Effects of Ulinastatin on The Platelet Parameter in Patients with Acute Pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

1.The First Department of Surgery,The 421th Hospital of PLA,Guangzhou510318,China;;
2.Department of General Surgery,West China Hospital,Sichuan University,Chengdu610041,ChinaCorresponding Author：YU Yong-yang, E-mail：yuyongyang@hotmail.com;

Corresponding author：

Keywords：

Acute pancreatitis,Platelet,Ulinastatin

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Objective To investigate the change of the platelet parameter and to study the therapeutic effects of ulinastatin (UTI) on platelet parameter in patients with acute pancreatitis (AP). Methods The data of 80 patients with AP were analyzed retrospectively. All patients were divided into two groups: mild acute pancreatitis (MAP, n=43) and severe acute pancreatitis (SAP, n=37). Thirty people who took the medical examination and whose results were normal were included as control group. The autocytometer was used to test PLT, PCT, MPV and PDW in different periods of SAP. Results On admission, there were no significant differences of PLT, PCT between MAP group and control group (P gt;0.05), but MPV and PDW in MAP group were higher than those of control group (p lt;0.05). Compared with MAP group, PLT and PCT decreased markedly in SAP group (p lt;0.01), while MPV and PDW significantly increased (p lt;0.05). After 1-week treatment of UTI, PLT and PCT in MAP group didn’t change dramatically, while MPV and PDW decreased significantly (p lt;0.05). While in SAP group, PLT and PCT increased significantly (p lt;0.05, p lt;0.01), and MPV and PDW decreased significantly (p lt;0.01, p lt;0.05). Compared with conventional treatment， PLT and PCT in MAP group increased significantly in UTI treatment group （p lt;0.05）, but there was no statistical difference in terms of MPV and PDW （P gt;0.05）. However, SAP group showed significant increase of PLT and PCT （p lt;0.01， p lt;0.05） and decrease of MPV and PDW in UTI treatment group compared with patients treated by conventional methods （p lt;0.01）. Conclusion The platelet parameter changes in patients with acute pancreatitis, and the changes of SAP patients are more mark than those of MAP patients. UTI can significantly increase PLT and PCT, and significantly decrease the activity of the platelet. Therefore, UTI may take a role in the treatment and prevention for SAP.

Citation： ZHUANG Yongjing,YU Yongyang,WU Guirong,LU Liangsheng. Effects of Ulinastatin on The Platelet Parameter in Patients with Acute Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(2): 122-125. doi: Copy

1.	<><><><><><><><> [1]冯文明,鲍鹰,陈秋强,等.血小板计数和持续全身炎症反应综合征预测急性胰腺炎并发多脏器功能不全的研究[J].中国急救医学,2001; 21(2):86.
2.	王兴鹏.中国急性胰腺炎诊治指南(草案)[J].中华消化杂志,2004; 24(3):190.
3.	贾鹏辉,张肇达.急性胰腺炎早期胰腺微循环的改变[J].中国普外基础与临床杂志,2005; 12(1):92.
4.	瞿建国,张建新,程国祚.急性坏死性胰腺炎胰外器官微循环改变及乌司他丁的影响[J].中国普外基础与临床杂志,2003; 10(3):234.
5.	余文,吴伟,张少辉,等.急性胰腺炎发病机理的研究进展[J].中国普外基础与临床杂志,2006; 13(6):733.
6.	Lukaszyk A,Bodzenta-Lukaszyk A,Gabryelewicz A,et al.Blood platelet function in canine acute pancreatitis with reference to treatment with Nafamostat mesilate (FUT-175)[J].Thromb Res,1992; 65(2):229.
7.	Mimidis K,Papadopoulos V,Kotsianidis J,et al.Alterations of platelet function,number and indexes during acute pancreatitis[J].Pancreatology,2004; 4(1):22.
8.	王海勇,叶惠江,求一秋.国产乌司他丁治疗急性胰腺炎的临床疗效观察[J].中华肝胆外科杂志,2003; 9(3):137.
9.	田秉璋,李永国,杨竹林,等.高压氧和乌司他丁联合治疗急性坏死性胰腺炎的实验研究[J].中国普外基础与临床杂志,2005; 12(5):438.
10.	Zaitsu M,Hamasaki Y,Tashiro K,et al.Ulinastatin,an elastase inhibitor,inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease[J].J Infect Dis,2000; 181(3):1101.

1. <><><><><><><><> [1]冯文明,鲍鹰,陈秋强,等.血小板计数和持续全身炎症反应综合征预测急性胰腺炎并发多脏器功能不全的研究[J].中国急救医学,2001; 21(2):86.
2. 王兴鹏.中国急性胰腺炎诊治指南(草案)[J].中华消化杂志,2004; 24(3):190.
3. 贾鹏辉,张肇达.急性胰腺炎早期胰腺微循环的改变[J].中国普外基础与临床杂志,2005; 12(1):92.
4. 瞿建国,张建新,程国祚.急性坏死性胰腺炎胰外器官微循环改变及乌司他丁的影响[J].中国普外基础与临床杂志,2003; 10(3):234.
5. 余文,吴伟,张少辉,等.急性胰腺炎发病机理的研究进展[J].中国普外基础与临床杂志,2006; 13(6):733.
6. Lukaszyk A,Bodzenta-Lukaszyk A,Gabryelewicz A,et al.Blood platelet function in canine acute pancreatitis with reference to treatment with Nafamostat mesilate (FUT-175)[J].Thromb Res,1992; 65(2):229.
7. Mimidis K,Papadopoulos V,Kotsianidis J,et al.Alterations of platelet function,number and indexes during acute pancreatitis[J].Pancreatology,2004; 4(1):22.
8. 王海勇,叶惠江,求一秋.国产乌司他丁治疗急性胰腺炎的临床疗效观察[J].中华肝胆外科杂志,2003; 9(3):137.
9. 田秉璋,李永国,杨竹林,等.高压氧和乌司他丁联合治疗急性坏死性胰腺炎的实验研究[J].中国普外基础与临床杂志,2005; 12(5):438.
10. Zaitsu M,Hamasaki Y,Tashiro K,et al.Ulinastatin,an elastase inhibitor,inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease[J].J Infect Dis,2000; 181(3):1101.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effects of Ulinastatin on The Platelet Parameter in Patients with Acute Pancreatitis

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