Expression of Growth Hormone Receptor in Human Gastric Cancer Tissue_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIANG Daoming ¹ , YANG Wei ² , ZHOU Dong ¹ , LIAO Gengjin ¹ , CHEN Jiayong ¹

1.Department of Emergency Surgery, The Second Affiliated Hospital, Kunming Medical College, Kunming 650101, China;;
2.Department of General Surgery, The First People’s Hospital of Yunnan Province, Kunming 650000, ChinaCorresponding Author: CHEN Jia-yong, E-mail: cjy125@163.com;

Corresponding author：

Keywords：

Growth hormone receptor; Stomach neoplasm; Immunohistochemistry

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To investigate the expression of growth hormone receptor (GHR) in human gastric cancer tissue.
　Methods 　The GHR was detected in samples of the human gastric cancer (57 cases) and the distal normal tissues (57 cases) by immunohistochemistry technique.
　Results 　The GHR expression positive rate was 80.7%(46/57) in the human gastric cancer tissues and 70.2%(40/57) in the distal normal tissues. There was no statistic difference between the human gastric cancer tissues and the distal normal tissues (P gt;0.05). There were also no statistic differences among the gastric cancer tissues of different differentiation, different tissue type, different gender and different age ranges (P gt;0.05).
　Conclusion 　It is similar that the expression of GHR between the human gastric cancer tissues and the distal normal tissues.

Citation： LIANG Daoming,YANG Wei,ZHOU Dong,LIAO Gengjin,CHEN Jiayong. Expression of Growth Hormone Receptor in Human Gastric Cancer Tissue. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(3): 208-210. doi: Copy

1.	Biolo G, Iscra F, Bosutti A, et al. Growth hormone decreases muscle glutamine production and stimulates protein synthesis in hypercatabolic patients [Ｊ]. Am J Physiol Endocrinol Metab, 2000; 279(2):E323.
2.	Shen XY, Holt RI, Miell JP, et al. Cirrhotic liver expresses low levels of the full-length and truncated growth hormone receptors [Ｊ]. J Clin Endocrinol Metab, 1998; 83(7):2532.
3.	Divisova J, Kuiatse I, Lazard Z, et al. The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth [Ｊ]. Breast Cancer Res Treat, 2006; 98(3):315.
4.	杨小东, 刘福坤, 许哲, 等. 生长激素受体在结直肠癌中的表达及其意义 [Ｊ]. 中华胃肠外科杂志, 2005; 8(3):252.
5.	Wu X, Wan M, Li G, et al. Growth hormone receptor overexpression predicts response of rectal cancers to pre-operative radiotherapy [Ｊ]. Eur J Cancer, 2006; 42(7):888.
6.	Scharf JG, Dombrowski F, Ramadori G. The IGF axis and hepatocarcinogenesis [Ｊ]. Mol Pathol, 2001; 54(3):138.
7.	van Garderen E, Schalken JA. Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system [Ｊ]. Mol Cell Endocrinol, 2002; 197(1-2):153.
8.	Weiss-Messer E, Merom O, Adi A, et al. Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells [Ｊ]. Mol Cell Endocrinol, 2004; 220(1-2):109.
9.	吴晓宇, 许哲, 陈彻, 等. 生长激素受体在结直肠癌发生过程中表达上调 [Ｊ]. 肠外与肠内营养, 2007; 14(2):73.
10.	向春华, 严律南, 林琦远, 等. 生长激素受体在人肝癌组织中的表达 [Ｊ]. 中国普外基础与临床杂志, 2002; 9(4):255.
11.	赵旭, 滕良珠, 辛涛, 等. 脑膜瘤的增殖活性与生长激素受体的表达 [Ｊ]. 中华神经外科杂志, 2005; 21(8):508.
12.	张富伟, 孙少川. 生长激素受体在胃癌及其转移淋巴结组织中的表达 [Ｊ]. 中华普通外科杂志, 2006; 11(5):377.
13.	梁道明，张毅，袁勇，等. 胃肠道恶性肿瘤组织中生长激素受体的表达 [Ｊ]. 昆明医学院学报， 2008； 29(3):10.
14.	Nagano M, Chastre E, Choquet A, et al. Expression of prolactin and growth hormone receptor genes and their isoforms in the gastrointestinal tract [Ｊ]. Am J Physiol, 1995; 268(3 Pt 1):G431.
15.	Wagner K, Hemminki K, Grzybowska E, et al. Polymorphisms in the growth hormone receptor: a case-control study in breast cancer [Ｊ]. Int J Cancer, 2006; 118(11):2903.
16.	Tacke J, Bolder U, Herrmann A, et al. Long-term risk of gastrointestinal tumor recurrence after postoperative treatment with recombinant human growth hormone [Ｊ]. JPEN J Parenter Enteral Nutr, 2000; 24(3):140.
17.	〖ＪＰ３〗段体德, 温先敏, 刘德权, 等. 生长激素联合顺铂及丝裂霉素对荷前胃癌小鼠的抑瘤作用研究 [Ｊ]. 云南医药, 2003; 24(4):261.
18.	陈嘉勇, 甘平, 梁道明, 等. 重组人生长激素在体外对人直肠癌细胞株HR8348增殖的影响 [Ｊ]. 中国普外基础与临床杂志, 2003; 10(4):362.
19.	Chen JY, Liang DM, Gan P, et al. In vitro effects of recombinant human growth hormone on growth of human gastric cancer cell line BGC823 cells [Ｊ]. World J Gastroenterol, 2004; 10(8):1132.
20.	Liang DM, Chen JY, Zhang Y, et al. Effects of recombinant human growth hormone on growth of human gastric carcinoma xenograft model in nude mice [Ｊ]. World J Gastroenterol, 2006; 12(24):3810.

1. Biolo G, Iscra F, Bosutti A, et al. Growth hormone decreases muscle glutamine production and stimulates protein synthesis in hypercatabolic patients [Ｊ]. Am J Physiol Endocrinol Metab, 2000; 279(2):E323.
2. Shen XY, Holt RI, Miell JP, et al. Cirrhotic liver expresses low levels of the full-length and truncated growth hormone receptors [Ｊ]. J Clin Endocrinol Metab, 1998; 83(7):2532.
3. Divisova J, Kuiatse I, Lazard Z, et al. The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth [Ｊ]. Breast Cancer Res Treat, 2006; 98(3):315.
4. 杨小东, 刘福坤, 许哲, 等. 生长激素受体在结直肠癌中的表达及其意义 [Ｊ]. 中华胃肠外科杂志, 2005; 8(3):252.
5. Wu X, Wan M, Li G, et al. Growth hormone receptor overexpression predicts response of rectal cancers to pre-operative radiotherapy [Ｊ]. Eur J Cancer, 2006; 42(7):888.
6. Scharf JG, Dombrowski F, Ramadori G. The IGF axis and hepatocarcinogenesis [Ｊ]. Mol Pathol, 2001; 54(3):138.
7. van Garderen E, Schalken JA. Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system [Ｊ]. Mol Cell Endocrinol, 2002; 197(1-2):153.
8. Weiss-Messer E, Merom O, Adi A, et al. Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells [Ｊ]. Mol Cell Endocrinol, 2004; 220(1-2):109.
9. 吴晓宇, 许哲, 陈彻, 等. 生长激素受体在结直肠癌发生过程中表达上调 [Ｊ]. 肠外与肠内营养, 2007; 14(2):73.
10. 向春华, 严律南, 林琦远, 等. 生长激素受体在人肝癌组织中的表达 [Ｊ]. 中国普外基础与临床杂志, 2002; 9(4):255.
11. 赵旭, 滕良珠, 辛涛, 等. 脑膜瘤的增殖活性与生长激素受体的表达 [Ｊ]. 中华神经外科杂志, 2005; 21(8):508.
12. 张富伟, 孙少川. 生长激素受体在胃癌及其转移淋巴结组织中的表达 [Ｊ]. 中华普通外科杂志, 2006; 11(5):377.
13. 梁道明，张毅，袁勇，等. 胃肠道恶性肿瘤组织中生长激素受体的表达 [Ｊ]. 昆明医学院学报， 2008； 29(3):10.
14. Nagano M, Chastre E, Choquet A, et al. Expression of prolactin and growth hormone receptor genes and their isoforms in the gastrointestinal tract [Ｊ]. Am J Physiol, 1995; 268(3 Pt 1):G431.
15. Wagner K, Hemminki K, Grzybowska E, et al. Polymorphisms in the growth hormone receptor: a case-control study in breast cancer [Ｊ]. Int J Cancer, 2006; 118(11):2903.
16. Tacke J, Bolder U, Herrmann A, et al. Long-term risk of gastrointestinal tumor recurrence after postoperative treatment with recombinant human growth hormone [Ｊ]. JPEN J Parenter Enteral Nutr, 2000; 24(3):140.
17. 〖ＪＰ３〗段体德, 温先敏, 刘德权, 等. 生长激素联合顺铂及丝裂霉素对荷前胃癌小鼠的抑瘤作用研究 [Ｊ]. 云南医药, 2003; 24(4):261.
18. 陈嘉勇, 甘平, 梁道明, 等. 重组人生长激素在体外对人直肠癌细胞株HR8348增殖的影响 [Ｊ]. 中国普外基础与临床杂志, 2003; 10(4):362.
19. Chen JY, Liang DM, Gan P, et al. In vitro effects of recombinant human growth hormone on growth of human gastric cancer cell line BGC823 cells [Ｊ]. World J Gastroenterol, 2004; 10(8):1132.
20. Liang DM, Chen JY, Zhang Y, et al. Effects of recombinant human growth hormone on growth of human gastric carcinoma xenograft model in nude mice [Ｊ]. World J Gastroenterol, 2006; 12(24):3810.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Growth Hormone Receptor in Human Gastric Cancer Tissue

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