 81(5)：1322.
24.	陈晓波,　杜军保, 耿彬，等.感染性和内毒素性休克大鼠动脉组织中硫化氢的变化 [J].基础医学与临床, 2003； 23(4)： 384.
25.	Zhang H, Zhi L, Moochhala SM， et al. Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis [J].J Leukoc Biol,2007； 82(4)：894.
26.	Zhang H, Hegde A, Ng SW, et al. Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury [J].J Immunol,2007； 179(6)：4153.
27.	Bhatia M, Wong FL, Fu D, et al. Role of hydrogen sulfide in acute pancreatitis and associated lung injury[J].FASEB J,2005； 19(6)： 623.
28.	Tamizhselvi R,Moore PK,Bhatia M.Hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells[J].J Cell Mol Med, 2007;11(2)：315.
29.	Collin M, Anuar FB, Murch O, et al. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia[J].Br J Pharmacol, 2005； 146（4）：498.
30.	Bhatia M， Sidhapuriwala J, Moochhala SM, et al. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat [J].Br J Pharmacol, 2005； 145（2）： 141.
31.	戴鸿雁, 凌亦凌, 黄新莉, 等.硫化氢在内毒素血症大鼠动脉舒张反应性改变中的作用及其与一氧化氮的关系 [J]. 河北医科大学学报， 2004； 25(6)： 355.
32.	Distrutti E, Sediari L, Mencarelli A, et al. Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels [J]. J Pharmacol Exp Ther, 2006； 16(1)：325.
33.	Lou LX,Geng B,Du JB， et al. Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats [J].Clin Exp Pharmacol Physiol, 2008； 35(2)：223.
34.	Fiorucci S,Santucci L,Distrutti E.NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizon [J]. Dig Liver Dis,2007； 39(12)：1043.
35.	Streng T,Axelsson HE,Hedlund P， et al. Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder [J].Eur Urol,2008； 53(2)： 391.

1. 10 杨广东，王睿. 硫化氢与细胞的增殖和凋亡[J]. 生物学报,2007; 59(2)： 133 11Bhatia M. Hydrogen sulfide as a vasodilator[J].IUBMB Life， 2005; 57(9)： 603.
2. Kimura H. Hydrogen sulfide as a neuromodulator[J].Mol Neurobiol, 2002; 26(1)：13.
3. Zhao W, Zhang J, Lu Y, et al. The vasorelaxant effect of H2S as a novel endogenous gaseous K(ATP) channel opener[J].EMBO J, 2001； 20(21)： 6008.
4. Geng B, Yang J, Qi Y, et al. H2S generated by heart in rat and its effects on cardiac function[J]. Biochem Biophys Res Commun, 2004; 313（2）：362.
5. Zhao W, Wang R.H2S-induced vasorelaxation and underlying cellular and molecular mechanisms[J]. Am J Physiol Heart Circ Physiol, 2002; 283(2)：H474.
6. Stipanuk MH, Beck PW. Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat[J].Biochem J, 1982； 206(2)： 267.
7. Hosoki R，　Matsuki N, 　Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide[J].Biochem Biophys Res Commun, 1997; 237(3)： 527.
8. Zhao W, Ndisang JF, Wang R. Modulation of endogenous production of H2S in rat tissues[J].Can J Physiol Pharmacol, 2003; 81(9)： 848.
9. owicka E, Betowski J. Hydrogen sulfide (H2S)-the third gas of interest for pharmacologists[J].Pharmacol Rep, 2007;59(1)： 4.
10. Yang G，　Sun X，　Wang R. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3[J].FASEB J， 2004; 18(14)： 1782.
11. 张清友，杜军保，张春雨，等.低氧性肺动脉高压形成中气体信号分子硫化氢对一氧化碳／血红素加氧酶途径的影响[J]. 中华结核和呼吸杂志， 2004； 27（10）： 659.
12. 陈晓波, 杜军保, 张春雨，等. 新型气体信号分子硫化氢对低氧大鼠肺动脉平滑肌细胞凋亡的影响[J].北京大学学报(医学版),2004； 36(4)： 341.
13. 阎辉，杜军保，唐朝枢.硫化氢对自发性高血压大鼠胸主动脉舒张反应的影响[J].中国药理学通报， 2003； 19（6）： 633.
14. Ali MY, Ping CY, Mok YY， et al. Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?[J]. Br J Pharmacol,2006； 149（6）：625.
15. Webb GD, Lim LH, Oh VM， et al.Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery[J]. J Pharmacol Exp Ther,2008； 324(2)： 876.
16. Elrod JW, Calvert JW, Morrison J, et al. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function [J]. Proc Natl Acad Sci U S A， 2007; 104(39)： 15560.
17. Chen YH， Yao WZ， Geng B， et al. Endogenous hydrogen sulfide in patients with COPD [J].Chest,2005; 128(5)：3205.
18. 伍蕊, 姚婉贞,陈亚红,等. 硫化氢在大鼠急性支气管哮喘模型中的变化及意义 [J].中华结核和呼吸杂志, 2007;30(7)： 522.
19. Eto K, Ogasawara M, Umemura K, et al. Hydrogen sulfide is produced in response to neuronal excitation [J]. J Neurosci, 2002; 22(9)：3386.
20. Lee SW, Hu YS, Hu LF, et al. Hydrogen sulphide regulates calcium homeostasis in microglial cells [J]. Glia, 2006; 54(2)：116.
21. García-Bereguiaín MA, Samhan-Arias AK, Martín-Romero FJ, et al. Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels[J]. Antioxid Redox Signal,2008； 10(1)：31.
22. Eto K, Asada T, Arima K, et al. Brain hydrogen sulfide is severely decreased in Alzheimer’s disease [J].Biochem Biophys Res Commun, 2002； 293（5）： 1485.
23. Zhi L, Ang AD, Zhang H, et al. Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway [J]. J Leukoc Biol,2007； 81(5)：1322.
24. 陈晓波,　杜军保, 耿彬，等.感染性和内毒素性休克大鼠动脉组织中硫化氢的变化 [J].基础医学与临床, 2003； 23(4)： 384.
25. Zhang H, Zhi L, Moochhala SM， et al. Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis [J].J Leukoc Biol,2007； 82(4)：894.
26. Zhang H, Hegde A, Ng SW, et al. Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury [J].J Immunol,2007； 179(6)：4153.
27. Bhatia M, Wong FL, Fu D, et al. Role of hydrogen sulfide in acute pancreatitis and associated lung injury[J].FASEB J,2005； 19(6)： 623.
28. Tamizhselvi R,Moore PK,Bhatia M.Hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells[J].J Cell Mol Med, 2007;11(2)：315.
29. Collin M, Anuar FB, Murch O, et al. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia[J].Br J Pharmacol, 2005； 146（4）：498.
30. Bhatia M， Sidhapuriwala J, Moochhala SM, et al. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat [J].Br J Pharmacol, 2005； 145（2）： 141.
31. 戴鸿雁, 凌亦凌, 黄新莉, 等.硫化氢在内毒素血症大鼠动脉舒张反应性改变中的作用及其与一氧化氮的关系 [J]. 河北医科大学学报， 2004； 25(6)： 355.
32. Distrutti E, Sediari L, Mencarelli A, et al. Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels [J]. J Pharmacol Exp Ther, 2006； 16(1)：325.
33. Lou LX,Geng B,Du JB， et al. Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats [J].Clin Exp Pharmacol Physiol, 2008； 35(2)：223.
34. Fiorucci S,Santucci L,Distrutti E.NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizon [J]. Dig Liver Dis,2007； 39(12)：1043.
35. Streng T,Axelsson HE,Hedlund P， et al. Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder [J].Eur Urol,2008； 53(2)： 391.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Gaseous Signal Molecule Hydrogen Sulfide and Diseases

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