The Application of Comparative Proteomics in Study of Tumor Marker_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHENG Shunzhen , ZOU Shengquan

Department of General Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China Corresponding Author： ZOU Sheng-quan, E-mail： sqzou@tjmu.edu.cn;

Corresponding author：

Keywords：

Proteome,Proteomics,Comparative proteomics,Tumor marker

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Objective The article introduces the present status of the application of comparative proteomics in study of tumor marker. Methods This essay review the present status and advances of the application of comparative proteomics in study of tumor marker through refer considerable literatures about proteome, proteomics and tumor marker. Results Follow the study of human genome deepening; the paradox between the finiteness of genes’ number and stability of genes’ structure and the variety of the life phenomena is more conspicuous. Then, the study of proteomics was pushed to the advancing front of life science research. The application of comparative proteomics to tumor research becomes a hot spot nowadays. Conclusion Screening tumor marker via comparative proteomics is an extremely promising research.

Citation： ZHENG Shunzhen,ZOU Shengquan,.. The Application of Comparative Proteomics in Study of Tumor Marker. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(2): 147-149. doi: Copy

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1. <><><><> [1]Wasinger VC,Cordwell SJ,Cerpa-Poljak A,et al.Progress with gene-product mapping of the Mollicutes:Mycoplasma genitalium[J].Electrophoresis,1995; 16(7):1090.
2. Wilkins MR,Sanchez JC,Gooley AA,et al.Progress with pr-oteome projects:why all proteins expressed by a genome should be identified and how to do it[J].Biotechnol Genet Eng Rev,1996; 13:19.
3. 白晓苏,任伟,张素华.血清蛋白组学的最新研究以及应用现状[J].中国临床康复,2005; 9(27):150.
4. Abbott A.And now for the proteome[J].Nature,2001; 409(6822):747.
5. Fields S.Proteomics.Proteomics in genomeland[J].Science,2001; 291(5507):1221.
6. Pandey A,Mann M.Proteomics to study genes and genomes[J].Nature,2000; 405(6788):837.
7. 吴在德,吴肇汉主编.外科学[M].第6版.北京:人民卫生出版社,2003:10.
8. Zolg W.The proteomic search for diagnostic biomarkers:lost in translation?[J].Mol Cell Proteomics,2006; 5(10):1720.
9. O’Farrell PH.High resolution two-dimensional electrophoresis of proteins[J].J Biol Chem,1975; 250(10):4007.
10. Klose J.Protein mapping by combined isoelectric focusing and electrophoresis of mouse tissues.A novel approach to testing for induced point mutations in mammals[J].Humangenetik,1975; 26(3):231.
11. Tonge R,Shaw J,Middleton B,et al.Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology[J].Proteomics,2001; 1(3):377.
12. 陈波,郑建伟,王剑明,等.人胆汁蛋白质组双向电泳图谱的建立与初步分析[J].中华肝胆外科杂志,2007; 13(8):536.
13. Chen B,Dong JQ,Chen YJ,et al.Two-dimensional electrophoresis for comparative proteomic analysis of human bile[J].Hepatobiliary Pancreat Dis Int,2007; 6(4):402.
14. 毕晔,宋现让,左文述.蛋白质组学在乳腺癌研究中应用的现状与展望[J].肿瘤防治杂志,2005; 12(20):1589.
15. Gorg A,Weiss W,Dunn MJ.Current two-dimensional electrophoresis technology for proteomics[J].Proteomics,2004; 4(12):3665.
16. Wilkins MR,Williams KL,Appel RD,et al.eds.Proveome Research:New frontiers in functional genomics[M].1st ed.Berlin:Springer-Verlag Press,1997:65-91.
17. Rohner TC,Staab D,Stoeckli M.MALDI mass spectrometric imaging of biological tissue sections[J].Mech Ageing Dev,2005; 126(1):177.
18. Le Naour F.Contribution of proteomics to tumor immunology[J].Proteomics,2001; 1(10):1295.
19. He QY,Cheung YH,Leung SY,et al.Diverse proteomic alterations in gastric adenocarcinoma[J].Proteomics,2004; 4(10):3276.
20. Petricoin EF,Liotta LA.SELDI-TOF-based serum proteomic pattern diagnostics for early detection of cancer[J].Curr Opin Biotechnol,2004; 15(1):24.
21. 黄成,樊嘉,周俭,等.肝细胞癌门静脉癌栓形成相关的血清蛋白质分子标记物研究[J].中华医学杂志,2005; 85(11):781.
22. Grnborg M,Bunkenborg J,Kristiansen TZ,et al.Comprehensive proteomic analysis of human pancreatic juice[J].J Proteome Res,2004; 3(5):1042.
23. Hong SH,Misek DE,Wang H,et al.An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer[J].Cancer Res,2004; 64(15):5504.
24. Ornstein DK,Gillespie JW,Paweletz CP,et al.Proteomic analysis of laser capture microdissected human prostate cancer and in vitro prostate cell lines[J].Electrophoresis,2000; 21(11):2235.
25. Meehan KL,Holland JW,Dawkins HJ.Proteomic analysis of normal and malignant prostate tissue to identify novel proteins lost in cancer[J].Prostate,2002; 50(1):54.
26. Kong F,Nicole White C,Xiao X,et al.Using proteomic approaches to identify new biomarkers for detection and monitoring of ovarian cancer[J].Gynecol Oncol,2006; 100(2):247.
27. Moshkovskii SA,Serebryakova MV,Kuteykin-Teplyakov KB,et al.Ovarian cancer marker of 11.7 kDa detected by proteomics is a serum amyloid A1[J].Proteomics,2005; 5(14):3790.
28. 冯钜涛,刘银坤,代智,等.血清蛋白质组分析技术筛选肝癌自发抗体[J].中华肝脏病杂志,2005; 13(11):832.
29. 李萃,肖志强,章晓鹏,等.人肺鳞癌组织的血清蛋白质组学的比较分析[J].中国生物化学与分子生物学报,2005; 21(3):357.
30. 李萃,肖志强,段朝军,等.人肺腺癌组织的血清蛋白质组学分析[J].中国医师杂志,2006; 8(8):1009.
31. Sauter ER,Zhu W,Fan XJ,et al.Proteomic analysis of nipple aspirate fluid to detect biologic markers of breast cancer[J].Br J Cancer,2002; 86(9):1440.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Application of Comparative Proteomics in Study of Tumor Marker

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