Advancement in Liver Transplantation for Hepatic Metastasis from Neuroendocrine Tumor_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JIN Shuguang , YAN Lnan

Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Liver transplantation; Neuroendocrine tumor; Neoplasm metastasis; Carcinoid; Recipient; Liver surgery

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Objective To summarize the application and advancement of liver transplantation for hepatic metastasis from neuroendocrine tumor. Methods Domestic and overseas publications on the study of liver transplantation for hepatic metastasis from neuroendocrine tumor in recent years were collected and reviewed. Results Liver transplantation can offer good relief of symptoms, long disease-free intervals, and potential cure in individual patients with hepatic metastatic tumor. Important selection criteria are well-differentiated tumors and a low proliferation rate (Ki67＜10%). Conclusion In carefully selected patients with metastatic neuroendocrine tumors, liver transplantation is an appropriate option.

Citation： JIN Shuguang,YAN Lnan. Advancement in Liver Transplantation for Hepatic Metastasis from Neuroendocrine Tumor. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(6): 449-451. doi: Copy

1.	Newton JN, Swerdlow AJ, dos Santos Silva IM, et al. The epidemiology of carcinoid tumours in England and Scotland [Ｊ]. Br J Cancer, 1994; 70(5): 939-942.
2.	Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13 715 carcinoid tumors [Ｊ]. Cancer, 2003; 97(4): 934-959.
3.	Helland SK, Prsch AM, Viste A. Carcinoid tumours in the gastrointestinal tract-a population-based study from Western Norway [Ｊ]. Scand J Surg, 2006; 95(3): 158-161.
4.	Oberg K. Management of neuroendocrine tumours [Ｊ]. Ann Oncol, 2004; 15 Suppl 4: iv293-iv298.
5.	Solcia E, Kloppel G, Sobin L Eds. Histological Typing of Endocrine Tumours [Ｍ]. 2nd ed. New York, USA: Springer, 2000: 38-74.
6.	Makowka L, Tzakis AG, Mazzaferro V, et al. Transplantation of the liver for metastatic endocrine tumors of the intestine and pancreas [Ｊ]. Surg Gynecol Obstet, 1989; 168(2): 107-111.
7.	Anthuber M, Jauch KW, Briegel J, et al. Results of liver transplantation for gastroenteropancreatic tumor metastases [Ｊ]. World J Surg, 1996; 20(1): 73-76.
8.	Dousset B, Saint-Marc O, Pitre J, et al. Metastatic endocrine tumors: medical treatment, surgical resection, or liver transplantation [Ｊ]. World J Surg, 1996; 20(7): 908-914.
9.	Lehnert T. Liver transplantation for metastatic neuroendocrine carcinoma: an analysis of 103 patients [Ｊ]. Transplantation, 1998; 66(10): 1307-1312.
10.	Ringe B, Lorf T, Dpkens K, et al. Treatment of hepatic metastases from gastroenteropancreatic neuroendocrine tumors: role of liver transplantation [Ｊ]. World J Surg, 2001; 25(6): 697-699.
11.	Lang H, Oldhafer KJ, Weimann A, et al. Liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Ann Surg, 1997; 225(4): 347-354.
12.	Curtiss SI, Mor E, Schwartz ME, et al. A rational approach to the use of hepatic transplantation in the treatment of metastatic neuroendocrine tumors [Ｊ]. J Am Coll Surg, 1995; 180(2): 184-187.
13.	Florman S, Toure B, Kim L, et al. Liver transplantation for neuroendocrine tumors [Ｊ]. J Gastrointest Surg, 2004; 8(2): 208-212.
14.	Frilling A, Malago M, Weber F, et al. Liver transplantation for patients with metastatic endocrine tumors: single-center experience with 15 patients [Ｊ]. Liver Transpl, 2006; 12(7): 1089-1096.
15.	Ahlman H, Friman S, Cahlin C, et al. Liver transplantation for treatment of metastatic neuroendocrine tumors [Ｊ]. Ann N Y Acad Sci, 2004; 1014: 265-269.
16.	Olausson M, Friman S, Cahlin C, et al. Indications and results of liver transplantation in patients with neuroendocrine tumors [Ｊ]. World J Surg, 2002; 26(8): 998-1004.
17.	Olausson M, Friman S, Herlenius G, et al. Orthotopic liver or multivisceral transplantation as treatment of metastatic neuroendocrine tumors [Ｊ]. Liver Transpl, 2007; 13(3):327-333.
18.	Rosenau J, Bahr MJ, von Wasielewski R, et al. Ki67, E-cadherin, and p53 as prognostic indicators of long-term outcome after liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Transplantation, 2002; 73(3): 386-394.
19.	van Vilsteren FG, Baskin-Bey ES, Nagorney DM, et al. Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival [Ｊ]. Liver Transpl, 2006; 12(3): 448-456.
20.	Le Treut YP, Delpero JR, Dousset B, et al. Results of liver transplantation in the treatment of metastatic neuroendocrine tumors. A 31-case French multicentric report [Ｊ]. Ann Surg, 1997; 225(4): 355-364.
21.	Routley D, Ramage JK, McPeake J, et al. Orthotopic liver transplantation in the treatment of metastatic neuroendocrine tumors of the liver [Ｊ]. Liver Transpl Surg, 1995; 1(2): 118-121.
22.	Le Treut YP, Grégoire E, Belghiti J, et al. Predictors of long-term survival after liver transplantation for metastatic endocrine tumors: an 85-case French multicentric report [Ｊ]. Am J Transplant, 2008; 8(6): 1205-1213.
23.	Lang H, Schlitt HJ, Schmidt H, et al. Total hepatectomy and liver transplantation for metastatic neuroendocrine tumors of the pancreas-a single center experience with ten patients [Ｊ]. Langenbecks Arch Surg, 1999; 384(4): 370-377.
24.	严律南, 王震侠. 肝癌肝移植的适应证及应用前景 [Ｊ]. 中国普外基础与临床杂志, 2006; 13(2): 132-134.
25.	陆敏强, 陈规划, 杨扬, 等. pTNM分期预测肝癌肝移植疗效的临床研究 [Ｊ]. 中国普外基础与临床杂志, 2004; 11(5): 393-395.
26.	严律南, 金立人, 李波, 等. 同种异体原位肝移植10例报告 [Ｊ]. 中国普外基础与临床杂志, 2000; 7(4): 231-234.
27.	徐明清, 严律南, 李波, 等. 肝移植治疗胰腺恶性β-细胞瘤肝转移一例 [Ｊ]. 中华外科杂志, 2008; 46(4): 319.

1. Newton JN, Swerdlow AJ, dos Santos Silva IM, et al. The epidemiology of carcinoid tumours in England and Scotland [Ｊ]. Br J Cancer, 1994; 70(5): 939-942.
2. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13 715 carcinoid tumors [Ｊ]. Cancer, 2003; 97(4): 934-959.
3. Helland SK, Prsch AM, Viste A. Carcinoid tumours in the gastrointestinal tract-a population-based study from Western Norway [Ｊ]. Scand J Surg, 2006; 95(3): 158-161.
4. Oberg K. Management of neuroendocrine tumours [Ｊ]. Ann Oncol, 2004; 15 Suppl 4: iv293-iv298.
5. Solcia E, Kloppel G, Sobin L Eds. Histological Typing of Endocrine Tumours [Ｍ]. 2nd ed. New York, USA: Springer, 2000: 38-74.
6. Makowka L, Tzakis AG, Mazzaferro V, et al. Transplantation of the liver for metastatic endocrine tumors of the intestine and pancreas [Ｊ]. Surg Gynecol Obstet, 1989; 168(2): 107-111.
7. Anthuber M, Jauch KW, Briegel J, et al. Results of liver transplantation for gastroenteropancreatic tumor metastases [Ｊ]. World J Surg, 1996; 20(1): 73-76.
8. Dousset B, Saint-Marc O, Pitre J, et al. Metastatic endocrine tumors: medical treatment, surgical resection, or liver transplantation [Ｊ]. World J Surg, 1996; 20(7): 908-914.
9. Lehnert T. Liver transplantation for metastatic neuroendocrine carcinoma: an analysis of 103 patients [Ｊ]. Transplantation, 1998; 66(10): 1307-1312.
10. Ringe B, Lorf T, Dpkens K, et al. Treatment of hepatic metastases from gastroenteropancreatic neuroendocrine tumors: role of liver transplantation [Ｊ]. World J Surg, 2001; 25(6): 697-699.
11. Lang H, Oldhafer KJ, Weimann A, et al. Liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Ann Surg, 1997; 225(4): 347-354.
12. Curtiss SI, Mor E, Schwartz ME, et al. A rational approach to the use of hepatic transplantation in the treatment of metastatic neuroendocrine tumors [Ｊ]. J Am Coll Surg, 1995; 180(2): 184-187.
13. Florman S, Toure B, Kim L, et al. Liver transplantation for neuroendocrine tumors [Ｊ]. J Gastrointest Surg, 2004; 8(2): 208-212.
14. Frilling A, Malago M, Weber F, et al. Liver transplantation for patients with metastatic endocrine tumors: single-center experience with 15 patients [Ｊ]. Liver Transpl, 2006; 12(7): 1089-1096.
15. Ahlman H, Friman S, Cahlin C, et al. Liver transplantation for treatment of metastatic neuroendocrine tumors [Ｊ]. Ann N Y Acad Sci, 2004; 1014: 265-269.
16. Olausson M, Friman S, Cahlin C, et al. Indications and results of liver transplantation in patients with neuroendocrine tumors [Ｊ]. World J Surg, 2002; 26(8): 998-1004.
17. Olausson M, Friman S, Herlenius G, et al. Orthotopic liver or multivisceral transplantation as treatment of metastatic neuroendocrine tumors [Ｊ]. Liver Transpl, 2007; 13(3):327-333.
18. Rosenau J, Bahr MJ, von Wasielewski R, et al. Ki67, E-cadherin, and p53 as prognostic indicators of long-term outcome after liver transplantation for metastatic neuroendocrine tumors [Ｊ]. Transplantation, 2002; 73(3): 386-394.
19. van Vilsteren FG, Baskin-Bey ES, Nagorney DM, et al. Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival [Ｊ]. Liver Transpl, 2006; 12(3): 448-456.
20. Le Treut YP, Delpero JR, Dousset B, et al. Results of liver transplantation in the treatment of metastatic neuroendocrine tumors. A 31-case French multicentric report [Ｊ]. Ann Surg, 1997; 225(4): 355-364.
21. Routley D, Ramage JK, McPeake J, et al. Orthotopic liver transplantation in the treatment of metastatic neuroendocrine tumors of the liver [Ｊ]. Liver Transpl Surg, 1995; 1(2): 118-121.
22. Le Treut YP, Grégoire E, Belghiti J, et al. Predictors of long-term survival after liver transplantation for metastatic endocrine tumors: an 85-case French multicentric report [Ｊ]. Am J Transplant, 2008; 8(6): 1205-1213.
23. Lang H, Schlitt HJ, Schmidt H, et al. Total hepatectomy and liver transplantation for metastatic neuroendocrine tumors of the pancreas-a single center experience with ten patients [Ｊ]. Langenbecks Arch Surg, 1999; 384(4): 370-377.
24. 严律南, 王震侠. 肝癌肝移植的适应证及应用前景 [Ｊ]. 中国普外基础与临床杂志, 2006; 13(2): 132-134.
25. 陆敏强, 陈规划, 杨扬, 等. pTNM分期预测肝癌肝移植疗效的临床研究 [Ｊ]. 中国普外基础与临床杂志, 2004; 11(5): 393-395.
26. 严律南, 金立人, 李波, 等. 同种异体原位肝移植10例报告 [Ｊ]. 中国普外基础与临床杂志, 2000; 7(4): 231-234.
27. 徐明清, 严律南, 李波, 等. 肝移植治疗胰腺恶性β-细胞瘤肝转移一例 [Ｊ]. 中华外科杂志, 2008; 46(4): 319.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Advancement in Liver Transplantation for Hepatic Metastasis from Neuroendocrine Tumor

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