Experimental Study on Iodine-125 Interstitial Brachytherapy in Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LU Ping ¹ , YANG Yong ¹ , LI Xiaogang ² , WANG Guangsheng ² , LI Bo ² , LUO Kaiyuan ²

1.Center of Vascular Surgery, Yunnan Province and Department of Vascular Surgery, The Second People’s Hospital of Yunnan Province, Kunming 650021, China;;
2.Center of Abdominal Surgery, Yunnan Province and Department of General Surgery, The Second People’s Hospital of Yunnan Province, Kunming 650021, China;

Corresponding author：

Keywords：

Breast cancer; Iodine-125 seed; Implantation; Brachytherapy

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Objective To investigate the effect of iodine-125 on inhibiting breast cancer growth and to explore its possible mechanism.
Methods The animal model of the MCF-7 tumor was established firstly through injection of the cells into nude mice. The animals were divided into two groups before the implantation of the iodine-125 granule into the tumor mass: control group (n=40, to implant no-load seeds, non-iodine-125 radioelement) and experimental group 〔n=40, to implant iodine-125 seeds (1.48×107 Bq) when the length of tumor was 8-10 mm〕. The width and length of tumor, in order to calculate the volume, were measured every three days to observe tumor growth curve and to calculate the rate of the tumor inhibition. When the length of tumor was 15-20 mm in the control group, 30 nude mice were killed in every group to detect the weight of tumor and histopathological changes. Other ten nude mice of each group were remained to be observed the national life span and survival rate for 90 days.
Results Within 90 days, the average survival time in control group and experimental group were significantly different (56.2 d vs. 74.8 d, P＜0.05). In control group the growth curve was continuously elevated, while experimental group showed a low flat curve. With iodine-125 treatment, the tumor growth decreased in experimental group with tumor inhibition rate 55.21%. The average tumor weight in control group and experimental group was (3.26±0.39) g and (1.46±0.17) g (t′=22.8962, P＜0.05). As compared with control group, under light microscope, the number of cancer cells was less, nuclear debris increased, and cancer structure was not obvious in experimental group.
Conclusion This study suggests that iodine-125 seed may inhibit the growth of breast cancer, which may be involved in direct radiation breakdown of tumor cells or induction of apoptosis and inhabitation of tumor angiogenesis.

Citation： LU Ping,YANG Yong,LI Xiaogang,WANG Guangsheng,LI Bo,LUO Kaiyuan. Experimental Study on Iodine-125 Interstitial Brachytherapy in Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(7): 510-513. doi: Copy

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15.	陆平, 杨镛, 李晓刚, 等. 125I 对乳腺肿瘤组织缺氧诱导因子1α的作用及其机制 [J]. 中华实验外科杂志, 2008; 25(1)： 2426.
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1. 罗小燕, 郑洁如, 赵玲杰, 等. 江门市2003~2007年乳腺癌发病状况分析 [J]. 实用预防医学, 2008; 15(5)： 14801481.
2. 李广灿. 1990年全球25种主要癌症发病率评估 [J]. 中国肿瘤, 2000; 9(6)： 260262.
3. 丁敏. 乳腺癌术后单纯胸壁局部复发20例临床分析 [J]. 杭州师范学院学报(医学版), 2007; 27(4)： 225227.
4. 杨春明. 乳腺癌治疗的现代概念 [J]. 中国普外基础与临床杂志, 2008; 15(7)： 467470.
5. 周军, 魏海梁, 辛旭, 等. 乳腺癌根治术后125I 粒子组织内照射近期疗效观察 [J]. 现代肿瘤医学, 2004; 12(5)： 468469.
6. 罗开元, 李波, 杨嵘, 等. 125I 粒子组织间放射治疗恶性肿瘤的临床应用 [J]. 中华医学杂志, 2001; 81(12)： 754755.
7. 罗开元, 毛文源, 李波, 等. 125I 粒子组织间永久植入治疗恶性肿瘤的疗效观察 [J]. 中华外科杂志, 2003; 41(2)： 122124.
8. 罗开元, 赵泉, 杨镛, 等. 125I 粒子组织间植入对大肠癌的抑制作用及其机制 [J].中华实验外科杂志, 2006; 23(1)： 7071.
9. 盖宝东, 舒振波, 丁大勇, 等. 125I 放射性粒子治疗胰腺癌 [J]. 中国普外基础与临床杂志, 2007; 14(5)： 582583.
10. 葛鹏磊, 李宁. 肝癌的125I 粒子植入治疗 [J]. 中国普外基础与临床杂志, 2007; 14(6)： 726727.
11. 池捷, 王晖, 吴关慧. 碘125粒子立体种植治疗晚期肿瘤 [J]. 广州医药, 2003; 34(5)： 1516.
12. 罗开元, 郑江华, 李波, 等. 125I 粒子永久性植入组织间放射治疗肝癌 [J]. 肝胆胰外科杂志, 2004; 16(1)： 2931.
13. 高莉娜. 125I 粒子组织间永久性植入治疗乳腺恶性肿瘤 [J]. 放射免疫学杂志, 2005; 18(5)： 353354.
14. 查金顺, 张桂仙, 黄明龙, 等. 肿瘤术中125I 组织间永久植入放疗 [J]. 中国现代医学杂志, 2003; 13(14)： 1214.
15. 陆平, 杨镛, 李晓刚, 等. 125I 对乳腺肿瘤组织缺氧诱导因子1α的作用及其机制 [J]. 中华实验外科杂志, 2008; 25(1)： 2426.
16. 甄林林, 武正炎, 范萍, 等. 人乳腺癌裸鼠移植模型的建立 [J]. 南京医科大学学报, 2001; 21(6)： 509510.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Experimental Study on Iodine-125 Interstitial Brachytherapy in Breast Cancer

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