Diagnosis and Treatment of Hepatic Focal Nodular Hyperplasia(Report of 9 Cases )_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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刘连新 ¹ , 宋宣 ¹ , 袁斌 ² , 刘冰 ¹ , 武林枫 ¹ , 姜洪池 ¹

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Keywords：

局灶性增生结节,肝脏,诊断,治疗

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目的探讨肝脏局灶性增生结节(FNH)的诊断和治疗。方法回顾性分析哈尔滨医科大学第一临床医学院1993年1月至2004年12月12年间收治并经病理检查证实的9例FNH的临床、影像学和病理学资料。
结果 FNH术前正确诊断率较低，该病多见于中、青年，多无乙型肝炎病毒感染，AFP检查正常，彩色多普勒检查多发现病灶有血管通过，CT动态扫描增强后早期有显著强化，MRI检查也有明显强化。结论 FNH在临床和影像学上均有一定特征，综合分析临床表现、实验室检查与多种影像学资料可提高正确诊断率。

Citation： 刘连新,宋宣,袁斌,刘冰,武林枫,姜洪池. Diagnosis and Treatment of Hepatic Focal Nodular Hyperplasia(Report of 9 Cases ). CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(2): 133-135. doi: Copy

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8.	Paradis V,Bièche I,Dargère D,et al.A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia[J].Gastroenterology,2003; 124(3):651.
9.	刘杰,宋彬,徐隽.肝脏局灶性病变的强化方式在其定性诊断中的价值[J].中国普外基础与临床杂志,2006; 13(4):474.
10.	Fabre A,Audet P,Vilgrain V,et al.Histologic scoring of liver biopsy in focal nodular hyperplasia with atypical presentation[J].Hepatology,2002; 35(2):414.
11.	Weimann A,Ringe B,Klempnauer J,et al.Benign liver tumors:differential diagnosis and indications for surgery[J].World J Surg,1997; 21(9):983.

1. <><><> [1]Bouyn CI,Leclere J,Raimondo G,et al.Hepatic focal nodular hyperplasia in children previously treated for a solid tumor.Incidence,risk factors,and outcome[J].Cancer,2003; 97(12):3107.
2. Scalori A,Tavani A,Gallus S,et al.Risk factors for focal nodular hyperplasia of the liver:an Italian case-control study[J].Am J Gastroenterol,2002; 97(9):2371.
3. Di Carlo I,Urrico GS,Ursino V,et al.Simultaneous occurrence of adenoma,focal nodular hyperplasia,and hemangioma of the liver:are they derived from a common origin?[J].J Gastroenterol Hepatol,2003; 18(2):227.
4. Herman P,Pugliese V,Machado MA,et al.Hepatic adenoma and focal nodular hyperplasia:differential diagnosis and treatment[J].World J Surg,2000; 24(3):372.
5. Luciani A,Kobeiter H,Maison P,et al.Focal nodular hyperplasia of the liver in men:is presentation the same in men and women?[J].Gut,2002; 50(6):877.
6. Reddy KR,Kligerman S,Levi J,et al.Benign and solid tumors of the liver:relationship to sex,age,size of tumors,and outcome[J].Am Surg,2001; 67(2):173.
7. Attal P,Vilgrain V,Brancatelli G,et al.Telangiectatic focal nodular hyperplasia:US,CT,and MR imaging findings with histopathologic correlation in 13 cases[J].Radiology,2003; 228(2):465.
8. Paradis V,Bièche I,Dargère D,et al.A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia[J].Gastroenterology,2003; 124(3):651.
9. 刘杰,宋彬,徐隽.肝脏局灶性病变的强化方式在其定性诊断中的价值[J].中国普外基础与临床杂志,2006; 13(4):474.
10. Fabre A,Audet P,Vilgrain V,et al.Histologic scoring of liver biopsy in focal nodular hyperplasia with atypical presentation[J].Hepatology,2002; 35(2):414.
11. Weimann A,Ringe B,Klempnauer J,et al.Benign liver tumors:differential diagnosis and indications for surgery[J].World J Surg,1997; 21(9):983.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Diagnosis and Treatment of Hepatic Focal Nodular Hyperplasia(Report of 9 Cases )

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