Liver Transplantation for Recurrent Liver Cancer after Resection_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Bo , YAN Lnan , YUAN Ding , ZENG Yong , WEN Tianfu , ZHAO Jichun , WANG Wentao , XU Mingqing , YANG Jiayin , MA Yukui , WEI Yonggang.

Liver Transplantation Center, Ｄepartment of Hepatic Surgery and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaCorresponding Author: LI Bo, E-mail: cdlibo@medmail.com.cn;

Corresponding author：

Keywords：

Liver cancer; Hepatectomy; Tumor Recurrence; Liver transplantation

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Objective 　To evaluate the outcome of liver transplantation in patients with recurrent liver cancer after resection.
　Methods 　Data of 23 patients underwent liver transplantation for recurrent liver cancer from April 2001 to March 2008 were retrospectively collected and analyzed.
　Results 　Previous history of liver resection had little negative effect in subsequent liver transplantation in technical aspect. Liver function recovered uneventfully after transplantation in all cases. Alpha fetoprotein (AFP) recovered to normal value in 13 of 17 cases with elevated AFP before transplantation within one month after operation. Five cases (21.74%) had postoperative complications. Nineteen cases (82.61%) were followed up, average follow-up duration were 610 days. There were 5 cases (26.32%) of cancer recurrence and 6 deaths during follow-up, survival rate was 68.42%.
　Conclusion 　Liver transplantation is a reasonable treatment for recurrent liver cancer after resection.

Citation： LI Bo,YAN Lnan,YUAN Ding,ZENG Yong,WEN Tianfu,ZHAO Jichun,WANG Wentao,XU Mingqing,YANG Jiayin,MA Yukui,WEI Yonggang.. Liver Transplantation for Recurrent Liver Cancer after Resection. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(3): 191-194. doi: Copy

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7.	Zavaglia C, De Carlis L, Alberti AB, et al. Predictors of long-term survival after liver transplantation for hepatocellular carcinoma [Ｊ]. Am J Gastroenterol, 2005; 100(12):2708.
8.	Baccarani U, Adani GL, Avellini C, et al. Comparison of clinical and pathological staging and long-term results of liver transplantation for hepatocellular carcinoma in a single transplant center [Ｊ]. Transplant Proc, 2006; 38(4):1111.
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11.	Poon RT, Fan ST. Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome [Ｊ]. Liver Transpl, 2004; 10(2 Suppl 1):S39.
12.	Poon RT. Optimal initial treatment for early hepatocellular carcinoma in patients with preserved liver function: transplantation or resection? [Ｊ]. Ann Surg Oncol, 2007; 14(2):541.
13.	Hu RH, Ho MC, Wu YM, et al. Feasibility of salvage liver transplantation for patients with recurrent hepatocellular carcinoma [Ｊ]. Clin Transplant, 2005; 19(2):175.
14.	Belghiti J, Cortes A, Abdalla EK, et al. Resection prior to liver transplantation for hepatocellular carcinoma [Ｊ]. Ann Surg, 2003; 238(6):885.
15.	Kim BW, Park YK, Kim YB, et al. Salvage liver transplantation for recurrent hepatocellular carcinoma after liver resection: feasibility of the milan criteria and operative risk [Ｊ]. Transplant Proc, 2008; 40(10):3558.

1. Llvoet JM. Updated treatment approach to hepatocellular carcinoma [Ｊ]. J Gastroenterol, 2005; 40(3):225.
2. ３ Adam R, Azoulay D, Castaing D, et al. Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy? [Ｊ]. Ann Surg, 2003; 238(4):508.
3. ４ Tanaka H, Kubo S, Tsukamoto T, et al. Recurrence rate and transplantability after liver resection in patients with hepatocellular carcinoma who initially met transplantation criteria [Ｊ]. Transplant Proc, 2005; 37(2):1254.
4. ５ Sala M, Fuster J, Llovet JM, et al. High pathological risk of recurrence after surgical resection for hepatocellular carcinoma: an indication for salvage liver transplantation [Ｊ]. Liver Transpl, 2004; 10(10):1294.
5. Tanaka S, Noguchi N, Ochiai T, et al. Outcomes and recurrence of initially resectable hepatocellular carcinoma meeting milan criteria: Rationale for partial hepatectomy as first strategy [Ｊ]. J Am Coll Surg, 2007; 204(1):1.
6. Fernández JA, Robles R, Marin C, et al. Can we expand the indications for liver transplantation among hepatocellular carcinoma patients with increased tumor size? [Ｊ]. Transplant Proc, 2003; 35(5):1818.
7. Zavaglia C, De Carlis L, Alberti AB, et al. Predictors of long-term survival after liver transplantation for hepatocellular carcinoma [Ｊ]. Am J Gastroenterol, 2005; 100(12):2708.
8. Baccarani U, Adani GL, Avellini C, et al. Comparison of clinical and pathological staging and long-term results of liver transplantation for hepatocellular carcinoma in a single transplant center [Ｊ]. Transplant Proc, 2006; 38(4):1111.
9. Onaca N, Davis GL, Goldstein RM, et al. Expanded criteria for liver transplantation in patients with hepatocellular carcinoma: a report from the International Registry of Hepatic Tumors in Liver Transplantation [Ｊ]. Liver Transpl, 2007; 13(3):391.
10. Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival [Ｊ]. Hepatology, 2001; 33(6):1394.
11. Poon RT, Fan ST. Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome [Ｊ]. Liver Transpl, 2004; 10(2 Suppl 1):S39.
12. Poon RT. Optimal initial treatment for early hepatocellular carcinoma in patients with preserved liver function: transplantation or resection? [Ｊ]. Ann Surg Oncol, 2007; 14(2):541.
13. Hu RH, Ho MC, Wu YM, et al. Feasibility of salvage liver transplantation for patients with recurrent hepatocellular carcinoma [Ｊ]. Clin Transplant, 2005; 19(2):175.
14. Belghiti J, Cortes A, Abdalla EK, et al. Resection prior to liver transplantation for hepatocellular carcinoma [Ｊ]. Ann Surg, 2003; 238(6):885.
15. Kim BW, Park YK, Kim YB, et al. Salvage liver transplantation for recurrent hepatocellular carcinoma after liver resection: feasibility of the milan criteria and operative risk [Ｊ]. Transplant Proc, 2008; 40(10):3558.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Liver Transplantation for Recurrent Liver Cancer after Resection

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